• 基本信息
    导师姓名: 陈磊 学科代码: 100100
    性别: 学科名称: 基础医学
    培养单位: 基础医学院 三级学科
    导师类型: 博士生导师 专业领域名称:
    联系方式: 专业领域代码:
    邮编: 邮箱地址: lei.chen@sjtu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    2017年9月第十三批生命科学组肠道微生物对人类慢性疾病的影响海外高层次人才 2017-05~2020-12 200万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Wenyu Zhou, M. Reza Sailani, Kévin Contrepois, Yanjiao Zhou, Sara Ahadi, Shana R. Leopold, Martin J. Zhang, Varsha Rao, Monika Avina, Tejaswini Mishra, Jethro Johnson, Brittany Lee-McMullen, Songjie Chen, Ahmed A. Metwally, Thi Dong Binh Tran, Hoan Nguyen, Xin Zhou, Brandon Albright, Bo-Young Hong, Lauren Petersen, Eddy Bautista, Blake Hanson,, Daniel Spakowicz, Amir Bahmani, Denis Salins, Benjamin Leopold, Melanie Ashland, Orit Dagan-Rosenfeld, Shannon Rego, Patricia Limcaoco, Elizabeth Colbert, Candice Allister, Dalia Perelman, Colleen Craig, Eric Wei, Hassan Chaib, Daniel Hornburg, Jessilyn Dunn, Liang Liang, Sophia Miryam Schüssler-Fiorenza Rose, Kim Kukurba, Brian Piening, Hannes Rost, David Tse, Tracey McLaughlin, Erica Sodergren, George M. Weinstock & Michael Snyder   Longitudinal multi-omics of host–microbe dynamics in prediabetes  Nature  2019  2019, 569: 663-671. 
    Li QZ1, Chang YZ, He ZM,, Zhou XW.  Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in RAW264.7 cells.  Journal of Cellular Physiology  2019  (2019) 
    Jiyu Tong, Guangchao Cao, Ting Zhang, Esen Sefik, Maria Carolina Amezcua Vesely, James P Broughton, Shu Zhu, Huabin Li, Bin Li,, Howard Y Chang, Bing Su, Richard A Flavell, Hua-Bing Li1  m6A mRNA methylation sustains Treg suppressive functions  Cell Research  2018  (2018) 
    Xiaoyan Yu, Yimin Lao, Xiao-Lu Teng, Song Li, Yan Zhou, Feixiang Wang, Xinwei Guo, Siyu Deng, Yuzhou Chang, Xuefeng Wu, Zhiduo Liu,, Li-Ming Lu, Jinke Cheng, Bin Li, Bing Su, Jin Jiang, Hua-Bing Li, Chuanxin Huang, Jing Yi,Qiang   SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation  Nature Communications  2018  2018, 9(1) 
    Qian Chen, Yiping Ren, Jihong Lu, Mark Bartlett,, Yan Zhang, Xiaokui Guo, Chang Liu  A Novel Prebiotic Blend Product Prevents Irritable Bowel Syndrome in Mice by Improving Gut Microbiota and Modulating Immune Response  Nutrients  2017  2017, 9(12). 
    Staudová B, Strouhal M, Zobaníková M, Cejková D, Fulton LL,, Giacani L, Centurion-Lara A, Bruisten SM, Sodergren E, Weinstock GM, Smajs D  Whole genome sequence of the Treponema pallidum subsp. endemicum strain Bosnia A: the genome is related to yaws treponemes but contains few loci similar to syphilis treponemes.   PLoS Negl Trop Dis  2014  Nov 6,8(11):e3261 
    Zhou Y, Burnham CA, Hink T,, Shaikh N, Wollam A, Sodergren E, Weinstock GM, Tarr PI, Dubberke ER Devin P; Martin, John C; Chen, Lei; Mitreva, Makedonka; Miller, Jason R; Haub, Kevin V; Dooling, David J; Mardis, Elaine R; Wilson, Richard K; Weinstock, George M; Warren, Wesley C , (*)  Phenotypic and genotypic analysis of Clostridium difficile isolates: a single-center study.  Clin Microbiol  2014  Dec,52(12):4260-6 
    Chen K,, Fan X, Wallis J, Ding L, Weinstock G.  TIGRA: a targeted iterative graph routing assembler for breakpoint assembly. Genome Res  Genome Res  2014  Feb,24(2):310-7 
    Zhou, Yanjiao ; Burnham, Carey-Ann D; Hink,, Lei; Shaikh, Nurmohammad; Wollam, Aye; Sodergren, Erica; Weinstock, George M; Tarr,Phillip I; Dubberke, Erik R  Phenotypic and genotypic analysis of Clostridium difficile isolates: a single-center study.  J Clin Microbiol  2014  52(12): 4260~4266 
    Cejková D, Zobaníková M,, Pospí?ilová P, Strouhal M, Qin X, Mikalová L, Norris SJ, Muzny DM, Gibbs RA, Fulton LL, Sodergren E, Weinstock GM, Smajs D.  Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence.  PLoS Negl Trop Dis  2012  Jan,6(1):e1471 
    e L, Hillier LW, Minx P, Thane N, Locke DP, Martin JC,, Mitreva M, Miller JR, Haub KV, Dooling DJ, Mardis ER, Wilson RK, Weinstock GM, Warren WC.  A vertebrate case study of the quality of assemblies derived from next-generation sequences  Genome Biol  2011  12(3):R31 
    Nelson, Karen E ; Weinstock, George M; Highlander, Sarah K; Worley,Kim C; Creasy, Heather Huot; Wortman, Jennifer Russo; Rusch, Douglas B;Mitreva, Makedonka; Sodergren, Erica; Chinwalla, Asif T; Feldgarden, Michael;Gevers, Dirk; Haas, Brian J; Madupu, Ramana; Ward, Doyle V; Birren, Bruce W;Gibbs, Richard A; Methe, Barbara; Petrosino, Joseph F; Strausberg, Robert L;Sutton, Granger G; White, Owen R; Wilson, Richard K; Durkin, Scott; Giglio,Michelle Gwinn; Gujja, Sharvari; Howarth, Clint; Kodira, Chinnappa D; Kyrpides,Nikos; Mehta, Teena; Muzny, Donna M; Pearson, Matthew; Pepin, Kymberlie; Pati,Amrita; Qin, Xiang; Yandava, Chandri; Zeng, Qiandong; Zhang, Lan; Berlin,,Lei; Hepburn, Theresa A; Johnson, Justin; McCorrison, Jamison;Miller, Jason; Minx, Pat; Nusbaum, Chad; Russ, Carsten; Sykes, Sean M;Tomlinson, Chad M; Young, Sarah; Warren, Wesley C; Badger, Jonathan; Crabtree,Jonathan; Markowitz, Victor M; Orvis, Joshua; Cree, Andrew; Ferriera, Steve;Fulton, Lucinda L; Fulton, Robert S; Gillis, Marcus; Hemphill, Lisa D; Joshi,Vandita; Kovar, Christie; Torralba, Manolito; Wetterstrand, Kris A;Abouellleil, Amr; Wollam, Aye M; Buhay, Christian J; Ding, Yan; Dugan, Shannon;FitzGerald, Michael G; Holder, Mike; Hostetler, Jessica; Clifton, Sandra W;Allen-Vercoe, Emma; Earl, Ashlee M; Farmer, Candace N; Liolios, Konstantinos;Surette, Michael G; Xu, Qiang; Pohl, Craig; Wilczek-Boney, Katarzyna; Zhu,Dianhui  A catalog of reference genomes from the human microbiome.  Scienc  2010  328(5981): 994~999  
    Ding L, Ellis MJ, Li S, Larson DE, Chen K, Wallis JW, Harris CC, McLellan MD, Fulton RS, Fulton LL, Abbott RM, Hoog J, Dooling DJ, Koboldt DC, Schmidt H, Kalicki J, Zhang Q,, Lin L, Wendl MC, McMichael JF, Magrini VJ, Cook L, McGrath SD, Vickery TL, Appelbaum E, Deschryver K, Davies S, Guli T, Lin L, Crowder R, Tao Y, Snider JE, Smith SM, Dukes AF, Sanderson GE, Pohl CS, Delehaunty KD, Fronick CC, Pape KA, Reed JS, Robinson JS, Hodges JS, Schierding W, Dees ND, Shen D, Locke DP, Wiechert ME, Eldred JM, Peck JB, Oberkfell BJ, Lolofie JT, Du F, Hawkins AE, OLaughlin MD, Bernard KE, Cunningham M, Elliott G, Mason MD, Thompson DM Jr, Ivanovich JL, Goodfellow PJ, Perou CM, Weinstock GM, Aft R, Watson M, Ley TJ, Wilson RK, Mardis ER.   Genome remodelling in a basal-like breast cancer metastasis and xenograft  Nature  2010  Apr 15,464(7291):999-1005.