基本信息

导师姓名：	王琛	学科代码：	100210
性别：	男	学科名称：	外科学
培养单位：	附属第九人民医院	三级学科	整形
导师类型：	硕士生导师	专业领域名称：
联系方式：	wangchen2369@163.com	专业领域代码：
邮编：	200011	邮箱地址：	wangchen2369@163.com

研究方向 (点击浏览详细信息)


干细胞与组织再生；瘢痕的基础和临床

社会任职


中华医学会医学美学与美容学分会干细胞学组委员
中华医学会整形外科分会干细胞转化应用学组委员
中国整形美容协会抗衰老分会青年委员
中整协瘢痕医学分会青年委员
上海市医学会医学美学与美容第七届委员会青年委员会副主任委员
中国医师协会美容与整形医师分会青年委员

科研项目

项目编号	项目名称	课题来源	起止年月	批准经费	承担职责
81971840	长链非编码RNA-ANHS抑制增生性瘢痕的作用机制研究	国家自然科学基金面上项目	2020-01~2023-12	55万元	课题负责人
YG2015QN09	应用脂肪干细胞与纳米电纺丝构建	上海交通大学“医工交叉研究基金”	2016-01~2018-12	12万元	课题负责人
ZZjdyx12100	miR-21调控Smad7基因表达在增生性瘢痕形成中的作用及机制	上海高校青年教师科研专项基金	2013-09~2016-08	4万元	课题负责人
~	miR-31/FIH轴调控HIF-1α通路促进增生性瘢痕发展的机制研究	上海交大医学院优秀青年教师人才计划	2013-09~2016-08	10万元	课题负责人
~	miR-21调控TGF-β通路在增生性疤痕形成中的作用及机制	第五届“九院优青培养计划”	2013-06~2016-05	6万元	课题负责人
810201204	力学刺激诱导miR-100诱导脂肪干细胞向平滑肌细胞分化的作用和机制	国家自然科学基金青年基金	2013-01~2015-12	23万元	课题负责人
11ZR1420300	应用脂肪干细胞构建双层结构的组织工程化血管修复小口径动脉缺损的实验研究	上海市自然科学基金	2011-04~2014-03	10万元	课题负责人

学术论文

作者	论文标题	期刊名	出版年	卷期页码
Yechi Qin, Guifei Li, Chen Wang （通讯作者）, Danqing Zhang, Lili Zhang, Haowei Fang, Shifeng Yan, Kunxi Zhang, and Jingbo Yin	Biomimetic Bilayer Scaffold as an Incubator to Induce Sequential Chondrogenesis and Osteogenesis of Adipose Derived Stem Cells for Construction of Osteochondral Tissue	ACS Biomater Sci Eng	2020	6,5,3070-3080
Yingying Zhang, Xueqin Li, Chen Wang （共同第一作者）, Mengying Zhang, Hui Yang, and Kun Lv	LncRNA AK085865 promotes macrophage M2 polarization in CVB3-induced viral myocarditis by regulating ILF2-ILF3 complex-mediated miRNA-192 biogenesis	Mol Ther Nucleic Acids	2020	21:441-451
Hong Y, Chen J, Fang H, Li G, Yan S, Zhang K, Wang C （通讯作者）, Yin J	All-in-One Hydrogel Realizing Adipose-Derived Stem Cell Spheroid Production and In Vivo Injection via "Gel-Sol" Transition for Angiogenesis in Hind Limb Ischemia	ACS Appl Mater Interfaces	2020	12(10):11375-11387
Zhou R, Wang C （共同第一作者）, Liang Y, Li X, Li Q	Anti-miR-200b promotes wound healing by regulating fibroblast functions in a novel mouse model	Acta Biochim Biophys Sin (Shanghai)	2019	51(10):1049-1055.
Chen J, Zhou R, Liang Y, Fu X, Wang D, Wang C （通讯作者）	Blockade of lncRNA-ASLNCS5088-enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation	FASEB J	2019	33(11):12200-12212
Wang X, Zhang Y, Jiang B, Zhang Q, Zhou R, Zhang L, Wang C （通讯作者）	Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism	Exp Cell Res	2017	361(2):201-209
Aji K, Zhang Y, Aimaiti A, Wang Y, Rexiati M, Azhati B, Tusong H, Cui L, Wang C. （通讯作者）	MicroRNA-145 regulates the differentiation of human adipose-derived stem cells to smooth muscle cells via targeting Krüppel-like factor 4	Mol Med Rep	2017	15(6):3787-3795
Li G, Zhou R, Zhang Q, Jiang B, Wu Q, Wang C （通讯作者）	Fibroproliferative effect of microRNA-21 in hypertrophic scar derived fibroblasts	Exp Cell Res	2016	345(1):93-9
Zhou R, Zhu L, Fu S, Qian Y, Wang D, Wang C （通讯作者）	Small diameter blood vessels bioengineered from human adipose-derived stem cells	Scientific Reports	2016	6:35422
Wen C, Yan H, Fu S, Qian Y, Wang D, Wang C （通讯作者）	Allogeneic Adipose-derived Stem Cells Regenerate Bone in a Critical-sized Ulna Segmental Defect	Exp Biol Med	2016	241(13):1401-9
Wang X, Chu J, Wen C, Fu S, Qian Y, Wo Y, Wang C （通讯作者）, Wang D	Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-β/Smad signaling in hypertrophic scar fibroblasts	Exp Cell Res	2015	332(2):202-11
Lv Y, Cao D, Guo F, Qian Y, Wang C （通讯作者）, Wang D	Abdominal wall reconstruction using a combination of free tensor fasciae lata and anterolateral thigh myocutaneous flap: a prospective study in 16 patients	Am J Surg	2015	210(2):365-73
Zhou R, Zhang Q, Zhang Y, Fu S, Wang C （通讯作者）	Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars	Exp Cell Res	2015	339(2):360-6
Gong L, Wang C （共同第一作者）, Sun Q, Li G, Wang D.	Effects of human adipose derived stem cells on the viability of rabbit random pattern flaps	Cytotherapy	2014	16(4):496-507
Gu H, Xiong Z, Yin X, Li B, Mei N, Li G, Wang C （通讯作者）	Bone regeneration in a rabbit ulna defect model: use of allogeneic adipose-derived stem cells with low immunogenicity	Cell Tissue Res	2014	358(2):453-64
Wang C, Cai Y, Zhang Y, Xiong Z, Li G, Cui L	Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression	PLoS One	2014	9(6):e100818
Wang C, Xiong Z, Xu J, Zhang L, Huang H, Li G	The distally based lateral sural neuro-lesser saphenous veno-fasciocutaneous flap: anatomical basis and clinical applications	J Orthop Traumatol	2014	15(3):215-23
Wang C, Guo F, Zhou H, Zhang Y, Xiao Z, Cui L	Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells	Tissue Eng Part A	2013	19(3-4):415-425
Gu H, Xiong Z, Xu J, Li G, Wang C （通讯作者）	Clinical and anatomical study of the distally based lesser saphenous veno-lateral sural neurocutaneous flap for lower extremity coverage	J Orthop Sci	2013	18(5):740-748
Wang C, Yin S, Cen L, Liu Q, Liu W, Cao Y, Cui L	Differentiation of adipose derived stem cells into contractile smooth muscle cells induced by TGF-β1 and BMP4	Tissue Eng Part A	2010	16(4):1201-1213
Wang C, Cen L, Yin S, Liu Q, Liu W, Cao Y, Cui L	A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells	Biomaterials	2010	31(4):621-630.