- 基本信息
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导师姓名：
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胡海燕
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学科代码：
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100214
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性别：
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女
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学科名称：
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肿瘤学
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培养单位：
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附属第六人民医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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肿瘤学 专业学位
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联系方式：
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xuri1104@163.com
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专业领域代码：
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105121
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邮编：
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200233
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邮箱地址：
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xuri1104@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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上海市医学会分子诊断青年委员会 副主委
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广东省小核酸药物开发工程技术研究中心副主任
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中国抗癌协会肉瘤专委会青年委员
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中华医学会上海市肿瘤分会乳腺癌学组委员
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上海市医学会肿瘤分会青年委员（协会秘书）
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- 科研项目
| 8207101854 | 基于类器官培养骨肉瘤来源的SNORA12外泌体上调Treg细胞TIGIT表达诱 导免疫抑制的机制研究 | 国家自然基金 |
2024-12~2013-12
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55万元
| 课题负责人 |
| 17PJ1407600 | 长非编码RNA,LINC01060,参与骨肉瘤转移机制的研究 | 上海市科学技术委员会 |
2017-07~2019-06
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20万元
| 课题负责人 |
| 81372873 | 长非编码RNA-UCA1调节循环肿瘤细胞抵抗NK细胞杀伤机制的研究 | 国家自然基金 |
2014-01~2017-12
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70万元
| 课题负责人 |
| 81072176 | NK 细胞杀伤效应诱导乳腺癌细胞免疫编辑后耐受的机制研究 | 国家自然基金 |
2011-01~2013-12
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31万元
| 课题负责人 |
| 30800489 | 口服mHags，AML/ETO菌蜕疫苗抗白血病的研究 | 国家自然基金 |
2009-01~2011-12
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20万元
| 课题负责人 |
| 2007B030703003 | 白血病口服疫苗的研究 | 广东省科技计划 |
2008-01~2009-12
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3万元
| 课题负责人 |
| WSTJJ200611165101061 | 光动力纳米－siRNA自体干细胞移植净化法的建立 | 广东卫生厅 |
2008-01~2009-12
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1万元
| 课题负责人 |
- 学术论文
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Yan Zhou,, Yang Dong, Tong Ji, Bing Zhang, Cheng Yang, Shuier Zheng,Lina Tang, Chenliang Zhou, Guowei Qian, Yujing Huang, Wenxi Yu, Hongtao Li,Yonggang Wang,Aina He, Zan Shen, Qiyuan Bao, Yingqi Hua, Hongyu Bai, Jiayi Zhao, Xiaoyi Li, Xiangrong Dai,Jianjun Zhang,Haiyan Hu, and Yang Yao
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First-in-Maintenance Therapy for Localized High-Grade Osteosarcoma: An Open-Label Phase I/II Trial of the Anti–PD-L1 Antibody ZKAB001
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Clinical Cancer Research
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2023
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29:764–74
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, Weiping Ji,Jin Huang,Yawen Zhang,Yan Zhou,Jianjun Zhang,Yang Dong,Ting Yuan,Qingcheng Yang,Xiaomin Ding,Lina Tang,Hongtao Li,Junyi Yin,Yonggang Wang,Tong Ji,Jia Fei,Bing Zhang,Peizhan Chen,Haiyan Hu*
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Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients
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CLNICAL AND TRANSLATIONAL MEDICINE
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2022
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12:e1072
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Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A,, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H,
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Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
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Nature Communication
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2020
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2020 12 10;111(1):6322.
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Yang Su, Yan Zhou, Yuan-jue Sun, Ya-Ling Wang, Jun-yi Yin, Yu-jing Huang, Jian-jun Zhang, Ai-na He, Kun Han, Hui-zhen Zhang, Yang Yao, Xiao-Bin Lv,
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Macrophage-derived CCL18 promotes osteosarcoma proliferation and migration by upregulating the expression of UCA1.
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Journal of Molecular Medicine
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2019
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97(1):49-61
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Wang YL, Shen Y, Xu JP, Han K, Zhou Y, Yang S, Yin JY, Min DL,
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Pterostilbene suppresses human endometrial cancer cells in vitro by down-regulating miR-663b
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Acta Pharmacol Sin.
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2017
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38(10):1394-1400
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Zhou Y, Wang X, Zhang J, He A, Wang YL, Han K, Su Y, Yin J, Lv X,
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Artesunate suppresses the viability and mobility of prostate cancer cells through UCA1, the sponge of miR-184
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Oncotarget
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2017
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8(11):18260-18270
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Zhou Y, Zhao RH, Tseng KF, Li KP, Lu ZG, Liu Y, Han K, Gan ZH, Lin SC,, Min DL1.
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Sirolimus induces apoptosis and reverses multidrug resistance in human osteosarcoma cells in vitro via increasing microRNA-34b expression
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Acta Pharmacol Sin
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2016
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37(4):519-29
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Zhou Y, Lin S, Tseng KF, Han K, Wang Y, Gan ZH, Min DL,
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Selumetinib suppresses cell proliferation, migration and trigger apoptosis, G1 arrest in triple-negative breast cancer cells
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BMC Cancer.
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2016
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21;16(1):818
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Deng L, Wang X, Jiang L, Yang J, Zhou X, Lu Z,
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Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes.
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Int J Biochem Cell Biol.
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2016
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81(Pt A):105-111
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Qing Y,, Liu Y, Feng T, Meng W, Jiang L, Sun Y, Yao Y.
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Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter.
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Cell Biol Int.
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2014
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38(5):563-70.
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, Lv XB, Wang X, Zhang B, Meng W, Yu F, Hu H
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Downregulation of miR-302c and miR-520c by 1,25(OH)2D3 treatment enhances the susceptibility of tumour cells to natural killer cell-mediated cytotoxicity.
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Br J Cancer
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2013
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109(3):723-30.
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,Hu HY,et al
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Down-Regulation MicroRNA-128 sensitizes breast cancer cell to chemodrugs by targeting Bax.
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Cell Biololgy Internal
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2013
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37(7):653-8
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,Yuan Liu,Xiuju Wang,Ling Jiang,Zhigang Lu,Xing zhang,Kunpeng Li,Haiyan Hu*.
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A novel recombinant Salmonella vaccine enhances the innate immunity of NK cells against acute myeloid leukaemia cells Kasumi-1 in vitro.
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Cell Biol Int.
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2013
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37(12):1320-9
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, Li KP, Wang XJ, Liu Y, Lu ZG, Dong RH, Guo HB, Zhang MX
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Set9, NF-κB and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells.
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Acta Pharmacol Sin
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2013
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34(1):157-66
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, Rui Huang, Chaoyang Song, Haiyan Hu*, Meixia Zhang
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Some viral microRNAs were up-regulated in megakaryocytes incubated with immune thrombocytopenia plasma.
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Eno J Hematology
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2013
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90(3):220–227
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,Hu HY,et al.
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MiR-34c oligonucleotide enhances chemosensitivity of Ishikawa cell to cisplatin by inducing apoptosis.
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Cell Biol Int
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2013
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37(6):577-83.
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, Shuqin Li, Xiuying Cui, Xiaobin Lv, Yu Jiao, Fengyan Yu, Herui Yao, Erwei Song, Minghui Wang, Yongsong Chen, Ling Lin.
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The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulphate proteoglycan 2 (HSPG2).
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J Bio Chem.
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2013
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288(16):10973-85.
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, Lu L, Xu J, Meng W, Qing Y, Liu Y, Zhang B, Hu H.
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Bortezomib induces apoptosis of endometrial cancer cells through microRNA-17-5p by targeting p21.
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Cell Biol Int
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2013
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37(10):1114-21.
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, Jia Fei,et al
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miRNA-21 regulates arsenic-induced anti-leukemia activity in myelogenous cell lines
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Medical Oncol
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2011
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28(1):211-218
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, Jia Fei,et
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Antisense oligonucleotide against miR-21 inhibits migration and induces apoptosis in leukemic K562 cells
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Leukemia & Lymphoma
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2010
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51(4):694-701
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