• 基本信息
    导师姓名: 李福彬 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式: 李福彬,博士,研究员,课题组长,上海市免疫学研究所,上海交通大学医学院基础医学院免疫学与微生物学系,上海市重庆南路280号西区5号楼1008室,邮编200025;邮箱: Fubin.Li@sjtu.edu.cn,电话:021-54592183(办公室) Fubin Li, Ph.D,Principal Investigator, Shanghai Institute of Immunology; Department of Immunology and Microbiology, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine Room 1008, West #5 Building, 280 South Chongqing Road, Shanghai 200025, China;Email: Fubin.Li@sjtu.edu.cn;Phone: +86-21-54592183 (office)
    邮箱地址: Fubin.Li@sjtu.edu.cn 邮编: 200025
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    没有社会任职信息
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    第十批“千人计划”青年人才项目“千人计划”青年人才项目中央组织部 2015-01~2017-12 200万元  课题负责人
    31422020基于抗体Fc的分子靶向治疗国家自然科学基金委员会优青项目 2015-01~2017-12 100万元  课题负责人
    31370934抑制型Fcgamma受体驱动激动型抗TNFR超家族成员抗体抗肿瘤活性的机制国家自然科学基金委员会面上项目 2014-01~2017-12 80万元  课题负责人
    2014CB943600淋巴细胞发育中的基因转录后调节网络研究中华人民共和国科学技术部 2014-01~2018-08 150万元  课题参与人
    “东方学者”计划上海高校特聘教授(东方学者)岗位计划上海市教育委员会 2013-09~2016-08 100万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Dahan R, Barnhart BC,, Yamniuk AP, Korman AJ, Ravetch JV.  Therapeutic activity of agonistic, human anti-CD40 monoclonal Abs requires selective FcγR-engagement  Cancer Cell  2016  29(6):820-31 
    Georgoudaki AM, Prokopec KE, Boura VF, Hellqvist E, Sohn S, ?stling J, Dahan R, Harris RA, Rantalainen M, Klevebring D, Sund M, Brage SE, Fuxe J, Rolny C,, Ravetch JV, Karlsson MC.  Reprogramming tumor associated macrophages by antibody targeting inhibits cancer progression and metastasis.   Cell Reports  2016  15(9):2000-11 
    Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G,, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H.  Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.  Nature Immunology  2015  16(6):642-52 
    , F., P. Smith, and J. V. Ravetch. 2014.  Inhibitory Fcgamma Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms.  Journal of Immunology  2014  192(7):3021-8. 
    , Ravetch JV.  Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo  Proc Natl Acad Sci U S A  2013  110(48):19501-6 
    Simpson TR,, Montalvo-Ortiz W, Sepulveda MA, Bergerhoff K, Arce F, Roddie C, Henry JY, Yagita H, Wolchok JD, Peggs KS, Ravetch JV, Allison JP, Quezada SA.  Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma  J Exp Med  2013  210(9):1695-710 
    Smith P, DiLillo DJ, Bournazos S,, Ravetch JV.  Mouse model recapitulating human Fcγ receptor structural & functional diversity  Proc Natl Acad Sci U S A  2012  109(16):6181-6 
    , Ravetch JV.  A general requirement for FcγRIIB co-engagement of agonistic anti-TNFR antibodies  Cell Cycle  2012  11(18):3343-4 
    , Ravetch JV.  Apoptotic & antitumor activity of death receptor antibodies require inhibitory Fcγ receptor engagement.  Proc Natl Acad Sci U S A  2012  109(27):10966-71 
    , Ravetch JV.  Inhibitory Fcγ receptor engagement drives adjuvant & anti-tumor activities of agonistic CD40 antibodies.  Science  2011  333(6045):1030-4 
    , Yan Y, Pieretti J, Feldman DA, Eckhardt LA.  Comparison of identical & functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation & class-switch recombination.  J Immunol  2010  185(10):6049-57 
    , Eckhardt LA.  A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.  J Exp Med  2009  206(1):153-67 
    Zhang B, Alaie-Petrillo A, Kon M,, Eckhardt LA.  Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory region.  J Immunol  2007  178(10):6297-306 
    Romov PA,, Lipke PN, Epstein SL, Qiu WG.  Comparative genomics reveals long, evolutionarily conserved, low-complexity islands in yeast proteins.  J Mol Evol  2006  63(3):415-25 
    Garrett FE, Emelyanov AV, Sepulveda MA, Flanagan P, Volpi S,, Loukinov D, Eckhardt LA, Lobanenkov VV, Birshtein BK.  Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development & in vivo occupancy at CTCF sites.  Mol Cell Biol  2005  25(4):1511-25.