• 基本信息
    导师姓名： 朱军 学科代码： 100201
    性别： 男 学科名称： 内科学
    培养单位： 附属瑞金医院 三级学科 血液病
    导师类型： 博士生导师 专业领域名称：
    联系方式： zhuj1966@yahoo.com 专业领域代码：
    邮编： 邮箱地址： zhuj1966@yahoo.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    青年千人计划 评委
    国家科技部专家库　成员
    法国巴黎第七大学博士生导师
    上海市科委专家库　成员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81970098程序性细胞死亡基因11（PDCD11）在斑马鱼胚胎组织特异性巨噬细胞发育中生物学作用的研究国家自然科学基金面上项目 2020-01~2023-12 55万元  课题负责人
    81770311先天性心脏病相关基因线粒体内膜稳定蛋白41（TAMM41）在模式生物斑马鱼胚胎心脏发育过程中生物学作用的研究国家自然科学基金面上项目 2018-01~2021-12 55万元  课题负责人
    31471375SUMO介导的泛素连接酶RNF4在斑马鱼胚胎造血发育中的生物学意义研究国家自然科学基金面上项目 2015-01~2018-12 80万元  课题负责人
    2012CB910300泛素－蛋白酶体：系统性发现其底物、发掘新作用机制及其生物学意义国家重大科学研究计划子课题 2012-01~2016-12 180万元  子课题负责人
    81070434PML/RARa融合蛋白DNA结合功能域与其细胞转化能力的相关性研究国家自然科学基金委员会 2011-01~2013-12 34万元  课题负责人
    07XD14022在模式生物体斑马鱼中蛋白质翻译后修饰(泛素及类泛素)的生物学意义研究上海市科委,学科带头人 2007-11~2009-11 35万元  课题负责人
    2006aa02z150蛋白质类泛素(sumo)化修饰机制及其在模式生物体中生物学意义的研究国家科技部,863项目 2007-01~2009-12 80万元  课题负责人
    30525006生物化学和分子生物学国家自然基金委,杰出青年 2006-01~2009-12 160万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Wang L, Gao S, Wang H, Xue C, Liu X, Yuan H, Wang Z, Chen S, Chen Z, de Thé H, Zhang Y, Zhang W,, Zhou J*  Interferon regulatory factor 2 binding protein 2b regulates neutrophil versus macrophage fate during zebrafish definitive myelopoiesis.   Haematologica   2020  105(2):325-337.  
    Yang R, Zhan M, Guo M, Yuan H, Wang Y, Zhang Y, Zhang W, Chen S, de The H, Chen Z, Zhou J,  Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway.   Cell Death Differ   2020  doi: 10.1038/s41418-020-0591-3 
    Wang Y, Liu X, Xie B, Yuan H, Zhang Y,  The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation.  Redox Biol   2020  28:101313. 
    Yang RM, Tao J, Zhan M, Yuan H, Wang HH, Chen SJ, Chen Z, de Thé H, Zhou J, Guo Y*,  TAMM41 is required for heart valve differentiation via regulation of PINK-PARK2 dependent mitophagy.  Cell Death Differ  2019  26(11):2430-2446 
    Yuan H*, Gao S, Chen H, Liu X, Zhou J, de The H,  Primitive macrophages are dispensable for HSPC mobilization and definitive hematopoiesis.  Blood   2019  134(9):782-784. 
    Xue C, Wang HH,, Zhou J*  The expression patterns of vestigial like family member 4 genes in zebrafish embryogenesis.  Gene Expr Patterns  2018  28:34-41 
    Wang L , Liu X, Wang H, Yuan H, Chen S, Chen Z, de The H, Zhou J*,  RNF4 regulates zebrafish granulopoiesis through the DNMT1-C／EBPα axis.  FASEB J  2018  32(9):4930-4940 
    Wen B , Yuan H, Liu X, Wang H, Chen S, Chen Z, de The H, Zhou J*,  GATA5 SUMOylation is indispensable for zebrafish cardiac development.   Biochimica et Biophysica Acta general subjects  2017  1861(7):1691-1701 
    Yang RM, Zhan M, Xu SW, Long MM, Yang LH, Chen W, Huang S, Liu Q, Zhou J,, Wang J*.  miR-3656 expression enhances the chemosensitivity of pancreatic cancer to gemcitabine through modulation of the RHOF/EMT axis  Cell Death Dis  2017  19;8(10):e3129 
    Yuan H, Zhang T, Liu X, Deng M, Zhang W, Wen Z, Chen S, Chen Z, de The H, Zhou J,  Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish.  Sci Rep  2015  5:9011 
    Yuan H, Wen B, Liu X, Gao C, Yang R, Wang L, Chen S, Chen Z, de The H, Zhou J,  CCAAT/enhancer-binding protein α is required for hepatic outgrowth via the p53 pathway in zebrafish.  Sci Rep  2015  5:15838 
    Liu X, Jia X, Yuan H, Ma K, Chen Y, Jin Y, Deng M, Pan W, Chen S, Chen Z, de The H, Zon LI, Zhou Y, Zhou J,  DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish.  J Hematol Oncol  2015  8(1):15 
    Liu X, Yuan H, Peres L, Chen S, Chen Z, de The H, Zhou J,  e DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.  PLoS One  2014  9(8):1-6 
    Chang-Bin Jing, Yi Chen, Mei Dong, Xiao-Lan Peng, Xiao-E Jia, Lei Gao, Ke Ma, Min Deng, Ting-Xi Liu, Leonard I. Zon,,Yi Zhou,Yong Zhou   Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish   Developmental Biology  2013  374(1):24- 
    Lallemand-Breitenbach V,, Chen Z and de The H.  Curing APL through PML/RARA degradation by As2O3  Trends in Molecular Medicine  2012  18:1-4 
    Yuan H, Zhou J, Deng M, Zhang Y, Chen Y, Jin Y, Zhu J, Chen SJ, de The H, Chen Z, Liu TX,  Sumoylation of CCAAT/enhancer-binding protein α promotes the biased primitive hematopoiesis of zebrafish.  Blood  2011  117(26):7014-20 
    Yuan H, Zhou J, Deng M, Liu X, Le Bras M, de Thé H, Chen SJ, Chen Z, Liu TX,  Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish  Cell Res  2010  20(2):185-96. 
    Nasr R, Lallemand-Breitenbach V,, Guillemin MC and de Thé H.   Therapy-induced PML/RARA Proteolysis and Acute Promyelocytic Leukemia Cure  Clin Cancer Res  2009  15(20):6321-6325 
    Lallemand-Breitenbach V, Jeanne M, Benhenda S, Nasr R, Lei M, Peres L, Zhou J,, Raught B,de Thé H.   Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway  Nat Cell Biol  2008  10(5):547-55. 
    Nasr R, Guillemin MC, Ferhi O, Soilihi H, Peres L, Berthier C, Rousselot P, Robledo-Sarmiento M, Lallemand-Breitenbach V, Gourme B, Vitoux D, Pandolfi PP, Rochette-Egly C,,de Thé H  APL leukemia initiating cell eradication through cooperative cAMP- RA- and arsenic-triggered PML/RARA degradation  Nature Medecine  2008  14(12):1333-42 
    , Nasr R, Peres L, Riaucoux F, Honore N, Berthier C, Kamashev D, Zhou J, Lavau C, Gronmeyer H and de Thé H.  RXR is an essential component of the oncogenic PML/RARA complex in vivo  Cancer Cell  2007  12(1):23-35. 
    Zhou J, Peres L, Honore N, Nasr R,,de Thé H  Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization.  Proc Natl Acad Sci U S A  2006  103(24):9238-43. 
    Condamine W, Takahashi Y,, Puvion-Dutilleul F, Guegan S, Janin A and de The H  Characterization of endogenous human promyelocytic leukemia isoforms.  Cancer Res.  2006  66(12):6192-8. 
    , Zhou J, Peres L, Riaucoux F, Honore N, Kogan SC and De Thé H.  PML/RAR Sumolation is essential for leukemic transformation.  Cancer Cell  2005  7:143-153 
    Lallemand V,, Chen Z and De Thé H  From mice to patients: lessons from the APL model  Nature Review Cancer  2005  5:821-827