研究生导师

肥胖症的发病机制与临床干预研究

2026-01~2030-12，国家自然基金项目 ，肥胖发生机制与干预研究 （原国家杰青项目），课题负责人

2025-01~2026-12，国家自然基金项目 ，糖脂代谢功能小分子与蛋白互作及其调控代谢 性疾病发生的机制，子课题负责人

2025-01~2028-12，国家自然基金项目 ，肥胖新基因G蛋白耦联受体LGR4致胖机制及生 物阻断剂开发，课题负责人

2024-08~2028-07，科技部项目 ，关键膳食组分干预肥胖的全国多中心随机对照临床研究，子课题负责人

2022-12~2025-12，科技部项目 ，中国人极端肥胖队列与精细分型研究，课题负责人

2022-11~2027-11，省级其他 ，“脑肠轴”对话调控肠道油脂吸收机制及其在肥胖发生中的作用研究，课题负责人

2020-08~2022-07，省级其他 ，青少年肥胖病的发病机制与干预研究，课题负责人

2020-01~2022-12，省级其他 ，R-Spondins/LGR4 通路调控能量平衡与糖脂代谢的机制研究，课题负责人

2020-01~2020-12，国家自然基金项目 ，性别决定关键基因调控能量平衡与糖脂代谢的机制研 究，课题负责人

2019-09~2020-08，省级其他 ，Jiangnan Diet Intervention Study，课题负责人

2019-06~2022-03，省级其他 ，构建多种动物模型探究经典Wnt信号通路参与肥胖症发生和脂肪棕色化的分子机制，课题负责人

2019-01~2021-12，科技部项目 ，肠道与下丘脑在糖尿病发生发展中的作用及干预新方案研究，子课题负责人

2018-07~2021-06，省级其他 ，Wnt信号通路与肥胖发生，课题负责人

2016-07~2019-06，省级其他 ，LGR4/Wnt/beta-catenin信号通路与肥胖发生，课题负责人

2016-01~2018-01，国家自然基金项目 ，肥胖症发病机制，课题负责人

2016-01~2019-12，国家自然基金项目 ，NPC1促进中国青少年肥胖发生的遗传与机制研究，课题负责人

2014-01~2017-12，国家自然基金项目 ，LGR4调节米色脂肪前体细胞定向分化机制及肥胖治疗应用，课题负责人

2012-01~2012-12，国家自然基金项目 ，GPR48在昼夜节律异常与能量代谢紊乱中的作用，课题负责人

2011-01~2014-12，国家自然基金项目 ，G蛋白偶联受体家族成员GPR48在能量平衡与肥胖发生中的作用研究，课题参与人

Muye Tong, Yanru Chen, Beite Song, Jie Hong, Weiqiong Gu, Juan Shen, Huanjie Yang, Huimin Xia, Qian Li, Yufei Chen, Shaoqian Zhao, Qianqian Lyu, Wenzhi Xue, Qinyun Ma, Houde Zhou, Huixuan Wu, Yihua Guo, Zhiwen Cao, Yuxiao Zhao, Minchun Zhang, Xuejiang Gu, Jie Zheng, Yifei Zhang, Jieli Lu, Guang Ning, Yufang Bi, Weiqing Wang, Ruixin Liu, Jiqiu Wang， The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity，Science Translational Medicine ，2026，18(836):eadw0458

Xiaoliu Shi, Xiao Hu, Xinlei Fang, Liangjie Jia, Fangchao Wei, Ying Peng, Menghao Liu, Aibo Gao, Ke Zhao, Fengyi Chen, Xiaoli Hu, Jie Hong, Guang Ning, Yongfeng Song*, Jiqiu Wang*, Yiguo Wang*，A feeding-induced myokine modulates glucose homeostasis，Nature Metabolism，2025，7(1): 68-83

Aijun Long, Yazhuo Wang, Yihua Guo, Jie Hong, Guang Ning, Zhuoxian Meng*, Jiqiu Wang*, Yiguo Wang*，A famsin-glucagon axis mediates glucose homeostasis，Cell Metabolism，2025，37(3): 629-639

Chao Wu, Fangming Yang, Huanzi Zhong, Jie Hong, Huibin Lin, Mingxi Zong, Huahui Ren, Shaoqian Zhao, Yufei Chen, Zhun Shi, Xingyu Wang, Juan Shen, Qiaoling Wang, Mengshan Ni, Banru Chen, Zhongle Cai, Minchun Zhang, Zhiwen Cao, Kui Wu, Aibo Gao, Junhua Li, Cong Liu, Minfeng Xiao, Yan Li, Juan Shi, Yifei Zhang, Xun Xu, Weiqiong Gu, Yufang Bi, Guang Ning*, Weiqing Wang*, Jiqiu Wang*, Ruixin Liu*，Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption，Cell Host Microbe，2024，32(8): 1301-1314

Qianqian Lyu, Wenzhi Xue, Ruixin Liu, Qinyun Ma, Vikram Babu Kasaragod, Shan Sun, Qian Li, Yanru Chen, Mingyang Yuan, Yuying Yang, Bing Zhang, Aifang Nie, Sheng Jia, Chongrong Shen, Po Gao, Weifang Rong, Chenxi Yu, Yufang Bi, Chunlei Zhang, Fajun Nan, Guang Ning, Zihe Rao, Xiuna Yang, Jiqiu Wang*, Weiqing Wang* ，A brain-to-gut signal controls intestinal fat absorption，Nature，2024，634(8035): 936-943

Xingyu Wang, Zhongle Cai, Qiaoling Wang, Chao Wu, Yingkai Sun, Zhifeng Wang, Xiaoqiang Xu, Wenzhi Xue, Zhiwen Cao, Minchun Zhang, Yinmeng Zhu, Huibin Lin, Yi Zhang, Mingyang Yuan, Yuxiao Zhao, Aibo Gao, Yuqiang Yu, Yufang Bi, Guang Ning*, Weiqing Wang*, Jiqiu Wang*, Ruixin Liu*，Bacteroides methylmalonyl-CoA mutase produces propionate that promotes intestinal goblet cell differentiation and homeostasis，Cell Host Microbe，2024，32(1): 63-78

Zhiyin Zhang#, Na Chen#, Nan Yin#, Ruixin Liu#, Yang He#, Danjie Li, Muye Tong, Aibo Gao, Peng Lu, Yuxiao Zhao, Huabing Li, Junfang Zhang, Dan Zhang, Weiqiong Gu, Jie Hong, Weiqing Wang, Lu Qi, Guang Ning, Jiqiu Wang*，The rs1421085 variant within FTO promotes brown fat thermogenesis，Nat Metab，2023， doi: 10.1038/s42255-023-00847-2

Yingkai Sun#, Juan Zhang#, Jie Hong#, Zhongyun Zhang#, Peng Lu#, Aibo Gao, Mengshan Ni, Zhiyin Zhang, Huanjie Yang, Juan Shen, Jieli Lu, Wenzhi Xue, Qianqian Lv, Yufang Bi, Yi Arial Zeng, Weiqiong Gu, Guang Ning, Weiqing Wang*, Ruixin Liu*, Jiqiu Wang*，Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity，Adv Sci，2023，10(12):e2207152

Ningning Zhang#, Mingyang Yuan#, Jiqiu Wang*，LGR4: A New Receptor Member in Endocrine and Metabolic Diseases，Endocr Rev，2023，44(4):647-667

Wen Liu#, Danjie Li#, Minglan Yang#, Long Wang#, Yu Xu#, Na Chen, Zhiyin Zhang, Juan Shi, Wen Li, Shaoqian Zhao, Aibo Gao, Yufei Chen, Qinyun Ma, Ruizhi Zheng, Shujing Wu, Yifei Zhang, Yuhong Chen, Shuwen Qian, Yufang Bi, Weiqiong Gu, Qiqun Tang, Guang Ning, Ruixin Liu, Weiqing Wang, Jie Hong, Jiqiu Wang*，GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning，EBioMedicine，2022，78:103969

Lingfang Zhuang, Kangni Jia, Chen Chen, Zhigang Li, Jiaxin Zhao, Jian Hu, Hang Zhang, Qin Fan, Chunkai Huang, Hongyang Xie, Lin Lu, Weifeng Shen, Guang Ning, Jiqiu Wang*, Ruiyan Zhang*, Kang Chen*, Xiaoxiang Yan*，DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics，Circulation，2022，145(11):829-846

Yaogan Luo#, Jiqiu Wang*,#, Liang Sun#, Weiqiong Gu#, Geng Zong, Boyu Song, Chongrong Shen, Puchen Zhou, Yufei Chen, Yanpu Wu, Huibin Lin, He Zheng, Mengshan Ni, Xiaowei Yang, Yanru Chen, Xinming Xu, Juan Zhang, Juan Shi, Ru Zhang, Jinfen Hu, Hong Hou, Ling Lu, Xiaoqiang Xu, Liming Liang, Ruixin Liu, Xiaoran Liu, Huaixing Li, Jie Hong, Weiqing Wang, Xu Lin*, Guang Ning*，Isocaloric-restricted Mediterranean diet and Chinese diets high or low in plants in adults with prediabetes，J Clin Endocrinol Metab，2022，dgac303

Yuying Yang, Yanman Zhou, Jingzun Xu, Lihao Sun, Bei Tao, Weiqing Wang, Jiqiu Wang*, Hongyan Zhao*, Jianmin Liu*，Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/β-catenin pathway，J Bone Miner Res，2021，36(8):1605-1620

Aibo Gao#, Junlei Su#, Ruixin Liu#, Shaoqian Zhao, Wen Li, Xiaoqiang Xu, Danjie Li, Juan Shi, Bin Gu, Juan Zhang, Qi Li, Xiaolin Wang, Yifei Zhang, Yu Xu, Jieli Lu, Guang Ning, Jie Hong, Yufang Bi, Weiqiong Gu*, Jiqiu Wang*, Weiqing Wang*，Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome，Nat Commun，2021，12(1):7080

Jie Hong, Tingting Bo, Liuqing Xi, Xiaoqiang Xu, Naying He, Yafeng Zhan, Wanyu Li, Peiwen Liang, Yufei Chen, Juan Shi, Danjie Li, Fuhua Yan, Weiqiong Gu, Weiqing Wang, Ruixin Liu, Jiqiu Wang*, Zheng Wang*, Guang Ning，Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity，J Clin Endocrinol Metab，2021，106(9):e3619-e3633

Juan Shi, Guoqing Bao, Jie Hong, Simin Wang, Yufei Chen, Shaoqian Zhao, Aibo Gao, Ru Zhang, Jingfen Hu, Wenjie Yang, Fuhua Yan, Ankang Lyu, Ruixin Liu, Bin Cui, Yuhong Chen, Jiabin Jin, Baiyong Shen, Yifei Zhang, Weiqiong Gu, Dagan Feng, Weiqing Wang, Jiqiu Wang*, Xiuying Wang*, Guang Ning*，Deciphering CT texture features of human visceral fat to evaluate metabolic disorders and surgery-induced weight loss effects，EBioMedicine，2021，69:103471

Chunkai Huang, Daopeng Dai, Hongyang Xie, Zhenbing Zhu, Jian Hu, Min Su, Mingyao Liu, Lin Lu , Weifeng Shen, Guang Ning, Jiqiu Wang*, Ruiyan Zhang*, Xiaoxiang Yan*，Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair，Cir Res，2020，10.1161/CIRCRESAHA.119.315807

Maopei Chen, Peng Lu, Qinyun Ma, Yanan Cao, Na Chen, Wen Li, Shaoqian Zhao, Banru Chen, Juan Shi, Yingkai Sun, Hongbin Shen, Liangdan Sun, Juan Shen, Qijun Liao, Yifei Zhang, Jie Hong, Weiqiong Gu, Ruixin Liu*, Guang Ning*, Weiqing Wang*, Jiqiu Wang*，CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes，Sci Adv，2020，6(2):eaax9605

Pei Liu, Sixia Huang, Shifeng Ling, Shuqin Xu, Fuhua Wang, Wei Zhang, Rujiang Zhou, Lin He, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Congxia Hu, Xiaodong Zhao, Haley O. Tucker, Jiqiu Wang*, Xizhi Guo*.，Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization.，Nat Commun，2019，10(1):5070

Yang He#, Ruixin Liu#, Mingting Zhu, Wenbin Shen, Jing Xie, Zhiyin Zhang, Na Chen, Chang Shan, Xin zhi Guo, Yide Lu, Bei Tao, Lihao Sun, Hongyan Zhao, Rui Guo, Biao Li, Simin Liu, Guang Ning*, Jiqiu Wang*, Jianmin Liu*，The browning of white adipose tissue and body weight loss in primary hyperparathyroidism，EBioMedicine，2019，Feb;40:56-66

Xuemin Gong#, Yunfeng Li#, Jie Luo#, Jiqiu Wang#, Jian Wei#, Juqiong Wang, Ting Xiao, Chang Xie, Jie Hong, Guang Ning, Xiongjie Shi, Boliang Li, Wei Qi*, Baoliang Song*，Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance，Nat Met，2019，doi.org/10.1038/s42255-019-0065-4

Yaoyu Zou, Tinglu Ning, Juan Shi, Maopei Chen, Lin Ding, Ya Huang, Sophie Kauderer, Min Xu, Bin Cui, Yufang Bi, Simin Liu, Jie Hong, Ruixin Liu, Guang Ning*, Jiqiu Wang*，Association of a gain-of-function variant in LGR4 with central obesity，Obesity，2017，25(1):252-260

Yaoyu Zou#, Peng Lu#, Juan Shi, Wen Liu, Minglan Yang, Shaoqian Zhao, Na Chen, Maopei Chen, Yingkai Sun, Aibo Gao, Qingbo Chen, Zhiguo Zhang, Qinyun Ma, Tinglu Ning, Xiayang Ying, Jiabin Jin, Xiaxing Deng, Baiyong Shen, Yifei Zhang, Bo Yuan, Sophie Kauderer, Simin Liu, Jie Hong, Ruixin Liu, Guang Ning*, Weiqing Wang*, Weiqiong Gu*, Jiqiu Wang*，IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants Are Associated with Human Obesity Risk，EBioMedicine，2017，24:64-75

Ruixin Liu#, Jie Hong#, Xiaoqiang Xu#, Qiang Feng#, Dongya Zhang#, Yanyun Gu#, Juan Shi, Shaoqian Zhao, Wen Liu, Xiaokai Wang, Huihua Xia, Zhipeng Liu, Bin Cui, Peiwen Liang, Liuqing Xi, Jiabin Jin, Xiayang Ying, Xiaolin Wang, Xinjie Zhao, Wanyu Li, Huijue Jia, Zhou Lan, Fengyu Li, Rui Wang, Yingkai Sun, Minglan Yang, Yuxin Shen, Zhuye Jie, Junhua Li, Xiaomin Chen, Huanzi Zhong, Hailiang Xie, Yifei Zhang, Weiqiong Gu, Xiaxing Deng, Baiyong Shen, Xun Xu, Huanming Yang, Guowang Xu, Yufang Bi, Shenghan Lai, Jian Wang, Lu Qi, Lise Madsen, Jiqiu Wang, Guang Ning*, Karsten Kristiansen*, Weiqing Wang*，Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention，Nature Medicine，2017，doi: 10.1038/nm.4358

Ruixin Liu#, Yaoyu Zou#, Jie Hong#, Min Cao#, Bin Cui#, Huiwen Zhang, Maopei Chen, Juan Shi, Tinglu Ning, Shaoqian Zhao, Wen Liu, Hui Xiong, Cuijie Wei, Zhengqing Qiu, Weiqiong Gu, Yifei Zhang, Wanyu Li, Lin Miao, Yingkai Sun, Minglan Yang, Rui Wang, Qinyun Ma, Min Xu, Yu Xu, Tiange Wang, Kei-hang Katie Chan, Xianbo Zuo, Haoyan Chen, Lu Qi, Shenghan Lai, Shumin Duan, Baoliang Song, Yufang Bi, Simin Liu*, Weiqing Wang*, Guang Ning*, Jiqiu Wang*，Rare Loss-of-Function Variants in NPC1 Predispose to Human Obesity，Diabetes，2017，66(4):935-947

Jian Luo, Zhengfeng Yang, Yu Ma, Zhiying Yue, Hongyu Lin, Guojun Qu, Jinping Huang, Wentao Dai, Chenghai Li, Chunbing Zheng, Leqin Xu, Huaqing Chen, Jiqiu Wang, Dali Li, Stefan Siwko, Josef M Penninger, Guang Ning, Jianru Xiao, Mingyao Liu ，LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption，Nature Medicine，2016，22:539-546

Jiqiu Wang#, Ruixin Liu#, Feng Wang#, Jie Hong, Xiaoying Li, Maopei Chen, Yingying Ke, Xianfeng Zhang, Qinyun Ma, Rui Wang, Juan Shi, Bin Cui, Weiqiong Gu, Yifei Zhang, Zhiguo Zhang, Weiqing Wang, Xuefeng Xia, Mingyao Liu and Guang Ning*，Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.，Nat Cell Biol，2013，15:1455-1463

Jiqiu Wang, Xiaoying Li, Yingying Ke, Yan Lu, Feng Wang, Nengguang Fan, Haiyan Sun, Huijie Zhang, Ruixin Liu, Jun Yang, Lei Ye, Mingyao Liu, and Guang Ning* ，GPR48 Increases Mineralocorticoid Receptor Gene Expression，J Am Soc Nephrol，2012，23:281-293