杜艳华
性 别:女
联系电话:
邮箱地址:yhdu@shsmu.edu.cn
培养单位:基础医学院
学科/专业
研究方向
科研项目
代表性论文
科研获奖
专利授权
2025-11~2027-12,2025年度国家科技重大专项新型组织方式项目,子课题7,分拨80万
,肿瘤微环境对胰腺癌异质性及治疗抵抗的调控作用与机制研究,课题参与人
2025-01~2028-12,国家自然科学基金委员会-面上项目
,基于不同治疗模式的单细胞组学数据解析胰腺癌肿瘤微环境调控其耐药性的靶标和机制,课题负责人
2023-04~2026-03,上海市科学技术委员会-“科技创新行动计划“自然科学基金 (面上项目)
,胰腺癌一线化疗过程中的肿瘤微环境重塑及抗药机制研究,课题负责人
2022-11~2025-12,中华人民共和国科技部-国家重点研发项目,子课题2,分拨20万
,皮肤恶性肿瘤多组学分子特征全景图谱绘制与分子分型体系构建,课题参与人
2020-06~2023-06,青年教师基金
,多组学解析结直肠癌肿瘤微环境以探索潜在治疗靶点,课题负责人
Zhang Y.*, Du Y.*, Wang J.*, Wang D.*,Single-cell analysis of chemotherapy-induced remodeling reveals CD276-driven basal-like chemoresistance in pancreatic cancer,Gastroenterology,2026,170(4):769-786
Du Y.*, Zhao Y.*, Li J.*,PLXDCl+ Tumor-associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in pancreatic Ductal Adenocarcinoma,Advanced Science,2025,12(18): e2415756
Du Y.*, Shi J.*,Integration of Pan-Cancer Single-Cell and Spatial Transcriptomics Reveals Stromal Cell Features and Therapeutic Targets in Tumor Microenvironment,Cancer Research,2024,84(2): 192–210
Zhang Y.#, Du Y.#, Wang Q#,A stepwise mode of TGFβ-SMAD signaling and DNA methylation regulates naive-to-primed pluripotency and differentiation,Nature Communications,2024,15(1): 10123
Du Y. *, Ding X. *,The spatial multi-omics revolution in cancer therapy: Precision redefined,Cell Reports Medicine ,2024,5(9): 101740
Wang H.*, Du Y.*, Huang S.*,Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis,Nature Communications,2024,15(1): 4827
Dong Y.*, Qian G*, Chen Y.*, Zhang Z.*, Du Y.*,Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy,Nature Communications,2023,14(1): 2540
Chen X.*, Du Y.*, Broussard G.*,Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning, Nature,2022,605(7911): 722-727
Du Y.#, Ye Y.#,Tumor-associated macrophages, dendritic cells, and neutrophils: biological roles, crosstalk, and therapeutic relevance,Medical Review,2021,1(2): 222-243
Ma L*, Du Y.*, Hui Y*, Li N*,Developmental programming and lineage branching of early human telencephalon,The EMBO Journal,2021,40(21): e107277
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