- 基本信息
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导师姓名：
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黄正蔚
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学科代码：
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100302
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性别：
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男
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学科名称：
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口腔临床医学
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培养单位：
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口腔医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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口腔医学 专业学位
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联系方式：
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huangzhengwei@shsmu.edu.cn
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专业领域代码：
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105200
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邮编：
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200011
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邮箱地址：
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huangzhengwei@shsmu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华口腔医学会牙体牙髓病学专业委员会 常务委员
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中华口腔医学会口腔生物学专业委员会 常务委员
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上海口腔医学会牙体牙髓病专委会 副主任委员
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- 科研项目
| 82071104 | 变异链球菌经磷酸转移酶系统对密度感应信号分子AI-2的转运及作用机制的研 究 | 国家自然科学基金面上项目 |
2021-01~2024-12
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13万元
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| 81570964 | 变异链球菌LuxS密度感应与代谢流相关性研究 | 国家自然基金委,面上项目 |
2016-01~2019-12
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68.5万元
| 课题负责人 |
| 81371143 | 妊娠期口腔核心微生物群特征及其对健康维持的研究初探 | 国家自然基金委,面上项目 |
2014-01~2014-12
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16万元
| 课题负责人 |
| 12QH1401400 | 核心微生物群在人类口腔健康维持中的作用初探 | 上海市青年科技启明星计划（跟踪） |
2012-09~2014-09
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20万元
| 课题负责人 |
| 81070826 | 变异链球菌luxS代谢旁路的研究初探 | 国家自然基金委,面上项目 |
2011-011~2013-12
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32万元
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| 09QA1403700 | 头颈部肿瘤放疗对口腔生态系的干扰机制研究 | 上海市科委，青年科技启明星A跟踪资助项目 |
2009-07~2011-06
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15万元
| 课题负责人 |
| 09QA1403700 | 头颈部肿瘤放疗对口腔生态系的干扰机制研究 | 上海市启明星计划项目 |
2009-06~2011-06
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15万元
| 课题负责人 |
| S30206-fzd02 | 密度感应信号对根管再感染中微生态系的影响机制研究 | 上海市重点学科（口腔基础医学）科研项目计划 |
2009-01~2011-12
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30万元
| 课题负责人 |
| 30872886 | 变形链球菌密度感应欺骗行为规避机制的研究初探 | 国家自然基金委,面上项目 |
2009-01~2011-12
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30万元
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| 教外司 留 [2008]890 | 口腔生物膜药物渗透屏障的数字化分析 | 留学回国人员科研启动基金 |
2009-01~2010-12
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5万元
| 课题负责人 |
| 30400497 | 变型链球菌luxS基因在种属间密度感应种作用的初探 | 国家自然基金委,面上项目 |
2005-01~2007-12
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21万元
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- 学术论文
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Yuan K#, Hou L, Jin Q#, Niu C, Mao M, Wang R*, Huang Z*.
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Comparative transcriptomics analysis of Streptococcus mutans with disruption of LuxS/AI-2 quorum sensing and recovery of methyl cycle.
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Archives of oral biology
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2021
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2021 July , 127, 105137.
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Dong T#, Zhao F#, Yuan K, Zhu X, Wang N, Xia F, Lu Y*, Huang Z*
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Association Between Serum Thyroid-Stimulating Hormone Levels and Salivary Microbiome Shifts
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Front Cell Infect Microbiol
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2021
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2021 Feb 26;11:603291
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Zhang P, Yuan K, Jin Q, Zhao F, Huang Z*.
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Presence of voids after three obturation techniques in band-shaped isthmuses: a micro-computed tomography study.
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BMC Oral Health.
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2021
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2021 May 1;21(1):227
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Wenzhen Lin#; Xiaohan Zhu#; Li Gao; Mengying Mao; Daming Gao; Zhengwei Huang
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Osteomodulin positively regulates osteogenesis through interaction with BMP2
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Cell Death Dis.
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2021
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2021 Feb 1;12(2):147
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Jin Q#, Li P#, Yuan K, Zhao F, Zhu X, Zhang P, Huang Z*
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Extracellular vesicles derived from human dental pulp stem cells promote osteogenesis of adipose-derived stem cells via the MAPK pathway
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J Tissue Eng
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2020
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2020 Dec 2;11:2041731420975569
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Fen Zhao#, Ting Dong#, Ke-Yong Yuan, Ning-Jian Wang, Fang-Zhen Xia, Di Liu, Zhi-Min Wang, Rui Ma*, Ying-Li Lu*, Zheng-Wei Huang*
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Shifts in the Bacterial Community of Supragingival Plaque Associated With Metabolic-Associated Fatty Liver Disease
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Front. Cell. Infect. Microbiol
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2020
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2020 Dec 15;10:581888.
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Jin Qiaoqiao#,Yuan Keyong#, Lin Wenzhen, Niu Chenguang, Ma Rui*, Huang Zhengwei
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Comparative characterization of mesenchymal stem cells from human dental pulp and adipose tissue for bone regeneration potential
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Artificial Cells, Nanomedicine and Biotechnology
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2019
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2019 Dec;47(1):1577-1584
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Lin W#, Gao L#, Jiang W, Niu C, Yuan K, Hu X, Ma R*, Huang Z*
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The role of osteomodulin on osteo/odontogenic differentiation in human dental pulp stem cells
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BMC Oral Health
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2019
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2019 Jan 22;19(1):22
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Hu X#, Wang Y#, Gao L, Jiang W, Lin W, Niu C, Yuan K, Ma R*, Huang Z*.
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The Impairment of Methyl Metabolism From luxS Mutation of Streptococcus mutans.
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Front Microbiol.
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2018
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12;9:404.
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Yuan K, Niu C, Xie Q, Jiang W, Gao L, Ma R, Huang Z*.
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Apical stress distribution under vertical compaction of gutta-percha and occlusal loads in canals with varying apical sizes: a three-dimensional finite element analysis.
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Int Endod J.
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2018
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51(2):233-239.
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Lin W#, Jiang W#, Hu X, Gao L, Ai D, Pan H, Niu C, Yuan K, Zhou X, Xu C*, Huang Z*.
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Ecological Shifts of Supragingival Microbiota in Association with Pregnancy.
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Front Cell Infect Microbiol.
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2018
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15;8:24.
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Fan L#, Yuan K#, Niu C, Ma R*, Huang Z*.
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A cone-beam computed tomography study of the mesial cervical concavity of maxillary first premolars.
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Arch Oral Biol.
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2018
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92:79-82.
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Niu C, Yuan K, Ma R, Gao L, Jiang W, Hu X, Lin W, Zhang X*, Huang Z*.
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Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway.
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Mol Med Rep.
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2017
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16(4):4879-4886.
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Niu C#, Xiao F#, Yuan K, Hu X, Lin W, Ma R, Zhang X*, Huang Z.*.
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Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption.
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Front Pharmacol.
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2017
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12;8:626.
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He Z, Liang J, Zhou W, Xie Q, Tang Z, Ma R, Huang Z*.
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Effect of the quorum-sensing luxS gene on biofilm formation by Enterococcus faecalis.
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Eur J Oral Sci.
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2016
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124(3): 234-240.
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Gao L, Hu Y, Wang Y, Jiang W, He Z, Zhu C, Ma R, Huang Z*.
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Exploring the variation of oral microbiota in supragingival plaque during and after head-and-neck radiotherapy using pyrosequencing.
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Arch Oral Biol.
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2015
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60(9):1222-1230.
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Jiang WX#, Hu YJ#, Gao L, He ZY, Zhu CL, Ma R, Huang ZW*.
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The impact of various time intervals on the supragingival plaque dynamic core microbiome.
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PLoS One.
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2015
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10(5): e0124631.
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He Z, Liang J, Tang Z, Ma R, Peng H, Huang Z*.
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Role of the luxS Gene in Initial Biofilm Formation by Streptococcus mutans.
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J Mol Microbiol Biotechnol.
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2015
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25(1):60-68.
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Yue-jian Hu, Qian Wang, Yun-tao Jiang, Rui Ma, Wen-wei Xia, Zi-sheng Tang, Zheng Liu, Jing-ping Liang, Zheng-wei Huang*.
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Characterization of oral bacterial diversity of irradiated patients by high-throughput sequencing.
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Int J Oral Sci.
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2013
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5(1):21-5.
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Yue-jian Hu, Zi-yang Shao, Qian Wang, Yun-tao Jiang, Rui Ma, Zi-sheng Tang, Zheng Liu, Jing-ping Liang, Zheng-wei Huang*.
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Exploring the dynamic core microbiome of plaque microbiota during head-and-neck radiotherapy using pyrosequencing.
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PLoS ONE
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2013
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8(2): e56343.
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Qian Wang, Zhiyan He, and Yuejian Hu, et al.
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luxS Mutant Regulation: Quorum Sensing Impairment or Methylation Disorder?
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Sensors
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2012
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12(5), 6176-6185.
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Zhiyan HE,Qian WANG,and Yuejian HU,et al.
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Use of the quorum sensing inhibitor, furanone C-30, to interfere with biofilm formation by Streptococcus mutans and its luxS mutant strain.
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International Journal of Antimicrobial Agents[J]
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2012
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40(1): 30-35.
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Zi-Yang SHAO, Zi-Sheng TANG, Chao YAN, Yun-Tao JIANG, Rui MA , Zheng LIU, Zheng-Wei HUANG
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Effects of intensity-modulated radiotherapy on human oral microflora.
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J. Radiat. Res.
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2011
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52(6):834-9.
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Huang Z, Jiang Y, Liang J.
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Pathogenesis could be one of the anti-cheating mechanisms for Pseudomonas aeruginosa society.
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Med Hypotheses.
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2011
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76(2):166-8.
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Ma R, Liu J, Jiang YT, Liu Z, Tang ZS, Ye DX, Zeng J, Huang ZW
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Modeling of diffusion transport through oral biofilms with the inverse problem method.
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Int J Oral Sci.
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2010
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2(4):190-7.
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变形链球菌luxS基因缺失对生物膜早期形成的影响
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中华口腔医学杂志
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2009
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44(2): 72-75
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, Z. Liu, R. Ma etc
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luxS-Based Quorum-Sensing Signaling Affects Biofilm Formation in Streptococcus mutans.
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Journal of Molecular Microbiology and Biotechnology
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2009
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17:12-19
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变异链球菌luxS基因缺陷突变株生物学性状的初步观察
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中华微生物学和免疫学杂志
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2008
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28(4): 330-333
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变形链球菌电击转化条件的优化研究
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中国微生态学杂志
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2007
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19(5): 404-405
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变形链球菌luxS基因同源重组克隆载体的构建实验
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华西口腔医学杂志
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2006
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24(1): 70-72
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差异显示技术对变形链球菌生物膜基因表达差异的研究
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中华微生物学和免疫学杂志
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2005
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25(9): 777-780
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差异显示技术对变形链球菌生物膜基因表达差异的研究
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中华微生物学和免疫学杂志
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2005
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25(9): 777-780
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,周学东,肖悦
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11种天然药物对乳酸杆菌生长与产酸影响的体外研究
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上海口腔医学
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2005
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14(1)：67-70
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,周学东,李继遥
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口腔生物膜体外模型的建立和应用评估
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牙体牙髓牙周病学杂志
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2004
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14 (9)：481-484
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