• 基本信息
    导师姓名: 吴学锋 学科代码: 100100
    性别: 学科名称: 基础医学
    培养单位: 基础医学院 三级学科
    导师类型: 博士生导师 专业领域名称:
    联系方式: 上海市黄浦区重庆南路280号西7楼207. 电话:021-54660871, 021-63846590-776684;实验室电话:021-63846590-776748. 专业领域代码:
    邮编: 200025 邮箱地址: xuefengwu@shsmu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    2016国家高层次人才计划国家高层次人才计划 2017-09~2020-09 200万元  课题负责人
    N/A新进青年教师启动计划上海交通大学 2017-01~2019-12 20万元  课题负责人
    31670910泛素缀合酶Ubc13在树突状细胞中的免疫调控功能及机制研究国自然面上项目 2017-01~2020-12 70万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Todoric J, Antonucci L, Di Caro G, Li N,, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M.   Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.   Cancer Cell  2017  32(6):824-839.e8. 
    Kaneda MM, Messer KS, Ralainirina N, Li H, Leem C, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA,, Karin M, Sasik R, Cohen EE, Varner JA.   PI3Kγ is a molecular switch that controls immune suppression  Nature  2016  539(7629):437-442. 
    , M Karin.  Emerging roles of Lys63-linked polyubiquitylation in immune responses.  Immunol Rev.  2015  266(1):161-74. 
    , W Zhang, J Font-Burgada, T Palmer, AS Hamil, SK Biswas, M Poidinger, N Borcherding, Q Xie, LG Ellies, N Lytle, LW Wu, J Yang, SF Dowdy, T Reya, M Karin.  Ubiquitin-conjugating Enzyme Ubc13 Controls Breast Cancer Metastasis through a TAK1-p38 MAP Kinase Cascade.  PNAS  2014  111(38): 13870-5. 
    Li N,, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M.  Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice .  J Clin Invest.  2013  123(5):2231-43. 
    Zhang W, Tan W,, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M.  A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1 .  Cancer Cell  2013  23(5):647-59. 
    Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X,, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC.  Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion effector-like T cells .  Nat Immunol.  2012  13: 481-490. 
    Hu H*,, Jin W, Chang M, Cheng X and Sun S-C.  Noncanonical NF-κB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development .  PNAS  2011  108(31):12827-32. 
    , Zhang M* and Sun S-C.  Mutual regulation between deubiquitinase CYLD and Retroviral Oncoprotein Tax .  Cell & Bioscience  2011  1(1):27. 
    Xu G, Y-C Lo, Q Li, G Napolitano,, X Jiang, Karin M and Wu H.  Crystal structure of the inhibitor of κB kinase β (IKKβ).  Nature  2011  472 (7343):325-30. 
    Lee A*,, H Cheng, X Zhou, X Cheng, and S-C Sun.  CARMA1 regulation of Treg development involves modulation of IL-2 receptor signaling .  J. Biol Chem.   2010  285(21): 15696-703. 
    , M Yamamoto, S Akira, and S-C Sun.  Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13 .  PNAS  2009  106 (49): 20836-41. 
    Zhang M*,, AJ Lee, W Jin, M Chang, A Wright, T Imaizumi, and S-C Sun.   Regulation of IKK-related kinases and antiviral responses by tumor suppressor CYLD .  J Biol Chem.  2008  283(27): 8621-6. 
    , S-C Sun.  Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating Tak1-IKK physical association .  EMBO Rep.  2007  8(5): 510-5.