张慧慧
性 别：女 联系电话： 邮箱地址：huizha@shsmu.edu.cn 培养单位：基础医学院
学科/专业 研究方向 科研项目 代表性论文 科研获奖 专利授权
2021-01~2024-12，国家自然科学基金面上项目
，系统性红斑狼疮中自身反应性CD11c+B细胞的分化途径及其调控机制研究，课题负责人 2017-01~2019-12，国家自然科学基金青年项目
，谷氧还蛋白2在B细胞发育中的作用与机制，课题负责人 2015-03~2018-03，上海市教委
，上海市高校特聘教授（青年）东方学者计划，课题负责人 2015-01~2018-12，上海市科委自然科学基金面上项目
，Fc-huCD40L融合蛋白的抗肿瘤活性及其副作用的研究，课题负责人
Zhao R, Zhang H, Zhang Y, Li D, Huang C, Li F.，In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation.，Front Immunol.，2020，10;11:1025. doi: 10.3389/fimmu.2020.01025. eCollection 2020. Li M, Lazorchak A, Ouyang X, Zhang H, Liu H, Arojo O, Yan L, Jin J, Han Y, Qu G, Xu X, Liu X, Zhang W, Wang Q, Liu D, Li F, Su B.，Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation，Cellular and Molecular Immunology，2019，16(9):757-769. Zhang W, Zhang H, Liu S, Xia F, Kang Z, Zhang Y, Liu Y, Xiao H, Chen L, Huang C, Shen N, Xu H, Li F.，Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus.，PNAS，2019，116 (37) 18550-18560. Xiaobo Liu, Yingjie Zhao, Huan Shi, Yan Zhang, Xueying Yin, Mingdong Liu, Huihui Zhang, Yongning He, Boxun Lu, Tengchuan Jin and Fubin Li.，Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumor activities through biophysical flexibility.，Nature Communications，2019，4206 Du Y, Zhang H, Montano S, Hegestam J, Ekberg N, Holmgren A, Brismar K, and Ungerstedt J.，Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes.，Acta diabetologica，2014，51,225-32 Zhang H, Du Y, Zhang X, Lu J, and Holmgren A.，Glutaredoxin2 Reduces both Thioredoxin2 and Thioredoxin1 and Protects Cells from Apoptosis Induced by Auranofin and 4-Hydroxynonenal.，Antioxid. Redox Signal.，2014，21,669-81 Du Y, Zhang H, Zhang X, Lu J, and Holmgren A. ，Thioredoxin 1 is inactivated due to oxidation induced by peroxiredoxin under oxidative stress and reactivated by glutaredoxin system.，J. Biol. Chem.，2013，288, 32241-7 Ungerstedt J, Du Y, Zhang H, Nair D, and Holmgren A.，In vivo redox state of human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).，Free Radic. Biol. Med.，2012，53, 2002-7 Du Y, Zhang H, Lu J, and Holmgren A.，Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.，J. Biol. Chem.，2012，287, 38210-9 Zhang H, and Zhong L.，Opposing regulation of histamine-induced calcium signaling by sodium selenite and ebselen via alterations of thiol redox status.，Eur. J. Pharmacol.，2010，626, 276-82 Zhang H, Cao D, Cui W, Ji M, Qian X, and Zhong L.，Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate.，Free Radic. Biol. Med. ，2010，49, 2010-8 Cao D, Zhang Y, Zhang H, Zhong L, and Qian X.，Systematic Characterization of the Covalent Interactions between (-)-Epigallocatechin Gallate and Peptides at Physiological Conditions by Mass Spectrometry.，Rapid Commun. Mass Spectrom.，2009，23, 1147-57
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