- 基本信息
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导师姓名：
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蔡蓉
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学科代码：
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100100
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性别：
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女
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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上海市重庆南路280号，上海交通大学医学院西院7号楼，200025， rongcai@shsmu.edu.cn
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专业领域代码：
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邮编：
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邮箱地址：
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ccairong@126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 82173352 | 自噬降解SIRT3抑制CD133+GSCs干性及其机制 | 国家自然科学基金面上项目 |
2022-01~2025-12
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53万元
| 课题负责人 |
| 81872230 | Nrf2 的SUMO1修饰应答丝氨酸饥饿通过ROS-PHGDH轴调控肝癌生长 | 国家自然科学基金面上项目 |
2019-01~2022-12
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53万元
| 课题负责人 |
| 81572691 | SENP1调控磷酸戊糖途径抑制肿瘤细胞生长及其分子机制 | 国家自然科学基金面上项目 |
2016-01~2019-12
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52万元
| 课题负责人 |
| 2015CB910400 | 代谢应激和肿瘤发生发展中蛋白质修饰动态调控及生理病理效应 | 国家重点基础研究发展计划 |
2015-01~2019-12
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1500万元
| 课题参与人 |
| 13ZR1422900 | SUMO特异性蛋白酶1在心衰中的作用及分子基础 | 上海市自然基金 |
2013-07~2016-06
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10万元
| 课题负责人 |
| 30800636 | 核基质结合区共存性增强子活化PI3Kγ基因转录的调控机制 | 国家自然科学基金青年项目 |
2009-01~2011-12
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20万元
| 课题负责人 |
- 学术论文
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Xiaohe Li, Wenlong Zhang, Zhengcao Xing, Shuming Hu, Geqiang Zhang, Tiange Wang, Tianshi Wang, Qiuju Fan, Guoqiang Chen, Jinke Cheng, Xianguo Jiang,
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Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11
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Cell Death Dis
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2024
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15(2): 168
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Shuming Hu, Yuan Yuan, Ruihan Yan, Huikang Xie,, Jiaqian Xu
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NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma
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Biochem Biophys Res Commun
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2024
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708(14)
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Kezhou Wang, Wei Zhou, Gaolei Hu, Lifeng Wang,, Tian Tian
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TFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity
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Cell Mol Life Sci
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2023
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80(12): 358
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Ruihan Yan, Bingyi Lin, Wenwei Jin, Ling Tang, Shuming Hu,
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NRF2, a Superstar of Ferroptosis
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Antioxidants
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2023
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12(9):1739
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Xiangyun Wei, Xiaohe Li, Shuming Hu, Jinke Cheng,
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Regulation of Ferroptosis in Lung Adenocarcinoma
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International Journal of Molecular Science
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2023
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24(19): 14614
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Rongyu Zhang, Jinhong Chen, Saiyang Wang, Wenlong Zhang,Quan Zheng,
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Ferroptosis in Cancer Progression
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Cells
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2023
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12(14):1820
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Wenlong Zhang, Xiaohe Li, Jiaqian Xu, Ying Wang, Zhengcao Xing, Shuming Hu, Qiuju Fan, Shaoyong Lu, Jinke Cheng, Jianmin Gu,
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The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis
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Cancers
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2022
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14(21): 5233
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Zhou W, Hu G, He J, Wang T, Zuo Y, Cao Y, Zheng Q, Tu J, Ma J,, Chen Y, Fan Q, Dong B, Tan H, Wang Q, Xue W, Cheng J.
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SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization
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Cell Reports
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2022
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39(2):110660
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He J, Shangguan X, Zhou W, Cao Y, Zheng Q, Tu J, Hu G, Liang Z, Jiang C, Deng L, Wang S, Yang W, Zuo Y, Ma J,, Chen Y, Fan Q, Dong B, Xue W, Tan H, Qi Y, Gu J, Su B, Eugene Chin Y, Chen G, Wang Q, Wang T, Cheng J.
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Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
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Nat Commun
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2021
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12(1): 4371
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Wang Y, Tian J, Huang C, Ma J, Hu G, Chen Y, Wang T,, Zuo Y, Tan H, Fan Q, Dong B, Xue W, Yi J, Chen G, Tu J, Cheng J.
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P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint.
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Cell Discovery
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2020
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6:21
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Jiaqian Xu, Haoyan Guo, Zhengcao Xing, Wenlong Zhang, Jianli He, Jinke Cheng,
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Mild oxidative stress reduces NRF2 SUMOylation to promote Kras/Lkb1/Keap1 mutant lung adenocarcinoma cell migration and invasion
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Oxid Med & Cell Longev
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2020
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ID 6240125
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Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J,, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Jing Yi, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J.
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SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism
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Mol Cell
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2019
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75(4): 823-834
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Haoyan Guo, Jiaqian Xu, Quan Zheng, Jianli He, Wei Zhou, Kezhou Wang, Xia Huang,Qiuju Fan, Jiao Ma, Jinke Cheng, Wenhan Mei, Rong Xing,
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NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis
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Cancer Lett
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2019
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466: 39-48
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Tingting Yu,Yong Zuo,,Xian Huang,Shuai Wu,Chenxi Zhang,Y.Eugene Chin,Dongdong Li,Zhening Zhang,Nansong Xia,Qi Wang,Hao Shen,Xuebiao Yao,Zhong-Yin Zhang,Song Xue,Lei Shen,Jinke Cheng
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SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop
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J Mol Cell Biol
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2017
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9(2):144-153
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Kezhou Wang,Wei Zhou,Qi Cai,Jinke Cheng,,Rong Xing*
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SUMOylation of KLF4 promotes IL-4 induced macrophage M2 polarization.
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Cell Cycle
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2017
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16(4):374-381
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J Cai, Y Zuo, T Wang, Y Cao,, F-L Chen, J Cheng, and J Mu.
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A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppresive activity
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Oncogene
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2016
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35(37): 4949-56
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, Jianmin Gu, Haipeng Sun, Xiaobing Liu,, Wenhan Mei, Yitao Qi, Song Xue, Shuxun Ren, Joseph E. Rabinowitz, Yibin Wang, Edward T.H. Yeh, and Jinke Cheng.
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Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy
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J Mol Cell Cardiol
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2015
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79(2):115-122
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Jianmin Gu, Yuqi Fan, Xiaobing Liu, Lihuang Zhou, Jinke Cheng,, Xue S*
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SENP1 protects against myocardial ischemia/reperfusion injury via a HIF1α-dependent pathway
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Cardiovasc Res
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2014
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104(1):83-92
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, Tingting Yu, Chao Huang, Xuefeng Xia, Xiaobing Liu, Jianmin Gu, Song Xue, Edward T.H. Yeh, Jinke Cheng
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SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC1α
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J Biol Chem
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2012
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287(53):4446-470
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