- 基本信息
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导师姓名：
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陈晓东
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学科代码：
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100210
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性别：
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男
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学科名称：
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外科学
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培养单位：
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附属新华医院
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三级学科
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骨外
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导师类型：
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博士生导师
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专业领域名称：
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外科学 专业学位
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联系方式：
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021-25077950
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专业领域代码：
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105111
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邮编：
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200092
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邮箱地址：
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chenxdmd@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国医师协会骨科分会常务委员
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国际髋关节协会委员
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中华外科杂志通讯编委
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中华医学会骨科分会关节外科学组委员
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中华创伤骨科杂志通讯编委
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中华骨科杂志通讯编委
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上海市医学会骨科分会关节外科学组副组长
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中华手外科杂志编委
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中华医学会骨科分会基础学组委员
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中华解剖与临床杂志编委
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中国医师协会骨科分会关节外科委员会保髋组组长
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中国医师协会骨科分会常委
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国际骨科学杂志编委
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中华临床医师杂志编委
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- 科研项目
| 82172473 | 核仁小RNA SNORD14d协同宿主基因HSC70调控骨关节炎发生机制研究 | 国自然面上项目 |
2022-01~2025-12
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55万元
| 课题负责人 |
| YG2019ZDA22 | 数字化影像学辅助下股骨颈基底部旋转截骨治疗股骨头坏死的临床应用以及疗效分析 | 上海交通大学 |
2020-01~2022-12
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100万元
| 课题负责人 |
| 19ZR1433100 | 骨关节炎中M1巨噬细胞外泌体源性miR-212调控软骨细胞自噬的机制 | 上海市科委 |
2019-07~2022-06
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20万元
| 课题负责人 |
| 18JXO08 | 新华-渥太华不同围手术期管理方式对初次髋关节置换效果影响的比较观察 | 新华医院 |
2019-03~2022-03
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15万元
| 课题负责人 |
| 16CR2036B | 基于力敏感分子的先天性髋关节发育不良生物标志物筛选及早期防治策略研究 | 促进市级医院临床技能与临床创新三年行动计划疑难疾病精准诊治攻关项目 |
2016-12~2019-06
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60万元
| 课题负责人 |
| 20134002 | Bernese髋臼周围截骨术中确定髋臼截骨块前倾角度的方法学研究 | 卫生局 |
2014-01~2016-12
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10万元
| 课题负责人 |
| 2015XH011 | 中枢性偏瘫上肢功能恢复的外科新技术开发与推广 | 横向 |
2013-07~2016-06
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36万元
| 课题负责人 |
| 81171705 | 不同类型假体的骨界面应变对成骨细胞Ⅰ型胶原合成的影响 | 国家自然基金委,面上项目 |
2012.1.1-~2015.12.31
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58万元
| 课题负责人 |
| 08YZ37 | 压应力对构建半月板代谢及生物力学影响 | 上海市教委,发展基金 |
2008-01~2009-12
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8万元
| 课题负责人 |
| 30471748 | 应力调控骨髓间质干细胞分化为骨骼肌细胞的研究 | 国家自然基金委,面上项目 |
2005-01~2007-12
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21万元
| 课题负责人 |
- 学术论文
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Sun X, Jiao X, Yang X, Ma J, Wang T, Jin W, Li W, Yang H, Mao Y, Gan Y, Zhou X, Li T, Li S,, Wang J
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3D bioprinting of osteon-mimetic scaffolds with hierarchical microchannels for vascularized bone tissue regeneration.
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Biofabrication
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2022
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22;14(3)
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Peng J, Xiao F, Zhu J, Shen C, Li Y, Han X, Cui Y,
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Characteristics of the patellofemoral joint of patients with DDH and the effects of Bernese periacetabular osteotomy on the patellofemoral joint.
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BMC Musculoskelet Disord
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2022
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8;23(1):337
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Li Z, Chen K, Liu P,, Zheng G
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Entropy and distance maps-guided segmentation of articular cartilage: data from the Osteoarthritis Initiative.
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Clin Orthop Relat Res
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2022
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17(3):553-560
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Xiao F, Peng J, Li Y, Zhou X, Ma D, Dai L, Yuan J,, Wang C
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Small Noncoding RNAome Changes During Human Bone Marrow Mesenchymal Stem Cells Senescence In Vitro.
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Front Endocrinol (Lausanne)
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2022
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13;13:808223
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Junfeng Zhu#; Kangming Chen#; Jianping Peng; Yang Li; Chao Shen i*; Xiaodong Chen*
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Femoral neck rotational osteotomy: a modified method for treating necrotic femoral heads with large and laterally located lesions
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Journal of Hip Preservation Surgery
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2021
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Vol. 00, No. 0, pp. 1–8
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Xu LY, Chen KM, Peng JP, Zhu JF, Shen C,
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Outcomes After Management of Subspine and Femoroacetabular Impingement Using a Direct Anterior Mini-Open Approach.
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Orthopaedic Journal of Sports Medicine
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2021
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9(12):91-96.
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李扬,刘怡卓,沈超,朱俊峰,彭建平,肖飞,崔一民,郭亚平,
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生物玻璃/壳聚糖三维多孔支架的抗感染性能和生物相容性研究
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生物骨科材料与临床研究
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2020
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v.17;No.99(02), 55-60.
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CL Wang,B Zuo,D Li,JF Zhu,
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The long noncoding rna h19 attenuates force-driven cartilage degeneration via mir-483–5p/dusp5
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Biochemical and Biophysical Research Communications
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2020
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529(2), 210-217.
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Bin Zuo1*, Jun Feng Zhu1*, Xu Yi Wang2, Cheng Long Wang1,
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Outcome of the modified Dunn procedure in severe slipped capital femoral epiphysis
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Journal of Orthopaedic Surgery and Research
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2020
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3;15(1):506. doi: 10.1186/s13018-020-02036-3.
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Zhu J, Li Y, Chen K, Xiao F, Shen C, Peng J
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Iliopsoas tendonitis following total hip replacement in highly dysplastic hips: a retrospective study.
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Journal of orthopaedic surgery and research
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2019
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2019;14:145
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Wang X, Liu S, Peng J, Zhu Z, Zhang L, Guan J,
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Development of a novel customized cutting and rotating template for Bernese periacetabular osteotomy
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Journal of orthopaedic surgery and research
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2019
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2019;14:217.
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Li, Wang H, He JY, Wang CL, Feng WJ, Shen C
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Inflammatory and fibrosis infiltration in synovium associated with the progression in developmental dysplasia of the hip.
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Molecular medicine reports
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2019
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2019;19:2808-16.
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Min Hu, Fei Xiao, Qin-Fei Ke, Yang Li,, Ya-Ping Guo.
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Cerium-doped Whitlockite Nanohybrid Scaffolds Promote New Bone Regeneration via SMAD Signaling Pathway
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Chemical Engineering Journal
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2018
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359 (2019) 1–12
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Gao Y#, Xiao F#, Wang C, Wang C, Cui P, Zhang X*,
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Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells
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J Cell Biochem
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2018
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;119(8):6986-6996
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Li, Wang C, Li Z, Wang H, He J, Zhu J, Zhang Y, Shen C, Xiao F, Gao Y, Zhang X,, Wang P, Peng J, Cai G, Zuo B, Yang Y, Shen Y, Song W, Zhang X, Shen L, Chen X
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Nano-sized Al2O3 particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts
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Cell Death Dis
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2018
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6;9(8):840
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Xiao F#, Wang C#, Wang C#, Gao Y, Zhang X*,
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BMPER Enhances Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells
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Cell Physiol Biochem
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2018
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45(5):1927-1939
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Li, Wang H, Li Z, Wang C, Xiao F, Gao Y, Zhang X, Wang P, Peng J, Cai G, Zuo B,, Qi J, Qian N, Deng L, Song W, Zhang X, Shen L, Chen X
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The inhibition of RANKL expression in fibroblasts attenuate CoCr particles induced aseptic prosthesis loosening via the MyD88-independent TLR signaling pathway
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Biochem Biophys Res Commun
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2018
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503(2):1115-1122
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Wang CL#, Xiao F#, Wang CD, Zhu JF, Shen C, Zuo B, Wang H, Li D, Wang XY, Feng WJ, Li ZK,, Zhang X*, Chen XD*
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Gremlin2 Suppression Increases the BMP-2-Induced Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Via the BMP-2/Smad/Runx2 Signaling Pathway
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J Cell Biochem
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2017
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118(2):286-297
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Wang CL,, Chen XD
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Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip
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Biochem Biophys Res Commun
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2017
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1;485(2):400-408
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Feng WJ, Wang H,
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Severe cartilage degeneration in patients with developmental dysplasia of the hip
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IUBMB Life
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2017
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69(3):179-187
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Wang CL, Li D,
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Anti-inflammatory and anti-osteoarthritis effects of tectorigenin
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Biol Open
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2017
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15;6(8):1130-1136
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Wang X#, Peng J#, Li, Zhang L,, Jiang L*, Chen X*
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Does the optimal position of the acetabular fragment should be within the radiological normal range for all developmental dysplasia of the hip? A patient-specific finite element analysis
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J Orthop Surg Res
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2016
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4;11(1):109
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Xuyi W#, Jianping P#, Junfeng Z, Chao S,, Xiaodong C*
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Application of three-dimensional computerised tomography reconstruction and image processing technology in individual operation design of developmental dysplasia of the hip patients
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Int Orthop
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2016
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40(2):255-65
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Zuo B, Zhang X,
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microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2
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J Bone Miner Res.
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2015
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30(2):330-45.
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Wang H, Zhang X, He JY, Zheng XF, Li D, Li Z, Zhu JF, Shen C, Cai GQ,
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Increasing expression of substance P and calcitonin gene-related peptide in synovial tissue and fluid contribute to the progress of arthritis in developmental dysplasia of the hip.
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Arthritis Res Ther.
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2015
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12;17(1):4.
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Zhu J, Shen C,, Cui Y, Peng J, Cai G.
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Total hip arthroplasty with a non-modular conical stem and transverse subtrochanteric osteotomy in treatment of high dislocated hips.
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J Arthroplasty.
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2015
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30(4):611-4
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C.Shen. G.Q.Cai. J.P. Peng. X.D. Chen（通讯作者）
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Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling
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Osteoarthritis Cartilage
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2015
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23 2279—2287
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Chao Shen,Wen Gu,Gui-Quan Cai, Jian-Ping Peng,
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Autophagy protects meniscal cells from glucocorticoids-induced apoptosis via inositol trisphosphate receptor signaling
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Apoptosis
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2015
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20:1176–1186
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Wang H, Zheng XF, Zhang X, Li Z, Shen C, Zhu JF, Cui YM,
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Increasing substance P levels in serum and synovial tissues from patients with developmental dysplasia of the hip (DDH).
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BMC Musculoskelet Disord.
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2014
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19;15:92
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Shen C,, Yan J.
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Nitric oxide inhibits autophagy in human chondrocytes: comment on the article by Sasaki et al.
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Arthritis& Rheumatism
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2013
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65(1):287-8
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张跃辉,
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THE ROLE AND CLINICAL SIGNIFICANCE OF YES-ASSOCIATED PROTEIN 1 IN HUMAN OSTEOSARCOMA
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INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
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2013
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（26）167-177
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何继业,郑新峰,蒋盛旦,蒋雷生,
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Sympathetic neuron can promote osteoblast differentiation through BMP signaling pathway
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Cellular Signalling
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2013
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（25）1372–1378
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沈超,
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Efficacy of treatment in peri-pelvic Morel–Lavallee lesion: a systematic review of the literature
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Arch Orthop Trauma Surg
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2013
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(133):635-640
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朱俊峰,
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Mid-term results of Bernese periacetabular osteotomy
for developmental dysplasia of hip in middle aged patients
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nternational Orthopaedics
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2013
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（37）：589-594
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Shen L,, Zhang YH.
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MicroRNA-128 promotes proliferation in osteosarcoma cells by downregulating PTEN.
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Tumour Biol.
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2013
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35(3):2069-74.
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,王晖
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wnt信号通路中的分子及配体参与成骨与破骨细胞间的转化
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中国组织工程研究与临床康复
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2012
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16(20):3789-3792
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王鹏,崔一民,
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完全脱钙骨基质与骨髓间充质干细胞体外诱导构建组织工程纤维软骨
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中国组织工程研究与临床康复
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2011
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15(8):1350-1354
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朱俊峰,崔一民,沈超,蔡贵泉,
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Bernese 截骨联合骨软骨成形术治疗髋关节发育不良
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中国骨肿瘤骨病
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2011
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10(5):435-440
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王晖,
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软骨组织工程生物反应器研究进展
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国际骨科学杂志
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2011
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32(3):161-163
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,崔一民,沈超,朱俊峰,吴冰,宋煊
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Stoppa入路在髋臼骨折中的应用
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中华骨科杂志
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2011
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31(11):1245-1249
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王晖,崔一民,朱俊峰,周贤德,朱传敏,
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力学刺激联合诱导因子对组织工程软骨的影响
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中国修复重建外科杂志
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2011
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25(11):1377-1382
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蔡贵泉,崔一民,
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骨髓间充质干细胞向纤维软骨细胞表型的诱导分化
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中国组织工程研究与临床康复
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2010
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14(2):218-222
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,催一民,沈超,张翔,王宇仁,朱俊峰,周之德
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髋臼周围截骨术治疗髋关节发育不良
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中华骨科杂志
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2010
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30(2):143-147
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王颖,
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PAO治疗成人DDH的预后影响因素
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解剖与临床
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2010
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15(5):376-378
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王鹏,崔一民,
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半月板组织工程支架材料的研究进展
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临床骨科杂志
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2010
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13(5):559-562
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沈超,马捷,
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The use of ?-TCP in the surgical treatment of tibial plateau fracture
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Knee Surg Sports Traumatol Arthrosc
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2009
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17(12):1406-1411
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Cementless total hip arthroplasty in patients older than 70 years
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J Shanghai Second Med University
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2008
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20(2):77-81
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