研究生导师

自身免疫病及肿瘤的发病机制及免疫干预研究

2022-07~2023-06，上海市科委 ，PRMT5促进宫颈癌PD-L1表达及抑制肿瘤浸润T细胞功能的细胞和分子机制，课题负责人

2019-11~2023-12，国家重点研发计划 ，利用新型 CAR-T 治疗复发难治 T 细胞淋巴瘤的临床研究，课题参与人

2017-01~2020-12，国家自然科学基金面上项目 ，CD8+CXCR3+T细胞调控Tfh细胞功能的分子机制及其在系统性红斑狼疮中作用的机制研究，课题负责人

2014-01~2016-12，上海市教委创新基金重点项目 ，IL-7/IL-7R调控类风关滑膜炎症和骨破坏分子机制研究，课题负责人

2014-01~2018-12，科技部973课题 ，遗传变异调控AS自身免疫紊乱的分子机制研究，课题参与人

2013-01~2016-12，国家自然科学基金面上项目 ，阻断IL-7/IL-7R信号通路治疗类风关细胞与分子机制研究，课题负责人

2011-01~2013-12，国家自然科学基金面上项目 ，TNFa下调类风关Treg细胞磷酸化Foxp3表达及促进Th17细胞分化机制研究，课题负责人

2009-01~2011-12，国家自然科学基金面上项目 ，Qa-1限制性调节性CD8+T细胞系建立、特性及效应机制研究，课题负责人

Wang Z, Li Z, Wang G, Sun Y, Yuan Y, Nie H，Salubrinal alleviates collagen-induced arthritis through promoting P65 degradation in osteoclastogenesis，Int J Mol Sci，2021，22(7):3501

Jiang Y, Yuan Y, Chen M, Li S, Bai J, Zhang Y, Sun Y, Wang G, Xu H, Wang Z, Zheng Y, Nie H，PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression，Theranostics，2021，11(18):9162-9176

Duan W, Sun Y, Wu M, Zhang Z, Zhang T, Wang H, Li F, Yang L, Xu Y, Liu ZJ, Hua T, Nie H, Cheng J，Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis，Eur J Med Chem，2021，226:113878

Xu H, Cai L, Li Z, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y, Nie H，Dual effect of IL-7/IL-7R signalling on the osteoimmunological system: a potential therapeutic target for rheumatoid arthritis，Immunology，2021，164(1):161-172

Yuan Y, Nie H，Protein arginine methyltransferase 5: a potential cancer therapeutic target，Cell Oncol (Dordr)，2021，44(1):33-44

Wei W, Wang Y, Sun Q, Jiang C, Zhu M, Song C, Li C, Du G, Deng Y, Nie H, Tang G.，Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus，J Oral Pathol Med，2019，doi: 10.1111/jop.12938

Yang L, Chen S, Zhao Q, Sun Y, Nie H，The Critical role of Bach2 in shaping the balance between CD4+ T cell subsets in immune-mediated diseases，Mediators Inflamm，2019，2609737

Jiang Y, Chen M, Nie H, Yuan Y，PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations，Human Vaccines and Immunotherapeutics，2019，1571892

Xu H, Cai L, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y, Nie H. ，Paeoniflorin ameliorates collagen-induced arthritis via suppressing nuclear factor-kB signalling pathway in osteoclast differentiation，Immunology，2018，154: 593-603

Wei J, Wu J, Xu W, Nie H, Zhou R, Wang R, Liu Y, Tang G, Wu J. ，Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1?signaling pathway，Cell Death Dis，2018，9(6): 599

Wang Y, Shang S, Sun Q, Chen J, Du G, Nie H, Han X, Tang G，Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus，Oral Surg Oral Med Oral Pathol Oral Radiol. ，2018，125(5):459-467

Han Zhang, Yuanyuan Qi, Yuanyang Yuan, Li Cai, Haiyan Xu, Lili Zhang, Bing Su, Hong Nie.，Paeoniflorin ameliorates experimental autoimmune encephalomyelitis via inhibition of dendritic cell function and Th17 cell differentiation.，Sci Rep，2017，7: 41887

Zheng Y, Huang L, Ge W, Yang M, Ma Y, Xie G, Wang W, Bian B, Li L, Nie H, Shen L. ，Protein arginine methyltransferase 5 inhibition upregulates Foxp3+ regulatory T cells frequency and function during the ulcerative colitis，Front Immunol，2017，0.747222

Li Cai, Haiyan Xu, Han Zhang, Lili Zhang, Guojue Wang, Hong Nie.，Blockade of IL-7Rα alleviates collagen-induced arthritis via inhibiting Th1 cell differentiation and CD4+ T cell migration.，Mol Immunol. ，2016，79: 83-91

Zheng Y, Sun L, Jiang T, Zhang D, He D, Nie H，TNFa promotes Th17 cell differentiation through IL-6 and IL-1b produced by monocytes in rheumatoid arthritis，J Immunol Res，2014，385352:1-12

Qianqian Yin, Chuanxu Liu, Yingli Wu, Shaofang Wu, Yan Wang, Xia Zhang, Xiaojuan Hu, Jianxin Pu, Ying Lu, Huchen Zhou, Honglin Wang, Hong Nie, Handong Sun, Guoqiang Chen.，Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-?B signaling，J Immunol，2013，191(5): 2115-2125

Hong Nie, Yingxia Zheng, Runsheng Li, Taylor B Guo, Dongyi He, Lei Fang, Xuebin Liu, Lianbo Xiao, Xi Chen, Bing Wan, Y Eugene Chin, Jingwu Z Zhang ，Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis，Nat. Med.，2013，19(3): 322-328

Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu ，Stimulation of TLR4 by LMW-HA induces metastasis in human papillary thyroid carcinoma through CXCR7，Clin Dev Immunol，2013，712561:1-9

Quanye Sun,Yingxia Zheng, Xia Zhang, Xiaojuan Hu, Yuanxia Wang, Shimin Zhang, Dongqing Zhang, Hong Nie，Novel immunoregulatory properties of EGCG on reducing inflammation in EAE，Frontiers in Bioscience, Landmark，2013，18:332-342