学科/专业 研究方向 科研项目 代表性论文 科研获奖 专利授权
2017-09~2020-09，国家高层次人才计划
，国家高层次人才计划，课题负责人 2017-01~2019-12，上海交通大学
，新进青年教师启动计划，课题负责人 2017-01~2020-12，国自然面上项目
，泛素缀合酶Ubc13在树突状细胞中的免疫调控功能及机制研究，课题负责人
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. ，Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. ，Cancer Cell，2017，32(6):824-839.e8. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem C, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. ，PI3Kγ is a molecular switch that controls immune suppression，Nature，2016，539(7629):437-442. Wu X, M Karin.，Emerging roles of Lys63-linked polyubiquitylation in immune responses.，Immunol Rev.，2015，266(1):161-74. Wu X, W Zhang, J Font-Burgada, T Palmer, AS Hamil, SK Biswas, M Poidinger, N Borcherding, Q Xie, LG Ellies, N Lytle, LW Wu, J Yang, SF Dowdy, T Reya, M Karin.，Ubiquitin-conjugating Enzyme Ubc13 Controls Breast Cancer Metastasis through a TAK1-p38 MAP Kinase Cascade.，PNAS，2014，111(38): 13870-5. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M.，Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice .，J Clin Invest.，2013，123(5):2231-43. Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M.，A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1 .，Cancer Cell，2013，23(5):647-59. Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC.，Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion effector-like T cells .，Nat Immunol.，2012，13: 481-490. Hu H*, Wu X*, Jin W, Chang M, Cheng X and Sun S-C.，Noncanonical NF-κB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development .，PNAS，2011，108(31):12827-32. Xu G, Y-C Lo, Q Li, G Napolitano, Wu X, X Jiang, Karin M and Wu H.，Crystal structure of the inhibitor of κB kinase β (IKKβ).，Nature，2011，472 (7343):325-30. Wu X*, Zhang M* and Sun S-C.，Mutual regulation between deubiquitinase CYLD and Retroviral Oncoprotein Tax .，Cell and Bioscience，2011，1(1):27. Lee A*, Wu X*, H Cheng, X Zhou, X Cheng, and S-C Sun.，CARMA1 regulation of Treg development involves modulation of IL-2 receptor signaling .，J. Biol Chem. ，2010，285(21): 15696-703. Wu X, M Yamamoto, S Akira, and S-C Sun.，Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13 .，PNAS，2009，106 (49): 20836-41. Zhang M*, Wu X*, AJ Lee, W Jin, M Chang, A Wright, T Imaizumi, and S-C Sun. ，Regulation of IKK-related kinases and antiviral responses by tumor suppressor CYLD .，J Biol Chem.，2008，283(27): 8621-6. Wu X, S-C Sun.，Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating Tak1-IKK physical association .，EMBO Rep.，2007，8(5): 510-5.
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