学科/专业 研究方向 科研项目 代表性论文 科研获奖 专利授权
2026-03~2032-02，
引进人才启动基金，上海交通大学医学院基金，课题负责人 2026-03~2032-02，
引进人才启动基金，上海市免疫学研究所基金，课题负责人 2026-01~2028-12，
国家高层次青年人才，人工智能驱动的肿瘤免疫治疗疗效预测及新靶点发现，课题负责人
Tian-Gen Chang, Eldad D Shulman, Eytan Ruppin，Liquid surrogates of spatial tumor ecosystems，Cell Research，2026，1-2 Danh-Tai Hoang, Tian-Gen Chang, Cristina R Ferrone, Ze’ev A Ronai, Eytan Ruppin，AI-Driven Pathology and Blood-Based Biomarkers: A Golden Opportunity to Democratize Precision Oncology，Cancer Discovery，2026，852-856 Jean-Christophe Marine, Osnat Bartok, Shira Sagie, Pietro Paolo Vitiello, Alberto Bardelli, Chen Weller, Tian-Gen Chang, Claudia Tonelli, Stefani Spranger, Eytan Ruppin, Yardena Samuels，Mapping intratumor heterogeneity across layers for advancing immunotherapy，Cell，2026，2416-2440 T Cantore, DT Hoang, LR Pal, A Stemmer, TG Chang, SR Dhruba, E Shulman, E Campagnolo, JS Lee, J Levy, K Yao, I Liao, SM Stemmer, SJ Sammut, S Lipkowitz, PS Rajagopal, M Filipits, C Caldas, Y Yuan, NU Nair, E Ruppin，Predicting neoadjuvant breast cancer therapy response using BRIDGE from tumor transcriptomics and histopathology，Annals of Oncology，2026，- Eldad D Shulman, Emma M Campagnolo, Roshan Lodha, Youngmin Chung, Amos Stemmer, Thomas Cantore, Beibei Ru, Tian-Gen Chang, Sumona Biswas, Saugato Rahman Dhruba, Sumeet Patiyal, Sushant Patkar, Andrew Wang, Ranjan K Barman, Chuhan Wang, Rohit Paul, Sarath Chandra Kalisetty, Tom Hu, MacLean P Nasrallah, Ellis Patrick, Jean Yang, Yuan Yuan, Karine Sargsyan, Amy Plotkin, Padma Sheila Rajagopal, Stephen-John Sammut, Stanley Lipkowitz, Peng Jiang, Carlos Caldas, Simon RV Knott, Kenneth Aldape, Joo Sang Lee, Danh-Tai Hoang, Eytan Ruppin，AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology，Cell，2026，4225-4240 Tian-Gen Chang, Jay Friedman, Paul E. Clavijo, Yvette Robbins, Marco Craveiro, Angel Huynh, Mohd Saleem Dar, Xinping Yang, Yingying Cao, Cem M. Sievers, Christopher Silvin, Christian Samaniego Davila, Michael C. Kelly, James W. Hodge, Nancy P. Judd, Wojciech K. Mydlarz, Vassiliki Saloura, Alejandro A. Sch?ffer, Eytan Ruppin, Clint T. Allen，Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity，Science Immunology，2025，10(114):eadz2273 Xiaojuan Fan, Tian-Gen Chang, Chuyun Chen, Markus Hafner, Zefeng Wang，Analysis of RNA translation with a deep learning architecture provides new insight into translation control，Nucleic Acids Research，2025，53(7): gkaf277 Tian-Gen Chang, Aris Spathis, Alejandro A. Sch?ffer, Niki Gavrielatou, Fengshen Kuo, Dongya Jia, Sumit Mukherjee, Cem Sievers, Panagiota Economopoulou, Mirian Anastasiou, Myrto Moutafi, Lipika R. Pal, Joris Vos, Andrew Sangho Lee, Stanley Lam, Karena Zhao, Peng Jiang, Clint T. Allen, Periklis Foukas, Georgia Gomatou, Grégoire Altan-Bonnet, Luc G. T. Morris, Amanda Psyrri, Eytan Ruppin，Tumor and blood B cell abundance outperforms established immune checkpoint blockade response prediction signatures in head and neck cancer，Annals of Oncology，2025，36(3): 309-320 Tian-Gen Chang, Seongyong Park, Alejandro A. Sch?ffer, Peng Jiang, Eytan Ruppin，Hallmarks of artificial intelligence contributions to precision oncology，Nature Cancer，2025，6: 417–431 Tian-Gen Chang, Yingying Cao, Hannah J. Sfreddo, Saugato Rahman Dhruba, Se-Hoon Lee, Cristina Valero, Seong-Keun Yoo, Diego Chowell, Luc G. T. Morris, Eytan Ruppin，LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic features，Nature Cancer，2024，5: 1158–1175 Yingying Cao, Tian-Gen Chang, Sahil Sahni, Eytan Ruppin，Reusability report: Leveraging supervised learning to uncover phenotype-relevant biology from single-cell RNA sequencing data，Nature Machine Intelligence，2024，6: 307–314 Tian-Gen Chang, Yingying Cao, Eldad D. Shulman, Uri Ben-David, Alejandro A. Sch?ffer, Eytan Ruppin，Optimizing cancer immunotherapy response prediction by tumor aneuploidy score and fraction of copy number alterations，npj Precision Oncology，2023，07:54:00.000
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