研究生导师

病原菌致病机制及宿主天然免疫反应

2025-01~2029-12， 科技部项目，病原菌与宿主免疫互作的分子动态修饰与调控机制，子课题负责人

2023-01~2026-12，国家自然科学基金 ，L-阿拉伯糖促进沙门菌肠道定植和系统性感染的分子机制，课题负责人

2019-01~2023-12，国家自然科学基金委重点项目 ，蛋白质翻译后修饰调控沙门菌双组份系统PhoP/PhoQ机制及 意义，课题负责人

2018-01~2021-12，国家自然科学基金 ，乙酰化修饰调节沙门菌双组份系统PhoP磷酸化的机制及意义，课题负责人

2016-01~2020-12，国家重点研发计划 ，病原菌核糖体调节因子的发现、鉴定及调控机制研究，课题参与人

2015-01~2017-12，上海市教委 ，上海高校特聘教授(东方学者)跟踪计划，课题负责人

2015-01~2018-12，上海市公共卫生三年行动计划重点学科建设项目 ，传染病与卫生微生物学，课题参与人

2015-01~2019-12，科技部973计划 ，表观修饰与病原细菌适应性进化，课题负责人

2014-01~2016-12，国家自然科学基金委面上项目 ，细胞壁脂类与耐利福平结核分枝杆菌致病性关系的研究，课题负责人

2013-01~2016-12，国家自然科学基金委面上项目 ，肠出血型大肠埃希菌VI型分泌系统分泌蛋白鉴定及功能研究，课题负责人

2012-01~2014-12，上海市科委，青年科技启明星(跟踪) ，结核分枝杆菌未知功能ABC超家族转运蛋白的研究，课题负责人

2011-01~2013-12，国家自然科学基金委面上项目 ，结核分枝杆菌DnaA乙酰化修饰与DNA复制调控的研究，课题负责人

2010-01~2012-12，上海市教委 ，上海高校特聘教授(东方学者)，课题负责人

2009-07~2011-06，上海市科委，青年科技启明星A ，结核分枝杆菌MazG功能研究及其与无毒株H37Ra表型的关系，课题负责人

2009-01~2011-12，国家自然科学基金委面上项目 ，细胞毒素坏死因子(CNF1)的分泌及其作用机制，课题负责人

2009-01~2013-12，科技部973计划 ，结核杆菌微进化的研究，课题负责人

Xu Z, Tang H, Yan M, Li H, Zhou A, Chen Y, Yan C, Karakousis PC, Ni J, Wang D, Tao J, Wu W, Xie Q, Lu J, Zhan L*, Sun Y*, Zhao W*, Yao Y*，A copper uptake ABC transport system is essential for Mycobacterium tuberculosis virulence，Emerg Microbes Infect，2026，15(1):2668753.

Wang Z, Tang H, Huang W, Wang C, Chen Y, Yu J, Zhou T, Wen B, Ni J, Wang D, Tao J, Zhu S, Lyu L, Chen L, Li J, Kuang Q, Yu D, Liu J, Pan L, Zhang M, Xu Y, Zhao GP, Lu J*, Yao Y*，Salmonella-derived heam inhibits macrophage phagocytosis and promotes infection in mice，Nat Microbiol，2026，11(6):1722-1738

Sun Z, Dong C, Zhou P, Guan Q, Cui Z, Xia Y, Yao Y*，Type VI secretion system degeneration accelerates intestinal epithelial cell death in Escherichia coli O157:H7，PLoS Pathog，2026，22(3): e1014039

Zhang C, Zhou T, Li C, Wang D, Tao J, Zhu C, Lu J, Ni J*, Yao Y*，Deciphering novel enzymatic and non-enzymatic lysine lactylation in Salmonella，Emerg Microbes Infect，2025，14(1): 2475838

Tang H, Wang Z, Li C, Yu J, Huang W, Zhou T, Zhang C, Wen B, Wang C, Zhu C, Wang D, Tao J, Lu J, Ni J*, Yao Y*，Disruption of sulfur transferase complex increases bacterial intramacrophage persistence，PLoS Pathog，2025，21(5): e1013136

Yu J, Tang H, Chen Y, Wang Z, Huang W, Zhou T, Wen B, Wang C, Gu S, Ni J, Tao J, Wang D, Lu J*, Xie Q*, Yao Y*，Salmonella utilizes L-arabinose to silence virulence gene expression for accelerated pathogen growth within the host，Gut Microbes，2025，17(1): 2467187

Zhou X, Zhang H, Wang Y, Wang D, Lin Z, Zhang Y, Tang Y, Liu J, Yao Y*, Zhang Y*, Pan L*，Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity，Nat Commun，2025，16(1): 3099

Zhou N, Yu J, Liu X, Li C, Tang H, Lyu L, Wu C, Chen Y, Zhang J, Ni J, Wang D, Tao J, Wu W, Zhang Y, Feng Y, Chao Y, Lu J*, He P*, Yao Y*，Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection，Cell Rep，2025，44(1): 115214

Zhong L, Xu D, He J, Sun L, Fan G, Zhu T, Yao Y*, Feng T*, Cui Z*，Pre-exposure to phage particles reduces their antibacterial therapeutic efficacy both in vitro and in vivo，Int J Med Microbiol，2025，318: 151649

Yu J, Tang H, Zhou N, Wang Z, Huang W, Chen Y, Wang D, Ni J, Lu J*, Yao Y*，Dietary L-arabinose-induced gut dysbiosis exacerbates Salmonella infection outcome，mSystems，2024，9(8): e0052224

Zhang W, Lyu L, Xu Z, Ni J, Wang W, Lu L, Yao Y，Integrative DNA methylome and transcriptome analysis reveals DNA adenine methylation is involved in Salmonella enterica Typhimurium response to oxidative stress，Microbiol Spectr，2023，e02479-23

Ni J, Li S, Lai Y, Wang Z, Wang D, Tan Y, Fan Y, Lu J, Yao Y，Global profiling of ribosomal protein acetylation reveals essentiality of acetylation homeostasis in maintaining ribosome assembly and function，Nucleic Acids Res，2023，51(19):10411-10427

Wang D, Ni J, Li J, Gao Y, Ni F, Zhang Z, Fang J, Lu J, Yao Y，Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation，PLoS Pathog，2023，19(2):e1011189

Wang Z, Zhu S, Li C, Lyu L, Yu J, Wang D, Xu Z, Ni J, Gao B, Lu J, Yao Y，Gene essentiality profiling reveals a novel determinant of stresses preventing protein aggregation in Salmonella，Emerg Microbes Infect，2022，11(1): 1554-71

Sun Z, Zhou N, Zhang W, Xu Y, Yao Y，Dual role of CsrA in regulating the hemolytic activity of Escherichia coli O157:H7，Virulence，2022，13(1): 859-74

Li J, Liu S, Su Y, Ren J, Sang Y, Ni J, Lu J*, Yao Y*，Acetylation of PhoP K88 is involved in regulating Salmonella virulence，Infect Immun，2021，89(3):e00588-20

Su Y, Li J, Zhang W, Ni J, Huang R, Wang Z, Cheng S, Wang Y, Tian Z, Zhou Q, Lin D, Wu W, Tang CM, Liu X*, Lu J*, Yao Y*，Methylation of PhoP by CheR regulates Salmonella virulence，mBio，2021，12(5): e02099-21

Zhou A, Li J, Xu Z, Ni J, Guo J, Yao Y*, Wu W*，Whole-genome comparative and pathogenicity analysis of Salmonella enterica subsp. enterica serovar Rissen，G3:Genes Genomes Genetics，2020，10(7):2159-70

Ren J, Sang Y, Qin R , Su Y, Cui Z, Mang Z, Li H, Lu S, Zhang J, Cheng S, Liu X, Li J, Lu J, Wu W, Zhao GP, Shao F, Yao YF，Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation，Emerg Microbes Infect，2019，8(1):55-69

Yu X, Fu F, Kong W, Xuan Q, Wen D, Chen X, He Y, He L, Guo J, Zhou A, Xi Y, Ni L, Yao YF, Wu W，Streptococcus agalactiae inhibits Candida albicans hyphal development and diminishes host vaginal mucosal TH17 response，Front Microbiol，2018，0.5125

Xu Z, Zhou A, Wu J, Zhou A, Li J, Zhang S, Wu W, Karakousis PC, Yao YF，Transcriptional approach for decoding the mechanism of rpoC compensatory mutations for the fitness cost in rifampicin-resistant Mycobacterium tuberculosis，Front Microbiol，2018，2.385417

Ren J, Sang Y, Lu J, Yao YF，6S RNA is involved in acid resistance and invasion of epithelial cells in Salmonella enterica serovar Typhimurium，Future Microbiol，2017，12:1045-57

Wan B, Zhang Q, Ni J, Li S, Wen D, Li J, Xiao H, He P, Ou H, Tao J, Teng Q, Lu J, Wu W, Yao YF，Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS)，PLoS Pathog，2017，e1006246

Li S, Zhang Q, Xu Z, Yao YF，Acetylation of lysine 243 inhibits the oriC binding ability of DnaA in Escherichia coli，Front Microbiol，2017，0.81875

Ren J, Sang Y, Lu J, Yao YF ，Protein acetylation and its role in bacterial virulence，Trends Microbiol，2017，25(9):768-779

Sang Y, Ren J, Qin R, Liu S, Cui Z, Cheng S, Liu X, Lu J, Tao J, Yao YF，Acetylation regulates protein stability and DNA-binding ability of HilD, thus modulating Salmonella Typhimurium virulence，J Infect Dis，2017，216(8):0118-26

Zhang Q, Zhou A, Li S, Ni J, Tao J, Lu J, Wan B, Li S, Zhang J, Zhao S, Zhao GP, Shao F, Yao YF. ，Reversible lysine acetylation is involved in DNA replication initiation by regulating activities of initiator DnaA in Escherichia coli，Sci Rep，2016，6:30837

Sang Y, Ren J, Ni J, Tao J, Lu J, Yao YF，Protein acetylation is involved in Salmonella enterica serovar Typhimurium virulence.，J Infect Dis，2016，213(11):1836-45

Wan B, Zhang Q, Tao J, Zhou A, Yao YF, Ni J，Global transcriptional regulation by H-NS and its biological influence on the virulence of Enterohemorrhagic Escherichia coli，Gene，2016，588(2):115-23

Ren J, Sang Y, Tan Y, Tao J, Ni J, Liu S, Fan X, Zhao W, Lu J, Wu W, Yao YF，Acetylation of lysine 201 inhibits the DNA-binding ability of PhoP to regulate Salmonella virulence，PLoS Pathog，2016，e1005458

Qin R, Sang Y, Ren J, Zhang Q, Li S, Cui Z, Yao YF，The bacterial two-hybrid system uncovers the involvement of acetylation in regulating of Lrp activity in Salmonella Typhimurium，Front Microbiol，2016，1.586111

Zhang Q, Wan B, Zhou A, Ni J, Xu Z, Li S, Tao J, Yao YF，Whole genome analysis of a multiple drug-resistant Beijing/W strain of Mycobacterium tuberculosis with large genomic deletions，Gene，2016，582(2):128-36

Tan Y, Xu Z, Tao J, Ni J, Zhao W, Lu J, Yao YF，A SIRT4-like auto ADP-ribosyltransferase is essential for the environmental growth of Mycobacterium smegmatis，Acta Biochim Biophys Sin (Shanghai)，2016，48(2):145-52

Ren J, Sang Y, Lu J, Zhao M, Yao YF，Acetylation regulates survival in acid stress of Salmonella Typhimurium，Appl Environ Microbiol，2015，81(17):5675-82

Tao J, Sang Y, Teng Q, Ni J, Yang Y, Tsui S, Yao YF，Heat shock proteins IbpA and IbpB are required for NlpI-participated cell division in Escherichia coli.，Front Microbiol，2015，06:51:00.000

Xu Z, Zhou A, Ni J, Zhang Q, Wang Y, Lu J, Wu W, Karakousis PC, Lu S, Yao YF，Differential expression of miRNAs and their relation to active tuberculosis，Tuberculosis，2015，95(4):395-403

Zhou A, Ni J, Xu Z, Wang Y, Lu S, Wu W, Karakousis PC, Yao YF，Metabolomics specificity of tuberculosis plasma revealed by 1H-NMR spectroscopy，Tuberculosis，2015，95(3):294-302

Zhou A, Ni J, Xu Z, Wang Y, Lu S, Sha W, Karakousis PC, Yao YF，Application of 1H-NMR spectroscopy-based metabolomics to sera of tuberculosis patients，J Proteome Res，2013，12(10):4642-9

Zhou Y, Tao J, Yu H, Ni J, Zeng L, Teng Q, Kim KS, Zhao GP, Guo XK, Yao YF，Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells，Infect and Immun，2012，80(3):1243-51

Zhou A, Nawaz M, Duan Y, Moore J, Millar C, Xu J, Yao YF，Molecular characterization of isoniazid resistant Mycobacterium tuberculosis isolates from Xi’an, China，Microb Drug Resist，2011，17(2):275-81

Zhou A, Nawaz M, Xue X, Karakousis P, Yao YF, Xu J，Molecular genotyping study of Mycobacterium tuberculosis in Xi’an, China using MIRU-VNTR typing system，Int J Tuberc Lung Dis，2011， 15(4):517-22

Lu LD, Sun Q, Fan XY, Zhong Y, Yao YF, Zhao GP，Mycobacterial MazG Is A Novel NTP Pyrophosphohydrolyase Involved in Oxidative Stress Response，J Biol Chem，2010， 285(36):28076-85

Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao YF, Ning Z, Zeng R, Xiong Y, Guan K, Zhao S, Zhao G，Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux， Science，2010， 327(5968):1004-7

Yao YF, Xie Y, Perace D, Zhong Y, Lu J, Tao J, Guo X, Kim KS，The type III secretion system is involved in the invasion and intracellular survival of Escherichia coli K1 in human brain microvascular endothelial cells， FEMS Microbiol Lett，2009， 300(1):18-24

Parthasarathy G, Yao YF, Kim KS，Flagella promote Escherichia coli K1 association with and invasion of human brain microvascular endothelial cells (HBMEC)， Infect and Immun，2007， 75(6):2937-45

Yao YF, Vuong C, Kocianova S, Villaruz A, Lai Y, Sturdevant D, Otto M，Characterization of the Staphylococcus epidermidis accessory-gene regulator response: Quorum-sensing regulation of resistance to human innate host defense， J Infect Dis，2006， 193(6):841-8

Yao YF, Xie Y, Kim KS，Genomic comparison of E. coli K1 strains isolated from the cerebrospinal fluid of patients with meningitis， Infect and Immun，2006， 74(4):2196-206

Kocianova S, Vuong C, Yao YF, Carmody A, Otto M，Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis， J Clin Invest，2005， 115(3):688-94

Yao YF, Sturdevant D, Villaru A, Xu L, Gao Q, Otto M，Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics， Infect and Immun，2005， 73(3):1856-60

Yao YF, Sturdevant D, Otto M，Genome-wide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into S. epidermidis biofilm pathophysiology， J Infect Dis，2005， 191(2):289-98

Vuong C, Kocianova S, Yao YF, Carmody AB, Otto M，Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo， J Infect Dis，2004， 190(8):1498-505

Yao YF, Zhang WW, Jiao RS, Zhao GP, Jiang WH， Efficient isolation of total RNA from antibiotic-producing bacterium Amycolatopsis mediterranei U32， J Microbiol Meth，2002， 51(2):191-5

一种CDC42乙酰化的特异性抗体、制备方法及应用(ZL 2022 1 1242236.7)，2025