研究生导师

自身免疫病发病机制及免疫调节

2019-01~2022-12，国家自然科学基金 ，前列腺素E2经MEKK2信号通路对Tfh细胞分化的调控作用及其在类风湿关节炎中的致病机制研究，课题负责人

2017-01~2019-12，上海市卫生和计划生育委员会 ，人源化抗-CD277抗体对类风湿关节炎中Th17/Treg亚群的调控作用研究，课题负责人

2015-01~2017-12，上海交通大学医工交叉项目 ，MEKK2对炎症性肠病的作用机制及其肠道菌群诊断芯片的研究，课题负责人

2014-01~2016-12，上海市教育委员会 ，MEKK2/3对Th17细胞IL-21信号通路的影响及其在类风湿关节炎中作用，课题负责人

2014-01~2016-12，国家自然科学基金 ，MEKK2/3对类风湿关节炎Th17细胞中IL-21信号通路的影响和作用机制研究，课题负责人

2013-01~2015-12，上海市卫生局 ，类风湿关节炎中诱导Tfh向Treg分化的可塑性机制研究，课题负责人

2012-10~2015-09，上海市科委 ，Tfh向Treg分化的可塑性及其在类风湿关节炎中的调控作用，课题负责人

Guo C, Wu N, Niu X, Wu Y, Chen D, Guo W.，Comparison of T Helper Cell Patterns in Primary Open-Angle Glaucoma and Normal-Pressure Glaucoma.，Med Sci Monit.，2018，24:1988-1996

Song J, Liu H, Zhu Q, Miao Y, Wang F, Yang F, Cheng W, Xi Y, Niu X, He D, Chen G.，T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-κB.，Biomed Res Int.，2018，2018:4901591

Xu D, Yao M, Wang Y, Yuan L, Hoeck JD, Yu J, Liu L, Yeap YYC, Zhang W, Zhang F, Feng Y, Ma T, Wang Y, Ng DCH, Niu X, Su B, Behrens A, Xu Z.，MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.，PLoS Biol.，2018，16(12):e2006613

Zhao Q, Cheng W, Xi Y, Cao Z, Xu Y, Wu T, Li C, Niu X, Chen G.，IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis，Mol Immunol. ，2018，93:20-30

Niu X, Deng S, Li S, Xi Y, Li C, Wang L, He D, Wang Z, Chen G.，Therapeutic effect of ergotope peptides on CIA by down-regulation of inflammatory and Th1/Th17 responses and induction of regulatory T cells.，Mol Med. ，2016，22:608-620

Zhou L, Cao T, Wang Y, Yao H, Du G, Chen G, Niu X, Tang G. ，Frequently Increased but Functionally Impaired CD4+CD25+ Regulatory T Cells in Patients with Oral Lichen Planus. ，Inflammation.，2016，39(3):1205-15

Xu Y, Zhu Q, Song J, Liu H, Miao Y, Yang F, Wang F, Cheng W, Xi Y, Niu X, He D, Chen G. ，Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis.，Mediators Inflamm.，2015，2015:356040

Li C, Xi Y, Li S, Zhao Q, Cheng W, Wang Z, Zhong J, Niu X, Chen G.，Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation.，Mol Immunol.，2015，67(2 Pt B):444-54

Cheng W, Zhao Q, Xi Y, Li C, Xu Y, Wang L, Niu X, Wang Z, Chen G.，IFN-β inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis.，Mol Immunol. ，2015，64(1):152-62

Niu X, Chen G.，Clinical biomarkers and pathogenic-related cytokines in rheumatoid arthritis.，J Immunol Res.，2014，2014:698192

Xiaoyin Niu, Guangjie Chen.，IL-21 and Related Diseases.，J Clin Cell Immunol.，2013，2013:1-008

Shan Li, Xiaoyin Niu, Yebin Xi, Shaohua Deng, Chengzhen Li, Qing Zhao, Guangjie Chen.，T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis.，Clinical and Developmental Immunology.，2013，2013:967301

Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, Watowich SS, Dong C. ，The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. ，Nat Immunol.，2013，14(7):732-40

Tong Z, Yang XO, Yan H, Liu W, Niu X, Shi Y, Fang W, Xiong B, Wan Y, Dong C.，A protective role by interleukin-17F in colon tumorigenesis.，PLoS One. ，2012，7(4):e34959

Niu X, He D, Deng S, Li W, Xi Y, Xie C, Jiang T, Zhang JZ, Dong C, Chen G.，Regulatory immune responses induced by IL-1 receptor antagonist in rheumatoid arthritis. ，Mol Immunol.，2011，49(1-2):290-6

Deng S, Xi Y, Wang H, Hao J, Niu X, Li W, Tao Y, Chen G.，Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis.，Cell Immunol.，2010，265(2):105-10

Niu X, He D, Zhang X, Yue T, Li N, Zhang JZ, Dong C, Chen G.，IL-21 regulates Th17 cells in rheumatoid arthritis.，Hum Immunol.，2010，71(4):334-41

Chen G, Zhang X, Li R, Fang L, Niu X, Zheng Y, He D, Xu R, Zhang JZ.，Role of osteopontin in synovial Th17 differentiation in rheumatoid arthritis. ，Arthritis Rheum.，2010，62(10):2900-8

Deng S, Xi Y, Wang H, Hao J, Niu X, Li W, Tao Y, Chen G.，Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis. ，Cell Immunol.，2010，265(2):105-10

Chen M, Chen G, Nie H, Zhang X, Niu X, Zang YC, Skinner SM, Zhang JZ, Killian JM, Hong J. ，Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS. ，Eur J Immunol. ，2009，39(9):2525-36