- 基本信息
|
导师姓名：
|
张欣欣
|
学科代码：
|
100201
|
|
|
性别：
|
女
|
学科名称：
|
内科学
|
|
培养单位：
|
附属瑞金医院
|
三级学科
|
传染病
|
|
导师类型：
|
博士生导师
|
专业领域名称：
|
内科学 专业学位
|
|
联系方式：
|
zhangxinxinrj@163.com
上海市瑞金二路197号瑞金医院感染科
|
专业领域代码：
|
105101
|
|
邮编：
|
200025
|
邮箱地址：
|
xin-xin-zhang@163.com
|
- 研究方向 (点击浏览详细信息)
- 社会任职
| |
|
中华医学会肝脏病学分会常委
|
|
中国病毒病杂志编委
|
|
曾任上海医学病毒学分会主任委员
|
|
中华肝脏病杂志编委
|
|
中华传染病杂志编委
|
|
J of Hepatology Editorial Board member（2015-2018）
|
|
法国科学院中法基金会博士后俱乐部前任主席
|
|
上海医学会肝病学分会顾问
|
|
中华医学会微生物与免疫分会常委
|
- 科研项目
| 81974301 | 乙型肝炎病毒特定突变通过TLR2信号通路异常活化介导感染慢性化及其机制研究 | 国家自然科学基金 |
2020-01~2023-12
|
55万元
| 课题负责人 |
| 2018ZX10302204-001-003 | 乙肝抗病毒治疗过程中临床终点事件精准预测体系的建立 | 国家十三五科技重大专项 |
2018-01~2020-12
|
222.76万元
| 子课题负责人 |
| 2017ZX10202202-001-003 | 提高HBeAg阳性慢乙肝临床治愈率新方案的研究 | 国家十三五科技重大专项 |
2017-01~2020-12
|
60.72万元
| 子课题负责人 |
| 2017ZX10202202-002-003 | 提高HBeAg阴性慢乙肝临床治愈率新方案的研究 | 国家十三五科技重大专项 |
2017-01~2020-12
|
64.4万元
| 子课题负责人 |
| 81672069 | 乙型肝炎病毒多重突变在急性肝衰竭发病中的作用及其机制的研究 | 国家自然科学基金 |
2017-01~2020-12
|
57万元
| 课题负责人 |
| SHDC12016101 | 提高HBeAg阳性慢性乙型肝炎抗病毒治疗应答率的新方案及预测指标的研究 | 上海申康医院发展中心(市级医院新兴前沿技术联合攻关项目) |
2016-10~2019-10
|
180万元
| 课题负责人 |
| 16410711900 | 基于病毒学指标和宿主免疫应答状态的慢性乙型肝炎个体化抗病毒治疗新方案及其机制的研究 | 上海市科委国际合作课题 |
2016-07~2019-06
|
50万元
| 课题负责人 |
| 81371860 | 乙型肝炎病毒亚病毒颗粒对抗病毒治疗应答的影响及其机制的研究 | 国家自然基金委 |
2014-01~2017-12
|
70万元
| 课题负责人 |
| 2013ZX10002001 | 提高HBeAg阳性慢性乙型肝炎患者HBsAg阴转率抗病毒/免疫治疗新方案的研究 | 国家十二五重大专项 |
2013-01~2015-12
|
64万元
| 子课题负责人 |
| S2012GR0046 | 基于糖链生物标志物的疾病早期诊断新技术 | 国家国际科技合作专项 |
2012-03~2015-05
|
20万元
| 子课题负责人 |
| 81171616 | 乙型肝炎病毒表面抗原糖基化变异的生物学功能研究 | 国家自然科学基金 |
2012－01~2015-12
|
58万元
| 课题负责人 |
| 2012ZX10002007 | 乙型肝炎重症化转归预警预测 | 国家十二五重大专项 |
2012－01~2015-12
|
115万元
| 子课题负责人 |
| | 慢性乙型肝炎患者免疫状态评估与分析 | 中法合作项目 |
2012-01~2014-12
|
238万元
| 课题负责人 |
| 11DZ2291900 | 乙型肝炎病毒生物信息数据共享平台建设与应用 | 上海市科委 |
2012-01~2013-09
|
25万元
| 子课题负责人 |
| 11410701700 | 乙型肝炎病毒包膜蛋白糖基化变异对病毒适应性的影响研究 | 上海市科委政府间国际科技合作项目 |
2011-10~2013-09
|
50万元
| 课题负责人 |
| 30872251 | 乙型肝炎病毒准种特性及相互作用对抗病毒疗效影响的研究 | 国家自然基金委,面上项目 |
2009-01~2011-12
|
33万元
| 课题负责人 |
| 2009ZX10004－314 | 乙型肝炎病毒表型分析技术和耐药监测网络的建立及应用 | 国家十一五重大专项 |
2009-01~2011-12
|
791万元
| 课题负责人 |
| 2008ZX10002－007 | 影响乙型病毒性肝炎重症化转归的机制研究 | 国家十一五重大专项 |
2008-10~2010-12
|
138万元
| 子课题负责人 |
| 08410709100 | 乙型肝炎病毒准种因素与抗病毒疗效关系的研究 | 上海市科委，国际合作项目 |
2008-09~2010-09
|
30万元
| 课题负责人 |
| 08XD1402800 | 乙型肝炎病毒变异及耐药机制的研究 | 上海市科委,学科带头人 |
2008-07~2010-07
|
40万元
| 课题负责人 |
| 08GWD08 | 乙型肝炎病毒表型分析及其耐药机制的研究 | 上海市卫生局，学科带头人 |
2008-07~2010-07
|
30万元
| 课题负责人 |
| 30671839 | 丙型肝炎病毒F蛋白在人体抗病毒免疫反应中作用的研究 | 国家自然基金委,面上项目 |
2007-01~2009-12
|
27万元
| 课题负责人 |
| 2005CB523104 | 乙性肝炎病毒耐药机制的研究 | 国家科技部,973项目 |
2005-12~2010-11
|
150万元
| 子课题负责人 |
| 30471523 | 丙性肝炎病毒F蛋白细胞表位及其免疫功能的研究 | 国家自然基金委,面上项目 |
2005-01~2007-12
|
20万元
| 课题负责人 |
- 学术论文
|
Cesheng Li, Ding Yu, Xiao Wu, Hong Liang, Zhijun Zhou, Yong Xie, Taojing Li, Junzheng Wu, Fengping Lu, Lu Feng, Min Mao, Lianzhen Lin, Huanhuan Guo, Shenglan Yue, Feifei Wang, Yan Peng, Yong Hu, Zejun Wang, Jianhong Yu, Yong Zhang, Jia Lu, Haoran Ning, Huichuan Yang, Daoxing Fu, Yanlin He, Dongbo Zhou, Tao Du, Kai Duan, Demei Dong, Kun Deng, Xia Zou, Ya Zhang, Rong Zhou, Yang Gao,, Xiaoming Yang.
|
Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
|
NATURE COMMUNICATIONS
|
2021
|
12:4144
|
|
Jing Li, Lihong Qu, Xuehua Sun, Yanhong Liu, Qiming Gong, Demin Yu, Donghua Zhang, Jiehong Jiang, Jia Chen, Dong Wei, Yue Han, Yueqiu Gao, Qin Zhang, Weimin She, Liang Chen, Jiming Zhang,
|
Peg-interferon alpha add-on Tenofovir disoproxil fumarate achieved more HBsAg loss in HBeAg positive chronic hepatitis B na?ve patients
|
J Viral Hepat
|
2021
|
on line
|
|
Chuanmiao Liu, Xiaoqi Yu, Chunming Gao, Li Zhang, Hui Zhai, Yanan Hu, Enhui Liu, Qiong Wang, Yu Gao, Dong Wei, Donghua Zhang, Yue Han,
|
Characterization of Antibody Responses to SARS-CoV-2 in Convalescent COVID-19 Patients
|
J Med Virol
|
2021
|
93:2227–2233
|
|
Hu Li, Wei Huang, Mingjie Wang, Peizhan Chen, Li Chen,
|
Tandem Mass Tag?based quantitative proteomics analysis of metabolic associated fatty liver disease induced by high fat diet in mice
|
Nutr Metab
|
2021
|
17:97
|
|
Jing Li, Qiming Gong, Peilin Xie, Junyu Lin, Jia Chen, Dong Wei,Demin Yu,Yue Han,
|
Prognostic value of anti‐HBc quantification in hepatitis B virus related acute‐on‐chronic liver failure
|
Journal of Gastroenterology and Hepatology
|
2021
|
36:1291–1299
|
|
Tingting Liu, Jing Dai, Zhitao Yang, Xiaoqi Yu, Yanping Xu, Xinming Shi, Dong Wei, Zihan Tang, Guanqun Xu, Wenxin Xu, Yu Liu, Ce Shi, Qi Ni, Chengde Yang,, Xuefeng Wang, Erzhen Chen, Jieming Qu.
|
Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort study
|
Science Bulletin
|
2021
|
on line
|
|
Mingjie Wang, Li Chen, MinHui Dong, Jing Li, Beidi Zhu, Zhitao Yang, Qiming Gong, Yue Han, Demin Yu, Donghua Zhang, Fabien Zoulim, Jiming Zhang,
|
Viral quasispecies quantitative analysis: a novel approach for appraising the immune tolerant phase of chronic hepatitis B virus infection
|
Emerging Microbes & Infections
|
2021
|
10:842-851
|
|
Fei Ye, Wei Huang,Yuan Xue, Erjiang Tang,Mingjie Wang, Fengchun Shi, Dong Wei, Yue Han, Peizhan Chen,, Demin Yu.
|
Serum levels of ITGBL1 as an early diagnostic biomarker for hepatocellular carcinoma with hepatitis B virus infection
|
Journal of Hepatocellular Carcinoma
|
2021
|
8:285–300
|
|
Wei Huang, Demin Yu, Mingjie Wang, Yue Han, Junyu Lin, Dong Wei, Jialin Cai, Bin Li, Peizhan Chen,
|
ITGBL1 promotes cell migration and invasion through stimulating the TGF-β signalling pathway in hepatocellular carcinoma
|
Cell Proliferation
|
2020
|
00:e12836
|
|
Wenxin Xu, Mingjie Wang, Demin Yu,
|
Variations in SARS-CoV-2 spike protein cell epitopes and glycosylation profiles during global transmission course of COVID-19
|
Frontiers in Immunology
|
2020
|
11:565278
|
|
Nanshan Chen*, Min Zhou*, Xuan Dong*, Jieming Qu*, Fengyun Gong, Yang Han, Yang Qiu, Jingli Wang, Ying Liu, Yuan Wei, Jia’an Xia, Ting Yu,, Li Zhang+.
|
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
|
The Lancet
|
2020
|
395:507-513
|
|
Xiaonan Zhang, Yun Tan, Yun Ling, Gang Lu, Feng Liu, Zhigang Yi, Xiaofang Jia, Min Wu, Bisheng Shi, Shuibao Xu, Jun Chen, Wei Wang, Bing Chen, Lu Jiang, Shuting Yu, Jing Lu, Jinzeng Wang, Mingzhu Xu, Zhenghong Yuan, Qin Zhang,, Guoping Zhao, Shengyue Wang, Saijuan Chen, Hongzhou Lu.
|
Viral and host factors related to the clinical outcome of COVID-19
|
Nature
|
2020
|
583:437-454
|
|
Kai Duana,Bende Liuc,Cesheng Lid,Huajun Zhange,Ting Yuf,Jieming Qug,Min Zhoug,Li Chen,Shengli Meng,Yong Hu, Cheng Peng, Mingchao Yuan, Jinyan Huan,Zejun Wang,Jianhong Yu, Xiaoxiao Gao,Dan Wang, Xiaoqi Yum,Li Li,Jiayou Zhang,Xiao Wu, Bei Li, Yanping Xu,Wei Chen,Yan Peng, Yeqin Hu,Lianzhen Lin, Xuefei Liu,Shihe Huang,Zhijun Zhou, Lianghao Zhang,Yue Wang, Zhi Zhang, Kun Deng, Zhiwu Xia, Qin Gong, Wei Zhang, Xiaobei Zheng,Ying Liu,Huichuan Yang,Dongbo Zhou,Ding Yu,Jifeng Hou,Zhengli Shi,Saijuan Chen,Zhu Chen,,Xiaoming Yang
|
Effectiveness of convalescent plasma therapy in severe COVID-19 patients
|
PNAS
|
2020
|
117(17):9490-9496
|
|
Huwen Wang, Zezhou Wang, Yinqiao Dong, Ruijie Chang, Chen Xu, Xiaoyue Yu, Shuxian Zhang, Lhakpa Tsamlag, Meili Shang, Jinyan Huang, Ying Wang, Gang Xu, Tian Shen,,Yong Cai.
|
Phase-adjusted estimation of the number of Coronavirus Disease 2019 cases in Wuhan, China
|
Cell Discovery
|
2020
|
6:10
|
|
Xiaoqi Yu, Dong Wei, Yongyan Chen, Donghua Zhang,
|
Retrospective detection of SARS-CoV-2 in hospitalized patients with influenza-like illness
|
Emerging Microbes & Infections
|
2020
|
9:1470-1473
|
|
Xiao-qi Yu, Ming-jie Wang, De-min Yu, Pei-zhan Chen, Ming-yu Zhu, Wei Huang, Yue Han, Qi-ming Gong#,
|
Comparison of serum hepatitis B virus RNA levels and quasispecies evolution patterns between entecavir and pegylated-interferon mono-treatment in chronic hepatitis B patients
|
J Clinical Microbiology
|
2020
|
on line
|
|
Mingjie Wang, Jianfeng Li, Xiaonan Zhang, Yue Han, Demin Yu, Donghua Zhang, Zhenghong Yuan, Zhitao Yang, Jinyan Huang,
|
An integrated software for virus community sequencing data analysis
|
BMC Genomics
|
2020
|
21:363
|
|
Wei Huang, Mingjie Wang, Qiming Gong, Demin Yu, Peizhan Chen, Junyu Lin, Yue Han, Yu Su, Lihong Qu,
|
Comparison of naturally occurring resistance-associated substitutions between 2008 and 2016 in Chinese chronic HCV infected patients
|
Microbial Drug Resistance
|
2019
|
25(6):944-950
|
|
Zhu MY, Chen PZ, Li J, Yu DM, Huang D, Zhu XJ, Han Y, Chen J, Huang W, Chen YY, Gong QM, Jiang JH, Zhang DH, Zhang Y, Zhang JM,
|
Serum M2BPGi level is a novel predictive biomarker for the responses to pegylated interferon-α treatment in HBeAg-positive chronic hepatitis B patients.
|
Journal of medical virology
|
2018
|
90(4):721-729
|
|
Dong Wei, De-Ming Yu, Ming-jie Wang, Dong-hua Zhang, Qi-jian Cheng, Jie-Ming Qu,
|
Genome-wide characterization of the seasonal H3N2 virus in Shanghai reveals natural temperature-sensitive strains conferred by the I668V mutation in the PA subunit
|
Emerging Microbes & Infections
|
2018
|
7:171
|
|
Mingjie Wang, Qiming Gong, Jiming Zhang, Liang Chen, Zhanqing Zhang, Lungen Lu, Demin Yu, Yue Han, Donghua Zhang, Peizhan Chen, Xiaonan Zhang, Zhenghong Yuan, Jinyan Huang,
|
Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis.
|
Scientific Report
|
2017
|
7:43446
|
|
Zhu MY, Zou X, Li Q, Yu DM, Yang ZT, Huang D, Chen J, Gong QM, Zhang DH, Zhang Y, Chen L, Chen PZ,
|
A novel noninvasive algorithm for the assessment of liver fibrosis in patients with chronic hepatitis B virus infection.
|
Journal of viral hepatitis
|
2017
|
24(7):589-598
|
|
Huang D, Sansas B, Jiang JH, Gong QM, Jin GD1, Calais V, Yu DM, Zhu MY, Wei D, Zhang DH, Inchauspé G,, Zhu R.
|
Recognition of Core- and Polymerase-derived immunogenic peptides included in novel therapeutic vaccine by T cells from Chinese chronic hepatitis B patients.
|
Journal of viral hepatitis
|
2017
|
24:66–74
|
|
Yue Han, Leilei Gu, Jing Liu, Xinhua Li, Mingjie Wang, Qiming Gong, Demin Yu, Zhitao Yang, Donghua Zhang, Huijuan Yang, Zhongliang Shen, Hongguang Zhu, Youhua Xie,
|
Association of Mutations in Toll-like Receptor 2 Signaling Genes With Fulminant Form of Hepatitis B–Related Acute Liver Failure.
|
Journal of Infectious Diseases
|
2017
|
215(8):1221-1230
|
|
Xia Zou, Ming-Yu Zhu, De-Min Yu, Wei Li, Dong-Hua Zhang, Fei-Jie Lu, Qi-Ming Gong, Feng Liu, Jie-Hong Jiang, Min-Hua Zheng, Atsushi Kuno, Hisashi Narimatsu, Yan Zhang,
|
Serum WFA+-M2BP levels for evaluation of early stages of liver fibrosis in patients with chronic hepatitis B virus infection.
|
Liver international
|
2017
|
37(1):35-44
|
|
Yuan Xue, Ming-Jie Wang, Zhi-Tao Yang, De-Min Yu, Yue Han, Dao Huang, Dong-Hua Zhang,
|
Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
|
Emerging microbes & infections
|
2017
|
6(3):e15.
|
|
Yuan Xue, Ming Jie Wang, Su Yuan Huang, Zhi Tao Yang, De Min Yu, Yue Han, Ming Yu Zhu, Dao Huang, Dong Hua Zhang, Qi Ming Gong,
|
Characteristics of CpG Islands and their quasispecies of full length hepatitis B virus genomes from patients at different phases of infection.
|
SpringerPlus
|
2016
|
5(1): 1630
|
|
Jie Chen, Dong-Hua Zhang, Cheng-Run Xuc, Ming-Yu Zhu, Zhi-Tao Yang, Qi-Ming Gong, De-Min Yu,
|
Quantitative hepatitis B surface antigen combined with hepatitis B eantigen as sustained virological response predictors during extendedtherapy with Peginterferon alfa-2a for hepatitis B e antigen-positivechronic hepatitis B.
|
Journal of Clinical Virology
|
2015
|
72: 88–94.
|
|
Xiaodong Li, Yan Liu, Pan Zhao, Yan Wang, Li Chen, Shaojie Xin,, Dongping Xu.
|
Investigation on drug-resistant mutations of hepatitis B virus (HBV) from 845 nucleos(t)ide analog-na?ve Chinese patients with chronic HBV infection
|
Anti-viral Therapy
|
2015
|
doi: 10.3851/IMP2813
|
|
Yue Han,Ling Gong,Jia Sheng,Feng Liu,Xin-Hua Li,Li Chen,De-Min Yu,Qi-Ming Gong,Pei Hao,
|
Prediction of Virological Response by Pretreatment Hepatitis B Virus Reverse Transcriptase Quasispecies Heterogeneity: the advantage of using Next Generation Sequencing
|
Clinical Microbiology and Infection
|
2015
|
21: 797e1-797e8
|
|
Zhi-Tao Yang,Su-Yuan Huang,Li Chen,Feng Liu,Xiao-Hui Cai,Yang-Fan Guo,Ming-Jie Wang,Yue Han,De-Min Yu,Jie-Hong Jiang,Dong-Hua Zhang,Qi-Ming Gong,Guo-Qing Zhang,Guo-Qing Zang,Zhong-Hua Lu,Li-Hua Huang,
|
Characterization of full-length genome of hepatitis B virus quasispecies in serum of patients with different phases of infection
|
Journal of Clinical Microbiology
|
2015
|
53(7):203-2214
|
|
Li Chen, Qiao-Rong Gan, Dong-Qing Zhang, Lv-Feng Yao, Rong-Sheng Lin, Qing Li, Ming-Hua Lin, De-Min Yu,, Chen Pan.
|
Increased intrahepatic quasispecies heterogeneity correlates with off-treatment sustained response to nucleos(t)ide analogues in HBeAg-positive chronic hepatitis B patients
|
Clinical Microbiology and Infection
|
2015
|
DOI: 10.1016/j.cmi.2015.10.007.
|
|
Baosen Jia, Minggao Guo, Gaiyun Li, Demin Yu,, Ke LAN, and Qiang Deng.
|
Hepatitis B core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7.
|
Journal of Virology
|
2015
|
89(4) :2041-2051.
|
|
Dao Huang,Marie Hennequi,Alexei Elvachev,Thierry Menguy,Nathalie Silvestre,DeMing Yu,Yue Han,Geneviève Inchauspé,,Ren Zhu
|
The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China
|
Arch Virol
|
2015
|
160:1125–1130
|
|
Xin-Hua Li, Qi-Ming Gong, Yun Ling, Chong Huang, De-MinYu, Lei-Lei Gu, Xiang-Wei Liao, Dong-Hua Zhang, Xi-Qi Hu, Yue Han, Xiao-Fei Kong,
|
Inherent lipid metabolic dysfunction in glycogen storage disease type IIIa
|
BBRC
|
2014
|
455:90-97
|
|
De-Min Yu, Xin-Hua Li, Vannary Mom, Zhong-Hua Lu, Xiang-Wei Liao, Yue Han, Christian Pichoud, Qi-Ming Gong, Dong-hua Zhang, Yan Zhang, Paul Deny, Fabien Zoulim,
|
Contribution of N-Glycosylation Mutations within Hepatitis B Virus Surface Major Hydrophilic Region to Immune Escape
|
J Hepatol
|
2014
|
60(3):515-22
|
|
Zhihua Qi, Gaiyun Li, Hao Hu, Chunhui Yang, Xiaoming Zhang, Qibin Leng, Youhua Xie, Demin Yu,, Yueqiu Gao, Ke LAN, and Qiang Deng
|
Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice
|
J Virol.
|
2014
|
88(14):8045- 8056
|
|
Feng Liu,De-Min Yu,Su-Yuan Huang,Jia-Lun Yu,Dong-Hua Zhang,Qi-Ming Gong,
|
Clinical Implications of Evolutionary Patterns of Homologous, Full-Length Hepatitis B Virus Quasispecies in Different Hosts after Perinatal Infection
|
Journal of Clinical Microbiology
|
2014
|
52(5):1556–1565
|
|
Lei-Lei Gu, Xin-Hua Li, Yue Han, Dong-Hua Zhang, Qi-Ming Gong,
|
A novel homozygous no-stop mutation in G6PC gene from a Chinese patient with glycogen storage disease type Ia
|
Gene
|
2014
|
536 :362-365
|
|
Zhuo Wang, Kai Zhu, Weiya Bai , Baosen Jia, Hao Hu, Dongming Zhou, Xiaoming Zhang,, Youhua Xie, Maryline Mancini-Bourgine, Marie-Louise Michel, Ke Lan, Qiang Deng
|
Adenoviral Delivery of Recombinant Hepatitis B Virus Expressing Foreign Antigenic Epitopes for Immunotherapy of Persistent Viral Infection
|
J Virol.
|
2014
|
88(5) : 3004-3015
|
|
Zhu X, Gong Q, Yu D, Zhang D, Gu L, Han Y, Chen J, Zhang Y,
|
Early serum hepatitis B virus large surface protein level: A stronger predictor of virological response to peginterferon alfa-2a than that to entecavir in HBeAg-positive patients with chronic hepatitis B.
|
J Clin Virol
|
2013
|
29 : 123-126.
|
|
Xiao-Fei Kong, Yue Han, Xin-Hua Li, De-Yong Gao,, Qi-Ming Gong.
|
Recurrent porphyria attacks in a Chinese patient with a heterozygous PBGD mutation
|
Gene
|
2013
|
524:401-402
|
|
Xiaonan Zhang; Zhanqing Zhang; Fahui Dai; Bisheng Shi; Liang Chen; Xinxin Zhang; Guoqing Zang; Jiming Zhang; Xiaorong Chen; Fangxing Qian; Yunwen Hu; Zhenghong Yuan
|
Comparison of circulating messenger RNA and microRNA as biomarkers for hepatitis B and C virus induced liver disease
|
Plos One
|
2013
|
18 (3) :92112-92114
|
|
Valeria Cento1, Carmen Mirabelli1, Salvatore Dimonte1, Romina Salpini1, Yue Han, Pascale Trimoulet, Ada Bertoli, Valeria Micheli, Guido Gubertini, Giuseppina Cappiello, Alberto Spanò, Roberta Longo,Martina Bernassola, Francesco Mazzotta, Giuseppe Maria De
|
Overlapping structure of HBV genome and immune selection pressure are are critical forces modulating HBV evolution
|
Journal of General Virology
|
2013
|
94:143-149
|
|
Ling Gong, Yue Han, Li Chen, Feng Liu, Pei Hao, Jia Sheng, Xin-Hua Li, De-Min Yu, Qi-Ming Gong, Fei Tian, Xiao-kui Guo,
|
Comparison of Next-Generation Sequencing and Clone-Based Sequencing in Analysis of Hepatitis B Virus Reverse Transcriptase Quasispecies Heterogeneity
|
J Clinical Microbiol
|
2013
|
51 (12) :4087-4094
|
|
Dongning Du, Xuejuan Zhu, Atsushi Kuno, Atsushi Matsuda, Chikayuki Tsuruno, Demin Yu, Yan Zhang, Yuzuru Ikehara, Yasuhito Tanaka,, Hisashi Narimatsu.
|
Comparison of LecT-Hepa and FibroScan for assessment of liver fibrosis in hepatitis B virus infected patients with different ALT levels
|
Clinica Chimica Acta
|
2012
|
413:1796-1799.
|
|
Xiaonan Zhang, Cuncun Chen, Min Wu, Liang Chen, Jiming Zhang,, Zhanqin Zhang, Jingdi Wu, Jiefei Wang, Xiaorong Chen, Tao Huang, Lixiang Chen, Zhenghong Yuan.
|
Plasma microRNA profile as a predictor of early virological response to interferon treatment in chronic hepatitis B patients.
|
Antiviral Therapy
|
2012
|
17:1243-1253
|
|
LING Yun,LIAO Xiang-Wei,LI Xin-Hua,HAN Yue,YANG Zhi-Tao,KONG Xiao-Fei,GU Lei-Lei,YU De-Ming,YAO Bi-Lian,ZHANG Dong-Hua,JIN Gen-Di,GONG Qi-Ming,
|
Human leukocyte antigen-DP loci are associated with the persistent infection of hepatitis B virus in Chinese population.
|
Journal of Microbes and lnfecions
|
2012
|
7(1):18-27
|
|
Xin-Hua Li,Yi Lu,Yun Ling,Qing-Chun Fu,Jie Xu,Guo-Qing Zang,Feng Zhou,De-Min Yu,Yue Han,Dong-Hua Zhang,Qi-Ming Gong,Zhi-Meng Lu,Xiao-Fei Kong,Jian-She Wang,
|
Clinical and molecular characterization of Wilson's disease in China: identification of 14 novel mutations
|
BioMedCentral medical genetics
|
2011
|
11;12(1):6
|
|
Xiang-wei Liao,Yun Ling,Xin-hua Li,Yue Han,Shen-ying Zhang,Lei-lei Gu,De-ming Yu,Chong Huang,Qin Zhan,Gen-di Jin,Zhi-meng Lu,Qi-ming Gong,
|
Association study of genetic variation in IL28B with the hepatitis C treatment-induced viral clearance in Chinese Han population
|
Antiviral Therapy
|
2011
|
16：141－147
|
|
Feng Liu,Li Chen,De-Min Yu,Lin Deng,Rong Chen,Yin Jiang,Liang Chen, Su-Yuan Huang,Qi-Ming Gong,
|
Evolutionary Patterns of Hepatitis B Virus Quasispecies under Different Selective Pressures: Correlation with Antiviral Efficacy
|
Gut
|
2011
|
60:1269-1277
|
|
Valentina Svichera,aleria Centoa, Romina Salpinia, Fabio Mercurioa, Maria Frauneb,Bastian Beggelb, Yue Hanc, Caterina Gorid, Linda Wittkope, Ada Bertoli f, Valeria Michelig,Guido Gubertinig, Roberta Longoh, Sara Romanoh, Michela Viscah, Valentina Gallinar
|
Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development
|
Digestive and Liver Disease
|
2011
|
43:975-983
|
|
Xuan-Yi Wang,,Xin Yao,Jie-Hong Jiang,You-Hua Xie,Zheng-Hong Yuan,Yu-Mei Wen
|
Serum HBeAg sero-conversion correlated with decrease of HBsAg and HBV DNA in chronic hepatitis B patients treated with a therapeutic vaccine
|
Vaccine
|
2010
|
28：8169-8174
|
|
De-Yong Gao,Gen-Di Jin,Bi-Lian Yao,Dong-Hua Zhang,Lei-Lei Gu,Zhi-Meng Lu,Qiming Gong,Yu-Chun Lone,Qiang Deng,
|
Characterization of the specific CD4+ T cell response against the F protein during chronic hepatitis C virus infection
|
PloS ONE
|
2010
|
5(12),e 14237
|
|
Xiao-Fei Kong, Michael Ciancanelli, Sami Al-Hajjar, Laia Alsina, Timothy Zumwalt, Jacinta Bustamante, Jacqueline Feinberg, Magali Audry, Carolina Prando, Vanessa Bryant1, Alexandra Kreins, Dusan Bogunovic, Rabih Halwani,, Laurent Abel, Damie
|
A novel form of human STAT1 deficiency impairing early but not late responses to interferons
|
Blood
|
2010
|
116:5895-5906
|
|
HAN Yue, HUANG Li Hua, LIU Chuan Miao, YANG Shu, LI Juan, LIN Zhi Mei, KONG Xiao Fei, YU De Min, ZHANG Dong Hua, JIN Gen Di, LU Zhi Meng, GONG Qi Ming,
|
Sequence analysis of Hepatitis B virus reverse transcriptase in treatment na?ve patients.
|
J Gastroenterolgy & Hepatology
|
2009
|
24:1417-1423.
|
|
Jia Jidong,Hong Ma,Wei Lai,,Mao Yuan Li,Wang LanLan,Gao Zhiliang,Hou Jinlin,Zhang Jun
|
Multicentre evaluation of the Elecsys? HBsAg II assay for detection of HBsAg in comparison with other commercially available assays
|
Med Microbiol Immunol
|
2009
|
198: 263-269
|
|
GONG Qi-Ming, Kong Xiao-Fei, Yang Zhi-Tao, Xu Jie, Wang Lin, Li Xin-Hua, Jin Gen-Di, Gao Jian, Zhang Dong-Hua, Jiang Jie-Hong, Lu Zhi-Meng,
|
Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection.
|
J Viral Hepatitis
|
2009
|
16:674-680.
|
|
Li Chen, Qian Zhang, De-min Yu, Mo-bin Wan,
|
Early changes of hepatitis B virus quasispecies during lamivudine treatment and its prediction for antiviral efficacy.
|
J Hepatology
|
2009
|
50:895-905.
|
|
Xiao-Fei Kong,Michael Ciancanelli1, Sami Al-Hajjar,Laia Alsina,Timothy Zumwalt,Jacinta Bustamante,Jacqueline Feinberg,Magali Audry,Carolina Prando, Vanessa Bryant,Alexandra Kreins,Dusan Bogunovic,,Laurent Abel,Damien Chaussabel,Saleh Al-Muhse
|
A novel form of cell type-specific partial IFN-γR1 deficiency caused by a germ line mutation of the IFNGR1 initiation codon
|
Human Molecular Genetics
|
2009
|
|
|
De-Yong Gao,, Gang Hou, Gen-Di Jin, Qiang Deng, Xiao-Fei Kong, Dong-Hua Zhang, Yun Ling, De-Min Yu, Qi-Ming Gong, Qin Zhan, Bi-Lian Yao and Zhi-Meng Lu.
|
Assessment of specific antibodies to F protein in sera of Chinese hepatitis C patients treated with interferon plus ribavarin.
|
J Clinical Microbiology
|
2008
|
46(11):3746-3751
|
|
Zhi-Tao Yang,, Xiao-Fei Kong, Dong-Hua Zhang, Shen-Ying Zhang, Jie-Hong Jiang, Qi-Ming Gong, Gen-Di Jin, Zhi-Meng Lu.
|
Polymorphisms of microsomal triglyceride transfer protein in different hepatitis B virus infected patients.
|
World J Gastroenterology
|
2008
|
14(35):5454-5460.
|
|
Xiao-Fei Kong, Jing Ye, De-Yong Gao, Qi-Ming Gong, Dong-Hua, Zhang, Zhi-Meng Lu, Yi-Ming Lu,
|
Identification of a Ferrochelatase Mutation in a Chinese Family with Erythropoietic Protoporphyria.
|
.J Hepatology
|
2008
|
48:375-379
|
|
Kong XF,, Gong QM, Gao J, Zhang SY, Wang L, Xu J, Han Y, Jin GD, Jiang JH, Zhang DH, Lu ZM
|
MxA Induction May Predict Sustained Virologic Responses of Chronic Hepatitis B Patients with IFN-alpha Treatment.
|
J Interferon Cytokine Research
|
2007
|
27(9):809-818
|
|
Shen-Ying Zhang, E Jouanguy, S Ugolini, A Smahi, G Elain, P Romero, D Segal, V Sancho-Shimizu, L Lorenzo, A Puel, C Picard, A Chapgier, S Plancoulaine, M Titeux, C Cognet, H von Bernuth, CL Ku, A Casrouge,, L Barreiro, J Leonard, C Hamilton
|
TLR3 Deficiency in Patients with Herpes Simplex Encephalitis
|
Science
|
2007
|
317:1522-1527
|
|
Kong XF,, Yu YY,Ying-Yan Yu, Qing Shi, Duan-Duan La, Chuan-De Zhu-Ge, Lin Deng, Qi-Ming Gong, Bai-Yong Shen, Cheng-Hong Peng,Hong-Wei Li
|
No mutation was found in the alpha-subunit of the mitochondrial trifunctional protein in one patient of severe acute fatty liver of pregnancy and her relatives
|
Journal of Gastroenterology and Hepatology
|
2006
|
22(12):2107-11
|
|