研究生导师

免疫调控异常与疾病

2023-01~2025-12，国家自然科学基金委专项项目 ，EGFR突变型肺癌免疫检查点抑制剂的耐药机制及干预策略，课题负责人

2023-01~2025-12，上海市卫健委卫生健康领军人才 ，基于嘌呤代谢的肿瘤局部“冷-热”转换调控机制及其免疫增效策略，课题负责人

2021-11~2024-12，国家重点研发计划项目 ，重要病原体复杂和多变免疫原的设计和优化研究，课题负责人

2020-10~2023-09，上海市科学技术委员会基础重点项目 ，NLRP4介导的I型干扰素应答参与肺癌肿瘤局部免疫微环境重塑和和免疫检查点治疗的影响机制，课题负责人

2020-01~2024-12，国家自然科学基金委重点项目 ，可注射水凝胶微球治疗卒中的免疫兼容性机制研究，课题参与人

2019-09~2022-06，上海市科学技术委员会临床重点项目 ，标志物指导下的肺癌免疫治疗人群选择策略的前瞻性研究，子课题负责人

2019-01~2022-12，国家自然科学基金面上项目 ，结核抗原特异性免疫记忆T细胞功能的代谢调控机制及其临床意义，课题负责人

2018-05~2021-05，上海市科委优秀学术带头人计划 ，抗结核免疫记忆应答调控新机制与新型疫苗设计策略，课题负责人

2017-09~2020-12，“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项 ，结核新疫苗的免疫学特征研究，子课题负责人

2017-09~2020-12，科技部“重大慢性非传染性疾病防控研究”重点专项 ，基于组学特征的肺癌免疫治疗疗效预测指标的构建和验证，课题参与人

Bao Y, He L, Miao B, Zhong Z, Lu G, Bai Y, Liang Q, Ling Y, Ji P, Su B, Zhao GP, Wu H, Zhang W, Wang Y*, Chen Y*, Xu J*，BBIBP-CorV vaccination accelerates anti-viral antibody responses in heterologous Omicron infection: A retrospective observation study in Shanghai.，Vaccine，2023，;41(20):3258-3265.

Yao CC, Sun RM, Yang Y, Zhou HY, Meng ZW, Chi R, Xia LL, Ji P, Chen YY, Zhang GQ, Sun HP, Lu S*, Yang C*, Wang Y*.，Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response，Cell Reports，2023，42(3):112186

Meng Z, Niu X, Xia L, Chen Y, Wang Z, Wang H, Ji P, Cui W*, Wang Y*, Lu S*，A 3D Ex Vivo Tumor-Immune Coculture System Mimicking In Vivo Tumor Environmental Stress on CD8+ T Cells Exhaustion.，Adv Biol (Weinh)，2023，19:e2200264.

Gao B, He L, Bao Y, Chen Y, Lu G, Zhang Y, Xu Y, Su B, Xu J, Wang Y*, Yeap LS*，Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection，Cell Res，2023，33(3):258-261

Gao S, Chen T, Wang Z, Ji P, Xu L*, Cui W*, Wang Y*，Immuno-activated mesenchymal stem cell living electrospun nanofibers for promoting diabetic wound repair，J Nanobiotechnology，2022，20(1):294

Khanniche A, Zhou L, Jiang B, Song J, Jin Y, Yin J, Wang S, Ji P, Shen H, Wang Y*, Xu H*.，Restored and enhanced memory T cell immunity in Rheumatoid Arthritis after TNFa blocker treatment.，Front Immunol，2019，1.032639

Chen YY#, Xiao JN#, Li Y#, Xiao YJ#, Xiong YQ, Liu Y, Wang SJ, Ji P, Zhao GP, Shen H, Lu SH, Fan XY*, Wang Y*，Mycobacterial lipoprotein Z triggers efficient innate and adaptive immunity for protection against Mycobacterium tuberculosis infection，Front Immunol，2019，2.590278

Jin Y*, Dong H*, Xia LL, Yang Y, Zhu Y, Shen Y, Zheng H, Yao C, Wang Y, Lu S*.，The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC.，J Thorac Oncol，2019，14(8):1378-1389.

Zhang MY#, Yao CC#, Cai J#, Liu S, Liu XN, Chen YY, Wang SJ, Ji P, Pan M, Kang ZJ*, Wang Y*，LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production，Journal of Translational Medicine，2019，17(1):37

Xia LL#, Liu YY#, Wang Y*.，PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions.，The Oncologist，2019，24(Specical Issue):S31-S41

Li W#, Zhang X#, Yang Y, Yin Q, Wang Y, Li Y, Wang C, Wong SM, Wang Y, Goldfine H, Akerley BJ, Shen H.，Recognition of conserved antigens by Th17 cells provides broad protection against pulmonary Haemophilus influenzae infection.，Proc Natl Acad Sci U S A.，2018，115(30):E7149-E7157

Liu YY#, Sha W#, Xu SQ, Gui XW, Xia LL, Ji P, Wang SJ, Zhao GP, Zhang X*, Chen YY*, Wang Y，Identification of HLA-A2-restricted mycobacterial lipoprotein Z peptides recognized by T Cells from patients with active tuberculosis infection.，Front Microbiol，2018，2.549306

Xiao JN#, XiongYQ#, Chen YY#, Xiao YJ, Ji P, Li Y, Wang SJ, Zhao GP, Cheng QJ, Lu SH*, Wang Y*，Determination of Lipoprotein Z-specific IgA in tuberculosis and latent tuberculosis infection.，Front Cell Infect Mcrobiol，2017，0.635417

Yang XY#, Wu JB#, Liu Y, Xiong Y, Ji P, Wang SJ, Chen YY, Zhao GP, Lu SH, Wang Y*，Identification of mycobacterial bacterioferritin B for immune screening of tuberculosis and latent tuberculosis infection. ，Tuberculosis (Edinb)，2017，107:119-125

Xiao YJ#, Sha W#, Tian ZF#, Chen YY, Ji P, Sun Q, Wang HY, Wang SJ, Fang Y, Wen HL, Zhao HM, Lu J, Xiao HP, Fan XY*, Shen H*, Wang Y*，Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis.，J Mol Med，2016，94(7):823-34

Yang C#, Khanniche A#, DiSpirito JR, Ji P, Wang S, Wang Y*, Shen H*，Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8(+) T Cells. ，Sci Rep. ，2016，6:27005

Ni C#, Chen YH#, Zeng MS#, Pei RJ, Du Y, Tang LQ, Wang MY, Hu YJ, Zhu HY, He MF, Wei XW, Wang S, Ning XK, Wang MN, Wang JF, Ma L，Chen XW, Sun Q, Tang H, Wang Y*, Wang XN*.，In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures，Cell Research，2015，25(7):785-800