• 基本信息
    导师姓名: 李宁丽 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式:
    邮箱地址: Ninglixiaoxue57@163.com 邮编:
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海免疫学会临床免疫学分会 委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    12JC1407700Cyr61上调IL-1b/Chemerin参与类风关骨破坏机制及免疫干预研究上海市科学技术委员会 2013-01~2015-12 40万元  课题负责人
    12DZ1941802SAA1β+/+纯合子基因型诊断试剂盒的实验室评估与性能优化上海市科学技术委员会 2013-01~2015-12 60万元  子课题负责人
    20130073110003Cyr61与银屑病发生发展的相关性及其机制研究教育部高等学校博士学科点专项科研基金资助(博导类) 2013-01~2016-12 12万元  课题负责人
    12JC1407702自拟蠲痹补肾方对类风湿关节炎临床疗效与作用机理研究上海市科学技术委员会 2013-01~2015-12 15万元  子课题负责人
    81172856探讨IL-17/Cyr61通路介导的类风关炎症与组织损伤新机制国家自然基金 2012-01~2015-12 60万元  课题负责人
    81072468IL-17上调类风关滑膜细胞Cyr61表达时转录因子作用和调控研究国家自然科学基金委员会 2011-01~2013-12 31万元  课题负责人
    2010CB529103类风湿关节炎发病的免疫学机制及其干预策略的研究科技部 2010-01~2015-12 180万元  课题参与人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Yue Sun, Jie Zhang, Rongfen Huo, Tianhang Zhai, Huidan Li, Pinru Wu, Xianjin Zhu, Zhou Zhou, Baihua Shen,  Paeoniflorin inhibits skin lesions in imiquimod-induced psoriasis-like mice by down regulating inflammation  International Immunopharmacology  2015  24:392–399 
    Xianjin Zhu, Yanfang Song, Rongfen Huo, Jie Zhang, Songtao Sun,Yong He, Huali Gao, Miaojia Zhang, Xiaoxuan Sun, Tianhang Zhai,Huidan Li, Yue Sun, Zhou Zhou, Baihua Shen,Lianbo Xiao,  Cyr61 participates in the pathogenesis of rheumatoid arthritis by promoting proIL-1 β production by fibroblast-like synoviocytes through an AKT-dependent NF- κ B signaling pathway  Clinical Immunology  2015  157:187–197 
    Jie Zhang, Huidan Li, Rongfen Huo, Tianhang Zhai, Haichuan Li, Yue Sun, Baihua Shen,  Paeoni?orin selectively inhibits LPS-provoked B cell function.  Journal of Pharmacological Sciences  2015  128:8-16 
    Sun Y, Zhang J, Zhou Z, Wu P, Huo R, Wang B, Shen Z, Li H, Zhai T, Shen B, Chen X*,  CCN1, a Pro-Inflammatory Factor, Aggravates Psoriasis Skin Lesions by Promoting Keratinocyte Activation  Journal of Investigative Dermatology  2015  Journal of Investigative Dermatology advance online publication, 23 July 2015; doi:10.1038/jid.2015.231 
    Xianjin Zhu, Jie Zhang, Rongfen Huo, Jinpiao Lin, Zhou Zhou,Yue Sun, Pinru Wu, Huidan Li, Tianhang Zhai, Baihua Shen,  Evaluation of the efficacy and safety of different tripterygium preparations on collagen-induced arthritis in rats  Journal of Ethnopharmacology  2014  158:283-290 
    Jinpiao Lin, Rongfen Huo, Lianbo Xiao, Xianjin Zhu, Jun Xie, Songtao Sun, Yong He, Jie Zhang, Yue Sun, Zhou Zhou, Pinru Wu, Baihua Shen, Dangsheng Li,  A Novel p53-miR-22-Cyr61 Axis in Synovial Cells Regulates Inflammation in Rheumatoid Arthritis  Arthritis & Rheumatology  2014  66: 49-59 
    Xianjin Zhu, Lianbo Xiao, Rongfen Huo, Jie Zhang, Jinpiao Lin, Jun Xie, Songtao Sun, Yong He, Yue Sun, Zhou Zhou, Baihua Shen,  Cyr61 Involved in Neutrophil Infiltration in Joints via Inducing IL-8 Production by Fibroblast-Like Synoviocytes in Rheumatoid Arthritis  Arthritis Research & Therapy  2013  15:R187 
    Jun Shi, Zhou Zhou, Wen Di,  Correlation of CD44v6 expression with ovarian cancer progression and Recurrence   BMC Cancer  2013  13:182 doi:10.1186/1471-2407-13-182 
    Jinpiao Lin, Rongfen Huo, Li Wang, Zhou Zhou, Yue Sun, Baihua Shen, Rongfang Wang,  A novel anti-Cyr61 antibody inhibits breast cancer growth and metastasis in vivo  Cancer Immunology Immunotherapy  2012  61:677-687 
    Jinpiao Lin,Lianbo Xiao, Guilin Ouyang, Yu Shen, Rongfen Huo, Zhou Zhou, Yue Sun, Xianjin Zhu, Jie Zhang, Baihua Shen,  Total Glucosides of Paeony Inhibits Th1/Th17 Cells via Decreasing Dendritic Cells Activation in Rheumatoid Arthritis  Cellular Immunology  2012  280: 156-163 
    Jinpiao Lin, Zhou Zhou, Rongfen Huo, Lianbo Xiao, Guilin Ouyang,Li Wang, Yue Sun, Baihua Shen, Dangsheng Li,  Cyr61 Promotes Th17 Differentiation through Inducing IL-6 Production by Fibroblast-Like Synoviocytes in Rheumatoid Arthritis.  Journal of Immunology  2012  188(11):5776-5784 
    Zhou Zhou, Jinpiao Lin, Rongfen Huo, Wenkang Huang, Jian Zhang, Li Wang, Yue Sun, Baihua Shen,  Total Glucosides of Paeony Attenuated Functional Maturation of Dendritic Cells via Blocking TLR4/5 Signaling in vivo.  International Immunopharmacology  2012  12:275-282 
    Li Wang, Jinpiao Lin, Zhou Zhou, Rongfen Huo, Baihua Shen,Yue Sun,  Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells  PloS ONE  2011  6(11):27289-27300 
    Yan Zhang, Li Wang, Dangsheng Li,  Taming regulatory T cells by autologous T cell immunization: a potential new strategy for cancer immune therapy  Int Immuunopharm  2009  9:593-595 
    Qiuyu Zhang, Juanjuan Wu, Qi Cao, Lianbo Xiao, Li Wang, Dongyi He, Guilin Ouyang, Jinpiao Lin, Baihua Shen, Yuan Shi, Yan Zhang, Dangsheng Li,  A Critical Role of Cyr61 in IL-17-dependent Proliferation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis  Arthritis & Rheumatology  2009  60(12):3602-3612 
    Fang Dua,Li Wang,Yan Zhang, Wei Jiang, Huiming Sheng, Qi Cao,Juanjuan Wu, Baihua Shen, Tianwei Shen, Jingwu Z. Zhang,Chunde Bao, Dangsheng Li,  Role of GADD45β in the regulation of synovial fluid T cell apoptosis in rheumatoid arthritis  Clinical Immunology  2008  128:238-247 
    Huiming Sheng, Ying Wang, Yuqing Jin, Qiuyu Zhang, Yan Zhang, Li Wang, Baihua Shen, Shuo Yin, Wei Liu, Lei Cui,  A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1  Cell Reseaerch  2008  18:846-857 
    Qi Cao, Li Wang, Fang Du, Huiming Sheng, Yan Zhang, Juanjuan Wu, Baihua Shen, Tianwei Shen, Jingwu Zhang, Dangsheng Li,  Down-regulation of CD4+CD25+ regulatory T cells may underlie enhanced anti-tumor immunity caused by immunization with activated autologous T cells  Cell Reseaerch  2007  17:627-637 
    Li Wang,Fang Du, Qi Cao, Huiming Shen, Baihua Shen, Yan Zhang, Yingna Diao, Jingwu Zhang,  Immunization with Autologous T Cells Enhances in vivo Anti-tumor Immune Responses mediated by up-regulation of GADD45β  Cell Reseaerch  2006  16:702-712