- 基本信息
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导师姓名：
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陈立
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学科代码：
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100201
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性别：
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男
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学科名称：
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内科学
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培养单位：
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附属瑞金医院
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三级学科
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消化系病
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导师类型：
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硕士生导师
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专业领域名称：
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内科学 专业学位
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联系方式：
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drchenli@163.com
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专业领域代码：
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105101
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邮编：
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201820
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邮箱地址：
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CLB1247@rjhn.com.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会肝病学分会青年委员
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上海市代谢相关脂肪性肝病学术联盟副主任委员
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中华医学会肝病学分会肝病相关消化病协作组委员
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中华医学会肝病学分会肝炎学组委员
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上海市医学会肝病专科分会肝纤维化学组委员
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中华肝脏病杂志青年编委
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中华传染病杂志通讯编委
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- 科研项目
| 82472258 | 肠道菌群通过5-脂氧合酶介导肝脏巨噬细胞铁死亡打破慢性HBV感染免疫耐受的作用研究 | 国家自然科学基金 |
2025-01~2028-12
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48万元
| 课题负责人 |
| 2024FYC2311000 | 慢性乙型肝炎临床治愈新策略及关键诊疗技术研发 | 国家重点研发计划 |
2025-01~2027-12
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40万元
| 子课题负责人 |
| 81770590 | 乙型肝炎病毒全基因组表观遗传修饰在核苷类似物停药复发中的作用机制研究 | 国家自然科学基金 |
2018-01~2021-12
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51万元
| 课题负责人 |
| 81472830 | GPC3嵌合 抗原受体基因修饰的T细胞靶向治疗肝细胞癌的研究 | 国家自然科学基金 |
2016-01~2019-12
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72万元
| 课题参与人 |
| 8100179 | 肝内乙型肝炎病毒准种分布和cccDNA甲基化在核苷类似物停药复发中的作用研究 | 国家自然科学基金 |
2011-01~2013-12
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20万元
| 课题负责人 |
- 学术论文
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,李东良
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免疫检查点抑制剂相关肝损伤临床诊治的若干问题与思考
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中华肝脏病杂志
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2025
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33(8): 806-810.
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,范建高
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从国际脂肪性肝病定义的变迁看2024版中国指南的工作定义与特色
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中国临床医学
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2025
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32(3): 321- 326.
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,张欣欣
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《慢性乙型肝炎防治指南（2022版）》乙型肝炎病毒感染自然史分期及其内涵的再探讨
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中华肝脏病杂志
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2024
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32(1):80-82
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Li H, Wang M, Chen P, Zhu M,
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A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis
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Biomed Pharmacother
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2024
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174:116617
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From metabolic dysfunction-associated fatty liver disease to metabolic dysfunction-associated steatotic liver disease: Controversy and consensus
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World J Hepatol
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2023
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27;15(12):1253-1257
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Lu M, Zhu M, Li H, Wang Q, Qian Y, Wang M,
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Factors associated with discordance in the assessment of fibrosis stage between transient elastography and liver biopsy in NAFLD patients
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Clin Res Hepatol Gastroenterol
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2023
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47(7):102183
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Zhu M,
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Hepatitis of unknown etiology in children: What we know and what we can do?
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Front Microbiol
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2022
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8;13:956887
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Wang Q, Zhou D, Wang M, Zhu M, Chen P, Li H, Lu M, Zhang X, Shen X, Liu T,
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A Novel Non-Invasive Approach Based on Serum Ceruloplasmin for Identifying Non-Alcoholic Steatohepatitis Patients in the Non-Diabetic Population
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Front Med
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2022
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20;9:900794
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Zhu M, Wang Q, Wang M, Wang S, Gong Q, Zhang X,
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Rare Hepatic Cryptococcosis Mimicked Metastatic Liver Cancer and Confirmed by Metagenomic Next-Generation Sequencing in an Immunocompetent Patient: A Case Report
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Infect Drug Resist
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2022
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30;15:5753-5758
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免疫耐受期慢性乙型肝炎病毒感染的诊断与治疗：在争鸣中前行
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中华传染病杂志
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2021
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39(12):711-714
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Wang M,, Dong M, Li J, Zhu B, Yang Z, Gong Q, Han Y, Yu D, Zhang D, Zoulim F, Zhang J, Zhang X
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Viral quasispecies quantitative analysis: a novel approach for appraising the immune tolerant phase of chronic hepatitis B virus infection
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Emerg Microbes Infect
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2021
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10(1):842-851
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Hu Li, Jin Ma, Leilei Gu, Peizhan Chen,, Xinxin Zhang.
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Serum Glycocholic Acid-to-Total Bile Acid Ratio Is Independently Associated with Nonalcoholic Fatty Liver Disease: A Retrospective Cross-Sectional Study.
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BioMed Research International
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2021
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148:e137
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Li H, Wang Q, Chen P, Zhou C, Zhang X,
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Ursodeoxycholic Acid Treatment Restores Gut Microbiota and Alleviates Liver Inflammation in Non-Alcoholic Steatohepatitic Mouse Model
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Front Pharmacol
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2021
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12:788558
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Li J, Ding J,, Hong L, Yu X, Ye E, Sun G, Zhang B, Zhang X, Sun Q.
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Epidemiological and clinical characteristics of three family clusters of COVID-19 transmitted by latent patients in China.
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Epidemiol Infect.
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2020
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148:e137
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Li H, Huang W, Wang M, Chen P,, Zhang X.
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Tandem Mass Tag-based quantitative proteomics analysis of metabolic associated fatty liver disease induced by high fat diet in mice.
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Nutr Metab (Lond)
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2020
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17(1):97.
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Leilei Gu,Bin Wang,Lu Liu,Qiaorong Gan,Xiaolong Liu,Lihong Chen,
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Hepatic fibrinogen storage disease and hypofibrinogenemia caused by fibrinogen Aguadilla mutation: a case report
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Journal of International Medical Research
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2020
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48(1) 1–7
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Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, Zhou M,, Meng S, Hu Y, Peng C, Yuan M, Huang J, Wang Z, Yu J, Gao X, Wang D, Yu X, Li L, Zhang J, Wu X, Li B, Xu Y, Chen W, Peng Y, Hu Y, Lin L, Liu X, Huang S, Zhou Z, Zhang L, Wang Y, Zhang Z, Deng K, Xia Z, Gong Q, Zhang W, Zheng X, Liu Y, Yang H, Zhou D, Yu D, Hou J, Shi Z, Chen S, Chen Z, Zhang X, Yang X.
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Effectiveness of convalescent plasma therapy in severe COVID-19 patients.
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Proc Natl Acad Sci U S A
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2020
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117(17):9490-9496.
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王庆玲、岳伟、张欣欣、陈立
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铁代谢异常与非酒精性脂肪性肝病的关系
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中华健康管理学杂志
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2020
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14(6):587-591
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Ying Zhang , Xiaocui Huang , Fang Luo , Yun Lei ,, Zuquan Weng , Longhua Guo , Zhenyu Lin
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Highly sensitive electrochemical immunosensor for golgi protein 73 based on proximity ligation assay and enzyme-powered recycling amplification
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Analytica Chimica Acta
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2018
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1040:150-157
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, Gan QR, Zhang DQ, Yao LF, Lin RS, Li Q, Lin MH, Yu DM, Zhang XX, Pan C.
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Increased intrahepatic quasispecies heterogeneity correlates with off-treatment sustained response to nucleos(t)ide analogues in e antigen-positive chronic hepatitis B patients.
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Clin Microbiol Infect
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2016
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22(2):201-7
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Yang ZT, Huang SY,, Liu F, Cai XH, Guo YF, Wang MJ, Han Y, Yu DM, Jiang JH, Zhang DH, Gong QM, Zhang GQ, Zang GQ, Lu ZH, Huang LH, Zhang XX
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Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection
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J Clin Microbiol
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2015
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53(7):2203-14
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Han Y, Gong L, Sheng J, Liu F, Li XH,, Yu DM, Gong QM, Hao P, Zhang XX
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Prediction of virological response by pretreatment hepatitis B virus reverse transcriptase quasispecies heterogeneity: the advantage of using next-generation sequencing
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Clin Microbiol Infect
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2015
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21(8):797.e1-8
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, Li XH, Zheng ZY, Lu XJ, Lin MH, Pan C, Liu JF.
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A novel ATP7B gene mutation in a liver failure patient with normal ceruloplasmin and low serum alkaline phosphatase
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Gene
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2014
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538(1):204-6
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, Zheng CX, Lin MH, Huang ZX, Li QG, Chen RH, Li Q, Pan C.
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Distinct quasispecies characteristics and positive selection within precore/core gene in HBV associated acute-on-chronic liver failure.
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Journal of Gastroenterology and Hepatology
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2013
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28(6):1040-6
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Gong L, Han Y,, Liu F, Hao P, Sheng J, Li XH, Yu DM, Gong QM, Tian F, Guo XK, Zhang XX
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Comparison of next-generation sequencing and clone-based sequencing in analysis of hepatitis B virus reverse transcriptase quasispecies heterogeneity.
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J Clin Microbiol
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2013
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51(12):4087-94
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Liu F,, Yu DM, Deng L, Chen R, Jiang Y, Chen L, Huang SY, Yu JL, Gong QM, Zhang XX
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Evolutionary patterns of hepatitis B virus quasispecies under different selective pressures: correlation with antiviral efficacy
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Gut
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2011
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60(9):1269-77
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, Zhang Q, Yu DM, Wan MB and Zhang XX.
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Early changes of hepatitis B virus quasispecies during lamivudine treatment and the correlation with antiviral efficacy
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Journal of Hepatology
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2009
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50: 895-905
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