- 基本信息
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导师姓名：
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汪泱
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学科代码：
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100210
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性别：
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女
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学科名称：
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外科学
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培养单位：
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附属第六人民医院
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三级学科
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骨外
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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02124056319
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专业领域代码：
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邮编：
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200233
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邮箱地址：
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wangy63cn@126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国研究型医院学会细胞外囊泡研究与应用专业委员会 副主任委员及治疗学组组长
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- 科研项目
| 21DZ2201300 | 临床级干细胞小细胞外囊泡规模化制备的技术标准研究与应用 | 上海市“科技创新行动计划”技术标准项目 |
2021-09~2024-09
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20万元
| 课题负责人 |
| 82072550 | ESC-sEVs调控软骨代谢稳态防治退行性骨关节炎的机制研究 | 国家自然科学基金 |
2021-01~2024-12
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55万元
| 课题负责人 |
| ZH2018ZDA20 | Diels-Alder反应构建的可注射透明质酸水凝胶干细胞外泌体控释材料修复关节软骨损伤的研究 | 上海交通大学医工交叉重点项目 |
2019-01~2021-12
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100万元
| 课题负责人 |
| 81871833 | 胚胎干细胞来源的外泌体调控BMSC的命运防治骨质疏松的作用与机制 | 国家自然科学基金 |
2019-01~2022-12
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70万元
| 课题负责人 |
| 81672254 | iPS-MSC来源的Exosome促进软骨组织再生修复的分子机理 | 国家自然科学基金 |
2017-01~2020-12
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72万元
| 课题负责人 |
| 81472152 | 生物工程化iPS-MSCs来源的外泌体修复缺血性组织损伤的作用及机制 | 国家自然科学基金 |
2015-01~2018-12
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72万元
| 课题负责人 |
| 81170640 | 利用患者特异iPS细胞模型研究多囊肾病的microRNA调控机制 | 国家自然科学基金 |
2012-01~2015-12
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65万元
| 课题负责人 |
| 2011ZX09102-010-01 | 基于诱导多能干细胞的重大疾病药物开发和治疗技术平台 | 国家科技重大专项“重大新药创制”子课题 |
2011-01~2013-12
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75万元
| 子课题负责人 |
| 30960385 | 人类诱导多能干细胞（iPS）向肾脏细胞分化及对肾损伤的修复作用 | 国家自然科学基金 |
2010-01~2012-12
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24万元
| 课题负责人 |
- 学术论文
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Luo L#, Wu Z#,, Li H*
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Regulating the production and biological function of small extracellular vesicles: current strategies, applications and prospects
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J Nanobiotechnology
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2021
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19(1):422
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Kai Feng#, Xuetao Xie#, Ji Yuan, Liangzhi Gong, Zhaochen Zhu, Juntao Zhang, Haiyan Li, Yunlong Yang*,
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Reversing the surface charge of MSC-derived small extracellular vesicles by εPL-PEG-DSPE for enhanced osteoarthritis treatment
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J Extracellular Vesicles
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2021
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10(13)
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Xia Y, Hu G, Chen Y, Yuan J, Zhang J, Wang S, Li Q,, Deng Z*
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Embryonic Stem Cell Derived Small Extracellular Vesicles Modulate Regulatory T Cells to Protect against Ischemic Stroke
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ACS Nano
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2021
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15(4):7370-7385
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Hu G, Xia Y, Chen B, Zhang J, Gong L, Chen Y, Li Q*,, Deng Z*
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ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis
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Mol Ther
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2021
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29(1):103-120
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Gong L, Chen B, Zhang J, Sun Y, Yuan J, Niu X, Hu G, Chen Y, Xie Z, Deng Z, Li Q*,
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Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells
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J Extracell Vesicles
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2020
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9(1):1800971
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Liu M, Qiu Y, Xue Z, Wu R, Li J, Niu X, Yuan J,, Wu Q*
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Small extracellular vesicles derived from embryonic stem cells restore ovarian function of premature ovarian failure through PI3K/AKT signaling pathway
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Stem Cell Res Ther
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2020
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11(1):3
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Hu G, Xia Y, Zhang J, Chen Y, Yuan J, Niu X, Zhao B, Li Q,, Deng Z*
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ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia
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Adv Sci
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2020
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7(10):1903330
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Ling X, Zhang G, Xia Y, Zhu Q, Zhang J, Li Q, Niu X, Hu G, Yang Y,, Deng Z*
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Exosomes from human urine-derived stem cells enhanced neurogenesis via miR-26a/HDAC6 axis after ischaemic stroke
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J Cell Mol Med
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2020
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24(1):640-654
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Xia Y, Ling X, Hu G, Zhu Q, Zhang J, Li Q, Zhao B,, Deng Z*
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Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke
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Stem Cell Res Ther
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2020
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11(1):313
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Bi Chen, Yongjin Sun, Juntao Zhang, Qingwei Zhu, Yunlong Yang, Xin Niu, Zhifeng Deng, Qing Li*,
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Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells
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Stem Cell Research &Therapy
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2019
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10:142
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Qingwei Zhu, Xiaozheng Ling, Yunlong Yang, Juntao Zhang, Qing Li, Xin Niu,Guowen Hu, Bi Chen, Haiyan Li,,* Zhifeng Deng*
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Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy
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Adv. Sci.
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2019
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1801899
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Ruoyu Wu, Chengsheng Huang, Qingkai Wu, Xiang Jia, Mengyu Liu1, Zhuowei Xue, Yu Qiu, Xin Niu,
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Exosomes secreted by urine-derived stem cells improve stress urinary incontinence by promoting repair of pubococcygeus muscle injury in rats
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Stem Cell Research &Therapy
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2019
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10:80
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Liu X, Yang Y, Li Y, Niu X, Zhao B,, Bao C, Xie Z, Lin Q*, Zhu L
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Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration
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Nanoscale
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2017
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9 (13)： 4430-4438
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Zhu Y, Wang Y, Zhao B, Niu X, Hu B, Li Q, Zhang J, Ding J, Chen Y*,
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Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis
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Stem Cell Research &Therapy
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2017
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8 (1)： 64
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LiuX.,YangY., NiuX., LinQ., ZhaoB. ,,ZhuL.
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An in situ photocrosslinkable platelet rich plasma–Complexed hydrogel glue with growth factor controlled release ability to promote cartilage defect repair
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Acta Biomaterialia
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2017
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5：1742-7061
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ChenB.,Li Q.,Zhao B.,
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Stem Cell-Derived Extracellular Vesicles as a Novel Potential Therapeutic Tool for Tissue Repair
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Stem Cells Translational Medicine
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2017
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10.1002/sctm.16-0477.
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Liu X., Li Q., Niu X., Hu B., Chen S., Song W., Ding J., Zhang C.,
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Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis
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International Journal of Biological Sciences
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2017
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13 (2)：232
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Yunlong Yang, Jieyuan Zhang, Zhenzhen Liu, Qiuning Lin, Xiaolin Liu, Chunyan Bao,,* Linyong Zhu*
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Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction
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Advanced Materials
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2016
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28(14):2724-30
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Qing Li, Bin Hu, Guo-wen Hu, Chun-yuan Chen, Xin Niu, Juan Liu, Shu-min Zhou, Chang-qing Zhang,,Zhi-Feng Deng*
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tRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis
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Scientific Report
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2016
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6:20850
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Zhen-zhen Jiang, Yu-mei Liu, Xin Niu, Jian-yong Yin, Bin Hu, Shang-chun Guo, Ying Fan,,Nian-song Wang*
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Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats
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Stem cell Reserch & therapy
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2016
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7:24
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Zhang J, Liu X, Li H, Chen C, Hu B, Niu X, Li Q, Zhao B, Xie Z,
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Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway
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Stem Cell Res Ther.
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2016
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7(1):136
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Zhang J, Yang Y, Chen Y, Liu X, Guo S, Zhu L,
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An in situ phototriggered-imine-crosslink composite hydrogel for bone defect repair
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J. Mater. Chem. B
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2016
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4,973-981
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Guo-wen Hu, Qing Li, Xin Niu, Bin Hu, Juan Liu, Shu-min Zhou, Shang-chun Guo, Hai-li Lang,Chang-qing Zhang,, Zhi-feng Deng*
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Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice
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Stem Cell Research & Therapy
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2015
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6:10
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Guan J, Zhang J, Li H, Zhu Z, Guo S, Niu X,, Zhang C*
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Human Urine Derived Stem Cells in Combination with β-TCP Can Be Applied for Bone Regeneration
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PLoS One
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2015
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10(5):e0125253
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Zhang J, Guan J, Niu X, Hu G, Guo S, Li Q, Xie Z, Zhang C*,
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Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis
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J Trans Med
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2015
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13:49
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Li Q, Tian SF, Guo Y, Niu X, Hu B, Guo SC, Wang NS,
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Transplantation of induced pluripotent stem cell-derived renal stem cells improved acute kidney injury.
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Cell Biosci.
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2015
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5:45.
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Guan J, Zhang J, Guo S, Zhu H, Zhu Z, Li H,, Zhang C*, Chang J
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Human urine-derived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt/β-catenin signaling pathway
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Biomaterials
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2015
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55:1-11
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Xiaolin Liu, Qing Li, Jiagen Sheng, Bin Hu, Zhenzhong Zhu,Shumin Zhou, Junhui Yin, Qiang Gong,, Changqing Zhang
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A unique plasma metabolomic signature of osteonecrosis of the femoral head
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Journal of orthopaedic research
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2015
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12:33-43
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Ji Liu, Huarong Nie, Zhengliang Xu, Fei Guo,Shangchun Guo, Junhui Yin,, Changqing Zhang*
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The construction of PRP-containing nanofibrous scaffolds for controlled release and their application to cartilage regeneration.
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Journal of Materials Chemistry B
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2015
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3, 581–591
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Zhu H, Cheng X, Niu X, Zhang Y, Guan J, Liu X, Tao S,, Zhang C*
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Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival
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Int J Biol Sci
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2015
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(10):1181-9
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Guan J, Zhang J, Zhu Z, Niu X, Guo S,, Zhang C*
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Bone morphogenetic protein 2 gene transduction enhances the osteogenic potential of human urine-derived stem cells
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Stem Cell Res Ther
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2015
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6:5
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Yinxin Fu, Junjie Guan, Shangchun Guo, Fei Guo, Xin Niu, Qiang Liu, Changqing Zhang, Hua rong Nie,
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Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis
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J Transl Med
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2014
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12(1): 274
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hui Qin, chenZhu, Zhiquan an,Yao Jiang, Yaochao Zhao,Jiaxin Wang, Xin liu, Bing hui, Xianlong Zhang,
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Silver nanoparticles promote osteogenic differentiation of human urine-derived stem cells at noncytotoxic concentrations
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Int J Nanomedicine
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2014
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9: 2469-2478
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ChunYuan Chen, Wei Liao, YuanLei Lou, Qing Li, Bin Hu,, ZhiFeng Deng*
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Inhibition of Notch signaling facilitates the differentiation of human-induced pluripotent stem cells into neural stem cells
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Mol Cell Biochem
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2014
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395(1-2): 291-298
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Ji Liu, Huarong Nie, Zhengliang Xu, Xin Niu, Shangchun Guo, Junhui Yin, Fei Guo, Gang Li,, Changqing Zhang*
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The Effect of 3D Nanofibrous Scaffolds on the Chondrogenesis of Induced Pluripotent Stem Cells and Their Application in Restoration of Cartilage Defects
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PLoS One
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2014
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9(11): e111566
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JunJie Guan, Xin Niu, FeiXiang Gong, Bin Hu, ShangChun Guo,YuanLei Lou,ChangQing Zhang, ZhiFeng Deng,
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Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology
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Tissue Eng Part A
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2014
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20(13-14): 1794-1806.
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Zhenzhong Zhu, Junhui Yin, Jun jie Guan, Bin Hu, Xin Niu, Dongxu Jin,, Changqing Zhang*
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Lithium stimulates human bone marrow derived mesenchymal stem cell proliferation through GSK-3beta-dependent beta-catenin/Wnt pathway activation
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FEBS J
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2014
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281(23):5371-89
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Bin Hu, Ye Guo, Chunyuan Chen, Qing Li, Xin Niu, Shangchun Guo, AijunZhang,, Zhifeng Deng*
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Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells
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Cell Mol Neurobiol
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2014
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34(6): 905-912
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Yuan T*, Liao W, Feng NH, Lou YL, Niu X, Zhang AJ,, Deng ZF#
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Human induced pluripotent stem cell-derived neural stem cells survive, migrate, differentiate, and improve neurologic function in a rat model of middle cerebral artery occlusion
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Stem Cell Res Ther
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2013
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4(3):73
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Guo F, Lv S, Lou Y, Tu W, Liao W,, Deng Z#
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Bone Marrow Stromal Cells Enhance the Angiogenesis in Ischemic Cortex After Stroke： Involvement of Notch Signaling
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Cell Biology International
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2012
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36：997–1004
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Lou YL, Guo F, Liu F, Gao FL, Zhang PQ, Niu X, Guo SC, Yin JH,, Deng ZF#
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miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia
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Mol Cell Biochem
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2012
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370:45-51
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Liu F, Lou Y-L, Wu J, Ruan Q-F, Xie A, Guo F, Cui S-P, Deng Z-F,
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Upregulation of MicroRNA-210 Regulates Renal Angiogenesis Mediated by Activation of VEGF Signaling Pathway under Ischemia/Perfusion Injury in vivo and in vitro.
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Kidney Blood Press Res
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2012
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35:182-191
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, Guo F, Pan C, Lou Y, Zhang P, Guo S, Yin J, Deng Z#
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Effects of low temperatures on proliferation related signaling pathways in the hippocampus after traumatic brain injury
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Experimental Biology and Medicine
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2012
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237(12):1424-1432
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Guo F*, Guo X, Xie A, Lou YL,
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The Suppressive Effects of Lanthanum on the Production of Inflammatory Mediators in Mice Challenged by LPS.
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Biol Trace Elem Res.
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2011
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142:693-703
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Huarong Nie, Xingxing Shen, Zhihua Zhou, Qingsong Jiang, Yiwang Chen, AnXi,, Charles C.Hanc.
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Electrospinning and characterization of konjac glucomannan/chitosan nano?brous scaffolds favoring the growth of bone mesenchymal stem cells.
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Carbohydrate Polymers.
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2011
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85(3):681-686
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Guo F, Lou YL,
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Exposure to Lanthanum compound diminishes LPS-Induced inflammation- associated gene expression: involvements of PKC and NF –κB signaling pathways.
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Biometals.
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2010
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23(4):669-680
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, Wei Tu, Yuanlei Lou, An Xie, Xianliang Lai, Fei Guo, Zhifeng Deng.
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Mesenchymal stem cells regulate the proliferation and differentiation of neural stem cells through Notch signaling.
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Cell Biol Int
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2009
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33(11):1173-1179
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,HU Feng,WANG Zhi-jian,WANG Gong-xian,ZHANG Zhong-hua,XIE Ping,CUI Su-ping．
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Administration of Bone Marrow-derived Stem Cells Suppresses Necrotic and Apoptotic Cell Death induced by Renal Ischemia-Reperfusion in Rats．
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Chinese Medical Journal
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2008
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121(3):268-271
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Guo Fei, Lou Yuanlei ,,Xie An, Li Guohui.
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Lanthanum Chloride Inhibiting the Expression of Inducible Nitric Oxide Synthase in RAW264.7 Macrophages Induced by Lipopolysaccharide.
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Journal of Rare Earths
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2007
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25（3):359-363
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,Zhifeng Deng,Xianliang Lai,Wei Tu
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Differentiation of human bone marrow stromal cells into neural-like cells induced by Sodium ferulate in vitro．
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Cellular & Molecular Immunology.
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2005
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2(3):225-229
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