- 基本信息
|
导师姓名：
|
王筱霞
|
学科代码：
|
100201
|
|
|
性别：
|
女
|
学科名称：
|
内科学
|
|
培养单位：
|
附属同仁医院
|
三级学科
|
肾病
|
|
导师类型：
|
博士生导师
|
专业领域名称：
|
内科学 专业学位
|
|
联系方式：
|
工作手机：18121226865
|
专业领域代码：
|
105101
|
|
邮编：
|
200336
|
邮箱地址：
|
Omaha198501@163.com
|
- 研究方向 (点击浏览详细信息)
- 社会任职
| |
|
国家自然科学基金同行评议专家
|
|
上海市医师协会肾脏内科医师分会委员
|
|
上海市医学会肾脏内科专科分会委员
|
- 科研项目
| 2023GHYGJC-ZDB03 | 血液净化用纳米纤维复合膜的临床前研究 | 医工交叉重点项目-上海市同仁医院-东华大学生物与医学工程学院 |
2023-10~2026-10
|
50万元
| 课题负责人 |
| 23DZ2304300 | 认识沉默杀手-慢性肾脏病 | 上海市科学技术委员会 |
2023-07~2024-12
|
50万元
| 课题负责人 |
| 82170745 | PE代谢重编程调控BTK构象与活性介导DKD系膜细胞表型转化的机制研究 | 国家自然科学基金委 |
2022-01~2025-12
|
55万元
| 课题负责人 |
| 81770718 | LncRNA-Gm26749作为ceRNA调控miR-196a-5p介导糖尿病肾病系膜细胞肥大的机制研究 | 国家自然科学基金委 |
2018-01~2021-12
|
56万元
| 课题负责人 |
| 81300602 | MicroRNA-195通过靶向抑制SLC2A3干扰足细胞葡萄糖摄取并导致足细胞损伤的机制研究 | 国家自然科学基金委 |
2014-01~2016-12
|
25万元
| 课题参与人 |
| 81270814 | MiR-26b 在糖尿病肾病系膜细胞肥大中异常表达的机制及功能研究 | 国家自然科学基金委 |
2013-01~2016-12
|
70万元
| 课题负责人 |
| 11410708500 | MicroRNAs靶向GSK3beta参与糖尿病肾病系膜细胞肥大的机制研究 | 上海市科委非政府间国际合作项目 |
2011-10~2013-10
|
25万元
| 课题参与人 |
| CJ2009 | TRPC6在糖尿病系膜细胞氧化应激中的机制及GSPD保护作用的研究 | 国家人事部留学归国人员基金 |
2009-09~2011-08
|
8万元
| 课题负责人 |
- 学术论文
|
Wang YZ, Zhu DY, Zhang N, Wang YL, Ding M, Xie XM, Shen E,
|
Identification of EA15, MIR22, LINC00472 as potential diagnostic markers for Diabetic Kidney Disease.
|
J Cell Physiol
|
2019
|
234(6): 8797-8803.
|
|
Miao N, Yin F, Xie H, Wang Y, Xu Y, Shen Y, Xu D, Yin J, Wang B, Zhou Z, Cheng Q, Chen P, Xue H, Zhou L, Liu J,, Zhang W, Lu L.
|
The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury.
|
Kidney Int.
|
2019
|
96(5):1105-1120.
|
|
Sun L, Ji Y, Wang Y, Zhu D, Chen F, Zhang N, Shen E,
|
Development and validation of a prediction model to estimate the probability of left-ventricular diastolic dysfunction stable maintenance hemodialysis patients without clinical heart failure.
|
Nephron .
|
2019
|
2:1-10
|
|
Linlin Sun, Yongqiang Ji, YonglanWang, Miao Ding, Xinmiao Xie, Dingyu Zhu,Fuhua Chen, Nan Zhang,
|
High-sensitive cardiac troponin T: a biomarker of left-ventricular diastolic dysfunction in hemodialysis patients;
|
J Nephrol
|
2018
|
31(6):967-973
|
|
Miao N, Wang B, Xu D, Wang Y, Gan X, Zhou L, Xue H, Zhang W,, Lu L.
|
Caspase-11 promotes cisplatin-induced renal tubular apoptosis through a caspase-3-dependent pathway.
|
Am J Physiol Renal Physiol.
|
2018
|
314(2): F269-F279
|
|
Wang YZ, Xu WW, Zhu DY, Zhang N, Wang YL, Ding M, Xie XM, Sun LL,
|
Specific expression network analysis of diabetic nephropathy kidney tissue revealed key methylated sites.
|
J Cell Physiol.
|
2018
|
233(10):7139-7147.
|
|
, Shen E, Wang Y, Li J, Cheng D, Chen Y, Gui D, Wang N
|
Cross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions.
|
Sci Rep.
|
2016
|
6: 31506.
|
|
Kong YL, Shen Y, Ni J, Shao DC, Miao NJ, Xu JL, Zhou L, Xue H, Zhang W,, （共同通讯作者）Lu LM.
|
Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway
|
Acta Pharmacol Sin.
|
2016
|
37(2): 217-27
|
|
, Shen E, Wang Y, Jiang Z, Gui D, Cheng D, Chen T, Wang N
|
MiR-196a Regulates High Glucose-Induced Mesangial Cell Hypertrophy by Targeting p27kip1
|
J Lab Autom.
|
2015
|
20(4): 491-9
|
|
Cheng D, Fei Y, Liu Y, Li J, Xue Q,, Wang N
|
HbA1C variability and the risk of renal status progression in Diabetes Mellitus: a meta-analysis
|
PLoS One
|
2014
|
9(12): e115509
|
|
Cheng D, Fei Y, Liu Y, Li J, Chen Y,, Wang N
|
Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus patients with moderate to severe renal impairment: a systematic review and meta-analysis.
|
PLoS One.
|
2014
|
9(10):e111543
|
|
Chen YQ,, Yao XM, Zhang DL, Yang XF, Tian SF, Wang NS
|
Abated microRNA-195 expression protected mesangial cells from apoptosis in early diabetic renal injury in mice.
|
J Nephrol
|
2012
|
25 (4):566-576
|
|
Chen YQ,, Yao XM, Zhang DL, Yang XF, Tian SF, Wang NS
|
MicroRNA-195 Promotes Apoptosis in Mouse Podocytes via Enhanced Caspase Activity Driven by BCL2 Insufficiency
|
Am J Nephrol
|
2011
|
34(6):549-559
|
|
Shen E, Diao X,, Chen R, Hu B
|
MicroRNAs involved in the mitogen-activated protein kinase cascades pathway during glucose-induced cardiomyocyte hypertrophy.
|
Am J Pathol
|
2011
|
179(2):639-50
|
|
, 陈玉强,汪年松
|
Rac1抑制剂上调糖尿病小鼠肾小球nephrin的表达
|
中国中西医结合肾病杂志
|
2010
|
11(7):592-594
|
|
,陈玉强,汪年松
|
糖尿病肾病早期miRNAs表达谱分析
|
中国中西医结合肾病杂志
|
2010
|
11(8):681-683
|
|
, Pluznick JL, Settles DC, Sansom SC
|
Association of VASP with TRPC4 in PKG-mediated inhibition of the store-operated calcium response in mesangial cells
|
Am J Physiol Renal Physiol
|
2007
|
293(6):1768-1776
|
|
, Pluznick JL, Wei P, Padanilam BJ, Sansom SC
|
TRPC4 forms store-operated Ca2+ channels in mouse mesangial cells
|
Am J Physiol Cell Physiol
|
2004
|
287(2):C357-64
|
|