• 基本信息
    导师姓名： 姚志荣 学科代码： 100206
    性别： 男 学科名称： 皮肤病与性病学
    培养单位： 附属新华医院 三级学科
    导师类型： 博士生导师 专业领域名称： 皮肤病与性病学 专业学位
    联系方式： yaozhirong@xinhuamed.com.cn 专业领域代码： 105106
    邮编： 200092 邮箱地址： yaozhirong@xinhuamed.com.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    中华医学会皮肤性病学分会“特应性皮炎研究中心” 首席专家
    上海交通大学医学院“遗传性皮肤病诊疗中心”主任
    世界华人皮肤科医师协会会长
    上海交通大学医学院皮肤病研究所所长
    中华皮肤科杂志 副总编辑
    中华医学会皮肤性病学分会儿童皮肤病学组 顾问
    中国医师协会皮肤性病学分会副会长
    国际特应性皮炎理事会（IEC）理事
    中华医学会皮肤性病学分会副秘书长
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    82230106靶向皮肤神经免疫单元的特应性皮炎干预策略与机制国家自然科学基金重点项目 2023-01~2027-12 261万元  课题负责人
    81874252生命早期分别经皮肤与消化道接触尘螨抗原引起皮肤屏障功能破坏小鼠皮肤与肠道调节性T细胞表达的差异及其机制国家自然科学基金面上项目 2019-01~2022-12 57万元  课题负责人
    2017ZZ02026儿童保健与皮肤病学（与张军教授共同主持）上海市重中之重临床医学中心和重点学科建设计划 2017-07~2020-06 50万元  课题负责人
    81630083炎症致特应性皮炎皮肤屏障功能破坏的机制和干预策略国家自然科学基金重点项目 2017-01~2021-12 275万元  课题负责人
    DLY201610利多卡因静脉封闭vs环孢素治疗18-70岁重度特应性皮炎发作期的多中心、随机双盲和平行对照研究上海交通大学医学院 2016-07~2021-05 100万元  课题负责人
    81472897利多卡因促进特应性皮炎调节性T细胞分化的作用及机制国家自然科学基金面上项目 2015-01~2018-12 65万元  课题负责人
     国家临床重点专科建设项目国家卫生部 2013-01~2015-12 500万元  课题负责人
    12411951600利多卡因静脉封闭治疗重度特应性皮炎的疗效与安全性上海市科委医学重点基金 2012-10~2015-09 20万元  课题负责人
    11JC1408400利多卡因对中间丝相关蛋白基因表达的影响及其抗炎作用新机制上海市科委 2012-01~2014-12 30万元  课题负责人
    81171544马拉色菌及其变应原致敏FLG突变小鼠的机制国家自然科学基金面上项目 2012-01~2015-12 58万元  课题负责人
    201202013特应性皮炎的病症管理与治疗国家卫生部 2012-01~2014-12 190万元  课题负责人
    30870108新生隐球菌同性、异性交配子代毒力差异和机制国家自然科学基金 2009-01~2011-12 30万元  课题负责人
    08JC1415900利多卡因静脉封闭治疗特应性皮炎的机制市科委 2008-10~2010-09 40万元  课题负责人
    2006042基因突变分析应用于遗传性大疱性表皮松解症的产前诊断研究上海市卫生局,局级课题 2007-01~2009-12 3万元  课题负责人
    08JC1415900利多卡因静脉封闭治疗特应性皮炎的机制上海市科委，基础重点项目 ~2010-09 40万元   
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Sun PY, Li HG, Xu QY, Zhang Z, Chen JW, Shen YH, Qi X, Lu JF, Tan YD, Wang XX, Li CX, Yang MY, Ma YZ, Lu Y, Xu TL, Shen JW, Li WG, Guo YF,  Lidocaine alleviates inflammation and pruritus in atopic dermatitis by blocking different population of sensory neurons.  Br J Pharmacol.  2023  May;180(10):1339-1361. 
    Zhang Z, Liang J, Wei R, Feng X, Wang L, Wang L, Zhao P, Yu H, Gu Y,  Facial Balamuthia mandrillaris infection with neurological involvement in an immunocompetent child.  Lancet Infect Dis.  2022  Mar;22(3):e93-e100. 
    Chen F, Ni C, Wang X, Cheng R, Pan C, Wang Y, Liang J, Zhang J, Cheng J, Chin YE, Zhou Y, Wang Z, Guo Y, Chen S, Htun S, Mathes EF, de Alba Campomanes AG, Slavotinek AM, Zhang S, Li M,  S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome  EMBO Mol Med  2022  May 9;14(5):e14904. 
    Cheng R, Zhang H, Zong W, Tang J, Han X, Zhang L, Zhang X, Gu H, Shu Y, Peng G, Huang L, Liu Q, Gao X, Guo Y,  Development and validation of new diagnostic criteria for atopic dermatitis in children of China  J Eur Acad Dermatol Venereol  2020  Mar;34(3):542-548. 
    Guo Y, Zhang H, Liu Q, Wei F, Tang J, Li P, Han X, Zou X, Xu G, Xu Z, Zong W, Ran Q, Xiao F, Mu Z, Mao X, Ran N, Cheng R, Li M, Li C, Luo Y, Meng C, Zhang X, Xu H, Li J, Tang P, Xiang J, Shen C, Niu H, Li H, Shen J, Ni C, Zhang J, Wang H, Ma L, Bieber T,  Phenotypic analysis of atopic dermatitis in children aged 1-12 months: elaboration of novel diagnostic criteria for in fants in China and estimation of prevalence  J Eur Acad Dermatol Venereol  2019  Aug;33(8):1569-1576. 
    Yu X, Zhang J, Xu K, Li M,  Skin involvement as the first symptom of rapidly progressive ALK-positive systemic anaplastic large cell lymphoma.  Clin Exp Dermatol  2017  42(5):539-542.  
    Yu X, Chen F, Ni C, Zhang G, Zheng L, Zhang J, Li C, A S,, Li M.  A Missense Mutation within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis.  J Invest Dermatol  2017  pii:S0022-202X(17)32935-4.  
    Xu Q, Li C, Zhang J, Ling B, Yu H,  Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review.  J Dermatol  2017  doi: 10.1111/1346-8138. 
    Wang Y, Cheng R, Lu Z, Guo Y, Yan M, Liang J, Huang P, Li M,  Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes.  J Dermatol Sci  2017  85(3):235-240. 
    Zhang J, Cheng R, Yu X, Sun Z, Li M,  Expansion of the genotypic and phenotypic spectrum of xeroderma pigmentosum in Chinese population.  Photodermatol Photoimmunol Photomed   2017  33(1):58-63.  
    Liang J, Huang P, Li H, Zhang J, Ni C, Wang Y, Shen J, Li C, Kang L, Chen J, Zhang H, Wang Z, Zhang Z,, Yao Z.  Mutations in IL36RN are associated with geographic tongue.  Hum Genet.   2017  136(2):241-252.  
    Yu X, Zhang J, Wu Z, Liu M, Chen R, Gu Y, Li M,  LUMBAR syndrome: A case manifesting as cutaneous infantile hemangiomas of the lower extremity, perineum and gluteal region, and a review of published work.  J Dermatol  2017  44(7):808-812.  
    Zhang J, Li M,  Updated review of genetic reticulate pigmentary disorders.  Br J Dermatol  2017  177(4):945-959.  
    Li CX, Li HG, Huang LT, Kong YW, Chen FY, Liang JY, Yu H ,  H19 lncRNA regulates keratinocyte differentiation by targeting miR-130b-3p  Cell Death Dis  2017  Nov 30;8(11)e3174 
    Cheng R, Guo Y, Huang L, Hao F, Gao X, Bieber T,  Current status in diagnosis of atopic dermatitis in China.  Allergy  2017  72(9):1277-1278.  
    Li M, Wang J, Zhang J, Ni C, Li X, Liang J, Cheng R, Li Z,  Genome-wide linkage and exome sequencing analyses identify an initiation codon mutation of KRT5 in a unique Chinese family with generalized Dowling–Degos disease  Br J Dermatol  2016  Mar;174(3):663-6. 
    Ni C, Zhang J, Zhang H, Cheng RH, JY, Li CX, Li M,  A novel mutation in the COL7A1 gene results in a unique phenotype of epidermolysis bullosa pruriginosa  J Eur Acad Dermatol Venereol  2016  Mar;30(3):535-6.  
    Shen J, Zhang J, Wang Z, Ni C, Li H, Cheng R, Liang J, Li M,  Gene diagnosis and prenatal genetic diagnosis of a case of dystrophic epidermolysis bullosa family caused by gonadosomatic mosaicism for the COL7A1 mutation Gly2043Arg in the pregnant mother  J Eur Acad Dermatol Venereol  2016  Sep;30(9):1627-9 
    Li M, Li Z, Wang J, Ni C, Sun Z, Wilson NJ, Zhang J, Chen F, Li X, Du X, Yu H, Zhang L, Smith FJ, Zhang G,  Mutations in the mevalonate pathway genes in Chinese patients with porokeratosis  J Eur Acad Dermatol Venereol.   2016  Sep;30(9):1512-7.  
    Ni C, Yan M, Zhang J, Cheng R, Liang J, Deng D, Wang Z, Li M,  A novel mutation in TRPV3 gene causes atypical familial Olmsted syndrome  Sci Rep  2016  Feb 23;6:21815.  
    Li M, Wang J, Li Z, Zhang J, Ni C, Cheng R,  Genome-wide linkage analysis and whole-genome sequencing identify a recurrent SMARCAD1 variant in a unique Chinese family with Basan syndrome  Eur J Hum Genet  2016  Aug;24(9):1367-70. 
    Li CX, Li HG, Zhang H, Cheng RH, Li M, Liang JY, Gu Y, Ling B,, Yu H.  andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore a23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice modelinduced atopic  Drug Des Devel Ther  2016  Feb 19;10:781-91 
    Cheng R, Yan M, Ni C, Zhang J, Li M,  Report of Chinese family with severe dermatitis, multiple allergies and metabolic wasting syndrome caused by novel homozygous desmoglein-1 gene mutation.  J Dermatol  2016  Oct;43(10):1201-1204.  
    Zhang J, Shen J, Cheng R, Ni C, Liang J, Li M,  Identification of a PTPN11 hot spot mutation in a child with atypical LEOPARD syndrome  Mol Med Rep  2016  Sep;14(3):2639-43.  
    Zhang J, Wang Y, Cheng R, Ni C, Liang J, Li M,  Novel MBTPS2 missense mutation causes a keratosis follicularis spinulosa decalvans phenotype: mutation update and review of the literature  Clin Exp Dermatol  2016  Oct;41(7):757-60 
    Zhang J, Yan M, Liang J, Li M,  A novel KRT5 mutation associated with generalized severe epidermolysis bullosa simplex in a 2?year?old Chinese boy  Exp Ther Med  2016  Nov;12(5):2823-2826. 
    Zhang J, Li M,  Molecular screening strategies for NF1-like syndromes with café-au-lait macules  Mol Med Rep  2016  Nov;14(5):4023-4029. 
    Zhang J, Zhang G, Ni C, Cheng R, Liang J, Li M,  Nagashima-type palmoplantar keratosis in a Chinese Han population  Mol Med Rep  2016  Nov;14(5):4049-4054 
    Guo Y, Li P, Tang J, Han X, Zou X, Xu G, Xu Z, Wei F, Liu Q, Wang M, Xiao F, Zong W, Shen C, Li J, Liu J, Luo Y, Chang J, Sheng N, Dong C, Zhang D, Dai X, Zhou J, Meng C, Niu H, Shi X, Zhang X, Xiang J, Xu H, Ran Q, Zhou Y, Li M, Zhang H, Cheng R, Gao X, Wang H, Gu H, Ma L,  Prevalence of Atopic Dermatitis in Chinese Children aged 1–7 ys  Sci Rep  2016  Jul 19;6:29751 
    Li H, Li C, Zhang H, Zhang L, Cheng R, Li M, Guo Y, Zhang Z, Lu Z, Zhuang Y, Yan M, Gu Y, Feng X, Liang J, Yu X, Wang H,  Effects of lidocaine on regulatory T cells in atopic dermatitis  J Allergy Clin Immunol  2016  Feb;137(2):613-617.e5.  
    Zhang J, Cheng R, Liang J, Ni C, Li M,  Lentiginous phenotypes caused by diverse pathogenic genes (SASH1 and PTPN11):clinical and molecular discrimination   Clin Genet  2016  Oct;90(4):372-7.  
    Zhang J, Cheng R, Ni C, Liang J, Li M,  First Mal de Meleda report in Chinese Mainland: two families with a recurrent homozygous missense mutation in SLURP-1  J Eur Acad Dermatol Venereol.   2016  May;30(5):871-3. 
    Zhang J, Cheng R, Liang J, Ni C, Li M,  Report of a child with sporadic familial progressive hyper- and hypopigmentation caused by a novel KITLG mutation  Br J Dermatol  2016  Dec;175(6):1369-1371. 
    Zhang J, Yan M, Cheng R, Ni C, Liang J, Li M,  A rare RECQL4 indel mutation in a Chinese patient with Rothmund–Thomson syndrome  J Eur Acad Dermatol Venereol  2016  Nov;30(11):e159-e161 
    Zhang J, Tong H, Fu X, Zhang Y, Liu J, Cheng R, Liang J, Peng J, Sun Z, Liu H, Zhang F, Lu W, Li M,  Molecular Characterization of NF1 and Neurofibromatosis Type 1 Genotype-Phenotype Correlations in a Chinese Population.  Sci Rep.  2015  2015 Jun 9;5:11291 
    Sun Z, Zhang J, Guo Y, Ni C, Liang J, Cheng R, Li M,  Genotype-phenotype correlation of xeroderma pigmentosum in a Chinese Han population.  Br J Dermatol.   2015  2015 Apr;172(4):1096-102 
    Feng X, Ling B, Yang X, Liao W, Pan W,  Molecular Identification of Candida Species Isolated from Onychomycosis in Shanghai, China.  Mycopathologia.   2015  2015 Dec;180(5-6):365-71 
    Feng X, Guan W, Guo Y, Yu H, Zhang X, Cheng R, Wang Z, Zhang Z, Zhang J, Li H, Zhuang Y, Zhang H, Lu Z, Li M, Yu H, Bao Y, Hu Y,  Genome sequence of a novel recombinant coxsackievirus a6 strain from shanghai, china, 2013.  Genome Announc.   2015  2015 Jan 8;3(1). pii: e01347-14 
    Feng X, Guan W, Guo Y, Yu H, Zhang X, Cheng R, Wang Z, Zhang Z, Zhang J, Li H, Zhuang Y, Zhang H, Lu Z, Li M, Yu H, Bao Y, Hu Y,  A novel recombinant lineage's contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012-2013.  Sci Rep  2015  2015 Jun 30;5:11700 
    Li H, Li C, Zhang H, Zhang L, Cheng R, Li M, Guo Y, Zhang Z, Lu Z, Zhuang Y, Yan M, Gu Y, Feng X, Liang J, Yu X, Wang H,  Effects of lidocaine on regulatory T cells in atopic dermatitis.  J Allergy Clin Immunol  2015  pii: S0091-6749(15)01102-1. 
    Guo YF, Pan WH, Cheng RH, Yu H, Liao WQ,  Successful treatment of neurological malignant atrophic papulosis in child by corticosteroid combined with intravenous immunoglobulin.  CNS Neurosci Ther.   2014  2014 Jan;20(1):88-91 
    Feng X, Wu Z, Ling B, Pan S, Liao W, Pan W,  Identification and differentiation of Candida parapsilosis complex species by use of exon-primed intron-crossing PCR.  J Clin Microbiol.  2014  2014 May;52(5):1758-61 
    Feng X, Wu J, Ling B, Yang X, Liao W, Pan W,  differentiation of clinically relevant yeast species closely related to Candida guilliermondii and Candida famata.  J Clin Microbiol.  2014  2014 Sep;52(9):3190-5 
    Li M, Han J, Lu Z, Li H, Zhu K, Cheng R, Jiao Q, Zhang C, Zhu C, Zhuang Y, Wang Y, Shi J, Guo Y, Wu R,  Prevalent and Rare Mutations in IL-36RN Gene in Chinese Patients with Generalized Pustular Psoriasis and Psoriasis Vulgaris.  J Invest Dermatol  2013  133(11):2637-9.  
    Feng X, Fu X, Ling B, Wang L, Liao W,  Development of a singleplex PCR assay for rapid identification and differentiation of Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. neoformans, Cryptococcus gattii, and hybrids.  J Clin Microbiol  2013  2013 Jun;51(6):1920-3 
    Li M, Cheng R, Liang J, Yan H, Zhang H, Yang L, Li C, Jiao Q, Lu Z, He J, Ji J, Shen Z, Li C, Hao F, Yu H,  Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease.  Am J Hum Genet  2013  2013 Jun 6;92(6):895-903 
    Li M, Cheng R, Shi M, Liu J, Zhang G, Liu Q, Yu H,  Analyses of FLG mutation frequency and filaggrin expression in isolated ichthyosis vulgaris (IV) and atopic dermatitis-associated IV  Br J Dermatol  2013  2013 Jun;168(6):1335-8 
    Cheng R, Li M, Guo Y, Yao Y, Gao C,  Three novel mutations in the SLCO2A1 gene in two Chinese families with primary hypertrophic osteoarthropathy.  Eur J Dermatol.  2013  2013 Sep-Oct;23(5):636-9 
    Jiao Q, Wang H, Hu Z, Zhuang Y, Yang W, Li M, Yu X, Liang J, Guo Y, Zhang H, Chen X, Cheng R,  Lidocaine inhibits staphylococcal enterotoxin-stimulated activation of peripheral blood mononuclear cells from patients with atopic dermatitis  Arch Dermatol Res  2013  2013 Sep;305(7):629-36 
    Zhang H, Chen X, Guo Y, Liang J, Tang L, Yu H,  Hutchinson-Gilford progeria syndrome: report of 2 cases and a novel LMNA mutation of HGPS in China.  J Am Acad Dermatol.   2013  2013 Oct;69(4):e175-6 
    Li M, Han J, Lu Z, Li H, Zhu K, Cheng R, Jiao Q, Zhang C, Zhu C, Zhuang Y, Wang Y, Shi J, Guo Y, Wu R,  Prevalent and rare mutations in IL-36RN gene in Chinese patients with generalized pustular psoriasis and psoriasis vulgaris.  J Invest Dermatol.   2013  2013 Nov;133(11):2637-9 
    Feng X, Fu X, Ling B, Wang L, Liao W, Pan W,  Rapid differentiation of cryptic species within Cryptococcus gattii by a duplex PCR assay.  J Clin Microbiol  2013  2013 Sep;51(9):3110-2 
    Li M, Liu Q, Liu J, Cheng R, Zhang H, Xue H, Bao Y,  Mutations analysis in filaggrin gene in northern China patients with atopic dermatitis  J Eur Acad Dermatol Venereol  2012  27(2):169-74 
    Cheng R, Li M, Zhang H, Guo Y, Chen X, Tao J, Jiang A, Gan J, Qi H, Yu H, Liao W,  Common FLG Mutation K4671X Not Associated with Atopic Dermatitis in Han Chinese in a Family Association Study  PLoS One  2012  7(11):e49158 
    Feng X, Ling B, Yang G, Yu X, Ren D,  Prevalence and distribution profiles of Candida parapsilosis, Candida orthopsilosis and Candida metapsilosis responsible for superficial candidiasis in a Chinese university hospital  Mycopathologia  2012  173(4):229-34 
    Li M, Liang JY, Sun ZH, Zhang H,  Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis (CIPA)  Genetics and Molecular Research  2012  11(3):2156-62 
    Li M, Lu Z, Cheng R, Li H, Guo Y,  IL36RN gene mutations are not associated with sporadic generalized pustular psoriasis in Chinese Patients  Bri J Dermatol  2012  doi: 10.1111/j.1365-2133. 2012.11195.x. 
    Li M, Liu JB, Liu Q, Yao M, Cheng R, Xue H, Zhou H,  Interactions between FLG Mutations and Allergens in Atopic Dermatitis  Arch Dermatol Res  2012  304(10):787-93 
    Li M, Cheng RH, Zhuang Y, Yao ZR  A recurrent mutation in the APCDD1 gene responsible for hereditary hypotrichosis simplex in a large Chinese family  Bri J Dermatol  2012  167(4):952-4 
    Li M, Jin C, Yang L, Lai M,  A novel complex insertion-deletion mutation in ADAR1 gene in a Chinese family with dyschromatosis symmetrica hereditaria  J Eur Acad Dermatol Venereol  2011  25(6):743-6 
    Sun LD, Xiao FL, Li Y, Zhou WM, Tang HY, Tang XF, Zhang H, Schaarschmidt H, Zuo XB, Foelster-Holst R, He SM, Shi M, Liu Q, Lv YM, Chen XL, Zhu KJ, Guo YF, Hu DY, Li M, Li M, Zhang YH, Zhang X, Tang JP, Guo BR, Wang H, Liu Y, Zou XY, Zhou FS, Liu XY, Chen   Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population  Nat Genet  2011  43:690-4 
    Feng X,, Ling B, Ren D, Liao W  Perilla frutescens seed agar, a new medium for identification of the Cryptococcus species complex: evaluation for all major molecular types  J Microbiol Methods  2011  84:359-61 
    Shi M, Zhang H, Chen X, Guo Y, Tao J, Qi H, Gan J,, Yu H, Liang J, Chen J, Yang L, Zhuang Y, Yan M, Gu Y, Yu X, Feng X, Yao Z  Clinical features of atopic dermatitis in a hospital-based setting in China  J Eur Acad Dermatol Venereol  2011  25(10):1206-12 
    Tang L, Liang J, Wang W, Yu L,  A novel mutation in MBTPS2 causes a broad phenotypic spectrum of ichthyosis follicularis, atrichia, and photophobia syndrome in a large Chinese family  J Am Acad Dermatol  2011  64(4):716-22 
    Zhang H, Guo Y, Wang W, Shi M, Chen X,  Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis  Allergy  2011  66(3):420-7 
    Li M, Chen X, Chen R, Bao Y,  Filaggrin gene mutations are associated with independent atopic asthma in Chinese patients  Allergy  2011  66(12):1616-7 
    Zhang H, Guo Y, Wang W, Yu X,  Associations of FLG mutations between ichthyosis vulgaris and atopic dermatitis in Han Chinese  Allergy  2011  66(9):1253-4 
    Feng X,, Ren D, Liao W  Rapid differentiation of VGII/AFLP6 genotype within Cryptococcus gattii by polymerase chain reaction  Diagn Microbiol Infect Dis  2010  68: 471-473 
    Yu H, Kong J, Gu Y, Ling B, Xi Z,  A child with coexistent juvenile xanthogranuloma and Langerhans cell histiocytosis  J Am Acad Dermatol  2010  62(2):329-32 
    Li M, Yang L, Li C, Jin C, Lai M, Zhang G, Hu Y, Ji J,  Mutational spectrum of the ADAR1 gene in dyschromatosis symmetrica hereditaria  Arch Dermatol Res  2010  302(6):469-76 
    Feng X,, Ren D, Liao W  Simultaneous identification of molecular and mating types within the Cryptococcus species complex by PCR-RFLP analysis  J Med Microbiol  2008  57:1481-90 
    Feng X,, Ren D, Liao W, Wu J  Genotype and mating type analysis of Cryptococcus neoformans and Cryptococcus gattii isolates from China that mainly originated from non-HIV-infected patients  FEMS Yeast Res  2008  8:930-8