- 基本信息
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导师姓名：
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张慧慧
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学科代码：
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100100
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性别：
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女
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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硕士生导师
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专业领域名称：
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联系方式：
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huizha@shsmu.edu.cn
上海市黄浦区重庆南路280号上海交通大学医学院西5号楼1004
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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huizha@shsmu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 32070885 | 系统性红斑狼疮中自身反应性CD11c+B细胞的分化途径及其调控机制研究 | 国家自然科学基金面上项目 |
2021-01~2024-12
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58万元
| 课题负责人 |
| 31600704 | 谷氧还蛋白2在B细胞发育中的作用与机制 | 国家自然科学基金青年项目 |
2017-01~2019-12
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20万元
| 课题负责人 |
| 2015 | 上海市高校特聘教授（青年）东方学者计划 | 上海市教委 |
2015-03~2018-03
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60万元
| 课题负责人 |
| 15ZR1436400 | Fc-huCD40L融合蛋白的抗肿瘤活性及其副作用的研究 | 上海市科委自然科学基金面上项目 |
2015-01~2018-12
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10万元
| 课题负责人 |
- 学术论文
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Zhao R,, Zhang Y, Li D, Huang C, Li F.
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In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation.
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Front Immunol.
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2020
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10;11:1025. doi: 10.3389/fimmu.2020.01025. eCollection 2020.
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Li M, Lazorchak A, Ouyang X,, Liu H, Arojo O, Yan L, Jin J, Han Y, Qu G, Xu X, Liu X, Zhang W, Wang Q, Liu D, Li F, Su B.
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Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation
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Cellular & Molecular Immunology
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2019
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16(9):757-769.
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Xiaobo Liu, Yingjie Zhao, Huan Shi, Yan Zhang, Xueying Yin, Mingdong Liu,, Yongning He, Boxun Lu, Tengchuan Jin & Fubin Li.
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Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumor activities through biophysical flexibility.
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Nature Communications
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2019
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4206
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Zhang W,, Liu S, Xia F, Kang Z, Zhang Y, Liu Y, Xiao H, Chen L, Huang C, Shen N, Xu H, Li F.
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Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus.
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PNAS
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2019
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116 (37) 18550-18560.
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, Du Y, Zhang X, Lu J, and Holmgren A.
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Glutaredoxin2 Reduces both Thioredoxin2 and Thioredoxin1 and Protects Cells from Apoptosis Induced by Auranofin and 4-Hydroxynonenal.
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Antioxid. Redox Signal.
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2014
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21,669-81
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Du Y,, Montano S, Hegestam J, Ekberg N, Holmgren A, Brismar K, and Ungerstedt J.
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Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes.
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Acta diabetologica
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2014
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51,225-32
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Du Y,, Zhang X, Lu J, and Holmgren A.
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Thioredoxin 1 is inactivated due to oxidation induced by peroxiredoxin under oxidative stress and reactivated by glutaredoxin system.
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J. Biol. Chem.
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2013
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288, 32241-7
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Du Y,, Lu J, and Holmgren A.
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Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.
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J. Biol. Chem.
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2012
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287, 38210-9
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Ungerstedt J, Du Y,, Nair D, and Holmgren A.
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In vivo redox state of human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).
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Free Radic. Biol. Med.
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2012
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53, 2002-7
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, and Zhong L.
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Opposing regulation of histamine-induced calcium signaling by sodium selenite and ebselen via alterations of thiol redox status.
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Eur. J. Pharmacol.
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2010
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626, 276-82
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, Cao D, Cui W, Ji M, Qian X, and Zhong L.
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Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate.
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Free Radic. Biol. Med.
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2010
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49, 2010-8
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Cao D, Zhang Y,, Zhong L, and Qian X.
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Systematic Characterization of the Covalent Interactions between (-)-Epigallocatechin Gallate and Peptides at Physiological Conditions by Mass Spectrometry.
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Rapid Commun. Mass Spectrom.
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2009
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23, 1147-57
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