研究生导师

王静

性别：女
联系电话：
邮箱地址：jingwang@shsmu.edu.cn
培养单位：基础医学院

学科/专业
研究方向
科研项目
代表性论文
科研获奖
专利授权

Xinqi Fan#; Yingjun Zhou#; Wenjuan Bai#; Xue Li; Liyuan Lin; Huibin Lin; Ming Yang; Xiaofei Yu; Jing Wang; Liang Lin; Wei Wang ，Intravital Imaging of Translocated Bacteria via Fluorogenic Labeling of Gut Microbiota In Situ，Proceedings of the National Academy of Sciences，2025，122(13): e2415845122
Jin Wang#, Wenying Zhao#, Wenjuan Bai#, Dong Dong, Hui Wang, Xin Qi, Ajitha Thanabalasuriar, Youqiong Ye, Tian-le Xu, Hecheng Li, Paul Kubes, Bin Li,*and Jing Wang*，PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung，The Journal of Clinical Investigation，2025，135(11):e183796
Kulle A#, Li Z#, Kwak A, Mancini M, Young D, Avizonis D, Groleau M, Baglole CJ, Behr MA, King IL, Divangahi M, Langais D, Wang J, Blagih J, Penz E, Dufour A, Thanabalasuriar A*， Alveolar macrophage function is impaired following inhalation of berry e-cigarette vapor，Proc Natl Acad Sci U S A，2024，121(40):e2406294121
Ding T#, Wang Y#, Meng Y, Wu E, Shao Q, Lin S, Yu Y, Qian J, He Q, Zhang J*, Wang J*,Kohane DS*, Zhan C*，Reciprocal interaction with neutrophils facilitates cutaneous accumulation of liposomes，ACS Nano，2024，18(28):18769-18784
Du X, Ren B, Li C, Li Q, Kan S, Wang X, Bai W, Wu C, Kassegne K, Yan H, Niu X, Yan M, Xu W, Wassmer S, Wang J*, Cheng G*, Wang Z*，PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury，Nat Commun，2024，15(1):881
Kang H#, Liu L#, Wang Y, Bai W, Luo Y*, Wang J*，Neutrophil-macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome，Cell Mol Immunol.，2024，21(7):689-706
He J, Cao Y, Zhu Q, Wang X, Cheng G, Wang Q, He R, Lu H, Weng Y, Mao G, Bao Y, Wang J, Liu X, Han F, Shi P, Shen XZ，Renal macrophages monitor and remove particles from urine to prevent tubule obstruction， Immunity，2024，57(1):106-123
Wang Y#, Wang J#, Zhang J#, Wang Y, Wang Y, Kang H, Zhao W, Bai W, Miao N, Wang J，Stiffness sensing via Piezo1 enhances macrophages efferocytosis and promotes resolution of liver fibrosis，Sci. Adv.，2024，10(23): eadj3289
Wu X, Zhao X, Li F, Wang Y, Ou Y, Zhang H, Li X, Wu X, Wang L, Li M, Zhang Y, Liu J, Xing M, Liu H, Tan Y, Wang Y, Xie Y, Zhang H, Luo Y, Li H, Wang J, Sun L, Li Y, Zhang H*，MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome，Cell Mol Immunol.，2024，21(11):1309-1321
Guo W#, Li Z#, Anagnostopoulos G, Kong WT, Zhang S, Chakarov S, Shin A, Qian J, Zhu Y, Bai W, Cexus O, Nie B, Wang J, Hu X, Blériot C, Liu Z, Shen B, Venteclef N, Su B*, Ginhoux F*，Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease，Immunity，2024，57(10):2310-2327.e6
Miao N, Wang J*，New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease，Cell Mol Immunol.，2024，21(1): 95-96
He H, Yang W, Su N, Zhang C, Dai J, Han F, Singhal M, Bai W, Zhu X, Zhu J, Liu Z, Xia W, Liu X, Zhang C, Jiang K, Huang W, Chen D, Wang Z, He X, Kirchhoff F, Li Z, Liu C, Huan J, Wang X, Wei W, Wang J, Augustin HG, Hu J，Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury，J Exp Med.，2023，220(2):e20211422
Zhao X, Li L, Sun H, Jiang X, Bai W, Wu N, Wang J, Su B，A novel reporter mouse line for studying alveolar macrophages，Sci China Life Sci.，2023，66(11):2527-2542
Wang J, Dong D, Zhao W, Wang J*，Intravital microscopy visualizes innate immune crosstalk and function in tissue microenvironment，Eur J Immunol，2023，54(1):e2350458
Wang YN, Wang YY, Wang J, Bai WJ, Miao NJ, Wang J*，Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response，J Immunother Cancer.，2023，11(8):e007253
Miao N, Wang Z, Wang Q, Xie H, Yang N, Wan Y, Wang J, Kang H, Bai W, Wang Y, He R, Yan K, Wang Y, Hu Q, Liu Z, Li F, Wang F, Ginhoux F, Zhang X, Yin J*, Lu L*, Wang J*，Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus，Nat Commun.，2023，14(1):872
Xu Y, Wang J, Ren H, Dai H, Zhou Y, Ren X, Wang Y, Feng S, Deng X, Wu J, Fu T, Nie T, He H, Wei T, Zhu B, Hui L, Li B, Wang J, Wang H, Chen L, Shi X, Cheng X. ，Human Endoderm Stem Cells Reverse Inflammation-Related Acute Liver Failure through Cystatin SN-Mediated Inhibition of Interferon Signaling，Cell Research，2023，33(2):147-164
Huang D, Zhang C, Xiao M, Li X, Chen W, Jiang Y, Yuan Y, Zhang Y, Zou Y, Deng L, Wang Y, Sun Y, Dong W, Zhang Z, Xie L, Yu Z, Chen C, Liu L, Wang J, Yang Y, Yang J, Zhao Y, Zheng J，Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells，Proc Natl Acad Sci U S A.，2023，120(13):e2210796120
Yang M, Jiang H, Ding C, Zhang L, Ding N, Li G, Zhang F, Wang J, Deng L, Liu J, Xu Y，STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion，Immunity，2023，56(5):1013-1026
An H, Qian C, Huang Y, Li J, Tian X, Feng J, Hu J, Fang Y, Jiao F, Zeng Y, Huang X, Meng X, Liu X, Lin X, Zeng Z, Guilliams M, Beschin A, Chen Y, Wu Y, Wang J, Oggioni MR, Leong J, Veening JW, Deng H, Zhang R, Wang H, Wu J, Cui Y, Zhang JR. ，Functional Vulnerability of Liver Microphages to Capsules Defines the Outcomes of Bacterial Septic Infections，J Exp Med.，2022，219(4):e20212032
Wang Y, Wang J*，Intravital Imaging of Inflammatory Response in liver Disease，Front Cell Dev Biol.，2022，10:922041
Wang C, Zhang L, Sun Z, Yuan X, Wu B, Cen J, Cui L, Zhang K, Li C, Wu J, Shu Y, Sun W, Wang J, Hui L*，Dedifferentiation-associated inflammatory factors of long-term expanded human hepatocytes exacerbate their elimination by macrophages during liver engraftment，Hepatology ，2022，76(6):1690-1705
Li D, Xiong W, Wang Y, Feng J, He Y, Du J, Wang J, Yang M, Zeng H, Yang Y, Wu N, Chen S*, Dong Z* ，SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors，Sci Immunol.，2022，7(67)
Yu Y, Wang RR, Miao NJ, Tang JJ Zhang YW, Lu XR, Yan PY, Wang J, Jia XM.，PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow，Nat Commun. ，2022，13(1):6857
Li G, Wang M, Ding T, Wang J, Chen T, Shao Q, Jiang K, Wang L, Yu Y, Pan F, Wang B, Wei X*, Qian J*, Zhan C，cRGD enables rapid phagocytosis of liposomal vancomycin for intracellular bacterial clearance，Journal of controlled release，2022，344:202-213
Wang Q, Zhu T, Miao N, Qu Y, Wang Z, Chao Y, Wang J, Wu W, Xu X, Xu C, Xia L, Wang F，Disulfiram bolsters T-cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling，EMBO J. ，2022，e110636
Jia J, Wang M, Meng J, Ma Y, Wang Y, Miao N, Teng J, Zhu D, Shi H, Sun Y, Liu H, Cheng X, Su Y, Ye J, Chi H, Liu T, Zhou Z, Wan L, Chen X, Wang F, Zhang H, Ben J*, Wang J*, Yang C*, Hu Q*.，Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset Still’s disease pathogenesis， Nat Commun.，2022，13(1):6804
Wang J, Wang J*，Neutrophils, functions beyond host defense，Cell Immunol. ，2022，379:104579
Zhao D, Yang F, Wang Y, Li S, Li Y, Hou F, Yang W, Liu D, Tao Y, Li Q, Wang J*, He F*, Tang L*，ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection， J Clin Invest. ，2021，e150489
Wang H, Ding T, Guan J, Liu X, Wang J, Jin P, Hou S, Lu W, Qian J, Wang W, and Zhan C*，Interrogation of folic acid-functionalized nanomedicines: The regulatory roles of plasma proteins reexamined，ACS Nano，2020，14:14779-14789
Yang X, Cheng X, Tang Y, Qiu X, Wang Z, Fu G, Wu J, Kang H, Wang J, Wang H, Chen F, Xiao X, Billiar T, Lu B*，The role of type 1 interferons in Gram-negative bacteria-induced coagulation，Blood ，2020，135 (14):1087-1100
Bartneck M, Wang J，Therapeutic Targeting of Neutrophil Granulocytes in Inflammatory Liver Disease，Front. Immunol，2019，1.984028
Wang J，Neutrophils in tissue injury and repair，Cell Tissue Res，2018，371(3):531-539
Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P，Visualizing the Function and Fate of Neutrophils in Sterile Injury and Repair.，Science，2017，358(6359): 111-116
Thanabalasuriar A, Neupane AS, Wang J, Krummel MF, Kubes P，iNKT cell emigration out of the lung vasculature requires neutrophils and monocyte-derived dendritic cells in inflammation.，Cell Reports，2016，16(12): 3260-72
Wang J, Kubes P，A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair.，Cell，2016，165(3): 668-78
Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong C, Petri B, Ransohoff R, Charo I, Jenne C, Kubes P，A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury，The Journal of Experimental Medicine，2015，212(4): 447-56
Kishida K, Kohyama M, Kurashima Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H，Negative regulation of DSS-induced experimental colitis by PILRa，International Immunology，2015，27(6): 307-14
Slaba I, Wang J, Kolaczkowska E, McDonald B, Lee WY, Kubes P，.Imaging the Dynamic Platelet-Neutrophil Response in Sterile Liver Injury and Repair in Mice，Hepatology，2015，62(5): 1590-605
Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA，Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.，The Journal of Experimental Medicine，2015，212(4): 447-56
Kuroki K, Wang J, Ose T, Yamaguchi M, Tabata S, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K，Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRa，Proceedings of the National Academy of Sciences，2014，111(24): 8877-82
Wang J, Arase H.，Regulation of immune response by neutrophils，Annals of the New York Academy of Sciences，2014，1319: 66-81
Wang J, Shiratorri I, Uehori J, Ikawa M, Arase H，Neutrophil infiltration during inflammation is regulated by PILRa via modulation of integrin activation，Nature Immunology，2013，14: 34-40
Kogure A, Shiratori I, Wang J, Lanier LL, Arase H，PANP is a novel O-glycosylated PILRa ligand expressed in neural tissues，Biochemical and Biophysical Research Communications，2011，405: 428-33
Arii J, Wang J, Morimoto T, Suenaga T, Akashi H, Arase H, Kawaguchi Y，A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor (PILRa) abrogates PILRa-dependent viral entry and reduces pathogenesis，Journal of Virology，2010，84: 10773-10783
Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H，Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor depends on specific sialylated O-linked glycans on gB，Journal of Virology，2009，83: 13042-13045
Tabata S, Kuroki K, Maita N, Wang J, Shiratori I, Arase H, Kohda D, Maenaka K，Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor alpha (PILRa)，ActaCrystallographica Section F: Structural Biology and Crystallization Communications，2008，64: 44-46.
Wang J, Shiratori I, Satoh T, Lanier LL, Arase H，An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR)，Journal of Immunology，2008，180: 1686-1693
Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H，PILRa is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B，Cell，2008，132: 935-944
Tabata S, Kuroki K, Wang J, Kajikawa M, Shiratori I, Kohda D, Arase H, Maenaka K.，Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors，Journal of Biological Chemistry，2008，283: 8893-8901