- 基本信息
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导师姓名：
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高丰厚
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学科代码：
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100208
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性别：
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男
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学科名称：
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临床检验诊断学
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培养单位：
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附属第九人民医院
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三级学科
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导师类型：
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硕士生导师
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专业领域名称：
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联系方式：
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上海宝山漠河路280号樟岭大楼312室
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专业领域代码：
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邮编：
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201900
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邮箱地址：
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fenghougao@163.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
- 科研项目
| 14401901500 | 异土木香内酯降解Bcr-Abl蛋白治疗CML的成药性研究 | 上海市科学技术委员会项目
“科技创新行动计划”生物医药领域科技支撑项目
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2014-01~2017-12
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40万元
| 课题负责人 |
| 13ZZ089 | 冬凌草甲素靶向TrxR诱导肿瘤细胞凋亡和衰老 | 上海市教育委员会重点项目 |
2013-01~2015-12
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16万元
| 课题负责人 |
| 81172322 | SUMO修饰hnRNP K蛋白在胃癌发生发展中的作用与分子机制 | 国家自然科学基金面上项目（医学部） |
2012-01~2015-12
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56万元
| 课题负责人 |
- 学术论文
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Liu SL,
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SUMO1/sentrin/SMT3 specific peptidase 2 modulates target molecules and its corresponding functions.
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Biochimie
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2018
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152:6-13
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Liu SL, Liu Z, Zhang LD, Zhu HQ, Guo JH, Zhao M, Wu YL, Liu F,
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GSK3β-dependent cyclin D1 and cyclin E1 degradation is indispensable for NVP-BEZ235 induced G0/G1 arrest in neuroblastoma cells.
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Cell Cycle
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2017
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6(24):2386-2395
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Zhu HQ,
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The Molecular Mechanisms of Regulation on USP2's Alternative Splicing and the Significance of Its Products.
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Int J Biol Sci.
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2017
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13(12):1489-1496
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Lu J,
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The Molecular Mechanisms and the Role of hnRNP K Protein Post- Translational Modification in DNA Damage Repair
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Curr Med Chem.
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2017
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24(6):614-621
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Zhang C, Lu J, Zhang QW, Zhao W, Guo JH, Liu SL, Wu YL, Jiang B,
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USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells
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Int J Biochem Cell Biol.
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2016
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79:209-221
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Lu J,
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Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression.
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Biomed Rep.
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2016
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4(6):657-663
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Zhang LD, Liu Z, Liu H, Ran DM, Guo JH, Jiang B, Wu YL,
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Oridonin enhances the anticancer activity of NVP-BEZ235 against neuroblastoma cells in vitro and in vivo through autophagy.
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Int J Oncol
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2016
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49(2):657-65
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Qin D, Wang W, Lei H, Luo H, Cai H, Tang C, Wu Y, Wang Y, Jin J, Xiao W, Wang T, Ma C, Xu H, Zhang J,, Wu YL
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CDDO-Me reveals USP7 as a novel target in ovarian cancer cells
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Oncotarget.
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2016
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7(47):77096-77109
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Lu J, Guo JH, Tu XL, Zhang C, Zhao M, Zhang QW,
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Tiron Inhibits UVB-Induced AP-1 Binding Sites Transcriptional Activation on MMP-1 and MMP-3 Promoters by MAPK Signaling Pathway in Human Dermal Fibroblasts.
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PLoS One.
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2016
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11(8):e0159998
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Wei W, Ma C, Cao Y, Yang L, Huang Z, Qin D, Chen Y, Liu C, Xia L, Wang T, Lei H, Yu Y, Huang M, Tong Y, Xu H,, Zhang J, Wu YL.
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Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells.
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Oncotarget.
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2016
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3873-83
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Liu H, Xu XF, Zhao Y, Tang MC, Zhou YQ,
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NS-398 promotes pancreatic cancer cell invasion by CD147 and MMP-2 via the activation of P38.
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Mol Med Rep.
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2016
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13(3):2208-14.
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Zhao W, Tian B, Wu C, Peng Y, Wang H, Gu WL,
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DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma.
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Pathol Res Pract.
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2015
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211(4):303-7.
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Qin DJ, Tang CX, Yang L, Lei H, Wei W, Wang YY, Ma CM,, Xu HZ, Wu YL.
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Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells.
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PLoS One.
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2015
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10(7):e0132337.
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Yang GL, Tao HR, Wang HW, Sun Y, Zhang LD, Zhang C, He W, Xu MH, Zhao JM,
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Ara-C increases gastric cancer cell invasion by upregulating CD-147-MMP-2/MMP?9 via the ERK signaling pathway.
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Oncol Rep.
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2015
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33(4):2045-51.
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Liu H, Xu XF, Zhao Y, Tang MC, Zhou YQ, Lu J,
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MicroRNA-191 promotes pancreatic cancer progression by targeting USP10.
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Tumour Biol.
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2014
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35(12):12157-63
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Guo YH, Zhang C, Shi J, Xu MH, Liu F, Yuan HH, Wang JY, Jiang B,
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Abnormal activation of the EGFR signaling pathway mediates the downregulation of miR?145 through the ERK1/2 in non-small cell lung cancer.
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Oncol Rep.
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2014
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31(4):1940-6
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He LC #,, Xu HZ, Zhao S, Ma CM, Li J, Zhang S, Wu YL.
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Ikaros inhibits proliferation and, through upregulation of Slug, increases metastatic ability of ovarian serous adenocarcinoma cells.
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Oncol Rep.
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2012
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28(4):1399-405
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Fang Y, Hu XH, Jia ZG, Xu MH, Guo ZY,
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Tiron protects against UVB-induced senescence-like characteristics in human dermal fibroblasts by the inhibition of superoxide anion production and glutathione depletion.
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Australas J Dermatol.
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2012
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53(3):172-80.
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郭跃辉,刘立宾,徐芒华,郭竹英,姜斌,李伟,
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生物素标记探
针-液相杂交-非变性PAGE检测非编码小RNA方法的建立和优化
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国际检验医学杂志
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2012
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33(6):645-7.
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, Feng Liu, Wei Wei, Li-Bin Liu, Mang-Hua Xu, Zhu-Ying Guo, Wei Li
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Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.
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Int J Mol Med.
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2012
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29(4):649-55
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Zhao M #,, Wang JY, Liu F, Yuan HH, Zhang WY, Jiang B.
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JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer.
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Lung Cancer.
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2011
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73(3):366-74
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Zhao M, Jiang B,
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Small Molecule Inhibitors of STAT3 for Cancer Therapy.
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Curr Med Chem
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2011
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18(26):4012-8
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,郭竹英,徐芒华,王世婷.
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冬凌草甲素诱导结直肠癌细胞SW-
1116凋亡与衰老的体内外实验研究
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上海交通大学学报（医学版）
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2010
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30(6): 683-8.
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, Tang Q, Yang P, Fang Y, Li W, Wu Y
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Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells.
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Int J Lab Hematol.
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2010
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32(1 Pt 1):e114-22
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, Hu XH, Li W, Liu H, Zhang YJ, Guo ZY, Xu MH, Wang ST, Jiang B, Liu F, Zhao YZ, Fang Y, Chen FY, Wu YL.
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Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc.
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BMC Cancer.
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2010
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10(1):610
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杨鹏高,方勇,郭竹英,徐芒华,王仕婷,
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冬凌草甲素诱导
结肠癌细胞凋亡的机制研究
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肿瘤
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2009
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29(9):842-6.
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, Wu YL, Zhao M, Liu CX, Wang LS, Chen GQ.
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Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction.
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Exp Cell Res.
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2009
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315(19):3250-8
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