研究生导师

Mechanisms of Broadly Neutralizing Antibody Generation

2026-01~2029-12，国家自然科学基金面上项目 ，抗体亲和力成熟中抗体基因串联突变发生与免疫选择的机制研究，课题负责人

2023-12~2027-11，上海交通大学“2030计划”B类项目 ，下一代抗体人源化小鼠模型构建与共性技术研究，课题负责人

2021-12~2026-11，国家重点研发计划 ，呼吸道病毒感染免疫应答的全景研究，课题参与人

2018-01~2020-12，国家自然科学基金委员会-青年科学基金项目(B类) ，B 淋巴细胞抗体多样化及抗病毒中和抗体进化，课题负责人

2018-01~2020-12，国家高层次人才计划 ，国家高层次人才计划，2017年，基础医学，课题负责人

2018-01~2020-12，国家自然科学基金委员会-国际合作中意项目 ，DNA脱氨酶AID在慢性淋巴性白血病发展中的病理机制研究，课题负责人

2017-01~2020-01，国家自然科学基金委员会-面上项目 ，广谱中和抗病毒抗体基因片段缺失的分子机制研究，课题负责人

You L.#, Zhang L.N.#, Ouyang S.Q.#, Gao B., Li Y.N., Li J.L., Wu N.B., Wang H., Sun S.Q., Li J.F., Yin Z., Xu Z.Y., Chen Y., Zhu Y.W., Zhang S.Y., Xu Z., Zhang T.Y., Liu Z.Y., Huang C.X., Li B., Qu J.M. *, Su B. *, Yeap L.S.* （叶菱秀），Multiple infections with omicron variants increase breadth and potency of omicron-specific neutralizing antibodies，Cell Discov，2025，11(1):49

Wang Y.Y., Meng F.L.*，Yeap L.S. *（叶菱秀），DNA flexibility can shape the preferential hypermutation of antibody genes，Trends Immunol，2024，45(3):167-176

Huang M.E.#, Qin Y.N.#, Shang Y.F.#, Hao Q., Zhan C.Z., Lian C.Y., Luo S.M., Liu L.D., Zhang S.X., Zhang Y., Wo Y., Li N., Wu S.H., Gui T.T., Wang B.B., Luo Y.F., Cai Y.N., Liu X.J.,Xu Z.Y., Dai P.F., Li S.M., Zhang L., Dong J.C., Wang J., Zheng X.Q., Xu Y.J., Sun Y.H., Wu W., Yeap L.S. *（叶菱秀）, Meng F.L.*，C-to-G editing generates double-strand breaks causing deletion, transversion and translocation，Nat Cell Biol，2024，26(2):294-304

Hao Q., Li J.F., Yeap L.S. （叶菱秀），Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation，Sci China Life Sci，2024，67(11):2344-2353

Wang Y.Y., Zhang S.X., Yang X.R., Hwang J.K., Zhan C.Z., Lian C.Y., Wang C., Gui T.T., Wang B.B., Xie X., Dai P.F., Zhang L., Tian Y., Zhang H.Z., Han C., Cai Y.N., Hao H., Ye X.F., Liu X.J., Liu J.Q., Cao Z.W., Huang S.H., Song J., Pan-Hammarstr?m Q., Zhao Y.F., Alt F.W., Zheng X.Q., Da L.T., Yeap L.S. *（叶菱秀）, Meng F.L*，Mesoscale dna feature in antibody-coding sequence facilitates somatic hypermutation，Cell，2023，186(10): 2193-2207.e19

Hao Q.#, Zhan C.Z.#, Lian C.Y., Luo S.M., Cao W.Y., Wang B.B, Xie X., Ye X.F., Gui T.T., Voena C., Pighi C., Wang Y.Y., Tian Y., Wang X., Dai P.F., Cai Y.N., Liu X.J., Ouyang S.Q., Sun S.Q., Hu Q.W., Liu J., Ye Y.Q., Zhao J.K., Lu A., Wang J.Y., Huang C.X., Su B., Meng F.L., Chiarle R.*, Pan-Hammarstr?m Q.*, Yeap L.S.* （叶菱秀），DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification，Sci Immunol，2023，8(81): eade1167

Wang Y.Y.#, Zhang S.X.#, Zheng X.Q., Yeap L.S. *（叶菱秀）, Meng F.L.*，A high-throughput protocol for deamination of long single-stranded DNA and oligo pools containing complex sequences，STAR Protoc，2023，4(4):102602

Gao B.#, He L.H.#, Bao Y.J.#, Chen Y.Y.#, Lu G.Z., Zhang Y., Xu Y.J., Su B., Xu J.*, Wang Y. *, Yeap L.S.* （叶菱秀），Repeated Vaccination of Inactivated SARS-CoV-2 Vaccine Dampens Neutralizing Antibodies Against Omicron Variants in Breakthrough Infection，Cell Res，2023，33(3): 258-261

Feng A.Q, Hao Q.*, Yeap L.S.* （叶菱秀），Contribution of rare mutational outcomes to broadly neutralizing antibodies，Acta Biochim Biophys Sin (Shanghai)，2022，54(6): 820-827

Tian Y.#, Lian C.Y.#, Chen Y.Y.#, Wei D., Zhang X.X., Ling Y. *, Wang Y. *, Yeap L.S.* （叶菱秀），Sensitivity and specificity of SARS-CoV-2 S1 subunit in COVID-19 serology assays，Cell Discov，2020，0.302083

Liu L.D., Lian C.Y., Yeap, L.S.*（叶菱秀）, Meng F.L.*，The development of neutralizing antibodies against SARS-CoV-2 and their common features，J Mol Cell Biol，2020，12(12): 980-986

Yeap, L.S.* （叶菱秀）, Meng F.L.*，Cis- and trans-factors affecting AID targeting and mutagenic outcomes in antibody diversification，Adv Immunol，2019，141: 51-103

Hwang J.K., Wang C., Du Z., Meyers R.M., Kepler T.B., Neuberg D., Kwong P.D., Mascola J.R., Gordon Joyce M., Bonsignori M., Haynes B.F., Yeap L.S.*（叶菱秀）, Alt F.W.* ，Sequence Intrinsic Somatic Mutation Mechanisms Contribute to Affinity Maturation of VRC01-class HIV-1 Broadly Neutralizing Antibodies，PNAS，2017，114(32): 8614-8619

Hwang J.K.#, Alt F.W., Yeap L.S.#（叶菱秀），Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.，Microbiol Spectr，2015，3(1):MDNA3-0037-2014

Yeap L.S.# （叶菱秀）, Hwang J.K.#, Du Z., Meyers R.M., Meng F.L., Jakubauskaite, A., Liu M., Mani V., Neuberg D., Kepler T.B., Wang, J.H., Alt F.W，Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes.，Cell，2015，163 (5): 1124-37

Yeap L.S. （叶菱秀）, Hayashi K., Surani M.A，ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage.，Epigenetics Chromatin，2009，2(1): 12-12