- 基本信息
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导师姓名：
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张旻
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学科代码：
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100201
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性别：
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女
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学科名称：
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内科学
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培养单位：
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附属第一人民医院
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三级学科
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呼吸系病
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导师类型：
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博士生导师
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专业领域名称：
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内科学 专业学位
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联系方式：
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上海市第一人民医院呼吸与危重症医学科，海宁路100号2号楼9楼
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专业领域代码：
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105101
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邮编：
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200080
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邮箱地址：
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13482345145@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国医药教育协会呼吸病康复专业委员会常务理事
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上海市医学会感染与化疗学会青年副主任委员
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中国老年医学会哮喘专业委员会委员
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上海市抗癌协会呼吸介入分会委员
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上海市女医师协会肺癌专委会常委
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中国研究型医院学会支气管哮喘专委会委员
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中国老年医学会哮喘专业委员会委员
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上海市医学会呼吸病学分会委员
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中国医师协会呼吸医师分会哮喘和呼吸变态反应疾病工作组委员兼秘书
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上海市药学会抗生素学会委员
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中华医学会呼吸分会哮喘学组专家组成员兼副组长
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中国医师协会呼吸医师分会委员
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中华医学生物工程杂志编委
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上海市中西医呼吸专委会常委
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海峡两岸医药卫生交流协会呼吸病专家委员会常委
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上海市医师协会呼吸内科分会副会长
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上海市医学会内科分会副主任委员
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上海市防痨协会常务理事
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- 科研项目
| 82270027 | 哮喘易感转录因子Bach2调控Treg细胞影响气道高反应性的作用机制研究 | 国家自然科学基金面上项目 |
2023-01~2026-12
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53万元
| 课题负责人 |
| CTCCR-2021B07 | 基于症状问卷﹑肺功能﹑全身及气道炎症指标﹑影像大数据深度学习/人工智能在支气管哮喘疗效预判及急性发作预警中的作用 | 院级特色研究计划 |
2021-12~2024-12
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50万元
| 课题负责人 |
| 02.06.01.21.13 | 上海市第一人民医院特色人才培养计划-上海领军人才 | 院级 |
2021-12~2024-12
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100万元
| 课题负责人 |
| SHD2020CR5 | 重症肺炎专病队列数据库与生物样本全息库建设 | 促进市级医院临床技能与临床创新三年行动计划共建单位 |
2020-12~2022-09
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26万元
| 课题参与人 |
| 20Z11900903 | 急性呼吸道传染病的早期识别与重症预警研究 | 上海市科委科创项目子课题 |
2020-12~2024-12
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31万元
| 子课题负责人 |
| 20Y11902400 | 通过深度学习的人工智能诊断模式在支气管哮喘早期诊断中的应用研究 | 上海市科委科创项目 |
2020-12~2023-12
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30万元
| 课题负责人 |
| 2020XGZX009 | 新型冠状病毒肺炎重症危险因素评估及早期个体化干预的临床研究 | 浙江大学医工交叉课题 |
2020-02~2021-02
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80万元
| 课题负责人 |
| YG2020YQ22 | 新型冠状病毒肺炎重症危险因素评估数据模型建立以及通过获益风险模型进行免疫调节及呼吸支持的临床研究 | 上海交通大学医工交叉课题 |
2020-02~2020-08
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70万元
| 课题负责人 |
| 2019SY042 | 慢性气道疾病肺功能/影像/炎症水平的规范化诊断和评估 | 上海市卫生系统先进适宜技术推广项目 |
2019-07~2022-06
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30万元
| 课题负责人 |
| 81873402 | STAT3/SOCS3信号通路在氧化应激诱导激素抵抗型哮喘中的作用机制研究 | 国家自然基金面上项目 |
2019-01~2022-12
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58万元
| 课题负责人 |
| 201740039 | 基于增强/沉默SOCS3基因表达干预激素抵抗型哮喘的研究 | 卫计委面上项目 |
2018-01~2020-12
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10万元
| 课题负责人 |
| 0703N16017 | 17α-羟孕酮对慢性氧化应激所致气道重塑的影响及作用机制研究 | 横向课题 |
2017-01~2019-12
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16.7万元
| 课题负责人 |
| 0703N14007 | 孕激素治疗慢性阻塞性肺病的动物模型药效学研究 | 其他委办局 |
2015-01~2015-12
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5.7万元
| 课题负责人 |
| 81100033 | IL-17A功能抑制对慢性氧化应激所致气道炎症/高反应性的直接作用及激素抵抗作用研究 | 国家自然科学基金 |
2012-01~2014-12
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22万元
| 课题负责人 |
- 学术论文
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Zhou Y#, Qiu Y#, Bao W, Han L, Xue Y, Zhang Y, Tian X, Fu Q, Lv C, Yin D,
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Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-life.
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Front Immunol.
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2023
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14:1107031.
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Pan Y#, Zhang X#, Sun Y#, Zhang Y, Bao W, Yin D, Zhang P,
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Cellular analysis and metagenomic next-generation sequencing of bronchoalveolar lavage fluid in the distinction between pulmonary non-infectious and infectious disease.
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Front Cell Infect Microbiol.
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2023
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12:1023978.
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Lei Zhao#, Jie Fang#, Yong Ji, Yingying Zhang, Xin Zhou, Junfeng Yin, Min Zhang*,
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K-means cluster analysis of characteristic patterns of allergen in different age: real life study.
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Clinical and Translational Allergy.
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2023
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13(7):e12281
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Shen Z, Wang Y, Bao A, Yang J, Sun X, Cai Y, Wan L, Huang C, Xu X, Niu J, Xia X, Shen C, Wei Y, Qiu H, Zhou K,, Tong Y, Song X.
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Metagenomic Next-Generation Sequencing for Pathogens in Bronchoalveolar Lavage Fluid Improves the Survival of Patients with Pulmonary Complications After Allogeneic Hematopoietic Stem Cell Transplantation.
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nfect Dis Ther.
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2023
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Online ahead of print.
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Zhang X#, Xu Z#, Lin J#, Xie G, Lv C,
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Sex differences of small airway function and FeNO in patients with mild asthma.
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Ann Allergy Asthma Immunol.
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2022
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S1081-1206(22)01916-0
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Ding F#, Han L#, Yin D, Zhou Y, Ji Y, Zhang P, Wu W, Chen J, Wang Z, Fan X, Zhang G,
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Development and validation of a simple tool composed of items on dyspnea, respiration rates, and C-reactive protein for pneumonia prediction among acute febrile respiratory illness patients in primary care settings.
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BMC Med.
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2022
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20(1):360
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Ding F, Han L, Fu Q, Fan X, Tang R, Lv C, Xue Y, Tian X,
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. IL-17 Aggravates Pseudomonas aeruginosa Airway Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
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Front Immunol.
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2022
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12:811803.
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Ding F, Han L, Xue Y, Yang IT, Fan X, Tang R, Zhang C, Zhu M, Tian X, Shao P,
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Multidrug-resistant Pseudomonas aeruginosa is predisposed to lasR mutation through up-regulated activity of efflux pumps in non-cystic fibrosis bronchiectasis patients.
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Front Cell Infect Microbiol.
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2022
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12:934439
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Huijuan Hao#, Yilin Pan#, Zichong Xu#, Zengchao Xu, Wuping Bao, Yishu Xue, Chengjian Lv, Jingwang Lin, Yingying Zhang,
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Prediction of bronchodilation test in adults with chronic cough suspected of cough variant asthma.
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Front Med (Lausanne).
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2022
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9:987887.
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Han L, Huang Y, Fu Q, Xue Y, Ding F,
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Tracking the response to Pseudomonas aeruginosa infection in ozone-induced chronic obstructive pulmonary disease mouse models.
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Biomed Pharmacother.
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2022
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150:112980
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Zhang X#, Zhang Y#, Zhou Y#, Yin D, Lv C, Lin J, Bao W*,
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Age-related circadian rhythm and variability of large- and small-airway function in healthy non-smoking adults: Data from 7-day diurnal and nocturnal home monitoring using an electronic portable spirometer.
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Front Public Health.
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2022
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17;10:946988.
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Bao W, Zhang Y, Hang J, Guo Y, Tang W, Yun C, Deng J, Jin M, Lai K, Yu H, Beekman M, Zhou X,
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Short-acting beta-2 agonist prescription patterns and clinical outcomes in Chinese patients with asthma: an observational study in mainland China for the SABINA programme.
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Ther Adv Respir Dis.
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2022
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16:17534666221115054.
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Xue Tian, Yishu Xue, Guogang Xie, Yan Zhou, Hui Xiao, Fengming Ding,
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(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRPS3 inflammasome pathway in rats with COPD.
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Toxicology and Applied Pharmacology
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2021
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429:115674
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, Meiling Jin,, Jiangtao Lin, Xiansheng Liu, Chuntao Liu, Mao Huang, Wen Wang, Liang Chen, Yijiang Huang, Jing Li, Qingling Zhang, Huahao Shen, Yali Yu, Wei Tang, Jianying Zhou, Hongju Liu, Liang Dong, Yan Hu, Hua Wu, Yanhong Li, Weidong Song, Ming Ouyang, Xiaoling Yuan, Tao Wang, Shengdao Xiong, Xin Zhou.
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Effectiveness of omalizumab in patients with severe allergic asthma: A retrospective study in China.
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Respir Med
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2021
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186:106522
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Lili Hou, Huijuan Hao, Gang Huang, Jinkai Liu, Li Yu, Lei Zhu, Huahao Shen,
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The Value of Small Airway Function Parameters and Fractional Exhaled Nitric Oxide for Predicting Positive Methacholine Challenge Test in Asthmatics of Different Ages With FEV1 ≥80% predicted.
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Clin Transl Allergy.
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2021
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11(1):e12007.
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Xue Y, Zhou Y, Bao W, Fu Q, Hao H, Han L, Zhang X, Tian X,
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STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.
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Front Mol Biosci
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2021
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8:717962
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Heng Zhang, Di Dai, Qianwen Hu, Fang Yang, Yishu Xue, Min Zhang Chuanxin Huang.
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Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development
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Cell Rep
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2021
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35(6):109096
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Feng-Ming Ding, Yun Feng, Lei Han, Yan Zhou, Yong Ji, Hui-Juan Hao, Yi-Shu Xue, Dong-Ning Yin, Zeng-Chao Xu, Shan Luo, Peng-Yu Zhang,
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Early fever is associated with clinical outcomes in patients with coronavirus disease.
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Frontiers in Public Health.
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2021
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9:712190
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Huijuan Hao, Wuping Bao, Yishu Xue, Yan Zhou, Zhixuan Huang, Dongning Yin, Yingying Zhang, Pengyu Zhang, Chengjian Lv, Lei Han, Xin Zhou, Junfeng Yin,
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Spirometric changes in bronchodilation tests as predictors of asthma diagnosis and treatment response in patients with FEV 1 ≥80% predicted.
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J Allergy Clin Immunol Pract.
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2021
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9(8):3098-3108.e4.
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Huaqiong Huang, Wen Hua, Ruchong Chen, Yue Hu, Songmin Ying, Chunhua Chi,, Kewu Huang, Huiguo Liu, Huahao Shen, Kefang Lai.
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Perspectives and Management of Atypical Asthma in Chinese Specialists and Primary Care Practitioners-A Nationwide Questionnaire Survey
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Front Med (Lausanne).
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2021
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8:727381
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Wuping Bao, Xue Tian, Huijuan Hao, Yubiao Jin, Xueqian Xie, Dongning Yin, Yingying Zhang, Xi Chen, Yishu Xue, Lei Han, Fu Yang,
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Is small airway dysfunction an abnormal phenomenon for patients with normal FEV 1 and FEV 1/FVC?
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Ann Allergy Asthma Immunol
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2021
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S1081-1206(21)01037-1
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Xie G, Ding F, Han L, Yin D, Lu H,
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The role of peripheral blood eosinophil counts in COVID-19 patients
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Allergy
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2020
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10.1111/all
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Xue Tian, Guogang Xie, Hui Xiao, Fengming Ding, Wuping Bao,
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CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-κB signaling pathways
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Cell Biosci .
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2019
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9:55.
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Xiao H, He M, Xie G, Liu Y, Zhao Y, Ye X, Li X,
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The release of tryptase from mast cells promote tumor cell metastasis via exosomes
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BMC Cancer.
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2019
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19(1)
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Yingying Zhang, Xingjing Li, Mudan He, Guoqing Zhang, Wuping Bao, Xia Fei, Xue Zhang,, Pengyu Zhang
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The effects of neutralizing anti-murine interleukin-17A monoclonal antibody on ozone-induced inflammation and glucocorticoids insensitivity in a murine model of asthma
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Biomed Pharmacother.
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2019
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114:108786.
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Lili Hou,Mark C Bellingham,Yong Huang,Pengyu Zhang, Xin Zhou,
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Central inspiratory activity rhythmically activates synaptic currents of airway vagal preganglionic neurons in neonatal rats.
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Neurosci Lett.
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2019
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694:231-237
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Zhang X#, Bao WP#, Fei X, Zhang YY, Zhang GQ, Zhou X,
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Progesterone attenuates airway remodeling and glucocorticoid resistance in a murine model of exposing to ozone
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Mol Immunol
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2018
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96:69-77
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Bao WP#, Zhang X#, Lv CJ, Bao LH, Yin FJ, Huang ZX, Wang B, Zhou X,
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The Value of Fractional Exhaled Nitric Oxide and Forced Mid-Expiratory Flow as Predictive Markers of Bronchial Hyperresponsiveness in Adults With Chronic Cough
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J Allergy Clin Immunol Pract
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2018
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6(4)1313-1320
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Feng-Ming Ding, Xing-Yi Zhang, Yu-Qing Chen, Ruo-Min Liao, Guo-Gang Xie, Peng-Yu Zhang, Ping Shao,
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Lentivirus-mediated overexpression of suppressor of cytokine signaling-3 reduces neutrophilic airway inflammation by suppressing T-helper 17 responses in mice with chronic Pseudomonas aeruginosa lung infections
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Int J Mol Med.
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2018
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41(4):2193-2200
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Xia Fei, Pengyu Zhang,, et al.
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IL-17A Monoclonal Antibody Partly Reverses the Glucocorticoids Insensitivity in Mice Exposed to Ozone
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Inflammation
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2017
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40(3)：788-797
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Xia Fei, Wuping Bao,, et al.
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Inhalation of progesterone inhibits chronic airway inflammation of mice exposed to ozone
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Molecular Immunology
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2017
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85:174-184
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Xia Fei, Xue Zhang,, et al.
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Cordycepin inhibits airway remodeling in a rat model of chronic asthma.
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Biomedicine & Pharmacotherapy
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2017
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88:335-341
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Fengming Ding, Ruomin Liao,, et al.
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SOCS3 is upregulated in lung CD4+ T cells in a mouse model of chronic PA lung infection and exogenous SOCS3 transfer suppresses Th17-mediated neutrophil recruitment in vitro
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Molecular Medicine Reports
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2017
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16(1):778-786
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, Xia Fei, Xin Zhou, et al.
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Role of neutralizing anti-murine interleukin-17A monoclonal antibody on chronic ozone-induced airway inflammation in mice
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Biomedicine & Pharmacotherapy
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2016
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83:247-256
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Feng Li*, Pengyu Zhang*,, Xin Zhou
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Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice
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American Journal of Respiratory Cell and Molecular Biology
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2016
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55(1):72-81
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Li F,, Hussain F, et al
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Inhibition of p38MAPK-dependent bronchial contraction after ozone by corticosteroids
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Eur J Clin Microbil Infect Dis
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2011
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37:933-942
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, Li qun, Zhou xin
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Relevance of lower airway bacterial colonization, airway inflammation, and pulmonary function in the stable stage of chronic obstructive pulmonary disease
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Eur J Clin Microbil Infect Dis
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2010
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2010.29
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