• 基本信息
    导师姓名： 党素英 学科代码： 100100
    性别： 女 学科名称： 基础医学
    培养单位： 基础医学院 三级学科
    导师类型： 硕士生导师 专业领域名称：
    联系方式： 专业领域代码：
    邮编： 200025 邮箱地址： suyingdang@shsmu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海市医学遗传学专科分会青年委员
    中国遗传学会会员
    上海市医学会罕见病专科分会委员
    中国病理生理学会会员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    22140904100基质金属蛋白酶Adamts18基因敲除导致遗传性肾病综合征小鼠模型的研究上海市2022年度“科技创新行动计划”实验动物研究领域项目 2022-03~2025-03 25万元  课题负责人
    16ZR1423700金属蛋白酶ADAMTS-18在血管新生中的作用及其分子机制上海市自然科学基金项目 2016-07~2019-06 20万元  课题负责人
    81200352利用基因剔除小鼠模型研究ADAMTS-18蛋白在动脉血栓形成和溶解中的作用国家自然基金 2013-01~2015-12 24万元  课题负责人
    20120073120113ADAMTS-18蛋白在动脉血栓形成中的作用研究中国教育部博士点新教师类基金 2013-01~2015-12 4万元  课题负责人
    13YZ024ADAMTS-18蛋白在动脉血栓形成和溶解中的作用研究上海市教委创新基金项目 2013-01~2015-12 8万元  课题负责人
    12ZR1421100利用基因剔除小鼠模型研究ADAMTS -18蛋白在肿瘤发生和转移中的作用及其机制上海市自然科学基金项目 2012-07~2015-06 10万元  课题负责人
    2011yjjADAMTS-18基因在肿瘤发生和转移中的作用研究上海交通大学医学院科技基金项目 2011-06~2013-05 2.5万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Nie J#,, Zhu R#, Lu T, Zhang W*.  ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis.  Breast Cancer Res.  2024  26(1), 19. 
    Yang N, Zhang Q, Ye S, Lu T, Sun M, Wang L, Wang M, Pan YH,, Zhang W*.  Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice  J Dent Res.  2022  101(2):226-234. 
    Wang L, Sun M, Zhang Q,, Zhang W*.  ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice  Exp Eye Res .  2022  218:109020. 
    Lin X, Wu T, Wang L,, Zhang W*  ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice.  Reprod Biol.   2021  21(3):100542. 
    Ye S, Yang N, Lu T, Wu T, Wang L, Pan YH, Cao X, Yuan X, Wisniewski T,, Zhang W*.  Adamts18 modulates the development of the aortic arch and common carotid artery.   iScience.  2021  24(6):102672. 
    Lin X, Wang C, Zhang Q, Pan YH,, Zhang W*  ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice.   Reprod Biol.   2021  21(3):100537. 
    Lu T, Lin X, Pan YH, Yang N, Ye S, Zhang Q, Wang C, Zhu R, Zhang T, Wisniewski TM, Cao Z, Ding BS,, Zhang W*.   ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.  iScience.  2020  20;23(9):101472.  
    Luan CJ, Guo W, Chen L, Wei XW, He Y, Chen Y,, Prior R, Li X, Kuang Y, Wang ZG, Van Den Bosch L, Gu MM.  CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model.  Acta Neuropathol Commun.   2020  8(1):32 
    Lu T, Zhang T, Wang C, Yang N, Pan YH,, Zhang W.  Adamts18 deficiency in zebrafish embryo causes defective trunk angiogenesis and caudal vein plexus formation.  Biochem Biophys Res Commun.  2020  521(4):907-913 
    Zhu R, Pan YH, Sun L, Zhang T, Wang C, Ye S, Yang N, Lu T, Wisniewski T,, Zhang W*.  ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.  Neuroscience.  2019  399:53-64 
    Zhu R, Cheng M, Lu T, Yang N, Ye S, Pan YH, Hong T,, Zhang W*.   A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice.  American Journal of Pathology  2018  188 (2):461-473. 
    , Bu D, Lu T, Wang Z, Liu J, Zhang W.  Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice.  Biochem Biophys Res Commun.   2018  496(4):1362-1368 
    Cui X,, Wang Y, Chen Y, Zhou J, Shen C, Kuang Y, Fei J, Lu L, Wang Z.  Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice.  Toxicol Lett.  2017  265:17-22. 
    Zhu R, Cheng M, Ye S, Liu M, Sun L, Lu T, Yang N, Hong T,, Zhang W*.  The development of monoclonal anti-ADAMTS18 antibodies with precise validation of ADAMTS18 post-translational modification status in living organisms.  Biochem Biophys Res Commun.   2017  492(3):404-411 
    Lu T#,, Zhu R, Wang Y, Nie Z, Hong T, Zhang W*.  Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer.  Oncotarget.  2017  8(12):18979-18990 
    Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J, Liu J,, Wang Z*.  Palladin is involved in platelet activation and arterial thrombosis.  Thromb Res.  2017  149:1-8 
    Zhou Y, Jing F, Shen N, Liu M, Wang J, Hong T,, Zhang W*.  Integrin GPIIIa49-57 is the pivotal switch controlling platelet fragmentation.   Platelets.  2015  26(7):693-8 
    Zhang F#,, Shu R, Xiang Y, Kuang Y, Fei J, Wang Z*.  Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon Tetrachloride Administration in Mice  Int J Toxicol.  2015  34(2):204-10. 
    Jian Tang, Wei Huang, Ning Shen, Hong T,, Zhang W*  Arg-Ser-775, 792 and 823 in spacer region of ADAMTS-18 is Critical for Thrombin Cleavage  Health.  2014  6: 2490-2498 
    Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL,, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG.  Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG.  World J Gastroenterol.   2014  20(2):498-508 
    Wang F, Wang PX, Wu XL,, Chen Y, Ni YY, Gao LH, Lu SY, Kuang Y, Huang L, Fei J, Wang ZG, Pang XF.  Deficiency of adiponectin protects against ovariectomy-induced osteoporosis in mice.   PLoS One.   2013  8(7):e68497. 
    Hong-Xin Zhang 1, Zi-Xing Liu, Yue-Ping Sun, Jiang Zhu, Shun-Yuan Lu, Xue-Song Liu, Qiu-Hua Huang, Yin-Yin Xie, Hou-Bao Zhu,, Hai-Feng Chen, Guang-Yong Zheng, Yi-Xue Li, Ying Kuang, Jian Fei, Sai-Juan Chen, Zhu Chen, Zhu-Gang Wang  Rig-I regulates NF-κB activity through binding to Nf-κb1 3'-UTR mRNA  Proc Natl Acad Sci U S A.   2013  110(16):6459-64. 
    Zhu H, Xu W, Zhang H, Liu J, Xu H, Lu S,, Kuang Y, Jin X, Wang Z.  Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.   Biochem Biophys Res Commun.  2013  438(1):97-102. 
    Fan J, Jing F,, Zhang W.  Protective effects of bifunctional platelet GPⅢa49-66ligand on myocardial ischemia-reperfusion injury in rats.   Health.  2013  5(7A3):15-20 
    Zhang W#,, Hong T, Tang J, Fan J, Bu D, Sun Y, Wang Z, Wisniewski T.  A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment.  Blood.   2012  120(14): 2889-98 
    , Hong T, Bu DW,J Tang,J Fan, Zhang W.  Optimized refolding and characterization of active C-terminal ADAMTS-18 fragment from inclusion bodies of Escherichia coli.  Protein Expr Purif.  2012  82：32-36. 
    , Bu DW, Hong T, Zhang W  A polyclonal antibody against active C-terminal ADAMTS-18 fragment.  Hybridoma.  2011  30 （6）：567-9 
    , Hong T, Ding BS, Zhang W.  A humanized single-chain variable fragment antibody against beta3 integrin in Escherichia coli.  Hybridoma.  2011  30 （6）：543-8 
    , Hong T, T Wisnewski, Zhang W.   Dissolution of pre-existing platelet thrombus by synergistic administration of low concentrations of bifunctional antibodies against β3 integrin.  PLoS One.   2011  6 （10）：e 27012. 
    Zhang W, Li YS, Nardi MA,, Yang J, Ji Y, Li Z, Karpatkin S, Wisniewski T.  Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus.  Blood.  2010  116(13):2336-44. 
    Zhang W,, Wang J, Nardi MA, Zan H, Casali P, Li Z.  Specific cross-reaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66.   Autoimmunity.   2010  43(8):682-9 
    Li Z, Nardi MA, Li YS, Zhang W, Pan R,, Yee H, Quartermain D, Jonas S, Karpatkin S.  C-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral stroke.  Blood.  2009  113(24):6051-60.