- 基本信息
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导师姓名：
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宋雷
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学科代码：
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100213
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性别：
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男
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学科名称：
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耳鼻咽喉科学
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培养单位：
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附属第九人民医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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lei.song@yale.edu
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专业领域代码：
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邮编：
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200120
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邮箱地址：
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Lei.song@vip.126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 8177040196 | 外毛细胞功能调控机理的研究 | 国家自然科学基金-面上项目 |
2018-01~2021-12
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78.16万元
| 课题负责人 |
- 学术论文
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Li J#, Liu S#, Song C#, Zhu T, Zhao Z, Sun W, Wang Y*,, Xiong W*
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Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies in Mice
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Neuroscience Bulletin
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2022
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38(3):17
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Sun Y#, Zhang Y#, Zhang D#, Wang G,, Liu Z*
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In vivo CRISPR-Cas9-mediated DNA chop identifies a cochlear outer hair cell-specific enhancer
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FASEB Journal
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2022
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36(4):e22233
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Wang Y., Sanghvi M., Gribizis A., Zhang Y.,, Morley B., Barson D. G., Santos-Sacchi J., Navaratnam D., Crair M.*
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Efferent feedback controls bilateral auditory spontaneous activity
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Nature Communications
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2021
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12(1):2449
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Yu Z#, Guotong L#, Yi W#, Na X, Xin L, Tingting D*, Wei X*,
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Prestin derived OHC surface area reduction underlies age-related rescaling of frequency place coding
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Hearing Research
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2021
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108406
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Xue N#,, Song Q, Santos-Sacchi, J., Wu H*, Navaratnam, D.*
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Genes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochlea
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Hearing Research
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2021
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108347
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Wang H., Li B., Lu Y., Han K., Sheng H., Zhou J., Qi Y., Wang X., Huang Z.,, Hua Y*.
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Real-time threshold determination of auditory brainstem responses by cross-correlation analysis
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iScience
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2021
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24(11):103285
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Jingjing Zhao#, Gen Li#, Xuan Zhao, Xin Lin, Yunge Gao, Nuno Raimundo, Geng-Lin Li, Wei Shang*, Hao Wu*,
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Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss
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Aging
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2020
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12(7):5590-5611
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Xin Lin#, Gen Li#, Yu Zhang, Jingjing Zhao, Jiawen Lu, Yunge Gao, Huihui Liu, Geng-Lin Li, Tao Yang,, Hao Wu*
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Hearing consequences in Gjb2 knock-in mice: implications for human p.V37I mutation
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Aging
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2019
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11(18):7416-7441
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Lynda El-Hassar,, Winston J T Tan, Charles H Large, Giuseppe Alvaro, Joseph Santos-Sacchi, Leonard K Kaczmarek
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Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice.
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Journal of Neuroscience
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2019
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39(24):4797-4813
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Zhang H, Pan H, Zhou C, Wei Y, Ying W, Li S, Wang G, Li C, Ren Y, Li G, Ding X, Sun Y, Li GL,, Li Y, Yang H, Liu Z.
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Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing.
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Development
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2018
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145(20). pii: dev168906
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Li C, Shu Y, Wang G, Zhang H, Lu Y, Li X, Li G,, Liu Z.
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Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea.
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Hearing Research
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2018
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364:12-24.
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Tan WJT,, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV.
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Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear.
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Antioxidants & Redox Signaling
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2017
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27(8):489-509
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,Santos-Sacchi J
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An electrical inspection of the subsurface cisternae of the outer hair cell.
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Biophysical Journal
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2015
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108(3):568-77
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McKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J,, Shadel GS.
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Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness.
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American Journal of Pathology
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2015
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185(12):3132-40
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Joseph Santos-Sacchi and Lei Song
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Chloride and salicylate influence prestin-dependent specific membrane capacitance: support for the area motor model
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J Biol Chem
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2014
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289(15):10823-30
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Joseph Santos-Sacchi and Lei Song
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Chloride-driven electromechanical phase lags at acoustic frequencies are generated by SLC26a5, the outer hair cell motor protein
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Biophys J
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2014
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107(1):126-33
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,Santos-Sacchi J
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Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5.
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Proceedings of the National Academy of Sciences of the United
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2013
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110(10):3883-8
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Ricci AJ, Bai JP,, Lv C, Zenisek D, Santos-Sacchi J.
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Patch-clamp recordings from lateral line neuromast hair cells of the living zebrafish.
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Journal of Neuroscience
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2013
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33(7):3131-4
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Raimundo N,, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS
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Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness
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Cell
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2012
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148(4):716-26
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Tao Wu,, Xiaorui Shi, Zhigeng Jiang, Santos-Sacchi and Alfred Nuttall
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Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell
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Hearing Research
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2011
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272(1-2): 117-24
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,Santos-Sacchi J
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Conformational State-Dependent Anion Binding in Prestin: Evidence for Allosteric Modulation
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Biophysical Journal
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2010
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98(3): 371–376
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,McGee JA,Walsh EJ
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The Influence of Thyroid Hormone Deficiency on the Development of Cochlear Nonlinearities
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Journal of the Association for Research in Otolaryngology
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2008
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9(4): 464–476
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,McGee JA,Walsh EJ
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Development of cochlear amplification, frequency tuning, and two-tone suppression in the mouse.
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Journal of Neurophysiology
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2007
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99(1):344-55
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,McGee JA,Walsh EJ
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Frequency-and Level-Dependent Changes in Auditory Brainstem Responses in Developing Mice
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Journal of Acoustical Society of America
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2006
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119(4):2242-57
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,McGee JA,Walsh EJ
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Consequences of combined maternal, fetal and persistent postnatal hypothyroidism on the development of auditory function in Tshr(hyt) mutant mice
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Brain Research
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2006
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1101(1):59-72
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Santos-Sacchi J,, Zheng J, Nuttall AL
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Control of mammalian cochlear amplification by chloride anions.
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Journal of Neuroscience
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2006
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26(15):3992-8
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Carlo Spirlì, Romina Fiorotto,, Joseph Santos-Sacchi, Lajos Okolicsanyi, Sara Masier, Loretta Rocchi, Maria Pia Vairetti, Marina De Bernard, Saida Melero, Tullio Pozzan, Mario Strazzabosco
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Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a CFTR-independent mechanism.
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Gastroenterology
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2005
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129(1):220-33
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,Seeger A,Santos-Sacchi J
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On membrane motor activity and chloride flux in the outer hair cell of Corti’s organ: lessons learned from the environmental toxin tributyltin
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Biophysical Journal
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2005
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88(3):2350-62
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