研究生导师

免疫调节与自身免疫病

2018-01~2021-10，国家自然科学基金，面上项目 ，关节滑膜肥大细胞的区域免疫特性及其介导的Th17活化和相互作用在类风湿关节炎发病中的研究，课题负责人

2014-01~2017-12，国家自然科学基金 ，IFN-β调控OPN/Th17炎性通路在多发性硬化中的机理研究，课题负责人

2012-01~2012-12，卫生局科技发展基金 ，β-干扰素对多发性硬化的免疫调节机制研究，课题负责人

2012-01~2014-12，上海市科委基础研究重点项目 ，IFN-β恢复多发性硬化Treg/Th17平衡作用机制的研究，课题负责人

2012-01~2014-12，上海市教委科研创新(重点) ，IFN-β恢复多发性硬化IFN-β在实验性自身免疫性脑脊髓炎中的免疫调节机制研究，课题负责人

2010-01~2012-12，国家自然基金，面上项目 ，免疫活性肽段ergotype在类风湿关节炎中的免疫调节作用研究，课题负责人

2009-01~2011-12，上海市教委基金 ，免疫活性肽段ergotope对类风湿关节炎的免疫干预研究，课题负责人

2008-01~2010-12，上海市卫生局,局级课题 ，类风湿关节炎中骨桥蛋白调控IL-17表达的机制及发病学意义，课题负责人

2007-11~2009-11，上海市科委,自然基金 ，骨桥蛋白调控IL-17表达在类风湿关节炎中发病机制的研究，课题负责人

Xinyue Du, Baiyang Ren, Chang Li, Qi Li, Shuo Kan, Xin Wang, Wenjuan Bai , Chenyun Wu, Kokouvi Kassegne, Huibo Yan , Xiaoyin Niu , Min Yan , Wenyue Xu, Samuel C. Wassmer, Jing Wang, Guangjie Chen ＆ Zhaojun Wang，PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury，Nature Communications. 2024;15:881 ，2024，881

Yunxuan Lei, Xin Guo, Yanping Luo , Xiaoyin Niu , Yebin Xi , Lianbo Xiao, Dongyi He, Yanqin Bian, Yong Zhang , Li Wang , Xiaochun Peng , Zhaojun Wang ＆ Guangjie Chen， Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis.，Nature Communications. 2024;15:113，2024，113

Qing Zhao, Wenjing Cheng, Yebin Xi, Zheyi Cao, Yunzhi Xu, Ting Wu, Chengzhen Li, Xiaoyin Niu, Guangjie Chen.，IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis. ，Molecular Immunology，2018，93:20–30

Xiao-Xiao Hou, Guangjie Chen, Amir M. Hossini, Tingting Hu, Lanqi Wang, Zhanyan Pan, Lingyi Lu, Ke Cao, Ying Ma, Christos C. Zouboulis, Longqing Xia, Qiang Ju.，Aryl Hydrocarbon Receptor Modulates the Expression of TNF-α and IL-8 in Human Sebocytes via the MyD88-p65NF-κB/p38MAPK Signaling Pathways. ，J Innate Immun. ，2018，46035

Cennan Yin1,Chenyun Wu, Xinyue Du, Yan Fang, Juebiao Pu, Jianhua Wu,Lili Tang, Wei Zhao, Yongqiang Weng, Xiaokui Guo, Guangjie Chen,Zhaojun Wang，PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS，.Frontiers in immunology，2018，2.186806

Jinglue Song, Hongli Liu, Qi Zhu, Yutong Miao, Feiyan Wang, Fan Yang, Wenjing Cheng, Yebin Xi, Xiaoyin Niu, Dongyi He,Guangjie Chen.，T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-??B，BioMed Research International ，2018，4901591:1

Wu Ting，Chen Guangjie，miRNAs Participate in MS Pathological Processes and Its Therapeutic Response，Mediators of Inflammation，2016，2016

Shicheng Guo ，Qi Zhu，Ting Jiang，Rongsheng Wang，Yi Shen，Xiao Zhu，Yan Wang，Fengmin Bai，Qin Ding，Xiaodong Zhou，Guangjie Chen ，Dong Yi He.，Genome-wide DNA methylation patterns in CD4+ T cells from Chinese Han patients with rheumatoid arthritis.，Modern Rheumatology，2016，1：1~7

Niu Xiaoyin，Deng Shaohua，Li Shan，Xi Yebin，Li Chengzhen，Wang Li，He Dongyi，Wang Zhaojun, Chen Guangjie，Effect of Ergotope Peptides on Collagen-Induced Arthritis by Downregulation of Inflammatory and Th1/Th17 Responses and Induction of Regulatory T cells.，Mol Immunol，2016，22：608~620

Li C, Xi Y, Li S, Zhao Q, Cheng W, Wang Z, Zhong J, Niu X, Chen G，Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation，Molecular Immunology，2015，pii: S0161-5890(15)30021-3. doi: 10.1016/j.molimm

Xu Yunzhi，Zhu Qi，Song Jinglve，Liu Hongli，Miao Yutong，Yang Fan，Wang Feiyan，Cheng Wenjing，Xi Yebin，Niu iaoyin，He Dongyi, Chen Guangjie，Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid，Mediators Inflamm，2015，2015:356040-356040

Xu YZ, Chen GJ，Mast Cell and Autoimmune Diseases，Mediators of Inflammation，2015，Volume 2015, Article ID 246126

Fang Y, Wu C, Chen Q, Wu J, Yang Y, Guo X, Chen G, Wang Z，SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development.，Acta Trop，2015，149:49-58

Cheng WJ, Zhao Q, Xi YB, Li CZ, Xu YZ, Wang L, Niu XY,Wang ZJ, Chen GJ，IFN-β inhibits infiltrated T cells accumulation in the central nervous system by reducing the expression of chemokines in experimental autoimmune encephalomyelitis，Molecular Immunology. ，2015，64:152-162.

Zhao Q, Chen GJ，Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases，BioMed Research International，2014，Volume 2014, Article ID 587376

Niu XY, Chen GJ，Clinical Biomarkers and Pathogenic-Related Cytokines in Rheumatoid Arthritis，Journal of Immunology Research，2014，Volume 2014, Article ID 698192

Cheng WJ, Chen GJ，Chemokines and Chemokine Receptors in Multiple Sclerosis. Mediators of Inflammation，Mediators of Inflammation，2014，2014:659206-14

Niu XY, Chen GJ，IL-21 and Related Diseases，Clinical and J Clin Cell Immunol，2013，2013:1-008

Li S, Niu XY, Xi YB, Deng SH, Li CZ, Zhao Q, Chen GJ.， T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis. ，Clinical and Developmental Immunology，2013，2013:967301-9

Chen M, Chen G(co-first author), Deng S, Liu X, Hutton GJ, Hong J.，IFN-? induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis. ，J Neuroimmunol.，2012，242:39-46

Niu XY, He DY, Deng SH, Li WY, Xi YB, Xie CY, Jiang T, Zhang J, Dong C, Chen GJ，Regulatory immune responses induced by IL-1 receptor antagonist inrheumatoid arthritis.，Molecular Immunology，2011，49:290-296

Deng SH, Xi YB, Wang H, Hao J, Niu XY, Li WY, Yue T, Chen GJ，Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis. ，Cell Immunol.，2010，265(2):105-10

Xiaoyin Niu, Dongyi He, Xin Zhang, Ningli Li, Jingwu Z Zhang, Chen Dong, Guangjie Chen.，IL-21 regulates Th17 cells in rheumatoid arthritis.，Human Immunology，2010，71(4):334-341

Guangjie Chen，Immunotherapy of Rheumatoid Arthritis：targeting on inflammatory cytokines and autoreactive T cells. ， Archivum Immunologiae et Therapiae Experimentalis，2010，58:27-36

Chen MY, Chen GJ(co-first author) , Nie H, Zhang X, Niu XY, Zang Y, Skinner SM, Zhang JW, Killian JM, Hong J. ，Regulatory effect of Interferon-Beta on Production of IL-17 and Osteopontin in CD4+ T Cells in Multiple Sclerosis. ，European Journal of Immunology.，2009，39(9):2525-2536

Han YP, Chen GJ，A Method of Analyzing the Structures of Misfolding Proteins like Prion Protein.，Proceeding of 2nd International Conference on Bioinformatics and Biomedical Engineering (iCBBE2008)，2008，1:253-255