• 基本信息
    导师姓名： 郑凌艳 学科代码： 100302
    性别： 女 学科名称： 口腔临床医学
    培养单位： 口腔医学院 三级学科
    导师类型： 博士生导师 专业领域名称： 口腔医学 专业学位
    联系方式： 上海市瞿溪路500号 专业领域代码： 105200
    邮编： 200011 邮箱地址： zhenglingyan73@163.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海市口腔医学会第三届口腔颌面外科专业委员会委员
    中华口腔医学会口腔颌面外科专业委员会专科会员
    中国医师协会口腔医师分会会员
    中华口腔医学会口腔颌面外科涎腺学组委员
    中华口腔医学会专科会员
    上海口腔医学会会员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    82170976组蛋白乙酰转移酶KAT6A介导CD4+T细胞糖代谢重编程在舍格伦综合征中的作用及机制研究国家自然科学基金面上项目 2022-01~2025-12 56万元  课题负责人
    JYJC202126单细胞测序下IgG4相关自免疫性唾液腺炎的免疫表达图谱上海交通大学医学院附属第九人民医院-上科大交叉项目 2022-01~2024-12 20万元  课题负责人
    YBKB202107口腔颌面部间隙感染生物样本库的建立上海交通大学医学院附属第九人民医院 2021-09~2024-08 25万元  课题负责人
    81970951去泛素化酶Usp13在TLR9介导唾液腺上皮细胞异常抗原递呈中的作用及机制研究国家自然科学基金面上项目 2020-01~2023-12 55万元  课题负责人
    81671004原发性舍格伦综合征中TLR9异常高表达的分子调控及发病机制研究国家自然科学基金面上项目 2017-01~2020-12 58万元  课题负责人
    16ZR1419000 TLR9信号通路负反馈调节功能障碍在原发性舍格伦综合征发病机制中的作用研究上海市科学技术委员会自然基金项目 2016-07~2019-06 20万元  课题负责人
    YG2015MS03PHA基可降解唾液腺导管专用支架的合成及应用研究上海交通大学医工交叉研究基金项目 2016-01~2018-12 21万元  课题负责人
    81100766TLR9依赖的p38MAPK信号通路的激活原发性舍格伦综合征发病机制中的作用国家自然科学基金青年项目 2012-01~2014-12 22万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Zhan T, Wang B, Fu J, Shao Y, Ye L, Shi H,  Artesunate inhibits Sj?gren's syndrome-like autoimmune responses and BAFF-induced B cell hyperactivation via TRAF6-mediated NF-κB signaling  Phytomedicine  2021  80:153381 
    Ye L, Shi H, Wu S, Yu C, Wang B,  Dysregulated interleukin 11 in primary Sj?gren's syndrome contributes to apoptosis of glandular epithelial cells  Cell Biology International  2020  44(1):327-335 
    Fu J, Shi H, Zhan T, Li H, Ye L, Xie L, Wang Z, Wang B,  BST-2/Tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-κB signaling in neoplastic B-lymphoid cells  Experimental Cell Research  2020  https://doi.org/10.1016/j.yexcr.2020.112399 
    Fu Jiayao, Shi Huan, Wang Baoli, Zhan Tianle, Shao Yanxiong, Ye Lei, Wu Shufeng, Yu Chuangqi,  LncRNA PVT1 links Myc to glycolytic metabolism upon CD4+ T cell activation and Sjogren's syndrome-like autoimmune response  Journal of Autoimmunity  2020  107:102358 
    Wu Shufeng, Wang Baoli, Yu Chuangqi, Wang Zhijun, Xie Lisong, Fu Jiayao, Shi Huan,  Juvenile recurrent parotitis: Soft foods contribute to the delayed development of salivary glands  Journal of Oral Rehabilitation   2020  47:485–493 
    Ye L, Shi H, Yu C, Fu J, Chen C, Wu S, Zhan T, Wang B,  LncRNA Neat1 positively regulates MAPK signaling and is involved in the pathogenesis of Sj?gren's syndrome  International Immunopharmacology  2020  88:106992. 
    Fu J, Shi H, Cao N, Wu S, Zhan T, Xie L, Wang Z, Ye L, Li C, Shen Y, Yu C,  Toll-like receptor 9 signaling promotes autophagy and apoptosis via divergent functions of the p38/JNK pathway in human salivary gland cells  Exp Cell Res  2019  375(2):51-59. 
    Chen C, Shi H, Wang B, Cao N, Yu C,  Aberrant expression of the innate restriction factor bone marrow stromal antigen-2 in primary Sjogren's syndrome  J Craniomaxillofac Surg  2018  46(11):1899-1904. 
    Wu S, Shi H, Cao N, Ye L, Yu C,  The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation  Acta Oto-Laryngologica  2018  138(12):1112-1116. 
    Shi H, Cao N, Pu Y, Xie L,, Yu C.   Long non-coding RNA expression profile in minor salivary gland of primary Sjogren’s syndrome.   Arthritis Res Ther   2016  18(1):109-122. 
    Gao Q, Yang C,, Hu Y.  Removal of Long-Term Broken Roots Displaced Into the Maxillary Sinus by Endoscopic Assistant.  J Craniofac Surg   2016  27(1), e77-e80. 
    , Yang C, Zhang W, Cai X, Jiang B, Wang B, Pu Y, Jin J, Guan X.  Comparison of multi-space infection of the head and neck in the elderly and non-elderly people PartⅡ: the influencing factors of the outcomes.  J Craniofac Surg   2015  26(2):581-584. 
    , Xie L, Wang Z, Shi H, Cao N, Yu C.   Endoscopic-assisted gland preserving therapy for the management of parotid gland sialolithiasis: Our preliminary experience.   J Craniomaxillofac Surg   2015  43(8):1650-1654. 
    Xie L,, Yu C, Yang C, Chen Z, Yun B, Kim E.  Foreign body induced sialolithiasis treated by sialoendoscopic intervention.   J Craniofac Surg  2014  25(4):1372-1375. 
    Shi H, Yu CQ, Xie LS, Wang ZJ, Zhang P,  Activation of TLR9-dependent p38MAPK pathway in the pathogenesis of primary Sjogren’s syndrome in NOD/Ltj mouse.  J Oral Pathol Med   2014  43(10):785-791. 
    , Yu CQ, Yang C, Xie LS, Shi H, Wang ZJ.   The serological profiles of subgroup of primary Sjogren’s syndrome correlation with the clinical features of parotid glands.   J Craniomaxillofac Surg   2014  42(7):1260-1264. 
    Xie L, Yu CQ,  Bilateral aplasia of the major salivary glands and unilateral atresia of lacrimal duct.   J Craniofac Surg  2013  24(2) :177-179. 
    , L. Y., Kim, E., Yu, C. Q., Yang, C., Park, J., Chen, Z. Z.   A retrospective case series illustrating a possible association between a widened hilum and sialolith formation in the submandibular gland.   J Craniomaxillofac Surg  2013  41(7):648-651.  
    , Yang C, Zhang W, Cai X, Jiang B, Wang B, Pu Y, Jin J, Kim E, Wang J, Zhang Z, Zhou L, Zhou J, Guan X.   Comparison of multi-space infections of the head and neck in the elderly and non-elderly: Part I the descriptive data.  J Craniomaxillofac Surg   2013  41（8）, e208-e212. 
    , Chuangqi Yu, Chi Yang.  Different Lymphoproliferative Disorders in Different Salivary Glands of Primary Sj?gren Syndrome.   J Craniofac Surg   2013  24(5): e462-e465.  
    , L, Yang, C, Zhang, W, Cai, X, Kim, E, Jiang, B, Guan, X.  Is there association between severe multispace infections of the oral maxillofacial region and diabetes mellitus?   J Oral Maxillofac Surg   2012  70(7)： 1565-1572. 
    , Yang C, Kim E, Zhang W, Cai X, Jiang B, Wang B, Pu Y, Jin J, Wang J, Zhang Z, Zhou L, Zhou J, Guan X.   The clinical features of severe multi-space infections of the head and neck in patients with diabetes mellitus compared to non-diabetic patients.  Br J Oral Maxillofac Surg   2012  50（8）: 757–761. 
    , Zhang Z, Yu C, Yang C.   Expression of Toll-like receptors 7, 8, and 9 in primary Sj?gren's syndrome.   Oral Surg Oral Med Oral Pathol Oral Radiol Endod   2010  109(6)：844-850. 
    , Yu C, Zhang Z, Yang C, Cai, X.  Expression of interferon regulatory factor 1, 3, and 7 in primary Sj?gren syndrome.   Oral Surgry, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology  2009  107(5)：661-668. 
    , Zhang Z, Yu C, Tu L, Zhong L, Yang C.  Association between IFN-α and primary Sjogren's syndrome.  Oral Surg Oral Med Oral Pathol Oral Radiol Endod   2009  107(1), e12-e18.