- 基本信息
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导师姓名：
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陈立
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学科代码：
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100201
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性别：
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男
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学科名称：
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内科学
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培养单位：
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附属瑞金医院
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三级学科
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消化系病
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导师类型：
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硕士生导师
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专业领域名称：
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内科学 专业学位
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联系方式：
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drchenli@163.com
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专业领域代码：
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105101
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邮编：
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201820
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邮箱地址：
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CLB1247@rjhn.com.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会肝病学分会青年委员
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中华医学会肝病学分会肝炎学组委员
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- 科研项目
| 81770590 | 乙型肝炎病毒全基因组表观遗传修饰在核苷类似物停药复发中的作用机制研究 | 国家自然科学基金 |
2018-01~2021-12
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51万元
| 课题负责人 |
| 81472830 | GPC3嵌合 抗原受体基因修饰的T细胞靶向治疗肝细胞癌的研究 | 国家自然科学基金 |
2016-01~2019-12
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72万元
| 课题参与人 |
| 8100179 | 肝内乙型肝炎病毒准种分布和cccDNA甲基化在核苷类似物停药复发中的作用研究 | 国家自然科学基金 |
2011-01~2013-12
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20万元
| 课题负责人 |
- 学术论文
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Hu Li, Jin Ma, Leilei Gu, Peizhan Chen,, Xinxin Zhang.
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Serum Glycocholic Acid-to-Total Bile Acid Ratio Is Independently Associated with Nonalcoholic Fatty Liver Disease: A Retrospective Cross-Sectional Study.
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BioMed Research International
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2021
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148:e137
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Li J, Ding J,, Hong L, Yu X, Ye E, Sun G, Zhang B, Zhang X, Sun Q.
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Epidemiological and clinical characteristics of three family clusters of COVID-19 transmitted by latent patients in China.
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Epidemiol Infect.
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2020
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148:e137
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Li H, Huang W, Wang M, Chen P,, Zhang X.
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Tandem Mass Tag-based quantitative proteomics analysis of metabolic associated fatty liver disease induced by high fat diet in mice.
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Nutr Metab (Lond)
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2020
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17(1):97.
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Leilei Gu,Bin Wang,Lu Liu,Qiaorong Gan,Xiaolong Liu,Lihong Chen,
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Hepatic fibrinogen storage disease and hypofibrinogenemia caused by fibrinogen Aguadilla mutation: a case report
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Journal of International Medical Research
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2020
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48(1) 1–7
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Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, Zhou M,, Meng S, Hu Y, Peng C, Yuan M, Huang J, Wang Z, Yu J, Gao X, Wang D, Yu X, Li L, Zhang J, Wu X, Li B, Xu Y, Chen W, Peng Y, Hu Y, Lin L, Liu X, Huang S, Zhou Z, Zhang L, Wang Y, Zhang Z, Deng K, Xia Z, Gong Q, Zhang W, Zheng X, Liu Y, Yang H, Zhou D, Yu D, Hou J, Shi Z, Chen S, Chen Z, Zhang X, Yang X.
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Effectiveness of convalescent plasma therapy in severe COVID-19 patients.
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Proc Natl Acad Sci U S A
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2020
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117(17):9490-9496.
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Ying Zhang , Xiaocui Huang , Fang Luo , Yun Lei ,, Zuquan Weng , Longhua Guo , Zhenyu Lin
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Highly sensitive electrochemical immunosensor for golgi protein 73 based on proximity ligation assay and enzyme-powered recycling amplification
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Analytica Chimica Acta
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2018
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1040:150-157
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, Gan QR, Zhang DQ, Yao LF, Lin RS, Li Q, Lin MH, Yu DM, Zhang XX, Pan C.
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Increased intrahepatic quasispecies heterogeneity correlates with off-treatment sustained response to nucleos(t)ide analogues in e antigen-positive chronic hepatitis B patients.
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Clin Microbiol Infect
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2016
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22(2):201-7
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Yang ZT, Huang SY,, Liu F, Cai XH, Guo YF, Wang MJ, Han Y, Yu DM, Jiang JH, Zhang DH, Gong QM, Zhang GQ, Zang GQ, Lu ZH, Huang LH, Zhang XX
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Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection
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J Clin Microbiol
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2015
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53(7):2203-14
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Han Y, Gong L, Sheng J, Liu F, Li XH,, Yu DM, Gong QM, Hao P, Zhang XX
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Prediction of virological response by pretreatment hepatitis B virus reverse transcriptase quasispecies heterogeneity: the advantage of using next-generation sequencing
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Clin Microbiol Infect
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2015
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21(8):797.e1-8
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, Li XH, Zheng ZY, Lu XJ, Lin MH, Pan C, Liu JF.
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A novel ATP7B gene mutation in a liver failure patient with normal ceruloplasmin and low serum alkaline phosphatase
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Gene
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2014
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538(1):204-6
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, Zheng CX, Lin MH, Huang ZX, Li QG, Chen RH, Li Q, Pan C.
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Distinct quasispecies characteristics and positive selection within precore/core gene in HBV associated acute-on-chronic liver failure.
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Journal of Gastroenterology and Hepatology
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2013
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28(6):1040-6
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Gong L, Han Y,, Liu F, Hao P, Sheng J, Li XH, Yu DM, Gong QM, Tian F, Guo XK, Zhang XX
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Comparison of next-generation sequencing and clone-based sequencing in analysis of hepatitis B virus reverse transcriptase quasispecies heterogeneity.
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J Clin Microbiol
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2013
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51(12):4087-94
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Liu F,, Yu DM, Deng L, Chen R, Jiang Y, Chen L, Huang SY, Yu JL, Gong QM, Zhang XX
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Evolutionary patterns of hepatitis B virus quasispecies under different selective pressures: correlation with antiviral efficacy
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Gut
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2011
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60(9):1269-77
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, Zhang Q, Yu DM, Wan MB and Zhang XX.
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Early changes of hepatitis B virus quasispecies during lamivudine treatment and the correlation with antiviral efficacy
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Journal of Hepatology
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2009
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50: 895-905
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