研究生导师

B淋巴细胞发育与恶变的分子机制研究

2019-01~2022-12，国家自然科学基金面上项目 ，Bcl6通过抑制PD-L1/2调控生发中心反应和分子机制，课题负责人

2018-08~2021-06，科技部重点研发 ，超声空化诱导的局部组织的免疫学效应和细胞分子机制，课题负责人

2016-01~2018-12，国家高层次人才计划 ，B细胞发育和恶变的转录机制，课题负责人

2015-09~2017-09，上海市科委 ，RD2结构域在生发中心和B细胞发育中的功能与作用机制，课题负责人

Zhang H, Hu Q, Zhang M, Yang F, Peng C, Zhang Z, Huang C，Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity，Front Immunol，2019，Sep 4;10:2050

Deng S,, Hu Q, Zhang H, Yang F, Peng C, Huang C，HDAC3 Inhibition Upregulates PD-L1 Expression in B-Cell Lymphomas and Augments the Efficacy of Anti-PD-L1 Therapy，Molecular Cancer Therapeutic ，2019，18(5):900-908

Peng C, Hu Q, Yang F, Zhang H, Li F, Huang C，BCL6-Mediated Silencing of PD-1 Ligands in Germinal Center B Cells Maintains Follicular T Cell Population.，Journal of Immunology，2019，202(3):704-713

Peng H, Yang F, Hu Q, Sun J, Peng C, Zhao Y, Huang C，The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity，Autophagy，2019，Jul 1:1-11

Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q，SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation，Nature Communication，2018，9(1):3157

Chen J, Jian X, Deng S, Ma Z, Shou X, Shen Y, Zhang Q, Song Z, Li Z, Peng H, Peng C, Chen M, Luo C, Zhao D, Ye Z, Shen M, Zhang Y, Zhou J, Fahira A, Wang Y, Li S, Zhang Z, Ye H, Li Y, Shen J, Chen H, Tang F, Yao Z, Shi Z, Chen C, Xie L, Wang Y, Fu C, Mao Y, Zhou L, Gao D, Yan H, Zhao Y, Huang C, Shi Y，Identification of recurrent USP48 and BRAF mutations in Cushing's disease，Nature Communication，2018， 9;9(1):3171

Sun J, Hu Q, Peng H, Peng C, Zhou L, Lu J, Huang C，The ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43，Journal of Biology Chemistry ，2018，25;293(21):8275-8284

Zhang Q, Peng C, Song J, Chen J, Song Z, Shou X, Shi Y, Huang C, Zhao Y.，Germline Mutations in CDH23, Encoding Cadherin-Related 23, Are Associated with Both Familial and Sporadic Pituitary Adenomas.，Am J Human Genet，2017，100(5): 817-823

Ma ZY, Song ZJ, Chen JH, Wang YF, Li SQ, Zhou LF, Mao Y, Li YM, Hu RG, Zhang ZY, Ye HY, Shen M, Shou XF, Li ZQ, Peng H, Wang QZ, Zhou DZ, Qin XL, Ji J, Zheng J, Chen H, Wang Y, Geng DY, Tang WJ, Fu CW, Shi ZF, Zhang YC, Ye Z, He WQ, Zhang QL, Tang QS, Xie R, Shen JW, Wen ZJ, Zhou J, Wang T, Huang S, Qiu HJ, Qiao ND, Zhang Y, Pan L, Bao WM, Liu YC, Huang C, Shi YY, Zhao Y，Recurrent gain-of-function USP8 mutations in Cushing’disease，Cell Res，2015，25(3):306-17

Huang C, Shi YY and Zhao Y，USP8 mutations in Cushing’s disease，Oncotarget，2015，6(21):18240-18241

Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A，The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers，Cell Reports，2014，8(5):1497-508

Huang C, Geng H, Boss I, Wang L, Melnick AM，Cooperative transcriptional repression by BCL6 and BACH2 in germinal centre B-cell differentiation，Blood，2014，123(7):1012-20

Sun Z, Huang C, He J, Lamb, Kristy L Kang X Shen WH Yin, Y， PTEN C-terminal deletion causes genomic instability and tumor development，Cell Reports，2014，6(5):844-54

Huang C, Hatzi K, Melnick AM， Lineage-specific functions of Bcl6 in immunity and inflammation are mediated through distinct biochemical mechanisms，Nature Immunology ，2013，14(4): 380-8

Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Carina Ng, Titz B, Hurtz C, Sadiyah F, Melnick AM, Müschen M，BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint，Nature Medicine，2013，19(8):1014-22