• 基本信息
    导师姓名: 王宏林 专业代码: 100100
    性别: 专业名称: 基础医学
    培养单位: 基础医学院 三级学科/
    专业领域:
    导师类型: 博士生导师 专业学位导师:
    联系方式: 上海市黄浦区重庆南路280号
    邮箱地址: honglin.wang@sjtu.edu.cn 邮编: 200025
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    上海优秀学术带头人
    中国免疫学会会员;美国免疫学会会员;中华中医药学会免疫学分会副主任委员
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    81725018银屑病免疫学机理及治疗新靶点国家杰出青年科学基金 2018-01~2022-12 350万元  课题负责人
    31570922皮肤区域免疫特性及银屑病靶向治疗新策略国家自然科学基金面上项目 2016-01~2019-12 72万元  课题负责人
    15431900800治疗银屑病新型候选化合物的研究上海市科学技术委员会 2015-07~2018-06 50万元  课题负责人
    31330026iTreg的表观调控及其在自身免疫性疾病中的作用机制国家自然科学基金重点项目 2014-01~2018-12 303万元  课题负责人
    2014CB541905狼疮靶器官受损相关炎症通路活化的细胞及分子调节机制研究国家重点基础研究计划(973计划)项目 2014-01~2018-12 232万元  课题负责人
    2012CB917100恶性肿瘤免疫负调控分子网络的形成与干预国家重点基础研究计划(973计划)项目 2012-01~2016-12 144万元  课题参与人
    91029730间充质干细胞参与非可控性炎症恶性转化的分子机制国家自然科学基金重大研究计划 2011-01~2013-12 70万元  课题负责人
    10PJ1406700皮肤真皮间充质干细胞治疗银屑病可行性和安全性的研究上海市科学技术委员会 2010-09~2012-09 25万元  课题负责人
    10410703300抗银屑病纯天然新药的研究上海市科学技术委员会 2010-04~2012-12 10万元  课题负责人
    30972787运用生物荧光GFP标记的CD4+CD25+调节性T细胞诊断早期胃癌的研究国家自然科学基金面上项目 2010-01~2012-12 30万元  课题负责人
    2010CB529700炎症过程中细胞间相互作用的信号转导机制及其应用研究国家重点基础研究计划(973计划)项目 2010-01~2014-12 54万元  课题参与人
    09140902600构建FOXP3-GFP银屑病小鼠模型的研究上海市科学技术委员会 2009-10~2011-09 20万元  课题负责人
    09140902600构建Foxp3-GFP银屑病小鼠模型的研究上海市科学技术委员会 2009-09~2011-09 20万元  课题负责人
    00000000诱导调节性T细胞治疗自身免疫性疾病的研究上海市教育委员会 2009-01~2011-12 50万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Wu R, Zeng J, Yuan J, Deng X, Huang Y, Chen L, Zhang P, Feng H, Liu Z, Wang Z, Gao X, Wu H,, Su Y, Zhao M, Lu Q  MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation  The Journal of Clinical Investigation  2018  2018;128(6):2551-2568. 
    Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, Xu Z, Liu Z, Cai W, Ke F, Zhang L, Zhou H, Wang H, Wang G, Chen X, Zhang H, Wang Z, Florent Ginhoux, Lu C, Su B,  RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease  EMBO Molecular Medicine  2017  May;9(5):589-604. 
    Ke F, Zhang L, Liu Z, Yan S, Xu Z, Bai J, Zhu H, Lou F, Cai W, Sun Y, Gao Y, Wang H,  sTNFR1 Released by Skin-Derived Mesenchymal Stem Cells is Critical for Inhibiting Th17 Cell Differentiation  Stem Cells Translational Medicine  2016  5(3):301-13 
    Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE,  NF-kB-Induced microRNA-31 Promotes Epidermal Hyperplasia by Repressing Protein Phosphatase 6 in Psoriasis  Nature Communications  2015  6:7652 
    Bai J, Liu Z, Xu Z, Ke F, Zhang L, Zhu H, Lou F, Wang H, Fei Y, Shi YL,  Epigenetic downregulation of SFRP4 contributes to epidermal hyperplasia in psoriasis  The Journal of Immunology  2015  194:4185-4198 
    Li H, Li C, Zhang H, Zhang L, Cheng R, Li M, Guo Y, Zhang Z, Lu Z, Zhuang Y, Yan M, Gu Y, Feng X, Liang J, Yu X,, Yao Z*  Effects of lidocaine on regulatory T cells in atopic dermatitis  Journal of Allergy and Clinical Immunology  2015  S0091-6749(15) 
    Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z, Deng J, Li QJ,  MicroRNA-31 Negatively Regulates Peripherally Derived Regulatory T Cell Generation by Repressing Retinoic Acid-Inducible Protein 3  Nature Communications  2015  6: 7639 
    Zhang QQ, Hu XW, Liu YL, Ye ZJ, Gui YH, Zhou DL, Qi CL, He XD,, Wang LJ*  CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment  Scientic Reports  2015  doi:10.1038/srep15948 
    Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, Wang Z, Wang H,  CCR6 is a Prognostic Marker for Overall Survival in Patients with Colorectal Cancer, and Its Overexpression Enhances Metastasis in vivo  PLoS ONE  2014  Jun 30;9(6):e101137. doi: 10.1371 
    Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B,  Autocrine IL-6 Drives Skin-Derived Mesenchymal Stem Cell Trafficking via Regulating Voltage-Gated Ca2+ Channels  Stem Cells  2014  2014 Jun 6. doi: 10.1002 
    Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z,, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B  The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3  Immunity  2013  39(2):272-85 
    Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D,, Liu W, Shi Y, Harley JB, Shen N, Qian Y  The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α  Nature Medicine  2012  18(7):1077-86. 
    Semple K, Nguyen A, Yu Y,, Anasetti C, Yu XZ  Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling  Blood  2011  117(11):3096-3103 
    Liu J, Zhang N, Li Q, Zhang W, Ke F, Leng Q, Wang H, Chen J,  Tumor-associated Macrophages Recruit CCR6+ Regulatory T cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice  PLoS ONE  2011  8(1):e19495 
    Li Q*, Ke F*, Zhang W, Shen X, Xu Q, Wang H, Yu XZ, Leng Q,  Plasmin Plays an Essential Role in Amplification of Psoriasiform Skin Inflammation in Mice  PLoS ONE  2011  6(2):e16483 
    , von Rohrscheidt J, Roehrbein J, Peters T, Sindrilaru A, Kess D, Preissner KT, Scharffetter-Kochanek K  Extracellular adherence protein of Staphylococcus aureus suppresses disease by inhibiting T cell recruitment in a mouse model of psoriasis  Journal of Investigative Dermatology  2010  130(3):743-754 
    , Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, Simmet T  Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis  The Journal of Immunology  2009  183(7):4755-4763 
    , Peters T, Sindrilaru A, Scharffetter-Kochanek K  Key role of macrophages in the pathogenesis of CD18 hypomorphic murine model of psoriasis  Journal of Investigative Dermatology  2009  29 (5):1100-1114 
    Sindrilaru A, Peters T, Schymeinsky J, Oreshkova T,, Gompf A, Mannella F, Wlaschek M, Sunderk?tter C, Rudolph KL, Walzog B, Bustelo XR, Fischer KD, Scharffetter-Kochanek K  Wound healing defect of Vav3-/- mice due to impaired beta2-integrin dependent macrophage phagocytosis of apoptotic neutrophils  Blood  2009  113(21):5266-5276 
    Peters T, Weiss JM, Sindrilaru A,, Oreshkova T, Wlaschek M, Maity P, Reimann J, Scharffetter-Kochanek K  Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity  Mechanisms of Ageing and Development  2009  130(9):564-587 
    , Kess D, Lindqvist AK, Peters T, Sindrilaru A, Wlaschek M, Blakytny R, Holmdahl R, Scharffetter-Kochanek K  A 9-cM region of chromosome 10 controls the T-cell dependent psoriasiform skin disease and arthritis in a murine psoriasis model  The Journal of Immunology  2008  180(8):5520-5529 
    , Peters T, Sindrilaru A, Kess D, Oreshkova T, Yu XZ, Seier AM, Schreiber H, Wlaschek M, Blakytny R, R?hrbein J, Schulz G, Weiss JM, Scharffetter-Kochanek K  TGF-alpha-dependent suppressive function of regulatory T-cells in a psoriasis murine model requires CD18 wild-type levels  The Journal of Clinical Investigation  2008  118(7):2629-2639 
    Kess D, Lindqvist AK, Peters T,, Zamek J, Nischt R, Broman KW, Blakytny R, Krieg T, Holmdahl R, Scharffetter-Kochanek K  Identification of susceptibility loci for skin disease in a murine psoriasis model  The Journal of Immunology  2006  177(7):4612-9 
    , Peters T*, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N, Stratis A, Renkl AC, Sunderk?tter C, Wlaschek M, Haase I, Scharffetter-Kochanek K  Activated Macrophages are Essential in a Murine Model for T Cell-Mediated Chronic Psoriasiform Skin Inflammation  The Journal of Clinical Investigation  2006  116(8):2105-2114 
    Peters T, Sindrilaru A,, Oreshkova T, Renkl AC, Kess D, Scharffetter-Kochanek K  CD18 in Monogenic and Polygenic Inflammatory Processes of the Skin  J Investig Dermatol Symp Proc  2006  126(Supl):7-15 
    Peters T, Sindrilaru A, Hinz B, Hinrichs R, Menke A, Al-Azzeh EA, Holzwarth K, Oreshkova T,, Kess D, Walzog B, Sulyok S, Sunderk?tter C, Friedrich W, Wlaschek M, Krieg T, Scharffetter-Kochanek K  Wound-healing defect of CD18 (-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation  The EMBO Journal  2005  24:3400-3410