研究生导师

免疫调节

2016-05~2019-04，上海市科学技术委员会-优秀学术带头人（A类） ，调节性T细胞功能稳定性及其应用，课题负责人

2016-01~2020-12，国家自然科学基金-杰青项目 ，分子免疫学，课题负责人

2014-09~2017-08，上海市科学技术委员会基础研究重大重点项目项目 ，肿瘤微环境FOXP3蛋白复合体调节的机制研究，课题负责人

2014-01~2018-12，国家重点基础研究计划（973计划） ，遗传变异调控AS自身免疫紊乱的分子机制研究，课题负责人

2014-01~2017-12，国家自然科学基金-面上项目 ，FOXP3蛋白泛素化与去泛素化修饰调控Treg细胞功能的机理研究，课题负责人

2014-01~2018-12，国家自然科学基金-重点项目 ，炎症因子对FOXP3+调节性T细胞分化与功能的动态影响及其机理研究，课题负责人

2012-01~2015-12，国家自然科学基金-面上项目 ，转录因子IRF4蛋白甲基化修饰及其转录调节功能的分子机理研究，课题负责人

Fang S, Huang Y, Liu X, Zhong S, Wang N, Zhao B, Li Y, Sun J, Wang Y, Zhang S, Gu P, Zjpi H, Li B, Fan X.，.Interaction Between CCR6+ Th17 Cells and CD34+ Fibrocytes Promotes Inflammation: Implications in Graves' Orbitopathy in Chinese Population，Invest Ophthalmol Vis Sci，2018，59 (6):2604-14

Ni Y, Hao J, Hou X, Du W, Yu Y, Chen T, Wei Z, Li Y, Zhu F, Wang S, Liang R, Li D, Lu Y, Liao K, Li B, Shi G，Dephosphorylated Polymerase I and Transcript Release Factor Prevents Allergic Asthma Exacerbations by Limiting IL-33 Release.，Front. Immunol,，2018，1.3625

Yi G, Guo S, Liu W, Wang H, Liu R, Tsun A, Jin G, Li B，Identification and functional analysis of heterogeneous FOXP3+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma，Science Bulletin，2018，63(15):972-81

Wang S, Li Y, Zhu F, Lin F, Luo X, Zhao B, Zhang P, Li D, Gao Y, Liang R, Liu L, Tsun A, Yuan X, Wu K, Li B，DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells，FEBS Lett，2017，2017,Jul;591(13):1929-1939. doi: 10.1002/1873-3468.12690

Lin R, Nie J, Ren J, Liang R, Li D, Wang P, Gao C, Zhuo C, Yang C, Li B，USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells，FEBS Lett，2017，Jun;591(12):1677-1686. doi: 10.1002/1873-3468.12668

Li YY, Lu Y, Wang SW, Han ZJ, Zhu FX, Ni YM, Liang R, Zhang Y, Leng Q, Wei G, Shi G, Zhu R, Li D, Wang HQ, Zheng SG, Xu HX, Tsun A and Li B，USP21 Prevents the Generation of T-helper-1-like Treg Cells，Nature Communications，2016，7:13559. doi: 10.1038/ncomms13559

Fang S, Huang Y, Wang S, Zhang Y, Luo X, Liu L, Zhong S, Liu X, Li D, Liang R, Miranda P, Gu P, Zhou H, Fan X, Li B，IL-17A exacerbates fibrosis by promoting the proinflammatory and profibrotic function of orbital fibroblasts in TAO，J Clin Endocrinol Metab，2016，doi: 10.1210/jc.2016-1882

Lu Y, Cai S, Nie J, Li Y, Shi G, Hao J, Fu W, Tan H, Chen S, Li B, Xu H，The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma，Biochem Pharmacol.，2016，100:61-72. doi:10.1016

Li YY and Li B*，A Translational Perspective of a Deubiquitinase Inhibitor in Antitumor Immunity，EBioMedicine，2016，13:7-8. doi: 10.1016

Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG, Li B，Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1，Proc Natl Acad Sci U S A.，2015，112(25):E3246-54

Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H, Li B，Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells，J Biol Chem.，2015，290(48):28675-82. doi:10.1074

Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L, Li B，TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression， J Biol Chem.，2015，290(48):29086-94. doi: 10.1074

Li B, Zheng SG，How regulatory T cells sense and adapt to inflammation，Cell Mol Immunol.，2015，12(5):519-20. doi: 10.1038

Wu Q, Nie J, Gao Y, Xu P, Sun Q, Yang J, Han L, Chen Z, Wang X, Lv L, Tsun A, Shen J, Li B，Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1，Sci Rep.，2015，5:16355. doi: 10.1038

Ni Y, Tao L, Chen C, Song H, Li Z, Gao Y, Nie J, Piccioni M, Shi G, Li B，The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33，Int J Mol Sci.，2015，16(11):27956-66.

Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, Zhang J, Yu D, Li B, Qian Z，Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment， J Virol.，2015，89(6):3049-61. doi: 10.1128

Nie J, Li YY, Zheng SG, Tsun A, Li B，FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases，Front Immunol.，2015，6:493. doi:10.3389

Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L, Ge S, Li B，Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt， J Immunol. Cutting edge，2015，194(9):4094-7. doi:10.4049

Zhou X, Tang J, Cao H, Fan H, Li B，Tissue resident regulatory T cells: novel therapeutic targets for human disease，Cell Mol Immunol.，2015，12(5):543-52. doi: 10.1038

Han L, Yang J, Wang X, Li D, Lv L, Li B，Th17 cells in autoimmune diseases，Front Med.，2015，9(1):10-9. doi: 10.1007

Li D, Kong C, Tsun A, Chen C, Song H, Shi G, Pan W, Dai D, Shen N, Li B，MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression，Sci Rep.，2015，5:14615. doi: 10.1038

Zhuo C, Xu Y, Ying M, Li Q, Huang L, Li D, Cai S, Li B，FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer，Immunol Res.，2015，61(3):338-47. doi: 10.1007

Wu Y, Yang L, Zhao J, Li C, Nie J, Liu F, Zhuo C, Zheng Y, Li B, Wang Z, Xu Y.，Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer.，Mol Cancer，2015，14(1):191. doi: 10.1186

Li Z, Li D, Tsun A, Li B，FOXP3+ regulatory T cells and their functional regulation，Cell Mol Immunol. ，2015，12(5):558-65. doi: 10.1038

Lin F, Luo X, Tsun A, Li Z, Li D, Li B，Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation，Int Immunopharmacol.，2015，(2):859-65. doi:10.1016

Song H, Tao L, Chen C, Pan L, Hao J, Ni Y, Li D, Li B, Shi G，USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation，Int J Clin Exp Pathol.，2015，8(9):10707-15

Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B，PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation，J Biol Chem.，2014，289(39):26872-81. doi: 10.1074

Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B，The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells，J Biol Chem.，2014，289(37):25546-55. doi: 10.1074

Gao Y, Lin F, Xu P, Nie J, Chen Z, Su J, Tang J, Wu Q, Li Y, Guo Z, Gao Z, Li D, Shen J, Ge S, Tsun A, Li B，USP22 is a positive regulator of NFATc2 on promoting IL2 expression，FEBS Lett. ，2014，588(6):878-83. doi: 10.1016

Tao L, Chen C, Song H, Piccioni M, Shi G, Li B，Deubiquitination and stabilization of IL-33 by USP21，Int J Clin Exp Pathol.，2014，7(8):4930-7

Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z, Li B，60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells，J Biol Chem.，2013，288(22):15537-46. doi: 10.1074

Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B，The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3，Immunity. ，2013，39(2):272-85. doi: 10.1016

Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G, Li B，Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3，J Biol Chem.，2013，288(13):9373-82. doi: 10.1074

Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A，Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation，J Biol Chem.，2013，288(49):35093-103. doi: 10.1074

Chen Z, Luo X, Lu Y, Zhu T, Wang J, Tsun A, Li B，Ubiquitination signals critical to regulatory T cell development and function，Int Immunopharmacol.，2013，16(3):348-52. doi: 10.1016

Gao Z, Gao Y, Li Z, Chen Z, Lu D, Tsun A, Li B，Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation，Int J Clin Exp Pathol.，2012，5(7):626-33