- 基本信息
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导师姓名：
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赵旭赟
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学科代码：
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100100
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性别：
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男
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学科名称：
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基础医学
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培养单位：
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基础医学院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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上海市重庆南路280号7号楼115
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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zhaobig_8888@hotmail.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 22ZR1479800 | 半胱氨酸过硫化代谢促进棕色脂肪形成和产热 的作用和机制 | 上海市原创探索项目 |
2022-04~2025-03
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50万元
| 课题负责人 |
| 21ZR1436500 | Zrsr1调控U12内含子剪切在非酒精性脂肪性肝病发 展过程中的作用 | 上海市面上项目 |
2021-07~2024-06
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20万元
| 课题负责人 |
| 82070894 | Zbtb7b调控脂肪细胞和免疫细胞通讯维持肥胖和糖尿病进展过程中胰岛素敏感性和代谢稳态的作用 | 基金委面上项目 |
2021-01~2024-12
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57万元
| 课题负责人 |
- 学术论文
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, Li S, Ji Y, Peng X, Qi L, Lin JD
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The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance
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Sci Adv
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2020
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6(20):eaay6191
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Liu T, Mi L, Xiong J, Orchard P, Yu Q, Yu L,, Meng ZX, Parker SCJ, Lin JD, Li S.
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BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
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Nat Commun
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2020
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11(1):2379
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, Li S, DelProposto JL, Liu T, Mi L, Porsche C, Peng X, Lumeng CN, Lin JD
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The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic health
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Mol Metab
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2018
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14:60-70
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, Xiong X, Liu T, Mi L, Peng X, Rui C, Guo L, Li S, Lin JD.
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Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis.
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Nat Commun
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2018
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9(1):2986
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Chen Z, Wang GX, Ma SL, Jung DY, Ha H, Altamimi T,, Guo L, Zhang P, Hu CR, Cheng JX, Lopaschuk GD, Kim JK, Lin JD.
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Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders
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Mol Metab
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2017
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6(8):863-872
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Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX,, Wu J, Lin JD.
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Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis
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Proc Natl Acad Sci USA
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2017
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114(34):E7111-E7120
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Mi L,, Li S, Yang G, Lin JD.
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Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation.
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Mol Metab
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2016
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6(1):101-110
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Wang GX,, Lin JD
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The brown fat secretome: metabolic functions beyond thermogenesis.
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Trends Endocrinol Metab
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2015
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26(5):231-237
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Shen SM, Guo M, Xiong Z, Yu Y,, Zhang FF, Chen GQ.
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AIF inhibits tumor metastasis by protecting PTEN from oxidation.
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EMBO Rep
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2015
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16(11):1563-80
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, Lin JD
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Long Noncoding RNAs: A New Regulatory Code in Metabolic Control
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Trends Biochem Sci
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2015
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40:586-596
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Wang GX,, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD
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The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuating hepatic lipogenesis.
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Nat Med
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2014
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20(12):1436-43
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, Li S, Wang GX, Yu Q, Lin JD
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A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation
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Mol Cell
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2014
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55(3):372-82
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Liu W, Shen SM,, Chen GQ
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Targeted genes and interacting proteins of hypoxia inducible factor-1
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Int J Biochem Mol Biol
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2012
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3(2):165-78
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Huang Y, Hou JK, Chen TT,, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ
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PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.
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Autophagy
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2011
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7(10):1132-44
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, Zhao KW, Jiang Y, Zhao M, Chen GQ
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Synergistic induction of galectin-1 by CCAAT/enhancer binding protein-? and hypoxia inducible factor-1? and its role in differentiation of acute myeloid leukemic cells.
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J Biol Chem
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2011
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286(42):36808-19
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, Chen TT, Xia L, Guo M, Xu Y, Yue F, Jiang Y, Chen GQ, Zhao KW.
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Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells
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Carcinogenesis
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2010
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31(8): 1367-75
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Zhao M, Duan XF,, Zhang B, Lu Y, Liu W, Cheng JK, Chen GQ
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Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells
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PloS One
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2009
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4(8):e6552
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Liao SH,, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M, Chen GQ
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Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells
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Proteomics
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2009
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9(15):3901-12
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