- 基本信息
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导师姓名：
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邓志锋
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学科代码：
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100210
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性别：
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男
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学科名称：
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外科学
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培养单位：
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附属第六人民医院
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三级学科
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神外
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导师类型：
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博士生导师
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专业领域名称：
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外科学 专业学位
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联系方式：
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02138297188
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专业领域代码：
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105111
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邮编：
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200233
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邮箱地址：
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dengzf63@126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会神经外科分会中国垂体腺瘤协作组 成员
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上海医师协会神经外科分会 委员
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中国医师协会神经外科分会 委员
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- 科研项目
| 82071371 | ESC-sEVs改善NSCs衰老促进老年脑卒中后神经再生的机制研究 | 国家自然科学基金 |
2021-01~2024-12
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70万元
| 课题负责人 |
| 81671209 | tRNA片段-非编码小RNA基因调控网络对脑卒中后血管新生的影响及机制研究 | 国家自然科学基金 |
2017-01~2020-12
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70万元
| 课题负责人 |
| 81471243 | LncRNA-miRNA相互对话调控脑缺血后血管新生及机制研究 | 国家自然科学基金 |
2015-01~2018-12
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70万元
| 课题负责人 |
- 学术论文
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Guo Y,Hu G,Xia Y,Li H,Yuan J,Zhang J,Chen Y,Guo H,Yang Y,Wang Y,
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Eliminating the original cargos of glioblastoma cell-derived small extracellular vesicles for efficient drug delivery to glioblastoma with improved biosafety
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Bioactive Materials
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2022
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16:204-217
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1. Xia Y, Hu G, Chen Y, Yuan J, Zhang J, Wang S, Li Q, Wang Y,
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Embryonic Stem Cell Derived Small Extracellular Vesicles Modulate Regulatory T Cells to Protect against Ischemic Stroke
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ACS nano
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2021
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2021，15(4), 7370–7385
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2. Hu G, Xia Y, Chen B, Zhang J, Gong L, Chen Y, Li Q, Wang Y,
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ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis
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Molecular therapy
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2021
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2021，29(1), 103–120
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Xia Y, Ling X, Hu G, Zhu Q, Zhang J, Li Q, Zhao B, Wang Y,
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Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke
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Stem Cell Res Ther
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2020
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11(1):313
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3. Hu G, Xia Y, Zhang J, Chen Y, Yuan J, Niu X, Zhao B, Li Q, Wang Y,
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ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia
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Advanced science
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2020
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2020，7(10), 1903330
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Ling X, Zhang G, Xia Y, Zhu Q, Zhang J, Li Q, Niu X, Hu G, Yang Y, Wang Y*,
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Exosomes from human urine-derived stem cells enhanced neurogenesis via miR-26a/HDAC6 axis after ischaemic stroke
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J Cell Mol Med
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2020
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24(1):640
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4. Zhu Q, Ling X, Yang Y, Zhang J, Li Q, Niu X, Hu G, Chen B, Li H, Wang Y,
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Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy
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Advanced science
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2019
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2019, 6(6), 1801899
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Zhu QW, Li Q,Niu X, Zhang GW, Ling XZ,Zhang JY, Wang Y,
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Extracellular Vesicles Secreted by Human Urine-Derived Stem Cells Promote Ischemia Repair in a Mouse Model of Hind- Limb Ischemia
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Cell Physiol Biochem
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2018
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47:1181-1192
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Liu, J.; Li, Q.; Zhang, K.-s.; Hu, B.; Niu, X.; Zhou, S.-m.; Li, S.-g.; Luo, Y.-p.; Wang, Y. *; Deng,,
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Downregulation of the long non-coding RNA Meg3 promotes angiogenesis after ischemic brain injury by activating notch signaling
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Molecular Neurobiology
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2017
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1-12
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Liu, J.; Zhou, X.; Li, Q.; Zhou, S.-M.; Hu, B.; Hu, G.-W.; Niu, X.; Guo, S.-C.; Wang,, Z.-F. *
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Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis
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BioMed Research International
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2017
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2957538. doi: 10.1155/2017/2957538
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Li, Q.; Hu, B.; Hu, G.-w.; Chen, C.-y.; Niu, X.; Liu, J.; Zhou, S.-m.; Zhang, C.-q.; Wang, Y. *; Deng,,
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tRNA-derived small non-coding RNAs in response to ischemia inhibit angiogenesis
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Scientific Reports
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2016
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6： 20850
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Guo-wen Hu, Qing Li, Xin Niu, Bin Hu, Juan Liu, Shu-min Zhou, Shang-chun Guo, Hai-li Lang,Chang-qing Zhang, Yang Wang*,
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Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice
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Stem Cell Research & Therapy
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2015
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6:10
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胡国文,李青,牛鑫,胡斌,刘鹃,郎海丽,沈晓黎,汪泱,
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人诱导多能干细胞定向分化为间充质干细胞的方法研究
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上海交通大学学报(医学版)
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2014
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(10):1428-1434
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胡国文,李青,牛鑫,胡斌,刘鹃,沈晓黎,汪泱,
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旋转超滤：一种提取细胞外泌体的新方法
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第二军医大学学报
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2014
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(06):598-602
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胡国文,周翔,汪泱,
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长链非编码ＲNA调控神经干细胞分化的研究进展
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上海交通大学学报(医学版)
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2014
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(07):1087-1091
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Bin Hu, Ye Guo, Chunyuan Chen, Qing Li, Xin Niu, Shangchun Guo, AijunZhang, Yang Wang,
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Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells
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CELLULAR AND MOLECULAR
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2014
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34(6): 905-912
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ChunYuan Chen, Wei Liao, YuanLei Lou, Qing Li, Bin Hu, Yang Wang*,
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Inhibition of Notch signaling facilitates the differentiation of human-induced pluripotent stem cells into neural stem cells
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MOLECULAR AND CELLULAR
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2014
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395(1-2): 291-298
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JunJie Guan, Xin Niu, FeiXiang Gong, Bin Hu, ShangChun Guo,YuanLei Lou,ChangQing Zhang,, Yang Wang*
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Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology
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Tissue Eng Part A
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2014
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20(13-14): 1794-1806
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Li Q, Wang Y,
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Pre-conditioned mesenchymal stem cells: a better way for cell-based therapy.
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Stem Cell Res Ther
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2013
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4(3)：63
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龚飞翔,汪泱,
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间充质干细胞移植治疗免疫性疾病的研究进展
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上海交通大学学报(医学版)
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2013
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(02)：235-239+244
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刘越,汪泱,廖伟,牛鑫,胡斌,
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大鼠缺血性脑损伤后室管膜下区miR-124的动态变化及意义
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中国微侵袭神经外科杂志
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2013
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(09)：417-419
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胡国文, 汪泱, 沈晓黎,
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外泌体及其在干细胞中的研究进展
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上海交通大学学报(医学版)
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2013
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(06). 868-873
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刘鹃, 汪泱, 沈晓黎,
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长链非编码RNAs及其调控血管新生的研究进展
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上海交通大学学报(医学版)
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2013
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(09)：1301-1305
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Yuan, T., W. Liao, N.H. Feng, Y.L. Lou, X. Niu, A.J. Zhang, Y. Wang,
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Human induced pluripotent stem cell-derived neural stem cells survive, migrate, differentiate, and improve neurological function in a rat model of middle cerebral artery occlusion
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Stem Cell Research & Therapy
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2013
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4(3)：73
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胡国文,汪泱,沈晓黎,
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外泌体及其在干细胞中的研究进展
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上海交通大学学报（医学版）
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2013
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33（6）：868-872
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Guo F, Lv S, Lou Y, Tu W, Liao W, Wang Y*, Deng Z*
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Bone Marrow Stromal Cells Enhance the Angiogenesis in Ischemic Cortex After Stroke： Involvement of Notch Signaling
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Cell Biology International
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2012
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36：997–1004
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Liu F, Lou YL, Wu J, Ruan QF, Xie A, Guo F, Cui SP, Deng ZF*, Wang Y*
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Upregulation of MicroRNA-210 Regulates Renal Angiogenesis Mediated by Activation of VEGF Signaling Pathway under Ischemia Perfusion Injury in vivo and in vitro signaling Cortex After Stroke： Involvement of Notch Signaling
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Kidney Blood Press Res
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2012
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35:182-191
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Wang Y, Guo F, Pan C, Lou Y, Zhang P, Guo S, Yin J, Deng Z*
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Effects of low temperatures on proliferation related signaling pathways in the hippocampus after traumatic brain injury signaling
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Experimental Biology and Medicine
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2012
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0：1-9
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Lou YL, Guo F, Liu F, Gao FL, Zhang PQ, Niu X, Guo SC, Yin JH, Wang Y*, Deng ZF*
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miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia
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Mol Cell Biochem
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2012
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370:45-51
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Wang Y,Tu W,Lou Y,Xie A,Lai X,Guo F,
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Mesenchymal stem cells regulate the proliferation and differentiation of neural stem cells through Notch signaling
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Cell Biology International
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2009
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33：1173-1179
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