研究生导师

免疫代谢

2016-01~2019-12，国家自然科学基金 ，PLZF对3型天然淋巴细胞(ILC3)发育和功能的调控作用及机制研究，课题参与人

2016-01~2019-12，国家自然科学基金面上项目 ，SUMO特异性蛋白酶1(SENP1)对脂肪组织巨噬细胞的调控作 用以及与2型糖尿病发生的关系，课题负责人

2014-01~2017-12，国家自然科学基金面上项目 ， B淋巴细胞调节肥胖诱导胰岛素抵抗的作用机制，课题负责人

2014-01~2017-12，国家高层次人才计划 ，获得性免疫系统在胰岛素抵抗和2型糖尿病中的作用及机制，课题负责人

Cai T, Qiu J, Ji Y, Li W, Ding Z, Suo C, Chang J, Wang J, He R, Qian Y, Guo X, Zhou L, Sheng H, Shen L, Qiu J.，IL-17-producing ST2+ group 2 Innate Lymphoid Cells play a pathogenic role in lung inflammation，J Allergy Clin Immunol. ，2019，143(1):229-244

Wang H, Shen L, Sun X, Liu F, Feng W, Jiang C, Chu X, Ye X, Jiang C, Wang Y, Zhang P, Zang M, Zhu D, Bi Y.，Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity.，Nat Commun.，2019，10(1):3254

McLaughlin T, Ackerman SE, Shen L, Engleman E. ，Role of innate and adaptive immunity in obesity-associated metabolic disease.，J Clin Invest ，2017，127(1): 5-13

Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng J. ，SENP1 regulates IFN-g-STAT1 signaling through STAT3-SOCS3 negative feedback loop，J Mol Cell Biol，2017，9(2):144-153

Shen L, Chng MH, Alonso MN, Yuan R, Winer DA, Engleman EG. ，B-1a Lymphocytes Attenuate Insulin Resistance.，Diabetes.，2015，64(2):593-603

Shen L, Zhang H, Caimol M, Benike CJ, Chakravarty EF, Strober S, Engleman EG. ，Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production.，Eur J Immunol，2015，45(2): 612-623

Winer DA, Winer S, Chng MH, Shen L, Engleman EG. ，B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance. ，Cell Mol Life Sci.，2014，71(6):1033-43

McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E.，T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans.，Arterioscler Thromb Vasc Biol.，2014，34(12):2637-43

Zhang B, Lo C, Shen L, Sood R, Jones C, Cusmano-Ozog K, Park-Snyder S, Wong W, Jeng M, Cowan T, Engleman EG, Zehnder J.，The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP ，Blood，2011，117(17):4569-4579

Winer D, Winer S, Shen L, Wadia P, Yantha J, Paltser G, Tsui H, Wu P, Davidson M, Alonso M, Leong H, Glassford A, Caimol M, Tedder T, McLaughlin T, Miklos D, Dosch HM, Engleman EG.，B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies，Nature Medicine，2011，17(5):610-617

Song XT, Evel-Kabler K, Shen L, Rollins L, Huang XF, Chen SY. ，，Nature Medicine，2008，14(3):258-265

Shen L, Evel-Kabler K, Strube R, Chen SY.，Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity.，Nature Biotechnology，2004，22(12):1546-53