- 基本信息
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导师姓名：
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李圣贤
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学科代码：
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100201
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性别：
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男
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学科名称：
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内科学
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培养单位：
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附属仁济医院
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三级学科
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内分泌与代谢病
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导师类型：
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硕士生导师
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专业领域名称：
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联系方式：
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rj_shengxianli@163.com
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专业领域代码：
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邮编：
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200127
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邮箱地址：
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rj_shengxianli@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 81671518 | PCOS卵泡液脂质谱改变对卵巢功能和辅助生殖结局的影响及机制的研究 | 国家自然科学基金面上项目 |
2017-01~2020-12
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57万元
| 子课题负责人 |
| 81471029 | 硫酸脱氢表雄酮在胰岛β细胞中的作用及其机制 的研究 | 国家自然科学基金面上项目 |
2015-01~2018-12
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73万元
| 课题负责人 |
- 学术论文
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Huang R, Xue X,, Wang Y, Sun Y, Liu W, Yin H, Tao T.
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Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats.
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J Cell Mol Med.
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2018
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22(7):3388-3396.
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Ma J, Yue J, Huang R, Liao Y,, Liu W.
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Reversion of aging-related DHEAS decline in mouse plasma alleviates aging-related glucose tolerance impairment by potentiation of glucose-stimulated insulin secretion of acute phase.
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Biochem Biophys Res Commun.
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2018
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500(3):671-675.
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Deng Y, Zhang Y,, Zhou W, Ye L, Wang L, Tao T, Gu J, Yang Z, Zhao D, Gu W, Hong J, Ning G, Liu W, Wang W.
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Steroid hormone profiling in obese and nonobese women with polycystic ovary syndrome.
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Sci Rep.
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2017
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7(1):14156.
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, Chu Q, Ma J, Sun Y, Tao T, Huang R, Liao Y, Yue J, Zheng J, Wang L, Xue X, Zhu M, Kang X, Yin H, Liu W.
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Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production?
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J Clin Endocrinol Metab.
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2017
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102(3):810-821.
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Feng R, Qian C, Liu Q, Jin Y, Liu L,, Liao Y, Zhou H, Liu W, Rayner CK, Ma J.
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Expression of sweet taste receptor and gut hormone secretion in modelled type 2 diabetes.
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Gen Comp Endocrinol.
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2017
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252:142-149.
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Liao Y, Huang R, Sun Y, Yue J, Zheng J, Wang L, Tao T, Ma J,, Liu W.
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An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients.
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Reprod Biol Endocrinol.
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2017
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15(1):9.
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, Liao Y, Wang L, Huang R, Yue J, Xu H, Zhou H, Lou Z, Hu Y, Liu W.
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Dysregulation of Hypothalamo-Pituitary-Adrenocortical Axis in Overweight Female Diabetic Subjects is Associated with Downregulation of Corticosteroid Receptors and 11β-HSD1 in the Brain.
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Horm Metab Res.
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2016
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48(3):178-184.
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Fan H, Dong W, Li Q, Zou X, Zhang Y, Wang J,, Liu W, Dong Y, Sun H, Hou Z.
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Ajuba Preferentially Binds LXRα/RXRγ Heterodimer to Enhance LXR Target Gene Expression in Liver Cells.
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Mol Endocrinol.
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2015
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29(11):1608-1618.
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Huang R, Zheng J,, Tao T, Ma J, Liu W.
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Characteristics and contributions of hyperandrogenism to insulin resistance and other metabolic profiles in polycystic ovary syndrome.
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Acta Obstet Gynecol Scand.
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2015
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94(5):494-500.
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Huang R, Yue J, Sun Y, Zheng J, Tao T,, Liu W.
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Increased serum chemerin concentrations in patients with polycystic ovary syndrome: Relationship between insulin resistance and ovarian volume.
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Clin Chim Acta.
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2015
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450:366-369
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Cao HM, Ye XP, Ma JH, Jiang H,, Li RY, Li XS, Guo CC, Wang ZQ, Zhan M, Zuo CL, Pan CM, Zhao SX, Zheng CX, Song HD.
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Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling.
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EBioMedicine.
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2015
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2(11):1718-1724.
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Lin T,, Xu H, Zhou H, Feng R, Liu W, Sun Y, Ma J.
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Gastrointestinal hormone secretion in women with polycystic ovary syndrome: an observational study.
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Hum Reprod.
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2015
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30(11):2639-44.
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Dong Y, Gao G, Fan H,, Li X, Liu W.
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Activation of the Liver X Receptor by Agonist TO901317 Improves Hepatic Insulin Resistance via Suppressing Reactive Oxygen Species and JNK Pathway.
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PLoS One.
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2015
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24;10(4):e0124778.
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Huang R, Zheng J,, Tao T, Liu W.
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Subclinical hypothyroidism in patients with polycystic ovary syndrome: distribution and its association with lipid profiles.
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Eur J Obstet Gynecol Reprod Biol.
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2014
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177:52-56.
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, Tao T, Wang L, Mao X, Zheng J, Zhao A, Liu W.
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The expression of 11β-HSDs, GR, and H6PDH in subcutaneous adipose tissue from polycystic ovary syndrome subjects.
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Horm Metab Res.
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2013
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45(11):802-807.
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Yue J, Wang L, Huang R,, Ma J, Teng X, Liu W.
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Dehydroepiandrosterone-sulfate (DHEAS) promotes MIN6 cells insulin secretion via inhibition of AMP-activated protein kinase.
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Biochem Biophys Res Commun.
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2013
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440(4):756-761.
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Tao T,, Zhao A, Zhang Y, Liu W
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Expression of the CD11c gene in subcutaneous adipose tissue is associated with cytokine level and insulin resistance in women with polycystic ovary syndrome.
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Eur J Endocrinol.
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2012
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167(5):705-713.
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Wang L,, Zhao A, Tao T, Mao X, Zhang P, Liu W.
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The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients.
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J Steroid Biochem Mol Biol.
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2012
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132(1-2):120-126.
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Tao T,, Zhao A, Mao X, Liu W.
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Early impaired β-cell function in chinese women with polycystic ovary syndrome.
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Int J Clin Exp Pathol.
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2012
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5(8):777-86.
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, Liu W, Wang LH, et al.
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Effects of menopause on hepatic 11beta-HSD1 activity and adrenal sensitivity to adrenocorticotropin in healthy non-obese women.
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Gynecological Endocrinology
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2011
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27(10):794-799.
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Hu Y, Liu W, Chen Y, Zhang M, Wang L, Zhou H, Wu P, Teng X, Dong Y, Zhou Jw, Xu H, Zheng J,, Tao T, Hu Y, Jia Y.
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Combined use of fasting plasma glucose and glycated hemoglobin A1c in the screening of diabetes and impaired glucose tolerance.
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Acta Diabetol.
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2010
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47(3):231-236.
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Li RY, Li XS, Shao L, Wu ZY, Du WH,, Zhao SX, Chen KM, Chen MD, Song HD.
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Influence of visceral adiposity on ghrelin secretion and expression in rats during fasting.
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J Mol Endocrinol.
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2009
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42(1):67-74.
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Zheng CX, Zhao SX, Wang P, Yu HM, Wang CF, Han B, Su B, Xiang Y, Li XS,, Ma QY, Zhang RX, Wan HY, Song HD.
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Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC.
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Oncol Rep.
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2009
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22(5):1057-1061.
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Yuan G, Chen X, Ma Q, Qiao J, Li R, Li X,, Tang J, Zhou L, Song H, Chen M.
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C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes.
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J Endocrinol.
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2007
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194(2):275-81.
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