- 基本信息
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导师姓名：
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王玉东
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学科代码：
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100211
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性别：
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男
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学科名称：
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妇产科学
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培养单位：
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附属国际和平妇幼保健院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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妇产科学 专业学位
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联系方式：
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华山路1961号国妇婴5号楼二楼
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专业领域代码：
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105115
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邮编：
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200030
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邮箱地址：
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owangyudong@126.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国医师协会妇产科医师分会 终生会员
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中国中西医结合妇科 常委
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上海市医学会妇产科分会 副主委
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中国医师协会整合盆底医学专业委员会副主委
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中国优生科学协会肿瘤生殖分会 主委
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中国医学装备委员会妇科分会 副主委
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中国妇产科临床杂志编委
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中国妇幼保健协会微创专业委员会 常委
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中国医师协会微无创妇科肿瘤分会 副主委
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世界内镜医师协会妇科分会 副会长
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中国非公协妇产科分会 副主委
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中国实用妇产与产科杂志编委
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- 科研项目
| YDZX20223100003006 | 子宫内膜癌保留生育功能新技术及体系建立 | 上海市科学技术委员会 |
2022-12~2024-11
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200万元
| 课题负责人 |
| 22XD1403500 | 氯丙嗪衍生物治疗子宫内膜癌及孕激素增敏机制 | 上海市科学技术委员会 |
2022-09~2025-08
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40万元
| 课题负责人 |
| XHLHGG202111 | 妊娠期妇科肿瘤规范化诊治及微无创方案的应用 | 徐汇区卫生健康委员会 |
2022-01~2024-12
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70万元
| 课题负责人 |
| SHDC12020130 | 相控聚焦超声截断治疗在子宫肌瘤的应用 | 上海申康医院发展中心 |
2020-12~2023-11
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100万元
| 课题负责人 |
| 20550760600 | 腹腔镜子宫切除术中举宫机器人的关键技术与临床转化 | 上海市科学技术委员会“科技创新行动计划”国际科技合作项目 |
2020-11~2022-11
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35万元
| 课题负责人 |
| shslczdzk06302 | 女性肿瘤生殖专科 | 上海市卫生健康委员会临床重点专科项目“展两翼” |
2019-08~2022-07
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300万元
| 课题负责人 |
| 17441907400 | 相控阵列聚焦超声子宫肌瘤治疗系统临床验证研究 | 上海市科委重点研发项目 |
2017-06~2020-09
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160万元
| 课题负责人 |
| SHDC12016111 | 市级医院新兴前沿技术联合攻关项目（SHDC12016111） | 上海申康医院发展中心市级医院新兴前沿技术联合攻关重大项目 |
2016-10~2019-09
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180万元
| 课题负责人 |
| YG2015ZD10 | 超声引导的pHIFU治疗妇科肿瘤的临床转化 | 上海交通大学 “医工交叉研究基金” |
2016-01~2018-12
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60万元
| 课题负责人 |
| 15411961100 | hcG超声阈值联合Lin28B/Let-7a比值快速诊断早期宫外孕的价值 | 上海市科委 |
2015-07~2017-10
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30万元
| 课题负责人 |
| SHDC12014208 | HCG比值联合超声诊断早期宫外孕的推广应用 | 上海市级重点项目 |
2014-12~2017-01
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15万元
| 课题负责人 |
| XBR2013097 | 子宫内膜癌分子诊断与保留生殖内分泌 | 上海市卫生局 |
2013-12~2016-10
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90万元
| 课题负责人 |
| 20124027 | HCG比值诊断早期宫外孕的前瞻性研究 | 上海市卫生局“常见病、多发病”重点项目 |
2012-11~2014-01
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10万元
| 课题负责人 |
| 81172477 | RANKL/OPG介导内膜癌上皮细胞间质化及孕激素的逆转机制 | 国家自然科学基金面上项目 |
2012-01~2015-01
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58万元
| 课题负责人 |
| 11ZR1440800 | Claudings介导子宫内膜癌细胞发生和转移的作用机制 | 上海市科委自然科学基金 |
2011-04~2014-03
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10万元
| 课题负责人 |
| 30801230 | β雌激素受体介导脱氢表雄酮替代治疗的选择性机制 | 国家自然基金委,青年项目 |
2009-01~2011-12
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20万元
| 课题负责人 |
| 30801229 | 孕激素受体B亚型共调节因子在子宫内膜癌孕激素耐药机制中的作用 | 国家自然科学基金 |
2008-01~2011-01
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20万元
| 课题参与人 |
| 30801230 | β雌激素受体介导脱氢表雄酮替代治疗的选择性机制 | 国家自然科学基金 |
2008-01~2011-01
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20万元
| 课题负责人 |
| 2005ZD006 | 早期子宫内膜癌规范化诊断方案及其优化应用多中心研究 | 上海市卫生局妇科肿瘤重点项目 |
2005-01~2008-01
|
25万元
| 子课题负责人 |
| 044Y066 | β雌激素受体介导脱氢表雄酮防治绝经后骨质疏松的作用 | 上海市卫生局青年基金 |
2004-01~2006-01
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2万元
| 课题负责人 |
- 学术论文
|
, Taowang Wang, Huanhuan Guo, Yaqing Wang, Dezhao Guo, Bo Lu, Ziyi Wang, Fangxun Zhong, Hesheng Wang, Jiangjing Yuan, Yuhong Li, Tak Hong Cheung, Yudong Wang, Yun-huiLiu
|
Design, Control, and Experiments of a Novel Robotic Uterine Manipulator with the Motorized3-DoF Manipulation Rod
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IEEE TRANS BIOMED ENG
|
2023
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70(7):2203-2214
|
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, Yingyao Wang, Lin Zhang, Qin Liu, Feizhou Jiang, Wenjie Hou, Yudong Wang*, Huapan Fang, Yueming Zhang
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Cancer cell membrane-enveloped dexamethasone normalizes the tumor microenvironment and enhances gynecologic cancer chemotherapy
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ACS Nano
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2023
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doi: 10.1021/acsnano.3c03013
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,Fan Qiong, Wang Jing, Yang Xiaoming, Yuan Jiangjing, Li Yuhong, Sun Xiao,Wang Yudong
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TRPS1 regulates the opposite effect of progesterone via RANKL in endometrial carcinoma and breast carcinoma
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Cell Death Discov
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2023
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9(1):185
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, Yaru Sheng, Xiao Sun, Yudong Wang
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New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions
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Cancer Metastasis Rev
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2023
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doi: 10.1007/s10555-023-10113-2
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, Qiong Fan, Yudong Wang,Yuhong Li
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Benign metastasizing uterine leiomyoma with lymphatic and pulmonary metastases: a case report and literature review
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BMC Womens Health
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2023
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23(1):154
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,Sheng Yaru
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Editorial: Diagnosis and treatment of gynecologic malignancies during pregnancy
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Front Oncol
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2023
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13:1143610
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, Li Yuhong, Bo Di, Wang Jiandong, Wang Yudong
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High-risk human papilloma virus infection in pregnant women: a descriptive analysis of cohorts from two centers
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J Investig Med
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2023
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70(7):1494-1500
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, Jing Wang, Linlin Yang, Lijuan Li, Xiaoyan Gao, Xiao Sun, Jingfeng Bai, Jichang Liu, Xin Pu, Yudong Wang
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Enhanced Chemodynamic Therapy Mediated by a Tumor-Specific Catalyst in Synergy with Mitophagy Inhibition Improves the Efficacy for Endometrial Cancer
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Small
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2023
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19(33):e2301497
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,Li Yuhong,Yang Xiaoming,Fan Qiong,Cao Dan,Wang Yudong
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Daily variations and levels of human chorionic gonadotropin before methotrexate treatment as predictors of treatment success
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J Obstet Gynaecol Res
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2022
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48(12):3128-3136
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, Gong Xiaodi, Yang Linlin, Li Lijuan, Gao Xiaoyan, Ni Ting, Yang Xiaoming, Fan Qiong, Sun Xiao, Wang Yudong
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Loss of exosomal miR-26a-5p contributes to endometrial cancer lymphangiogenesis and lymphatic metastasis
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Clin Transl Med
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2022
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12(5):e846
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, Liu Xiaohu, Cui Yunxia,Cheng Yang, Wu Huiwen,Wang Jing, Gong Xiaodi, Gao Xiaoyan, Yang Linlin, Li Jian, Sun Xiao, Mao Fei, Wang Yudong
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Novel chlorpromazine derivatives as anti-endometrial carcinoma agents with reduced extrapyramidal side effects
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Bioorg Chem
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2022
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127:106008
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, Gong Xiaodi, Wang Jing, Fan Qiong, Yuan Jiangjing, Yang Xiaoming, Sun Xiao, Li Yuhong, Wang Yudong
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Functional mechanisms of TRPS1 in disease progression and its potential role in personalized medicine
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Pathol Res Pract
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2022
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237:154022
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, Yuan Jiangjing, Wang Jing, Wang Liya, Li Yuhong, Wang Yudong
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Ovarian Mature Cystic Teratoma is an Independent Risk Factor for the Premature Rupture of Membranes in Pregnancy: a Single-Center Retrospective Study
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Int J Womens Health
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2022
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14:1477-1487
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,Shi TianMing,Gu ShengLan,Li YuHong, Yang XiaoMing, Fan Qiong, Wang YuDong
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A novel cervix carcinoma biomarker: Pathological-epigenomics, integrated analysis of MethylMix algorithm and pathology for predicting response to cancer immunotherapy
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Front Oncology
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2022
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12:1053800
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, Mao Zhanrui, Lu Qi, Xu Peng, Wang Chengyang, Xu Xiaona, Zhou Zhaowei, Zhang Tongsheng, Yu Wenqiang, Dong Shihua, Wang Yudong, Cheng Weiwei
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Hypermethylated PCDHGB7 as a Biomarker for Early Detection of Endometrial Cancer in Endometrial Brush Samples and Cervical Scrapings
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Frontiers in Molecular Biosciences
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2021
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8:774215
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, Ji Xiang, Niu Jianmei, Sun Taotao, Qian Zhaoxia, Li Yuhong, Yuan Jiangjing, Fan Qiong, Huang Qianwen, Bai Jingfeng, Wang Yudong
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Ultrasound-guided high-intensity focused ultrasound for devascularization of uterine fibroid: a feasibility study
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Ultrasound Med Biol
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2021
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47(9):2622-2635
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, Zheng Panchan, Sun Xiao, Zeng Judan, Cao Wenjiao, Gao Wuyuan, Wang Yudong, Wang Lihua
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Hsa_Circ_0001860 Promotes Smad7 to Enhance MPA Resistance in Endometrial Cancer via miR-520h
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Front Cell Dev Biol
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2021
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29;9:738189
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, Wu Huiwen, Yang Linlin, Huang Ting, Li Jian, Gong Xiaodi, Li Lijuan, Sun Xiao, Mao Fei, Wang Yudong
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Chlorpromazine Sensitizes Progestin-Resistant Endometrial Cancer Cells to MPA by Upregulating PRB
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Frontiers in Oncology
|
2021
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11:665832
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, Pu Xin, Wang Jing, Yang Linlin, Cui Yunxia, Li Lijuan, Sun Xiao, Liu Jichang, Bai Jingfeng, Wang Yudong
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Enhancing of Nanocatalyst-Driven Chemodynaminc Therapy for Endometrial Cancer Cells Through Inhibition of PINK1/Parkin-Mediated MitopHagy
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Int J Nanomedicine
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2021
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16: 6661-6679
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, Lu Qi, Xu Peng, Chen Limei, Duan Xiaoling, Mao Zhanrui, Zhang Baolong, Sui Long, Wang Yudong, Yu Wenqiang
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Hypermethylated PCDHGB7 as a universal cancer only marker and its application in early cervical cancer screening
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Clin Transl Med
|
2021
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11(6):e457
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|
Yiwei Wang, Xiao Sun, Ting Huang,
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Identification of a potential prognostic lncRNA-miRNA-mRNA signature in endometrial cancer based on the competing endogenous RNA network.
|
Journal of Cellular Biochemistry.
|
2019
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doi: 10.1002/jcb.29200.
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QI,LU, YIWEI,, XIAO,SUN,Yudong Wang
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The diagnostic role of the β-hCG discriminatory zone combined with the endometrial pattern for ectopic pregnancy in Chinese women
|
Scientific Reports
|
2019
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9(1):13781
|
|
Xiu Li, Chen Zhang, Yuhong Li , Jiangjing Yuan , Qi Lu ,
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Predictive values of the ratio of beta-human chorionic gonadotropin for failure of salpingostomy in ectopic pregnancy
|
Int J Clin Exp Pathol
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2019
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12(3):901-908
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Shenglan Gu, Ting Ni, Jing Wang, Liu Yao, Qiong Fan, Yiwei Wang, Ting Huang, Yiwei Chu, Xiao Sun,
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CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer
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J Imm Res
|
2018
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6156757
|
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T. Ni, Y. Liu, Y. Huang, X. Sun, J. Wang,
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Hysteroscopy combined dilatation and curettage, serum CA125 and CA19-9 play an important role in preserving fertility or endocrine function for early-stage endometrial cancer patients
|
European Journal of Gynaecological Oncology
|
2017
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XXXVIII（1）：49-53
|
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Yao Liu, Jing Wang, Ting Ni, Lihua Wang,, Xiao Sun
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CCL20 mediates RANK/RANKL-induced epithelial-mesenchymal transition in endometrial cancer cells
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Oncotarget
|
2016
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7(18): 25328-25339
|
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Qiong Meng, Xiao Sun, Jing Wang,, Lihua Wang.
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The important application of thioridazine in the endometrial cancer
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AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
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2016
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8(6): 2767~2775
|
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Ni T, Sun X, Shan B, Wang J, Liu Y, Gu SL and Wang YD
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Detection of circulating tumour cells may add value in endometrial cancer management
|
Eur J Obstet Gynecol Reprod Biol
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2016
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207: 1-4.
|
|
严琦, 赵文霞, 朱宇,
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微小RNA在诊断异位妊娠中的应用
|
中华医学杂志
|
2015
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95(27):2227-2229
|
|
JING WANG1*, XIAO SUN2*, HUIJUAN ZHANG3,
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MPA influences tumor cell proliferation, migration, and invasion induced by RANKL through PRB involving the MAPK pathway in endometrial cancer
|
ONCOLOGY REPORTS
|
2015
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33(2):70-9
|
|
孙笑,
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子宫内膜癌淋巴结切除的必要性
|
中国医师杂志
|
2015
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17(8):1127-1130
|
|
刘瑶,
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子宫内膜癌的孕激素拮抗及增敏机制
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国际妇产科学杂志
|
2015
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42(1):104-107
|
|
孟琼,孙笑,王晶,
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甲硫哒嗪联合孕激素抑制子宫内膜癌细胞增殖作用机制
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中华医学杂志
|
2015
|
95(19):1540-1544
|
|
周贇,李丽蟾,陆琦,
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血清β-HCG阴道超声阈值联合子宫内膜厚度诊断异位妊娠的价值
|
现代妇产科进展
|
2015
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24(8):577—579
|
|
Yan Q, Lu Q, Tao Y,, Zhao WX
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Diagnostic value of the plasmatic ADM level for early ectopic pregnancy
|
International Journal of Clinical and Experimental Pathology
|
2015
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8 (11) :14812-7
|
|
严琦, 陆琦,, 赵文霞
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血浆肾上腺髓质素水平对早期异位妊娠的诊断价值
|
上海交通大学学报
|
2015
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35(7):995-998
|
|
刘瑶,, 孙笑, 王晶
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RANKL对人子宫内膜癌细胞上皮间质转化的影响
|
现代妇产科进展
|
2015
|
24(8):41-44
|
|
Wang J, Liu Y, Wang L, Sun X,
|
Clinical prognostic significance and pro-metastatic activity of RANK/RANKL via the AKT pathway in endometrial cancer
|
Oncotarget
|
2015
|
7（5）：5564-5575
|
|
Lu Qi, Li Yuhong, Shi Hong, Lang Xiao,
|
The value of ratio of hCG, progesterone in local blood of pregnancy location versus venous blood in the diagnosis of ectopic pregnancy
|
Int J Clin Exp Med
|
2015
|
8(6):9477-9483
|
|
倪婷,
|
肿瘤细胞弥散机制及循环肿瘤细胞的检测和临床应用
|
国际肿瘤学杂志
|
2015
|
42(11):841-844
|
|
王晶,孙笑,王丽华,
|
PRB介导子宫内膜癌细胞对MPA敏感性的作用机制研究
|
中国药理学通报
|
2014
|
30(9):1252-1256
|
|
郑静, 孙笑, 王晶, 王丽华,
|
三氟拉嗪对人子宫内膜癌Ishikawa细胞的抑制作用
|
上海交通大学学报(医学版)
|
2014
|
34(5):609-612
|
|
, Teng YC, Zhang J, Sun F, Cheng WW.
|
Prediction of location of gestational sac for pregnancy of unknown location at first sight during exploratory surgery using the ratio of hCG in haemoperitoneum and venous serum
|
Eur J Obstet Gynecol Reprod Biol
|
2013
|
169(1):99-102
|
|
王晶,
|
早期子宫内膜癌临床分期准确性评估研究进展
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中国妇产科临床杂志
|
2013
|
14(4):372-374
|
|
Li X, Li Y, Qiu H,
|
Downregulation of claudin-7 potentiates cellular proliferation and invasion in endometrial cancer
|
Oncol Lett
|
2013
|
6(1):101-105
|
|
, TAO Min-fang, CHENG Wei-wei, LIU Xiao-hua, WAN Xiao-ping
|
Dehydroepiandrosterone indirectly inhibits human osteoclastic resorption via activating osteoblastic viability by the MAPK pathway
|
Chin Med J
|
2012
|
125(7):1230-1235
|
|
,陶敏芳,王丽华,黄勇,万小平
|
β雌激素受体介导脱氢表雄酮对OPG/RANKL的升调节
|
中国药理学通报
|
2012
|
28(4):486-9
|
|
, Tao MF, Wang L, Cheng WW, Wan XP
|
Selective regulation of
osteoblastic OPG and RANKL by dehydroepiandrosterone through activation of the estrogen receptor β-mediated MAPK signaling pathway
|
Horm Metab Res
|
2012
|
44(7):494-500
|
|
Qi Y, Wang J,, Ai Z, Teng Y
|
Peritoneal relative to venous serum
biomarker concentrations for diagnosis of ectopic pregnancy
|
Arch Gynecol Obstet
|
2012
|
285(6):1611-7
|
|
, Qiao W, Zhao X, Tao M
|
Quantitative assessment of the influence of hematopoietically expressed homeobox variant (rs1111875) on type 2 diabetes risk
|
Mol Genet Metab
|
2011
|
102(2):194-9
|
|
Wang L, Hao Q,, Wang WJ, Li DJ
|
Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells
|
Atherosclerosis
|
2011
|
214(1):47-57
|
|
,郎虓,陶敏芳,程蔚蔚
|
ERβ介导脱氢表雄酮对成骨细胞的选择性作用
|
中华妇产科杂志
|
2011
|
46(9):674-677
|
|
, Zhao H, Teng Y, Lu L, Tong J
|
Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy
|
Fertil Steril
|
2010
|
93(3):702-705
|
|
仇雅璟,
|
腹腔血与静脉血人绒毛膜促性腺激素比值诊断早孕合并黄体破裂
|
中华妇产科杂志
|
2010
|
45(8)639-40
|
|
孙旭妍,陶敏芳,
|
β雌激素受体沉寂表达载体的构建及表达
|
中国医药生物技术
|
2010
|
5(5):353-356
|
|
Ai Z, Wang J,, Lu L, Tong J, Teng Y
|
Overexpressed epidermal growth
factor receptor (EGFR)-induced progestin insensitivity in human endometrial carcinoma cells by the EGFR/mitogen-activated protein kinase signaling pathway
|
Cancer
|
2010
|
116(15):3603-13
|
|
, Kemi Cui, Hong Zhao, DaJin Li
|
Bushen Ningxin Decoction pharmacological serum promotes the proliferation
and suppresses the apoptosis of murine osteoblasts through MAPK pathway
|
Journal of Ethnopharmacology
|
2009
|
122(2):221-226
|
|
郎虓,,黄亚绢,罗来敏.
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COX-2与VEGF在子宫内膜腺癌肌层侵袭和淋巴转移
|
中国实用妇科与产科杂志
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2009
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25(6):441-443
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童剑倩,,罗来敏,陆丽华
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腹腔镜中转开腹手术20例临床分析
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现代妇产科进展
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2009
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18(1):76-77
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|
Wang L,, Wang WJ, Li DJ.
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Differential regulation of dehydroepiandrosterone and estrogen on bone and uterus in ovariectomized mice.
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Osteoporos Int
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2009
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20(1):79-92
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郎虓,,罗来敏
|
子宫内膜癌组织中COX-2的表达与细胞增殖的关系
|
中国医药指南
|
2009
|
7(5):1-3
|
|
郎虓,黄亚绢,
|
早期子宫内膜癌单独使用孕激素治疗的研究进展
|
中华妇产科杂志
|
2008
|
43(5):391-393
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|
Ling Wang,, Wen-Jun Wang, Ying Zhu and Da-Jin Li.
|
Dehydroepiandrosterone improves murine osteoblast growth and bone tissue morphometry via mitogen-activated protein kinase signaling pathway independent of either androgen receptor or estrogen receptor.
|
Journal of Molecular Endocrinology
|
2007
|
38(4):467–479
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|
,艾志宏,罗来敏.
|
保留生殖功能的子宫内膜癌治疗研究
|
国际肿瘤学杂志
|
2007
|
7:535-537
|
|
,李大金,王文君,等
|
补肾宁心方对小鼠绝经后骨质疏松的选择性作用
|
中华中医药杂志
|
2006
|
21(3):156-159
|
|
, Ling Wang, Dajin Li and Wenjun Wang
|
Dehydroepiandrosterone Inhibited the Bone Resorption through the
Upregulation of OPG/RANKL
|
Cellular & Molecular Immunology
|
2006
|
3(1):41-45
|
|
,童剑倩,罗来敏,等
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脱氢表雄酮对成骨细胞ERβ的上调节作用
|
中国药学杂志
|
2006
|
41(3):231-234
|
|
,李大金,王文君,等
|
补肾宁心方对小鼠绝经后骨质疏松的影响
|
中国中西医结合杂志
|
2005
|
25(11):1000-1003
|
|
,罗来敏,童剑倩,等
|
脱氢表雄酮抑制成骨细胞凋亡的实验研究
|
中华妇产科杂志
|
2005
|
40(12):844-845
|
|
,李大金,朱影
|
补肾宁心方对小鼠成骨细胞的增殖和抗凋亡作用
|
中国中西医结合杂志
|
2004
|
24(3):230-233
|
|
,李大金
|
雌激素受体家族及其相关的辅助分子
|
国外医学内分泌学分册
|
2004
|
24:57-59
|
|
,李大金,高建军
|
脱氢表雄酮抑制骨吸收的作用机制
|
中国药学杂志
|
2004
|
39(6):429-431
|
|
,李大金,袁敏敏,等
|
脱氢表雄酮通过丝裂活化蛋白激酶途径促进成骨细胞增殖的研究
|
中华老年医学杂志
|
2004
|
23(12):867-870
|
|
, Da-jin Li, Fang Lian, Jian-wei Zhang
|
Intratubal methotrexate injection combined with Chinese Herbal Medicine for tubal pregnancy and following pregnancy prognosis
|
Chi J Integr Med
|
2003
|
9(2):93-7
|
|
,李大金
|
绝经后骨质疏松症发生的分子机制
|
中华老年医学杂志
|
2003
|
22(3):187-188
|
|
LIAN Fang,, ZHANG Ning
|
Progress in study on shen-invigorating herbs used in promoting follicular development
|
CJIM
|
2003
|
9(1):76-78
|
|
, 李大金
|
半夏蛋白抗早孕研究的回顾与展望
|
中国中西医结合杂志
|
2003
|
23(6):475－7
|
|