- 基本信息
导师姓名:
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党素英
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学科代码:
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100100
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性别:
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女
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学科名称:
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基础医学
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培养单位:
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基础医学院
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三级学科
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导师类型:
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硕士生导师
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专业领域名称:
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联系方式:
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专业领域代码:
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邮编:
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200025
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邮箱地址:
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suyingdang@shsmu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海市医学遗传学专科分会青年委员
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中国遗传学会会员
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上海市医学会罕见病专科分会委员
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中国病理生理学会会员
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- 科研项目
22140904100 | 基质金属蛋白酶Adamts18基因敲除导致遗传性肾病综合征小鼠模型的研究 | 上海市2022年度“科技创新行动计划”实验动物研究领域项目 |
2022-03~2025-03
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25万元
| 课题负责人 |
16ZR1423700 | 金属蛋白酶ADAMTS-18在血管新生中的作用及其分子机制 | 上海市自然科学基金项目 |
2016-07~2019-06
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20万元
| 课题负责人 |
81200352 | 利用基因剔除小鼠模型研究ADAMTS-18蛋白在动脉血栓形成和溶解中的作用 | 国家自然基金 |
2013-01~2015-12
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24万元
| 课题负责人 |
20120073120113 | ADAMTS-18蛋白在动脉血栓形成中的作用研究 | 中国教育部博士点新教师类基金 |
2013-01~2015-12
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4万元
| 课题负责人 |
13YZ024 | ADAMTS-18蛋白在动脉血栓形成和溶解中的作用研究 | 上海市教委创新基金项目 |
2013-01~2015-12
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8万元
| 课题负责人 |
12ZR1421100 | 利用基因剔除小鼠模型研究ADAMTS -18蛋白在肿瘤发生和转移中的作用及其机制 | 上海市自然科学基金项目 |
2012-07~2015-06
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10万元
| 课题负责人 |
2011yjj | ADAMTS-18基因在肿瘤发生和转移中的作用研究 | 上海交通大学医学院科技基金项目 |
2011-06~2013-05
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2.5万元
| 课题负责人 |
- 学术论文
Nie J#,, Zhu R#, Lu T, Zhang W*.
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ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis.
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Breast Cancer Res.
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2024
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26(1), 19.
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Yang N, Zhang Q, Ye S, Lu T, Sun M, Wang L, Wang M, Pan YH,, Zhang W*.
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Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice
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J Dent Res.
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2022
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101(2):226-234.
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Wang L, Sun M, Zhang Q,, Zhang W*.
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ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice
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Exp Eye Res .
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2022
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218:109020.
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Lin X, Wu T, Wang L,, Zhang W*
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ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice.
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Reprod Biol.
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2021
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21(3):100542.
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Ye S, Yang N, Lu T, Wu T, Wang L, Pan YH, Cao X, Yuan X, Wisniewski T,, Zhang W*.
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Adamts18 modulates the development of the aortic arch and common carotid artery.
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iScience.
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2021
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24(6):102672.
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Lin X, Wang C, Zhang Q, Pan YH,, Zhang W*
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ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice.
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Reprod Biol.
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2021
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21(3):100537.
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Lu T, Lin X, Pan YH, Yang N, Ye S, Zhang Q, Wang C, Zhu R, Zhang T, Wisniewski TM, Cao Z, Ding BS,, Zhang W*.
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ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.
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iScience.
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2020
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20;23(9):101472.
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Luan CJ, Guo W, Chen L, Wei XW, He Y, Chen Y,, Prior R, Li X, Kuang Y, Wang ZG, Van Den Bosch L, Gu MM.
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CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model.
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Acta Neuropathol Commun.
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2020
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8(1):32
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Lu T, Zhang T, Wang C, Yang N, Pan YH,, Zhang W.
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Adamts18 deficiency in zebrafish embryo causes defective trunk angiogenesis and caudal vein plexus formation.
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Biochem Biophys Res Commun.
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2020
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521(4):907-913
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Zhu R, Pan YH, Sun L, Zhang T, Wang C, Ye S, Yang N, Lu T, Wisniewski T,, Zhang W*.
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ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.
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Neuroscience.
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2019
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399:53-64
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Zhu R, Cheng M, Lu T, Yang N, Ye S, Pan YH, Hong T,, Zhang W*.
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A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice.
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American Journal of Pathology
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2018
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188 (2):461-473.
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, Bu D, Lu T, Wang Z, Liu J, Zhang W.
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Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice.
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Biochem Biophys Res Commun.
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2018
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496(4):1362-1368
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Cui X,, Wang Y, Chen Y, Zhou J, Shen C, Kuang Y, Fei J, Lu L, Wang Z.
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Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice.
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Toxicol Lett.
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2017
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265:17-22.
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Zhu R, Cheng M, Ye S, Liu M, Sun L, Lu T, Yang N, Hong T,, Zhang W*.
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The development of monoclonal anti-ADAMTS18 antibodies with precise validation of ADAMTS18 post-translational modification status in living organisms.
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Biochem Biophys Res Commun.
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2017
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492(3):404-411
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Lu T#,, Zhu R, Wang Y, Nie Z, Hong T, Zhang W*.
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Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer.
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Oncotarget.
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2017
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8(12):18979-18990
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Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J, Liu J,, Wang Z*.
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Palladin is involved in platelet activation and arterial thrombosis.
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Thromb Res.
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2017
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149:1-8
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Zhou Y, Jing F, Shen N, Liu M, Wang J, Hong T,, Zhang W*.
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Integrin GPIIIa49-57 is the pivotal switch controlling platelet fragmentation.
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Platelets.
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2015
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26(7):693-8
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Zhang F#,, Shu R, Xiang Y, Kuang Y, Fei J, Wang Z*.
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Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon Tetrachloride Administration in Mice
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Int J Toxicol.
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2015
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34(2):204-10.
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Jian Tang, Wei Huang, Ning Shen, Hong T,, Zhang W*
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Arg-Ser-775, 792 and 823 in spacer region of ADAMTS-18 is Critical for Thrombin Cleavage
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Health.
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2014
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6: 2490-2498
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Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL,, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG.
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Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG.
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World J Gastroenterol.
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2014
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20(2):498-508
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Wang F, Wang PX, Wu XL,, Chen Y, Ni YY, Gao LH, Lu SY, Kuang Y, Huang L, Fei J, Wang ZG, Pang XF.
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Deficiency of adiponectin protects against ovariectomy-induced osteoporosis in mice.
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PLoS One.
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2013
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8(7):e68497.
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Hong-Xin Zhang 1, Zi-Xing Liu, Yue-Ping Sun, Jiang Zhu, Shun-Yuan Lu, Xue-Song Liu, Qiu-Hua Huang, Yin-Yin Xie, Hou-Bao Zhu,, Hai-Feng Chen, Guang-Yong Zheng, Yi-Xue Li, Ying Kuang, Jian Fei, Sai-Juan Chen, Zhu Chen, Zhu-Gang Wang
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Rig-I regulates NF-κB activity through binding to Nf-κb1 3'-UTR mRNA
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Proc Natl Acad Sci U S A.
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2013
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110(16):6459-64.
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Zhu H, Xu W, Zhang H, Liu J, Xu H, Lu S,, Kuang Y, Jin X, Wang Z.
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Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.
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Biochem Biophys Res Commun.
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2013
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438(1):97-102.
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Fan J, Jing F,, Zhang W.
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Protective effects of bifunctional platelet GPⅢa49-66ligand on myocardial ischemia-reperfusion injury in rats.
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Health.
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2013
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5(7A3):15-20
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Zhang W#,, Hong T, Tang J, Fan J, Bu D, Sun Y, Wang Z, Wisniewski T.
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A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment.
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Blood.
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2012
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120(14): 2889-98
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, Hong T, Bu DW,J Tang,J Fan, Zhang W.
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Optimized refolding and characterization of active C-terminal ADAMTS-18 fragment from inclusion bodies of Escherichia coli.
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Protein Expr Purif.
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2012
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82:32-36.
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, Bu DW, Hong T, Zhang W
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A polyclonal antibody against active C-terminal ADAMTS-18 fragment.
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Hybridoma.
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2011
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30 (6):567-9
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, Hong T, Ding BS, Zhang W.
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A humanized single-chain variable fragment antibody against beta3 integrin in Escherichia coli.
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Hybridoma.
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2011
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30 (6):543-8
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, Hong T, T Wisnewski, Zhang W.
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Dissolution of pre-existing platelet thrombus by synergistic administration of low concentrations of bifunctional antibodies against β3 integrin.
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PLoS One.
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2011
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6 (10):e 27012.
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Zhang W, Li YS, Nardi MA,, Yang J, Ji Y, Li Z, Karpatkin S, Wisniewski T.
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Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus.
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Blood.
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2010
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116(13):2336-44.
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Zhang W,, Wang J, Nardi MA, Zan H, Casali P, Li Z.
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Specific cross-reaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66.
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Autoimmunity.
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2010
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43(8):682-9
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Li Z, Nardi MA, Li YS, Zhang W, Pan R,, Yee H, Quartermain D, Jonas S, Karpatkin S.
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C-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral stroke.
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Blood.
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2009
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113(24):6051-60.
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