叶幼琼
性 别：女
联系电话：
邮箱地址：youqiong.ye@shsmu.edu.cn
培养单位：基础医学院
学科/专业
研究方向
科研项目
代表性论文
科研获奖
专利授权
肿瘤多组学与免疫治疗
2025-03~2026-03， 交大2030，多尺度解析肿瘤边界微环境在肿瘤调控与诊治中的作用，课题负责人
2025-01~2028-12，国家自然基金项目 ，肿瘤边界组分对结直肠癌免疫排除型微环境形成的调控机制，课题负责人
2025-01~2027-12，国家自然基金项目 ，肿瘤微环境与免疫治疗，课题负责人
2024-12~2027-11，科技部项目 ，单细胞时空组学大数据分析算法、软件与平台建设，子课题负责人
2023-09~2027-08，省级其他 ，基于多组学解析胆管癌的分子分型与精准诊疗，子课题负责人
2023-01~2023-12， 交大2030，多尺度解析肿瘤边界微环境在肿瘤调控与诊治中的作用，课题负责人
2023-01~2025-12， 国家重点研发计划，皮肤恶性肿瘤精准化防治体系研究”项目“探究关键靶点在皮肤恶性肿瘤发生与免疫逃逸中的作用和分子机制，课题参与人
2021-01~2024-12，国家自然基金项目 ，基于肿瘤组织/单细胞的多组学揭示低氧相关免疫特征以辅助肿瘤免疫治疗，课题负责人
2020-11~2022-10，省级其他 ，基于单细胞测序等方法解析结直肠癌微环境细胞互作以探索潜在治疗靶点，课题负责人
2020-07~2023-06，省自然科学基金 ，MMP2 / 9的小分子抑制剂SB-3CT通过调节PD-L1以增强肿瘤免疫治疗疗效，课题负责人
Li W#, Zhang D#, Peng E, Shen S, Alinejad-Rokny H, Liu Y*, Zheng J*, Jiang C*, Ye Y*. ，HiST: Histological Images Reconstruct Tumor Spatial Transcriptomics via MultiScale Fusion Deep Learning，Advanced Science，2026，13(13):e14351.
Zhang Y#, Du Y#, Wang J#, Wang D#, Li J, Zhang J, Zhao Y, Sun S, Sun H, Qi J, Bao R, Shao C, Zhang M, He X, Zhang L, Zhou C, Wang D, Su B*, Zou D*, Ye Y*. ，Single-Cell Analysis of Chemotherapy-induced Remodeling Reveals CD276-driven Basal-like Chemoresistance in Pancreatic Cancer，Gastroenterology，2026，170(4):769-786.
Guo ZZ#, Wu R#, Li W, Yang K, Ying X, Alinejad-Rokny H*, Ye Y*. ，Mapping biology in space: from spatial transcriptomics platforms to analytical tools and databases，Science Bulletin，2026，71(4):921-945.
Wang X#, Wang X#, Li H#, Liu S, Lu Y, Chen H, Cai X, Su S, Li B, Liu R, Hu W, Zhu X*, Zhang J*, Ye Y*, Li HB*. ，tRNA m1A modification orchestrates STING translation in macrophages to enhance antitumor immunity and CAR-macrophage immunotherapy，Cellular ＆ Molecular Immunology，2026，23(3):261-272.
Du Y, Zhao Y, Li J, Wang J, You S, Zhang Y, Zhang L, Yang J, Alinejad-Rokny H, Cheng S, Shao C, Zou D *, Ye Y *. ，PLXDC1+ Tumor-Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma，Advanced Science，2025，12(18):e2415756.
Miao S#, Li H#, Song X#, Liu Y, Wang G, Kan C, Ye Y*, Liu RJ*, Li HB*， tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells.，Journal of Experimental Medicine，2025，222(3):e20240559.
Zhang C#, Dong Y#, Liu Y#, Shi J, Han L *, Ye Y *.，CTTIME: A database for analyzing cancer therapy’s impact on tumor immune microenvironment，Genomics Proteomics Bioinformatics.，2025，Sep 22:qzaf086.
Ding X#, Wu Q#, Du Y, Ji MM, Yang H*, Hu Q*, Ye Y*. ，CDK16+ luminal progenitor cell-like tumor cells interacted with POSTN+ cancer-associated fibroblasts associate with chemo-resistance in breast cancer，Small Methods，2025，9(5):e2401192.
Wang F#, Bao R#, Xu S#, Li W#, Huang H#, Li R#, Ding X, Zhang Y, Yu X, Han Q, Du X, Wan J, Li S, Xiao Y, Zhao R, Cui X, Ye Y*, Sun J*, Zheng J*, Chen GQ*, Zou Q*. ，An age-related decrease in leptin contributes to CD8+ T cell aging in the tumor microenvironment.，Cell Reports Medicine，2025，6(9):102310.
Zhu Z, Li L, Ye Y*, Zhong Q*. ，Integrating bulk and single-cell transcriptomics to elucidate the role and potential mechanisms of autophagy in aging tissue，Cellular Oncology，2024，47(6):2183-2199.
Du Y#, Shi J#, Wang J, Xun Z, Yu Z, Sun H, Bao R, Zheng J, Li Z, Ye, Y.，Integration of Pan-Cancer Single-Cell and Spatial Transcriptomics Reveals Stromal Cell Features and Therapeutic Targets in Tumor Microenvironment，Cancer Research，2024，84(2):192-210.
Xiao J, Wang S, Chen L, Ding X, Dang Y, Han M, Zheng Y, Shen H, Wu S, Wang M, Yang D, Li N, Dong C, Hu M, Su C, Li W, Hui L, Ye, Y *, Tang H *, Wei B *, Wang H *. ，25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages，Immunity，2024，57(5):1087-1104.e7.
Chen W, He Y, Zhou G, Chen X *, Ye, Y *, Zhang G *, Liu H *. ，Multiomics characterization of pyroptosis in the tumor microenvironment and therapeutic relevance in metastatic melanoma，BMC Medicine，2024，22(1):24.
Wang H#, Du Y#, Huang S, Sun X, Ye Y, Sun H, Chu X, Shan X, Yuan Y, Shen L, Bi Y. ，Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis，Nature Comunications，2024，15(1):4827.
Lin S, Dai Y, Han C, Han T, Zhao L, Wu R, Liu J, Zhang B, Huang N, Liu Y, Lai S, Shi J, Wang Y, Lou M, Xie J, Cheng Y, Tang H, Yao H, Fang H, Zhang Y, Wu X , Shen L *, Ye Y *, Xue L *, Wu ZB *. ，Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage-tumor interaction axes among different lineages of pituitary neuroendocrine tumors，Genome Medicine，2024，16(1):60.
Ding R, Yu X, Hu Z, Dong Y, Huang H, Zhang Y, Han Q, Ni ZY *, Zhao R *, Ye, Y *, Zou Q *. ，Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells，Immunity，2024，57(3):528-540.e6.
Shi J#, Wei X#, Xun Z, Ding X, Liu Y, Liu L, Ye, Y. ，The Web-Based Portal SpatialTME Integrates Histological Images with Single-Cell and Spatial Transcriptomics to Explore the Tumor Microenvironment，Cancer Research，2024，84(8):1210-1220.
Du Y, Ding X, Ye Y. ，The spatial multi-omics revolution in cancer therapy: Precision redefined，Cell Reports Medicine，2024，5(9):101740.
Xun Z, Zhou H, Shen M, Liu Y, Sun C, Du Y, Jiang Z, Yang L, Zhang Q, Lin C *, Hu Q *, Ye Y *, Han L. *，Identification of Hypoxia-ALCAM (high) Macrophage- Exhausted T Cell Axis in Tumor Microenvironment Remodeling for Immunotherapy Resistance，Advanced Science，2024，11(33):e2309885.
Xun, Z., Ding, X., Yao Zhang, Zhang, B., Lai, S., Zou, D., Zheng, J., Chen, G., Su, B., Han, L.* ＆ Ye, Y.* ，Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis，Nature communications，2023，14(1):933.
Liu Y., Xun Z., Ma K.,Liang S., Li X., Zhou S., Sun L., Liu Y., Du Y., Guo X., Cui T., Zhou H., Wang J., Yin D., Song R., Zhang S., Cai W., Meng F., Guo H., Zhang B., Yang D., Bao R., Hu Q., Wang J., Ye, Y#., Liu L#. ，Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy，Journal of hepatology，2023，78(4):770-782.
Dong Y, Gao Q, Chen Y, Zhang Z, Du Y, Liu Y, Zhang G, Li S, Wang G, Chen X*, Liu H*, Han L*, Ye Y*. ，Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy，Nature communications，2023，14(1):2540.
Zhang Y, Yu X, Bao R, Huang H, Gu C, Lv Q, Han Q, Du X, Zhao XY, Ye Y*, Zhao R*, Sun J*, Zou Q*. ，Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses，Cell Metabolism，2023，35(12):2107-2118.e6.
Han D, Han Y, Guo W, Wei W, Yang S, Xiang J, Che J, Zhu L, Hang J, van den Ende T, van Laarhoven HWM, Li B, Ye Y*, Li H*.，High-dimensional single-cell proteomics analysis of esophageal squamous cell carcinoma reveals dynamic alterations of the tumor immune microenvironment after neoadjuvant therapy，Journal for ImmunoTherapy of Cancer，2023，11(11):e007847.
Wang G., Xie Z., Su J., Chen M., Du Y., Gao Q., Zhang G., Zhang H., Chen X.#, Liu H.#, Han L.* ＆ Ye Y*. ，Characterization of Immune-Related Alternative Polyadenylation Events in Cancer Immunotherapy.，82(19):3474-3485.，2022，82(19):3474-3485.
Qi J., Sun H., Zhang Y., Wang Z., Xun Z., Li, Z., Ding X., Bao R., Hong L., Ji W., Fang, F., Li H., Chen L., Zhong J., Zou D., Liu L., Han L., Ginhoux F., Ye, Y.* (lead contact), Su, B.*.，Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer，Nature Communications，2022，13(1):1742.
He, Y.#, Dong, Y.#, Chen, Y.#, Zhang, G., Zhang, H., Lei, G., Du, Y., Chen, X.*, Ye, Y*. ＆ Liu, H*. ，Multi-omics characterization and therapeutic liability of ferroptosis in melanoma.，Signal Transduction and Targeted Therapy，2022，7(1):268.
Liu Z.#, Ye Y.# , Liu Y., Liu Y., Chen H., Shen M., Wang Z., Huang S., Han L., Chen Z., He X.，RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1.，Cancer Research，2022，82(10):1937-1952.
Zhang, C., Wang, H., Yang, X., Fu, Z., Ji, X., Shi, Y., Zhong, J., Hu, W., Ye Y.*, Wang, Z.* ＆ Ni, D*. ，Oral zero-valent-molybdenum nanodots for inflammatory bowel disease therapy.，Science Advances，2022，8(37):eabp9882.
Chen, H., Yao, J., Bao, R., Dong, Y., Zhang, T., Du, Y., Wang, G., Ni, D., Xun, Z., Niu, X., Ye Y.*, Li H*. ，Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer.，Molecular Cancer，2021，20(1):29.
Shen L#, Ye Y#, Sun H#, Su B. ，ILC3 plasticity in microbiome-mediated tumor progression and immunotherapy.，Cancer Cell，2021，39(10):1308-1310.
Wang F; Zhang Y; Yu X; Teng X-L; Ding R; Hu Z; Wang A; Wang Z; Ye Y.* , Zou Q*.，ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.，Journal of Clinical Investigation，2021，131(19):e144318.
上海市卫生健康系统第二十届银蛇奖二等奖，省部级，2025
科学技术进步一等奖，国家级，2023
组织切片图像重建空间转录组表达多尺度深度学习模型软件 [简称: HiST] V1.0(软著登记号：2026SR0578956)，2026
结直肠癌肿瘤与微环境共演变解码器[简称：crcTMECODE] V1.0(软著登记号：2026SR0503579)，2026
基于智能嵌入的衰老状态分析软件 [简称：SENSAI] V1.0(软著登记号：2026SR0503568)，2026
空间转录组/多组学工具一站式检索与对比平台 [简称：SpatialToolDB] V1.0(软著登记号：2026SR0359108)，2026
结直肠癌肿瘤边界细胞亚群标志物组合及其应用(CN 116735874 B)，2025
结直肠癌生物标志物及其在诊断、预防、治疗及预后中的应用(CN 113899903 B)，2025
肿瘤空间微环境特征分析软件[Spatial TME]V1.0(软著登记号：2024SR0036916)，2024
单细胞水平的泛癌水平基质细胞分析软件[scPanStroma]V1.0(软著登记号：2024SR0029045)，2024
基于转录组的药物影响免疫微环境分析软件[CTTIME]V1.0(软著登记号：2024SR0030355)，2024
肿瘤-癌旁交界区微环境重构分析软件[简称：Cottrazm]v1.0(软著登记号：2022SR0294007)，2022