- 基本信息
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导师姓名：
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陈小华
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学科代码：
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100201
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性别：
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男
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学科名称：
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内科学
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培养单位：
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附属第六人民医院
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三级学科
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传染病
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导师类型：
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博士生导师
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专业领域名称：
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内科学 专业学位
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联系方式：
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专业领域代码：
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105101
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邮编：
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邮箱地址：
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chenxiaohua2000@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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担任《中华传染病杂志》编委
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上海市中西医结合器官纤维化委员会委员
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上海市医学会感染病分学委员
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上海市中西医结合传染病委员会 副主任委员
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中国医促会临床微生物与感染分会委员
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中国研究型医院学会感染病学委员会委员
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- 科研项目
| 82270630 | YTHDF2靶向识别m6A甲基化修饰ATG5调控CD8+T细胞在HDV感染免疫清除中的作用及机制研究 | 国家自然科学基金 |
2023-01~2026-12
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52万元
| 课题负责人 |
| SHDC2022CRD039 | 新型高通量基因芯片技术在骨关节感染病原学快速精准筛查中的临床应用研究 | 申康中心临床技能与临床创新研究型医师项目 |
2022-01~2024-09
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40万元
| 课题负责人 |
| 21140901100 | 基于诱导性多能干细胞的肝脏类器官HDV感染模型建立及其应用研究 | 上海市科委 |
2021-06~2024-06
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25万元
| 课题负责人 |
| 82070615 | 基于iPSC构建肝脏类器官探讨Tapasin调节CD8+T细胞自噬在HBV感染转归中的作用及机制研究 | 国家自然科学基金 |
2021-01~2024-12
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55万元
| 课题负责人 |
| 2020083 | 上海市人才发展资金 | 上海市人社局 |
2021-01~2023-12
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30万元
| 课题负责人 |
| SHDC2020CR6025 | 艾滋病专病数据库的建立和应用 | 申康中心 |
2020-12~2022-09
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20万元
| 子课题负责人 |
| GWV-3.1 | 上海市卫计委 | 上海市感染（传染）病临床诊治中心及其网络体系建设. |
2020-07~2022-06
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274万元
| 子课题负责人 |
| 81770589 | 树突状细胞来源的exosome胞内转运泛素化修饰的丁肝病毒抗原诱导T细胞分化在抑制HDV复制中的作用及免疫机制研究 | 国家自然科学基金 |
2018-01~2021-12
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51万元
| 课题负责人 |
| 17ZR1421500 | 富含分子伴侣Tapasin的骨髓树突状细胞来源外泌体诱导T细胞分化在乙肝病毒免疫清除中的作用及机制研究 | 上海市科委 |
2017-05~2020-04
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20万元
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| 201640283 | 基于高通量等离子体纳米金基质的抗体检测平台对HDV感染患者的筛选及临床应用研究 | 上海市卫计委
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2017-01~2019-12
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5万元
| 课题负责人 |
| 31000414 | 分子伴侣 Tapasin 修饰经胞内转运的CTL 表位肽诱导特异性CTL 的机制研究 | 国家自然科学基金
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2011-01~2013-12
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19万元
| 课题负责人 |
- 学术论文
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Mengjiao Lv, Ting Yao, Yi Zhang, Siyuan Ma, Jinmei Chen, Zhenghao Tang, Guoqing Zang,
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Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication.
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Journal of Medical Virology.
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2023
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95(4): e28746.
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Siyuan Ma, Mengjiao Lv,, Guoqing Zang, Zhenghao Tang, Yi Zhang, Weiwei Hu.
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Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism.
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Antiviral Res
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2023
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216:105662
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Jingwen Ai, Yi Zhang, Haocheng Zhang, Qiran Zhang, Zhangfan Fu, Ke Lin, Jieyu Song, Yuanhan Zhao, Mingxiang Fan, Hongyu Wang, Yang Zhou,, Chao Qiu, Wenhong Zhang.
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Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study.
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Emerg Microbes Infect.
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2022
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11(1):639-647.
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, Hongyu Wang, Jingwen Ai, Leer Shen, Lin Ke, Guanmin Yuan, Xiaohua Sheng, Xia Jin, Zhifeng Deng, Jie Xu, Guanzhu Lu, Shujie Chen, Jianpeng Cai, Yi Zhang, Haocheng Zhang, Sen Wang, Wenhong Zhang, Cunyi Fan.
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Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-center cohort study.
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Emerg Microbes Infect.
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2022
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11(1):2501-2509.
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Ting Yao, Weiwei Hu, Jinmei Chen, Leer Shen, Yongsheng Yu, Zhenghao Tang, Guoqing Zang, Yi Zhang,
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Collagen XV mediated the epithelial-mesenchymal transition to inhibit hepatocellular carcinoma metastasis.
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Journal of Gastrointestinal Oncology.
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2022
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13(5):2472-2484.
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Ting Yao, JinMei Chen, LeEr Shen, YongSheng Yu, ZhengHao Tang, GuoQing Zang, Yi Zhang,
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Astragalus polysaccharide alleviated hepatocyte senescence via autophagy pathway.
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Kaohsiung J Med Sci.
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2022
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38(5):457-468.
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Yi Zhang, Jinmei Chen, Xiaoli Yi, Zhiheng Chen, Ting Yao, Zhenghao Tang, Guoqing Zang, Xuejie Cao, Xiao-Feng Lian,
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Evaluation of the metagenomic next-generation sequencing performance in pathogenic detection in patients with spinal infection.
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Frontiers in Cellular and Infection Microbiology.
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2022
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12: 967584-
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Ting Yao, Mengjiao Lv, Siyuan Ma, Jinmei Chen, Yi Zhang, Yongsheng Yu, Guoqing Zang,
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Ubiquitinated Hepatitis D Antigen-Loaded Microvesicles Induce a Potent Specific Cellular Immune Response to Inhibit HDV Replication in Vivo.
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Microbiology Spectrum.
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2021
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9(3):e0102421.
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Ting Yao, Yi Zhang, Mengjiao Lv, Guoqing Zang, Soon Seng Ng,
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Advances in three-dimensional cell culture for liver preclinical studies.
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Acta Biochim Biophys Sin.
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2021
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53(6), 643–651.
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Ting Yao, Jin-Mei Chen, Le-Er Shen, Yong-Sheng Yu, Zheng-Hao Tang, Guo-Qing Zang, Yi Zhang,
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Astragalus polysaccharide alleviated hepatocyte senescence via autophagy pathway.
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Kaohsiung J Med Sci.
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2021
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2021 Dec 28
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Wu S, Zhang Y, Tang Y, Yao T, Lv M, Tang Z, Zang G, Yu Y,
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Molecular epidemiology and clinical characteristics of hepatitis delta virus (HDV) infected patients with elevated transaminases in Shanghai, China.
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BMC Infect Dis.
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2020
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20(1):565.
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Yi Zhang , Jie Chen , Shan-Shan Wu , Meng-Jiao Lv , Yong-Sheng Yu , Zheng-Hao Tang,, Guo-Qing Zang
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HOXA10 knockdown inhibits proliferation, induces cell cycle arrest and apoptosis in hepatocellular carcinoma cells through HDAC1.
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Cancer Manag Res
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2019
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11:7065-7076.
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Hu X, Tang Z, Ma S, Yu Y,, Zang G
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Tripartite motif-containing protein 7 regulates hepatocellular carcinoma cell proliferation via the DUSP6/p38 pathway.
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Biochem Biophys Res Commun.
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2019
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511(4):889-895.
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Mahale P, Aka P,, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR.
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Hepatitis D virus infection, cirrhosis and hepatocellular carcinoma in The Gambia.
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J Viral Hepat
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2019
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26(6):738-749.
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Ma S,, Tan Q, Dai S, Li D, Wu S, Yu Y, Zang G, Tang Z.
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An Engineered DC-Targeting Lentivector Induces Robust T Cell Responses and Inhibits HBV Replication in HBV Transgenic Mice via Upregulating T Cell Autophagy.
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Cell Physiol Biochem.
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2018
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48(3):1041-1059
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Zhang Y, Tao R, Wu SS, Xu CC, Wang JL, Chen J, Yu YS, Tang ZH,, Zang GQ
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TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A.
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J Exp Clin Cancer Res.
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2018
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37(1):116
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Wu S,, Tang Y, Zhang Y, Li D, Chen J, Wang J, Tang Z, Zang G, Yu Y.
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Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo.
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Acta Biochim Biophys Sin.
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2018
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50(2):181-190.
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Mahale P, Aka PV,, Liu P, Fram BJ, Wang AS, Simenel S, Tseng FC, Chen S, Edlin BR, Glenn JS, O'Brien TR.
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Hepatitis D Viremia Among Injection Drug Users in San Francisco.
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J Infect Dis.
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2018
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217(12):1902-1906.
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Ma S,, Tan Q, Li D, Dai S, Wu S, Yu Y, Zang G, Tang Z.
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An engineered novel lentivector specifically transducing dendritic cells and eliciting robust HBV-specific CTL response by upregulating autophagy in T cells.
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Cell Cycle.
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2018
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2018.1471312
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Tan Q, Ma S, Hu J,, Yu Y, Tang Z, Zang G.
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Adenovirus Vector Harboring the HBcAg and Tripeptidyl Peptidase II Genes Induces Potent Cellular Immune Responses In Vivo.
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Cell Physiol Biochem.
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2017
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41(2):423-438.
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Zhang Y, Wu SS,, Tang ZH, Yu YS, Zang GQ.
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Tripartite Motif Containing 52 (TRIM52) Promotes Cell Proliferation in Hepatitis B Virus-Associated Hepatocellular Carcinoma.
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Med Sci Monit.
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2017
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23:5202-5210.
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,Odgerel Oidovsambuu,Ping Liu,Rosslyn Grosely1,Menashe Elazar,Virginia D.Winn,Benjamin Fram,Zhang Boa,Hongjie Dai,
Bekhbold Dashtseren,Dahgwahdorj Yagaanbuyant,Zulkhuu Genden
Naranbaatar Dashdorj,Andreas Bungert,Naranjargal Dashdorj,Jeffrey S.Glenn
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A novel quantitative microarray antibody capture (Q-MAC) assay identifies an extremely high HDV prevalence amongst HBV infected Mongolians.
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Hepatology
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2017
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66(6):1739-1749.
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Tan Q, Ma S, Hu J,, Yu Y, Zang G, Tang Z.
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Role of tripeptidyl peptidase II in MHC class I antigen presentation: Biological characteristics, cellular crosstalk and signaling.
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Biomed Pharmacother.
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2016
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84:1954-1958.
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YUYAN TANG,JIELING WANG,YI ZHANG, MENG ZHUO, LINLIN SONG,ZHENGHAO TANG,GUOQING ZANG,,YONGSHENG YU
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Correlation between low Tapasin expression and impaired CD8+ T-cell function in patients with chronic hepatitis B
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Mol Med Rep
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2016
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14(4):3315-3322.
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, Yun-Chao GAO, Yi ZHANG, Zheng-Hao TANG, Yong-Sheng YU, Guo-Qing ZANG
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TUBERCULOSIS INFECTION MIGHT INCREASE THE RISK OF INVASIVE CANDIDIASIS IN AN IMMUNOCOMPETENT PATIENT
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Rev. Inst. Med. Trop. Sao Paulo
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2015
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57(3):273-275
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Tang YY, Tang ZH, Zhang Y, Zhuo M, Zang GQ,, Yu YS.
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The Fusion Protein of CTP-HBcAg18-27-Tapasin Mediates the Apoptosis of CD8+T Cells and CD8+ T Cell Response in HLA-A2 Transgenic Mice
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Hepat Mon
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2014
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14(2):e16161.
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, Tang Y, Zhang Y, Zhuo M, Tang Z, Yu Y, Zang G.
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Tapasin modification on the intracellular epitope HBcAg18-27 enhances HBV-specific CTL immune response and inhibits hepatitis B virus replication in vivo.
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Lab Invest.
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2014
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94(5):478-490
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, Lu H, Gao Y.
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FDG PET/CT showing erythema nodosum associated with tuberculous lymphadenitis.
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Clin Nucl Med.
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2013
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38(12):992-993.
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唐余燕, 余永胜, 卓 萌, 臧国庆, 汤正好,
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胞质转导肽-HBcAg18-27-Tapasin体外诱导HBV转基因小 鼠髓源性树突状细胞成熟及在T淋巴细胞增殖中的作用
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世界华人消化杂志
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2013
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21(2): 122-129
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, Liu H, Tang Z, Yu Y, Zang G.
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The modification of Tapasin enhances cytotoxic T lymphocyte activity of intracellularly delivered CTL epitopes via cytoplasmic transduction peptide.
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Acta Biochim Biophys Sin
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2013
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45(3):203-12.
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, Lai J, Pan Q, Tang Z, Yu Y, Zang G.
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The delivery of HBcAg via Tat-PTD enhances specific immune response and inhibits Hepatitis B virus replication in transgenic mice.
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Vaccine
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2010
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28(23):3913-3919
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, Yu Y, Pan Q, Tang Z, Han J, Zang G.
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Enhancement of cytotoxic T lymphocyte activity by dendritic cells loaded with Tat-protein transduction domain-fused hepatitis B virus core antigen.
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Acta Biochim Biophys Sin
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2008
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112(45):14302-14311
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