研究生导师

苏冰

性别：男
联系电话：13764072752
邮箱地址：bingsu@sjtu.edu.cn
培养单位：基础医学院

学科/专业
研究方向
科研项目
代表性论文
科研获奖
专利授权

Hu ZL, Qu GJ, Yu XY, Jiang HJ, Teng XL, Ding L, Hu QW, Guo WX, Zhou Y,Wang F, Li HB, Chen L, Jiang J, Su B, Liu JL, Zou Q.，Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+T Cells. ，Cell Metabolism.，2019，https://doi.org/10.1016/j.cmet.2019.05.016
X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou, B Su.，Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2.， J Mol Cell Biol.，2019，2019 Feb 1;11(2):93-106
M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li, B Su.， Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation. ， Cell Mol Immunol.，2019， 2019 Jan 31. doi: 10.1038/s41423-018-0185-x.
Zhaoyuan Liu, Yaqi Gu, Svetoslav Chakarov, Camille Bleriot, Immanuel Kwok, Xin Chen, Amanda Shin, Weijie Huang, Regine J. Dress, Charles-Antoine Dutertre, Andreas Schlitzer, Jinmiao Chen, Lai Guan Ng, Honglin Wang, Zhiduo Liu, Bing Su, and Florent Ginhoux.，Fate mapping via Ms4a3 expression history traces monocyte-derived cells.，Cell，2019， accepted
Xu YY, Ouyang XX,Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ, Su B, and Liu JL，Sin1 regulates ischaemia-induced microthrombosis through integrin?αIIbβ3-mediated outside-in signaling and hypoxia responses in platelets. Arteriosclerosis, Thrombosis, and Vascular Biology.， Arteriosclerosis, Thrombosis, and Vascular Biology. ，2018，2018 Dec;38(12):2793-2805.?
Jiyu Tong, Guangchao Cao, Ting Zhang, Esen Sefik, Maria Carolina Amezcua Vesely, James P Broughton, Shu Zhu, Huabin Li, Bin Li, Lei Chen, Howard Y Chang, Bing Su, Richard A Flavell, Hua-Bing Li.，m6A mRNA methylation sustains Treg suppressive functions，Cell Research，2018，82.10.1038/cr.2018.7.
Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B , Wu ZB. ， Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours.，Nature Communications. ，2018，2018 9:4624.
XY Yu, YM Lao, XL Teng, S Li, Y Zhou, FX Wang, XWGuo, SY Deng,YZ Chang, XF Wu, ZD Liu, L Chen, LM Lu, JK Cheng, B Li, B Su, J Jiang,HB Li , CX Huang, J Yi , Q Zou. ，ENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. ，Nature Communications. ，2018，2018: 9:3157
XM Fan, CH Wang,PL Shi,W Gao, JMGu,Y Geng,WL Yang,NB Wu,Y Wang,Y Xu,X Chen, L Zhang,KM Wang,B Su, JL Liu.，Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice. ，Blood Adv.，2018，2018 Jun 26;2(12):1439-1448.?
XYYu, XL Teng, FX Wang, YH Zheng, GJ Qu, Y Zhou, ZLHu, ZQ Wu, YZChang, L Chen, HB Li, B Su, LM Lu, ZD Liu, SC Sun, and Q Zou.，Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome.，J. Exp. Med.，2018，90. 2018. 3;215(9):2463-2476.
OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su. ，Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression.，J Immunol ，2018，2018; 201:908-915
Tan R, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X,?Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B, Lan L. ，Nek7 protects telomeres from oxidative DNA damage by phosphorylation and stabilization of TRF1，Mol Cell，2017，2765(17):30041-2.
Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, Xu Z, Liu Z, Cai W, Ke F, Zhang L, Zhou H， Wang H, Wang G, Chen X, Zhang H, Wang Z, Ginhoux F, Lu C, Su B, Wang H.，RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease. ，EMBO Mol Med.，2017，9(5):589-604
Zepp JA,Zhao J,Liu C,Bulek K,?Wu L,Chen X,Hao Y,Wang Z,Wang X,Ouyang W,Kalady MF,Carman J,?Yang WP,Zhu J, Blackburn C Huang YH, Hamilton TA1,Su B, LiX.，IL-17A-Induced PLET1 Expression Contributes to Tissue?Repair and Colon，J Immunol.，2017，199(11):3849-3857.
Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW2, Su B, Cookson MR, Li, KangZ，LRRK2?promotes?the?activation?of?NLRC4?inflammasome?during?Salmonella?， J Exp Med.，2017，214(10):3051-3066.
Wang Q, Tan R, Zhu X, Zhang Y, Tan Z, Su B, Li Y，Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression，Oncotarget，2016，7(9):10064-72
Greenblatt MB, Shin DY, Oh H, Lee KY, Zhai B, Gygi SP, Lotinun S, Baron R, Liu D, Su B, Glimcher LH, Shim JH，MEKK2 mediates an alternative β-catenin pathway that promotes bone formation，Proc Natl Acad Sci U S A，2016，113(9):E1226-35
Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C. Cantley, Alex Toker, Su B, Wenyi Wei，PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex，Cancer Discov，2015，5 (11): 1194-209
Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B，Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex，Nature Communications，2015，5.761806
Kaur S, Kroczynska B, Sharma B, Sassano A, Arslan AD, Majchrzak-Kita B, Stein BL, McMahon B, Altman JK, Su B, Calogero RA, Fish EN, Platanias LC，Critical roles for Rictor/Sin1 complexes in IFN-dependent gene transcription and generation of antiproliferative responses，J Biol Chem，2014，289(10):6581-91
Zhou XT, Chen DN, Xie ZQ, Peng Z, Xia KD, Liu HD, Liu W, Su B, Li JD.，Functional analysis of the distal region of the third intracellular loop of PROKR2，Biochem Biophys Res Commun，2013，439(1):12-7
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W.，Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis，Nat Cell Biol，2013，15(11):1340-50
Xing Chang, Adam S. Lazorchak, Dou Liu, Su B，Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation，Eur J Immunol，2012，42(6):1639-47
Fan Zhang, Adam Lazorchak, Dou Liu, Fanping Chen, Su B，Inhibition of the mTORC2 and chaperone pathways to treat leukemia，Blood，2012，119(25):6080-8
Su B, Estela Jacinto，Mammalian TOR signaling to the AGC kinases，Crit Rev Biochem Mol Biol，2011，46(6):527-47
You-Tong Wu, Weiming Ouyang, Adam S Lazorchak, Dou Liu, Han-Ming Shen, Su B，mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif，J Biol Chem，2011，286:14190-14198
Xing Chang, Fang Liu, Xiaofang Wang, Su B，MEKK2 and MEKK3 regulate TGF-b-mediated helper T cell differentiation，Immunity，2011，34:201-212
Adam S. Lazorchak, Su B，Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis，Protein and Cell，2011，2(7):523-530
Xiaofang Wang, Fan Zhang, Fanping Chen, Dou Liu, Yi Zheng, Yongliang Zhang, Chen Dong, Su B，MEKK3 regulates IFNg production in T cells through the Rac1/2 dependent MAPK cascades，J Immunol，2011，186:5791-5800
Adam S Lazorchak, Dou Liu, Valeria Facchinetti, Annarita Di Lorenzo, William C Sessa, David G Schatz, Su B，Sin1 suppresses rag1/2 and il7r gene expression through Akt2 in B cells，Mol Cell，2010，39:433-443
Xiaofang Wang, Yongliang Zhang, Valeria Facchinetti, Yuan Zhuang, Su B，MEKK3 Is Essential for Lymphopenia-Induced T cell Proliferation and Survival，J Immunol，2009，182(6):3597-3608
Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C. Newton, Yuxin Mao, Robert Q. Miao, William C. Sessa, Jun Qin, Pumin Zhang, Su B, Estela Jacinto，The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C，EMBO J，2008，27(14):1932-43
Kihwan Kim, Omar Duramad, Xiaofeng Qin and Su B.，MEKK3 is essential for lipopolysaccharide-induced il-6 and gm-csf production in macrophages.，Immunology. ，2007，120(2):242-50
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B， SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. ，Cell，2006，127(1):125-3
Dongyu Zhang, Valeria Fachinnetti, Xiaofang Wang, Qiaojia Huang, Jun Qin, Su B，Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor- and stress-pathways，EMBO J，2006，25:97-107
Jinke Cheng, Ling Yu, Dongyu Zhang, Qiaojia Huang, David Spencer, Su B.，Dimerization through the catalytic domain is essential for MEKK2 activation.，J. Biol. Chem，2005， 280:13477-82
Jinke Cheng, Dongyu Zhang, Kihwan Kim, Yingxin Zhao, Yingming Zhao, Su B，Mip1, an MEKK2 interacting protein, regulates MEKK2 dimerization and activation，Mol Cell Biol，2005，25(14):5955-5964
Jinke Cheng, Ling Yu, Dongyu Zhang, Qiaojia Huang, David Spencer, Su B，Dimerization through the catalytic domain is essential for MEKK2 activation，J. Biol. Chem.，2005，280:13477-82
Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu, Su B.，Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3.， Nature Immunology，2004，5:95-103
Zijian Guo, Gavin Clydesdale, Jinke Cheng, Kihwan Kim, Lin Gan, David J. McConkey, Stephen E. Ullrich, Yuan Zhuang*, Bing Su，Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-Cell receptor signal transduction，Mol Cell Biol，2002，22(16):5761-5768
Xu X, Su B., Barndt RJ, Chen H, Xin H, Yan G, Chen L, Cheng D, Heitman J, Zhuang Y, Fleischer S, Shou W.，FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. ， Transplantation ，2002，Jun 15;73(11):1835-8
Yang J, Lin Y, Guo Z, Cheng J, Huang H, Liao W, Chen Z, Liu Z, Su B，The essential role of MEKK3 in TNF-induced NF-kB activation，Nature Immunology，2001，2:620-624
Su B, Cheng JK, Yang J，MEKK2 mediates T cell co-stimulation of the JNK cascade and IL-2 gene expression，J Biol Chem，2001，276:14784-90
Xia Y, Makris C, Su B., Li EG, Yang JH, Nemerow GR, Karin M.，MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. ， PNAS，2000，97(10): 5243-5248
Lee H, Jiang F, Wang Q, Nicosia SV, Yang J, Su B., Bai W.，MEKK1 activation of human Estrogen receptor a and stimulation of the agonisttic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells.，Molecular Endocrinology，2000，14(11):1882-96
Yang J, Boerm M, McCarty M, Bucana C, Fidler J, Zhuang Y, Su B，Essential role of MEKK3 in early embryonic cardiovascular development，Nature Genetics，2000，24:309-313
Cheng J, Yang J, Xia Y, Karin, M., and Su B. ，Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. ， Mol Cell Biol，2000，20(7):2334-2341
Dong Z, Killion JJ, Kumar R, Eue I, Yang X, Lu W, Su B., Fidler IJ.，Activation of cytokine production, tumoricidal properties, and tyrosine phosphorylation of MAPKs in human monocytes by a new synthetic lipopeptide, JBT3002，J Leukocyte Biol，1998，63(6):766-774
Xia Y, Wu Z, Su B., Murray B, and Karin, M.，JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components: MEKK1 and JNK. ， J Leukocyte Bio，1998，63(6):766-774,
Xia Y, Wu Z, Su B., Murray B, and Karin, M. ，JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components: MEKK1 and JNK. ，Genes and Dev，1998，12(21):3369-3381
Wang Y, Su B., Sah VP, Brown JH, Han J, Chien KR.，Cardiac hypertrophy induced by Mitogen-activated Protein Kinase Kinase , a specific activator for c-jun NH2-terminal kinase in ventricular muscle cells.，J. Biol. Chem. ，1998，273:5423-5426
Cavigelli M, Dolfi F, Su B, Yoshioka K and Karin M， The tumor promoter arsenite stimulates AP-1 activity through inhibition of a JNK phosphatase. ， EMBO J，1996，15:6269-6279
Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S.，Shear stress activates both JNK and Erk kinase pathways. Mole.，Mole. Cell. Biol.，1996，16:5947-5954
Su B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y，JNK mediates signal integration during costimulation of T lymphocytes，Cell，1994，77:727-736
Derijard, B., Hibi, M., Wu, I-Huan, Barrett, T., Su B., Deng, T., Karin, M., and Davis, R.J，JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphrylates the cJun activation domain，Cell ，1994，76:1025-1037
Lee, S., Su B., Maher, S., and Bothwell, A.L.M.，Ly6A is required for antigen-specific response and expression of T cell receptor，EMBO J，1994，13:2167-2176
Su B., Waneck, G.L., Flavell, R.A. and Bothwell, A.L.M. ，The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E mediated T cell activation.，J. Cell Biol.，1991，2.112:337-384
Su B, Bothwell, A.L.M，Biosynthesis of a phosphatidylinositol-glycan-linked membrane protein: signals for posttranslational processing of the Ly-6E antigen，Mol. Cell. Biol.，1989，9: 3369-3376