- 基本信息
|
导师姓名：
|
李华芳
|
学科代码：
|
100205
|
|
|
性别：
|
女
|
学科名称：
|
精神病与精神卫生学
|
|
培养单位：
|
附属精神卫生中心
|
三级学科
|
|
|
导师类型：
|
博士生导师
|
专业领域名称：
|
精神病与精神卫生学 专业学位
|
|
联系方式：
|
lhlh_5@163.com
|
专业领域代码：
|
105105
|
|
邮编：
|
200030
|
邮箱地址：
|
lhlh5@yahoo.com.cn
|
- 研究方向 (点击浏览详细信息)
- 社会任职
| |
|
第九届药典委员会精神药物编写专家组成员
|
|
《中国新药与临床》第十届编委会编委
|
|
精神药物临床试验协作网 工作组组长（首届）
|
|
中华医学会精神科分会青年委员会委员
|
|
上海市药理学会临床药理专业委员会委员
|
|
中国GCP联盟 理事
|
|
中国睡眠研究会中医睡眠医学会专业委员会委员
|
|
国家食品药品监督管理局药品审评中心专家
|
|
《上海精神医学》第五届编委会编委
|
|
《中国临床药学杂志》编委
|
- 科研项目
| 19MC1911100 | 上海市精神心理疾病临床医学研究中心 | 上海市科委 |
2020-01~2022-12
|
1000万元
| 课题负责人 |
| XDA12040105-03 | 抗精神分裂症候选新药TPN672药效敏感及毒性生物标志物的发现-临床个体化治疗方案制定 | 中国科学院战略性先导科技专项 |
2018-01~2020-12
|
100万元
| 课题负责人 |
| 2018ZX09734-005 | 精神药物新药临床评价研究技术平台 | 国家科技部“重大新药创制”科技重大专项 |
2018-01~2020-10
|
1370.9万元
| 课题负责人 |
| TM201624 | 上海市精神卫生中心分中心建设 | 上海交通大学医学院转化医学协同创新合作研究项目 |
2016-12~2018-11
|
20万元
| 课题负责人 |
| DLY201620 | 非典型抗精神病药治疗精神分裂症长期结局的真实世界的多中心临床研究 | 上海市高峰高原交大医学院多中心临床研究项目 |
2016-01~2018-12
|
200万元
| 课题负责人 |
| TM201506 | 代谢组学技术在阿尔茨海默病和精神分裂症的诊断与治疗中的应用研究 | “上海交通大学医学院转化医学协同创新中心“ |
2015-01~2017-12
|
34万元
| 课题负责人 |
| 2014ZX09301307 | 天然药物5类新药安郁沛勃胶囊的临床研究 | 国际科技部“重大新药创制”科技重大专项 |
2014-01~2016-12
|
47.27万元
| 课题参与人 |
| 2012ZX09303 | 精神药物新药临床评价研究技术平台 | 国家科技部 “重大新药创制”科技重大专项 |
2012-08~2015-12
|
265.58万元
| 主要责任人 |
| XBR2011049 | 上海市卫生系统优秀人才课题 | 上海市卫生局 |
2011-11~2014-12
|
100万元
| 主要责任人 |
| 11411950200 | 慢性失眠的病因、诊断及临床综合评估与规范化治疗方案的多中心临床研究 | 上海市科委医学重点项目 |
2011-11~2014-09
|
200万元
| 主要责任人 |
| 2008ZX09312-003 | "重大新药创制“科技重大专项 精神药物新药临床评价研究技术平台 | 国家生物技术发展中心 |
2008-10~2010-12
|
1700万元
| 主要责任人 |
- 学术论文
|
Huang J, Chiovenda A, Shao Y, Ma H,, Good MD.
|
Low level of knowledge regarding diagnosis and treatment among inpatients with schizophrenia in Shanghai.
|
Neuropsychiatric Disease and Treatment
|
2018
|
14: 185–191
|
|
Yi-Min Yu, MD,* Ke-Run Gao, MD, PhD,, PhD,?Yi-Feng Shen, MD, PhD,* and Hua-Fang Li, MD, PhD*【通讯】
|
Efficacy and Safety of Agomelatine vs Paroxetine Hydrochloride in Chinese Han Patients with Major Depressive Disorder A Multicentre, Double-Blind, Noninferiority, Randomized Controlled Trial
|
J Clin Psychopharmacol
|
2018
|
38: 226–233
|
|
Duan Zeng,Shen He,Shunying Yu,Guanjun Li,Changlin Ma,Yi Wen,Yifeng Shen,Yimin Yu,
|
Analysis of the association of MIR124-1 and its target gene RGS4 polymorphisms with major depressive disorder and antidepressant response.
|
Neuropsychiatric Disease and Treatment
|
2018
|
14:715–723
|
|
Wang Xiaoliang, Wang Huifang【共通】,
|
Inhibition of iNOS ameliorates traumatic stress-induced deficits in synaptic plasticity and memory.
|
Psychiatry Research
|
2018
|
268：413–418
|
|
, Shen Y, Wang G, Shi J, Ma C, Xie S, Zhang H, Wang X, Li K, Xu X, Gu N【通讯】.
|
A 6-week, multicenter, double-blind, double-dummy, chlorpromazine-controlled non-inferiorityrandomized phase iiitrial to evaluate the efficacy and safety of quetiapine fumarate (SEROQUEL) extended-release (XR) in the treatment of patients with schizophrenia and acute episodes.Psychiatry Research.
|
Psychiatry Research.
|
2018
|
259:117-124.
|
|
Yan Li, Fan Zhang, Yanmei Xu, Joice Hu,
|
Pharmacokinetics, Safety, and Tolerability of Lamotrigine Chewable/Dispersible Tablet Following Repeat-Dose Administration in Healthy Chinese Volunteers.
|
Clinical Pharmacology in Drug Development
|
2018
|
00(0) 1–7
|
|
Jingjing Huang, Yang Shao,Huajian Ma, Weimin Yang,
|
Changing of Chinese psychiatrists’ attitudes toward consent process to treatment and its association with the China’s National Mental Health Law
|
International Journal of Psychiatry in Medicine
|
2018
|
0(0):1-11
|
|
,Yan Li,Yu Feng,Jianmin Zhuo,Ibrahim Turkoz,Maju Mathews,Wilson Tan.
|
Impact of time of initiation of once-monthly paliperidone palmitate in hospitalized Asian patients with acute exacerbation of schizophrenia: a post hoc analysis from the PREVAIL study.
|
Neuropsychiatric Disease and Treatment
|
2018
|
14： 1107–1117
|
|
Yifeng Shen,, PhD and Huafang Li [通讯], MD, PhD.
|
General Information on Clinical Psychopharmacology in China.
|
Journal of Clinical Psychopharmacology.
|
2018
|
38(2):107-110.
|
|
王晓良,黄晶晶,王飚,
|
HLA基因多态性与非典型抗精神病药物性肝损伤关联性研究
|
精神医学杂志
|
2016
|
29（5）：346-347
|
|
Guan L,,通讯】, Chen Z, Frick G, Nichols A.
|
An Assessment of the Pharmacokinetics and Tolerability of Single-Ascending Doses of Desvenlafaxine Administered to Healthy Chinese Subjects.
|
J Bioequiv Availab
|
2016
|
8: 099-105
|
|
Guanjun Li, Yingying Tang, Ling Yue, Jinghua Wang, Jianye Zhang, Shifu Xiao,
|
Diffusion tensor imaging of patients with behavioral variant frontotemporal dementia: a controlled study.
|
Int J Clin Exp Med
|
2016
|
9(2):1500-1509
|
|
, Niufan Gu, Hongyan Zhang, Gang Wang, Qingrong Tan, Fude Yang, Yuping Ning, Honggeng Zhang, Zheng Lu, Xiufeng Xu, Jianguo Shi, Chengge Gao, Lingjiang Li, Kerang Zhang, Hongjun Tian, Xiaoping Wang, Keqing Li, Huichun Li, Yi Xu, Shiping Xie, Xin Yu(通讯).
|
Efficacy and safety of quetiapine extended release monotherapy in bipolar depression: a multi-center, randomized, double-blind, placebo-controlled trial.
|
Psychopharmacology
|
2016
|
233(7):1289-97
|
|
张蕾,和申,余一旻,李妍,闻晖,乔颖,
|
原发性失眠人群特征、 睡眠质量及危险因素的研究
|
上海交通大学学报(医学版)
|
2016
|
36(5):689-694
|
|
Shen He, Xiaohua Liu, Kaida Jiang, Daihui Peng, Wu Hong, Yiru Fang,Yiping Qian, Shunying Yu,
|
Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder
|
Journal of Psychiatric Research
|
2016
|
78:65-71
|
|
W.Yu, X. Sun, Y Li,K.Wang,
|
Population pharmacokinetics of lithium carbonate in young male healthy Chinese volunteers.
|
Pharmacopsychiatry
|
2016
|
49(5):177-181
|
|
Ying Qiao, Lei Zhang, Shen He, Hui Wen, Yi-Min Yu, Chun-Hua Cao,
|
Plasma metabonomics study of first-Episode schizophrenia treated with olanzapine in female patients
|
Neuroscience Letters
|
2016
|
617： 270–276
|
|
,Ibrahim Turkoz,Fan Zhang.
|
Efficacy and safety of once-monthly injection of paliperidone palmitate in hospitalized Asian patients with acute exacerbated schizophrenia: an open-label, prospective, noncomparative study.
|
Neuropsychiatric Disease and Treatment
|
2016
|
12:15–24
|
|
王丽华,
|
氨磺必利致高泌乳素血症的临床特征和相关机制
|
精神医学杂志
|
2015
|
28（4）：307-310
|
|
Li X, Fan Y, Xiao S, Peng S, Dong X, Zheng X, Liu CC,, Xiao Z.
|
Decreased platelet 5-hydroxytryptamin (5-HT) levels: a response to antidepressants.
|
J Affect Disord
|
2015
|
21;187:84-90
|
|
黄晶晶,
|
精神障碍患者知情同意能力的评定方法。
|
中国心理卫生杂志
|
2015
|
29（6）：437-441
|
|
Gao K, Wang Q, Zhang Y, Wang D, Fu Y,,Yu S.
|
Association study of VEGFA polymorphisms with schizophrenia in Han Chinese population.
|
Neurosci Lett.
|
2015
|
590:121-125
|
|
孙秀佳,林治光,任娟娟,蒋平,刘红梅,李春波,
|
LC-MS/MS法检测人头发中利培酮及其代谢物9-羟利培酮含量的实验研究
|
现代生物医学进展
|
2015
|
0（12）： 2221-2224
|
|
, Jiansong Yang, Hongxin Zhao, Michael J. Fossler,and Chunrong Wang.
|
Effect of Tamsulosin on the Pharmacokinetics of Dutasteride in Chinese Male Healthy Volunteers.
|
Clinical Pharmacology in Drug Development
|
2015
|
4(6) 427–433
|
|
Wenjuan Yu, Hao Zhu, Yueming Wang, Guanjun Li, Lihua Wang,
|
Reactive Transformation and Increased BDNF Signaling by Hippocampal Astrocytes in Response to MK-801.
|
PLoS ONE
|
2015
|
10(12):1-13(e0145651. doi:10.1371/journal.pone.0145651,December 23,2015)
|
|
, Yao C, Shi J, Yang F, Qi S, Wang L, Zhang H, Li J, Wang C, Wang C, Liu C, Li L, Wang Q, Li K, Luo X, Gu N.
|
Comparative study of the efficacy and safety between blonanserin and risperidone for the treatment of schizophrenia in Chinese patients: A double-blind, parallel-group multicenter randomized trial.
|
J Psychiatr Res.
|
2015
|
69:102-109
|
|
Tao Wang, MD,, PhD; Huafang Li, MD, PhD; Shuhui Dong, MD; Ning Su, MD; Yuanyuan Liu, MD; Yan Cheng, MD; Jing Dai, MD; Cece Yang, MD; and Shifu Xiao, MD, PhD.
|
The Feasibility of Utilizing Plasma MiRNA107 and BACE1 Messenger RNA Gene Expression for Clinical Diagnosis of Amnestic Mild Cognitive Impairment.
|
J Clin Psychiatry
|
2015
|
2015;76(2):135–141
|
|
Zhiyang WANG, Xiufeng XU, Qingrong TAN, Keqing LI, Cui MA, Shiping XIE, Chengge GAO,Gang WANG,
|
Treatment of major depressive disorders with generic duloxetine and paroxetine: a multi-centered, double-blind,double-dummy, randomized controlled clinical trial.
|
Shanghai Arch Psychiatry
|
2015
|
27(4): 228-236
|
|
Liu H, Fu Y, Ren J, Yu S, Liu H, Jiang P, Dong Y,
|
Association between NR4A2 genetic variation and schizophrenia: A comprehensive systematic review and meta-analysis.
|
Neurosci Lett.
|
2015
|
598:85-90
|
|
, Jianfeng Luo , Chuanyue Wang, Shiping Xie, Xiufeng Xu, XiaopingWang,Wenjuan Yu ,Niufan Gu, John M. Kane.
|
Efficacy and safety of aripiprazole in Chinese Han schizophrenia subjects: a randomized, double-blind, active parallel-controlled, multicenter clinical trial.
|
Schizophr Res
|
2014
|
157:112-119
|
|
王丽华,
|
维拉唑酮在临床的应用状况。
|
中国临床药理学杂志
|
2014
|
30(9):862-864
|
|
Shen He, Tianhong Zhang, Bo Hong, Daihui Peng, Hui Su, Zhiguang Lin,Yiru Fang, Kaida Jiang, Xiaohua Liu,
|
Decreased serum fibroblast growth factor - 2 levels in pre- and post-treatment patients with major depressive disorder.
|
Neurosci Lett.
|
2014
|
579:168-172
|
|
于文娟,张蕾,
|
星形细胞在精神分裂症中的研究进展。
|
精神医学杂志
|
2014
|
27(4):309-311
|
|
, Ting LI, Guanjun Li, Jianfeng LUO.
|
Citalopram and Escitalopram in the treatment of major depressive disorder: a pooled analysis of 3 clinical trials.
|
Annals of Clinical Psychiatry
|
2014
|
26(4):281-287
|
|
和申,刘晓华,禹顺英,
|
MicroＲNA 在抑郁症发病机制中的作用
|
临床精神医学杂志
|
2014
|
24(3):204-206
|
|
Yimin YU,, Biao WANG Keqing LI, Xiufeng XU, Jianguo SHI, Chengge GAO, Qingrong TAN.
|
Efficacy and safety of generic escitalopram versus Lexapro in the treatment of major depression: a multicenter double-blinded randomized clinical trial.
|
Shanghai achives of psychiatry
|
2013
|
25(2):107-115
|
|
, Yan X, Li T, Xu J, Wang Q, Xu Y.
|
Efficacy of huadananshen mistura on insomnia: a randomized, double-blind, placebo-controlled, and multi-center clinical trial.
|
J Tradit Chin Med
|
2013
|
33(4):423-42
|
|
, Ting Li, Yan Li, Yifeng Shen.
|
Pharmacokinetics and Safety of Duloxetine Enteric-coated Tablets in Chinese Healthy Volunteers: A Randomized, Open-label, Single- and Multiple-dose study.
|
Clinical Psychopharmacology and Neuroscience
|
2013
|
11(1):28-33
|
|
李园园,严小蕾,
|
烟碱型乙酰胆碱受体基因多态与早发性精神分裂症的关联研究
|
中国神经精神疾病杂志
|
2013
|
39(1):17-22
|
|
159. Yan X, Huang S, Ma C, Shen Y, Gu N, Chen H, Wu W, Li S, Hong Z,
|
A randomized, double-blind, double-dummy, multicenter, controlled trial on brotizolam intervention in outpatients with insomnia.
|
Int J Psychiatry Clin Pract
|
2013
|
17(4):239-243
|
|
|
抑郁症急性期药物治疗的安全性
|
中华精神科杂志
|
2013
|
46(4):239-241
|
|
王娟,禹顺英,沈一峰,
|
促肾上腺皮质激素释放激素结合蛋白基因多态性与选择性5一羟色胺再摄取抑制剂疗效的关联研究。
|
中华精神科杂志
|
2013
|
46(2):65-70
|
|
Aihua Yuan,Weidong Li,Tao Yu,Chen Zhang,Dongxiang Wang,Dengtang Liu,Yifeng Xu,,Shunying Yu
|
SOX10 rs139883 Polymorphism Is Associated with the Age of Onset in Schizophrenia.
|
J Mol Neurosci
|
2013
|
50(2):333-8
|
|
李婷,,禹顺英
|
Reelin 在精神疾病中的研究进展
|
精神医学杂志
|
2012
|
25(1):75-77
|
|
152. Yuan A, Yi Z, Wang Q, Sun J, Li Z, Du Y, Zhang C, Yu T,, Li H, Yu S.
|
ANK3 as a risk gene for schizophrenia: new data in Han Chinese and meta analysis.
|
Am J Med Genet B Neuropsychiatr Genet.
|
2012
|
159(8):997-100
|
|
王娟 禹顺英 沈一峰 李华芳
|
促肾上腺皮质激素释放激素受体1基因多态性与抗抑郁药物疗效的关联研究
|
中国神经精神疾病杂志
|
2012
|
38(7):420-424
|
|
Yan Li,, Yan Liu, Xiaolei Yan, Ying Yue, Mincai Qian
|
Comparison of quetiapine and risperidone in Chinese Han patients with schizophrenia: results of a single-blind, randomized study
|
Curr Med Res Opin
|
2012
|
28(10):1725-1732
|
|
Xiaolei Y, Shuzhen H, Cui M, Yang S, Niufan G, Haibo C, Wenyuan W, Shunwei L, Zhen H,
|
A randomized, double-blind, double-dummy, multicenter, controlled trial on brotizolam intervention in outpatients with insomnia
|
Int J Psychiatry Clin Pract
|
2012
|
Oct 1. [Epub ahead of print]
|
|
|
5-羟色胺及去甲肾上腺素再摄取抑制剂的临床合理应用
|
临床合理用药杂志
|
2012
|
5(5):21-23
|
|
李园园,
|
新型非典型抗精神病药：伊潘立酮
|
中国临床药学杂志
|
2011
|
20(5):318-322
|
|
,许秀峰,李鸣,张明廉,王晓萍,施建安,贺佳,顾牛范
|
米那普仑与氟西汀治疗中国抑郁症的疗效和安全性比较
|
中国新药与临床杂志
|
2011
|
30(12):895-900
|
|
余一旻,,杨甫德 胡建 赵振环 董继承 陈红辉 许秀峰 李鸣 王刚 王晓萍 谢世平 唐济生 张晋碚 关念红 丁瑛 谭庆荣 李惠春 钟华 张鸿燕 谢光荣 孙学礼 顾牛范
|
可变剂量帕利哌酮缓释剂治疗急性期精神分裂症的疗效、耐受性及安全性.
|
上海精神医学
|
2011
|
22(6):349-353
|
|
Hongyan Zhang,, Liang Shu, Niufan Gu, Gang Wang, Yongzhen Weng, Shiping Xie, Xinbao Zhang, Ting Li, Cui Ma, Wei Yu, Bruce Parsons, Manjula Schou.
|
Double-blind comparison of ziprasidone and risperidone in the treatment of Chinese patients with acute exacerbation of schizophrenia
|
Neuropsychiatric disease and treatment
|
2011
|
7(n):1-9
|
|
, Chunyan Wu ,Xiufeng XU ,Ming Li,Minglian Zhang,Xiaoping Wang,Jianan Shi,Jia He,Niufan Gu
|
A comparison in efficacy and safety of milnacipran with fluoxetine in Chinese patients with major depressive disorder
|
Chinese Journal of new drugs and clinical remedies
|
2011
|
2011；30(1):895-900
|
|
, Qing Rui, Xiaoping Ning, Haiyan Xu, Niufan Gu
|
Double-blind comparison of ziprasidone and risperidone in the treatment of A comparative study of paliperidone palmitate and risperidone long-acting injectable therapy in schizophrenia
|
Neuro-Psychopharmacology and Biological Psychiatry
|
2011
|
35(4):1002-1008
|
|
王娟,
|
新型抗精神病药：阿塞那平
|
中国新药与临床杂志
|
2011
|
30(12):886-890
|
|
|
中国临床精神药理学的沿革
|
中国新药与临床杂志
|
2011
|
30(12):881-885
|
|
沈一峰,,李静,许秀峰,高成阁,于浩,顾牛范
|
艾司西酞普兰与西酞普兰治疗抑郁症的随机双盲多中心临床研究
|
中国新药与临床杂志
|
2011
|
30(12):901-906
|
|