研究生导师

病原菌与宿主相互作用机制

2020-08~2023-07，横向课题 ，耐药细菌多糖结合疫苗开发，课题负责人

2020-01~2023-12，国家自然基金面上项目 ，RIP1/RIP3介导的巨噬细胞程序性坏死在钩端螺旋体感染中的作用及机制研究，课题负责人

2019-07~2022-06，上海市科委 上海市自然基金 ，RIP1介导的细胞程序性坏死在钩端螺旋体感染中的作用及机制研究，课题负责人

2017-06~2020-05，横向课题 ，广谱多价肺炎多糖疫苗及多价肺炎多糖蛋白结合疫苗的研发，课题负责人

2015-01~2018-12，国家自然基金，面上项目 ，清道夫受体SR-A在抗钩端螺旋体天然免疫中作用机制的研究，课题负责人

2013-07~2016-06，上海市科委，自然基金面上项目 ，钩端螺旋体与巨噬细胞相互作用的初步研究，课题负责人

2010-01~2013-12，国家自然基金，面上项目 ，钩端螺旋体rel基因致病机理的研究，课题负责人

2009-01~2011-12，上海交通大学医学院 ，钩端螺旋体基因岛毒力相关基因功能的研究，课题负责人

Fupin Hu, Yuqing Pan, Heng Li, Renru Han, Xiao Liu, Ruijing Ma, Yongqin Wu, Heyuan Lun, Xiaohua Qin, Jiayin Li,Aixi Wang, Min Zhou, Bing Liu, Zhemin Zhou, Ping He.，Carbapenem resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study，Nature microbiology，2024，9(3):814-829

Lin Du, Yunqiang Wu, Yuqing Pan, Lingxia Wang, Haiwei Zhang, Jiayin Li, Ya'nan Liu, Haibing Zhang*, Ping He*，Lipopolysaccharide and glycolipoprotein coordinately triggered necroptosis contributes to the pathogenesis of Leptospira infection in mice，J Infect Dis，2023，228（7）: 944-956

Jie Wang, Ruijing Ma, Fen Pan, Yongqin Wu, Yuqing Pan, Yanan Liu, Fangyuan Yu, Jingran Yu, Heyuan Lun, Yingying Shi, Hong Zhang, Ping He.，The molecular epidemiology of prevalent Klebsiella pneumoniae strains and humoral antibody responses against Carbapenem-Resistant K. pneumoniae infections among pediatric patients in Shanghai.，mSphere，2022，26;7(5):e0027122

Yanchun Wang, Xia Fan, Lin Du, Boyu Liu, Haihan Xiao, Yan Zhang, Yunqiang Wu, Fuli Liu, Yung-Fu Chang, Xiaokui Guo, Ping He，Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages，Emerging Microbes and Infections，2021，10:1, 939-953

Jiayin Li, Yueying Sheng, Ruijing Ma, Mengsha Xu, Fuli Liu, Rong Qin, Mingxi Zhu, Xianchao Zhu and Ping He，Identification of a Depolymerase Specific for K64-Serotype Klebsiella pneumoniae: Potential Applications in Capsular Typing and Treatment，Antibiotics，2021，10, 144

Jiawei Ji, Qian Liu, Rui Wang, Tingting Luo, Xiaokui Guo, Mengsha Xu, Qian Yin, Xuetong Wang, Min Zhou, Min Li, Ping He.，Identification of a novel phage targeting methicillin-resistant Staphylococcus aureus In vitro and In vivo，Microbial Pathogenesis，2020，149:104317

Z Y Zhang, R Qin , Y H Lu , J Shen , S Y Zhang , C Y Wang , Y Q Yang, F P Hu , P He.，Capsular polysaccharide and lipopolysaccharide O type analysis of Klebsiella pneumoniae isolates by genotype in China，Epidemiol Infect.，2020，12;148:e191

Yunqiang Wu, Rui Wang, Mengsha Xu, Yanan Liu, Xianchao Zhu, Jiangfeng Qiu, Qiming Liu, Ping He*, Qingtian Li*，A Novel Polysaccharide Depolymerase Encoded by the Phage SH-KP152226 Confers Specific Activity against Multidrug-Resistant Klebsiella pneumoniae via Biofilm Degradation.， Front. Microbiol.，2019，2.338889

Wenxia Zhang, Yan Guo, Jiayin Li, Yiyuan Zhang, Yang Yang, Dong Dong, Demei Zhu, Ping He and Fupin Hu.，In vitro and in vivo Bactericidal Activity of Ceftazidime-avibactam against Carbapenemase–producing Klebsiella Pneumoniae. ，Antimicrob Resist Infect Control.，2018，0.390278

Jingwen Huang, Huahua Yi, Chunliu Zhao, Yifan Zhang, Liying Zhu, Bing Liu, Ping He, Min Zhou.， Glucagon-like peptide-1 receptor (GLP-1R) signaling ameliorates dysfunctional immunity in COPD patients.，Int J Chron Obstruct Pulmon Dis.，2018，13: 3191–3202

Xia B, Sun L, Fan X, Xiao H, Zhu Y, Qin J, Cai C, Zhao W, Chang YF, Zhang Y, Guo X, He P，A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4，Emerg Microbes Infect，2017，6(5):e36

Yunfen Hua, Tingting Luo, Yiqi Yang, Dong Dong, Rui Wang, Yanjun Wang, Mengsha Xu, Xiaokui Guo, Fupin Hu, Ping He.，Phage Therapy as a Promising New Treatment for Lung Infection Caused by Carbapenem-Resistant Acinetobacter baumannii in Mice.，Front. Microbiol，2017，2.179861

Song Z, Gu FF, Guo XK, Ni YX, He P, Han LZ，Antimicrobial Resistance and Molecular Characterization of Staphylococcus aureus Causing Childhood Pneumonia in Shanghai.，Front Microbiol.，2017，0.649306

Qiurui Zhang, Huanying Wan, Shaoguang Huang, Yan Zhang, Yanchun Wang, Xiaokui Guo, Ping He, Min Zhou. ，Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease，Clin Respir J，2016，10(1):22-31

Ran Dong, Liang Xie, Kaishun Zhao, Qiurui Zhang, Min Zhou， Ping He，Cigarette smoke-induced lung inflammation in chronic obstructive pulmonary disease mediated via LTB4/BLT1/SOCS1 pathway，International Journal of Chronic Obstructive Pulmonary Disease ，2015，22(11):31-41

WANG Ya Lin, QIN Jin Hong, ZHANG Cui Cai, GUO Xiao Kui, JIANG Xiu Gao, HE Ping. ，An Outbreak of Leptospirosis in Lezhi County, China in 2010 May Possibly Be Linked to Rainfall.， Biomed Environ Sci，2014，27(1): 56-59

Boyu Liu, Yanchun Wang, Xiaokui Guo, Weinan Zhu, Yan Zhang, Ping He, ，Carboxyfluorescein diacetate succinimidyl ester labeling method to study the interaction between Leptospira and macrophages. ，Journal of Microbiological Methods.，2014， 107: 205–213

Wang Y, Zhao S, Han L, Guo X, Chen M, Ni Y, Zhang Y, Cui Z, He P. ，Drug resistance and virulence of uropathogenic Escherichia coli from Shanghai, China.， J Antibiot (Tokyo). ，2014，67(12):799-805

Ping He, Cong Deng, BoYu Liu, LingBing Zeng, Wei Zhao, Yan Zhang, XuCheng Jiang, XiaoKui Guo, JinHong Qin.， Characterization of a bifunctional enzyme with (p)ppGpp-hydrolase/synthase activity in Leptospira interrogans.， FEMS Microbiol Lett ，2013，348：133–142.

Zelin Cui, Wenbin Shen, Zheng Wang, Haotian Zhang, Me Yao, Yanchun Wang, Lingbin Zeng, Yongzhang Zhu, Jinhong Qin, Ping He and Xiaokui Guo.，Complete Genome Sequence of Klebsiella pneumoniae Phage JD001. ，J Virol.，2012，86(24):13843.

Zhang Y, Lou XL, Yang HL, Zhang XY, Guo XK, He P and Jiang XC.，Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route.，BMC Infect Dis.，2012，

Lin T, Kwak YH, Sammy F, He P, Thundivalappil S, Sun G, Chao W, Warren HS.，Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin.，J Infect Dis.，2010， 202(4):624-32

Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P, Qin JH, Zhao GP, Wang SY, Guo XK. ，Development of O-antigen gene cluster-specific PCRs for rapid typing six epidemic serogroups of Leptospira in China. ，BMC. Microbiol.，2010，

Ping He, Yue-Ying Sheng, Yao-Zhou Shi, Xiu-Gao Jiang, Jin-Hong Qin, Zhi-Ming Zhang, Guo-Ping Zhao and Xiao-Kui Guo.，Genetic diversity among major endemic strains of Leptospira interrogans in China. ，BMC Genomics，2007，

Ping He, Xiang-Yan Zhang, Xiao-Kui Guo, Bao-Yu Hu, Xiao-Tian Huang,Yang Yang, and Guo-Ping Zhao.，Identification and analysis of Genes Present Specifically in Leptospira interrogens serovar Lai. ，Acta Biochimica et Biophysica Sinica,，2004， 36(12): 832-839