- 基本信息
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导师姓名：
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王宏林
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学科代码：
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100100
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性别：
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男
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学科名称：
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基础医学
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培养单位：
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附属第一人民医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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联系方式：
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上海交通大学医学院附属第一人民医院南院上海市新松江路650号
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专业领域代码：
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邮编：
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200025
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邮箱地址：
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honglin.wang@sjtu.edu.cn
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中华医学会皮肤性病学分会实验学组副组长
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中国免疫学会皮肤免疫学分会副主任委员
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上海优秀学术带头人
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中国免疫学会会员；美国免疫学会会员；
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中华中医药学会免疫学分会副主任委员
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- 科研项目
| 22140903100 | CD8-Tc17细胞介导银屑病小鼠模型开发及应用 | 上海市科委 |
2022-03~2025-03
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25万元
| 课题负责人 |
| 2021JCPT04 | 上海交通大学皮肤免疫疾病新药创制研究中心 | 上海交通大学 |
2021-07~2024-05
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150万元
| 课题负责人 |
| 82050009 | 东莨菪碱神经阻滞治疗银屑病的机制研究 | 国家自然科学基金原创探索项目 |
2021-01~2023-12
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300万元
| 课题负责人 |
| 20210102 | 小分子化合物CKBA治疗银屑病的临床试验及机制的探索性研究 | 上海交通大学“交大之星”(STAR) |
2021-01~2022-12
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400万元
| 课题负责人 |
| 2020YFA0112900 | 间充质干细胞治疗银屑病及银屑病型关节炎的临床研究 | 科技部国家重点研发计划“干细胞及转化研究”重点专项 |
2020-10~2024-12
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1442万元
| 课题负责人 |
| SHDC2020CR3061B | 非编码RNA31编码多 肽治疗炎症性肠炎的临床前研究 | 上海申康临床“五新”创新研发项目 |
2020-10~2022-09
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100万元
| 课题负责人 |
| 81930088 | Pri-miR-31编码多肽调控银屑病角质形成细胞生物学功能的作用及机制 | 国家自然科学基金重点项目 |
2020-01~2024-12
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297万元
| 课题负责人 |
| 81725018 | 银屑病免疫学机理及治疗新靶点 | 国家杰出青年科学基金 |
2018-01~2022-12
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400万元
| 课题负责人 |
| 31570922 | 皮肤区域免疫特性及银屑病靶向治疗新策略 | 国家自然科学基金面上项目 |
2016-01~2019-12
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72万元
| 课题负责人 |
| 15431900800 | 治疗银屑病新型候选化合物的研究 | 上海市科学技术委员会 |
2015-07~2018-06
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50万元
| 课题负责人 |
| 31330026 | iTreg的表观调控及其在自身免疫性疾病中的作用机制 | 国家自然科学基金重点项目 |
2014-01~2018-12
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303万元
| 课题负责人 |
| 2014CB541905 | 狼疮靶器官受损相关炎症通路活化的细胞及分子调节机制研究 | 国家重点基础研究计划（973计划）项目 |
2014-01~2018-12
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442万元
| 课题负责人 |
| 2012CB917100 | 恶性肿瘤免疫负调控分子网络的形成与干预 | 国家重点基础研究计划（973计划）项目 |
2012-01~2016-12
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144万元
| 课题参与人 |
| 91029730 | 间充质干细胞参与非可控性炎症恶性转化的分子机制 | 国家自然科学基金重大研究计划 |
2011-01~2013-12
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70万元
| 课题负责人 |
| 10PJ1406700 | 皮肤真皮间充质干细胞治疗银屑病可行性和安全性的研究 | 上海市科学技术委员会 |
2010-09~2012-09
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25万元
| 课题负责人 |
| 10410703300 | 抗银屑病纯天然新药的研究 | 上海市科学技术委员会 |
2010-04~2012-12
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10万元
| 课题负责人 |
| 30972787 | 运用生物荧光GFP标记的CD4+CD25+调节性T细胞诊断早期胃癌的研究 | 国家自然科学基金面上项目 |
2010-01~2012-12
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30万元
| 课题负责人 |
| 2010CB529700 | 炎症过程中细胞间相互作用的信号转导机制及其应用研究 | 国家重点基础研究计划（973计划）项目 |
2010-01~2014-12
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54万元
| 课题参与人 |
| 09140902600 | 构建FOXP3-GFP银屑病小鼠模型的研究 | 上海市科学技术委员会 |
2009-10~2011-09
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20万元
| 课题负责人 |
| 09140902600 | 构建Foxp3-GFP银屑病小鼠模型的研究 | 上海市科学技术委员会 |
2009-09~2011-09
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20万元
| 课题负责人 |
| 00000000 | 诱导调节性T细胞治疗自身免疫性疾病的研究 | 上海市教育委员会 |
2009-01~2011-12
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50万元
| 课题负责人 |
- 学术论文
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Xiaojie Cai, Maoying Han, Fangzhou Lou, Yang Sun, Qianqian Yin, Libo Sun, Zhikai Wang, Xiangxiao Li, Hong Zhou, Zhenyao Xu, Hong Wang, Siyu Deng, Xichen Zheng, Taiyu Zhang, Qun Li, Bin Zhou,
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Tenascin C+ papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis
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Nature Communications
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2023
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14(1):2004
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Jiajia Tong, Yan Li, Xiaojie Cai, Fangzhou Lou, Yang Sun, Zhikai Wang, Xichen Zheng, Hong Zhou, Ziyang Zhang, Zilong Fang, Wenxiang Ding, Siyu Deng, Zhenyao Xu, Xiaoyin Niu,
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CKBA suppresses mast cell activation via ERK signaling pathway in murine atopic dermatitis
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European journal of immunology
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2023
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53(9):e2350374
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Qianqian Yin,Libo Sun,Xiaojie Cai,Fangzhou Lou,Yang Sun,Bin Wang,Bowen Jiang,Lan Bao,Xia Li,Ningjing Song,Sibei Tang,Jing Bai,Zhikai Wang,Yue Wu,Hong Zhou,Hong Wang,Buwei Yu,Qifang Li,
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Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling-Mediated Sensory Neuron-Dendritic Cell Communication
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J Invest Dermatol
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2022
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S0022-202X(22)00007-0
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Hong Zhou
Fangzhou Lou
Jing Bai
Yang Sun
Wei Cai
Libo Sun
Zhenyao Xu
Zhaoyuan Liu
Lingyun Zhang
Qianqian Yin
Junxun Zhang
Yuanyuan Gao
Zhikai Wang
Liman Niu
Xiaojie Cai
Siyu Deng
Hong Wang
Li Xia
Florent Ginhoux
Qun Li
Honglin Wang
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A peptide encoded by pri-miRNA-31 represses autoimmunity by promoting Treg differentiation
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Embo reports
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2022
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4;23(5):e53475
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Zhikai Wang, Yang Sun, Fangzhou Lou, Jing Bai, Hong Zhou, Xiaojie Cai, Libo Sun, Qianqian Yin, Sibei Tang, Yue Wu, Li Fan, Zhenyao Xu, Hong Wang, Xiaoyu Hu,
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Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis
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Nature Communications
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2022
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13(1):7815
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Linjiao Chen, Jing Bai, Danhong Peng, Yuanyuan Gao, Xiaojie Cai, Junxun Zhang, Sibei Tang, Liman Niu, Yang Sun, Fangzhou Lou, Hong Zhou, Qianqian Yin, Zhikai Wang, Libo Sun, Xuemei Du, Zhenyao Xu, Hong Wang, Qun Li,
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SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation
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The journal of Immunology
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2021
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2021 Jan 22:ji2000036
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Wei Cai , Junxun Zhang , Hong Zhou , Xiangxiao Li , Fangzhou Lou , Yang Sun , Zhenyao Xu , Jing Bai , Qianqian Yin , Zhikai Wang , Libo Sun , Xiaojie Cai , Sibei Tang , Yue Wu , Li Fan , Hong Wang ,, Qun Li
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Protein phosphatase 6 (Pp6) is crucial for regulatory T cell function and stability in autoimmunity
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Genes and diseases
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2021
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17;9(2):562-575
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Liman Niu, Fangzhou Lou, Yang Sun, Libo Sun, Xiaojie Cai, Zhaoyuan Liu, Hong Zhou, Hong Wang, Zhikai Wang, Jing Bai, Qianqian Yin, Junxun Zhang, Linjiao Chen, Danhong Peng, Zhenyao Xu, Yuanyuan Gao, Sibei Tang, Li Fan,
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A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation
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Science advances
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2020
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6(21)
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FangzhouLou, YangSun, ZhenyaoXu, LimanNiu, ZhikaiWang,SiyuDeng, ZhaoyuanLiu, HongZhou, JingBai, Qianqian Yin, Xiaojie Cai, Libo Sun, Hong Wang, Qun Li, Zhouwei Wu, Xiang Chen, Jun Gu, Yu-Ling Shi, Wufan Tao, Florent Ginhoux,
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Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis
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Immunity
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2020
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53(1):204-216
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Li X, Cai W, Xi W, Sun W, Shen W, Wei T, Chen X, Sun L, Zhou H, Sun Y, Chen W, Gao P,, Li Q.
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MicroRNA-31 Regulates Immunosuppression in Ang II (Angiotensin II)-induced Hypertension by Targeting Ppp6C (Protein Phosphatase 6c).
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Hypertension
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2019
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73(5):e14-e24
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Bai J, Gao Y, Chen L, Yin Q, Lou F, Wang Z, Xu Z, Zhou H, Li Q, Cai W, Sun Y, Niu L, Wang H, Wei Z, Lu S, Zhou A, Zhang J,
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Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes
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EBioMedicine
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2019
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39: 575–590
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Wu R, Zeng J, Yuan J, Deng X, Huang Y, Chen L, Zhang P, Feng H, Liu Z, Wang Z, Gao X, Wu H,, Su Y, Zhao M, Lu Q
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MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation
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The Journal of Clinical Investigation
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2018
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2018;128(6):2551-2568.
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Liu Z, Bai J, Zhang L, Lou F, Ke F, Cai W,
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Conditional knockout of microRNA-31 promotes the development of colitis associated cancer
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Biochemical and Biophysical Research Communications
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2017
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490(1):62-68
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Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, Xu Z,
Liu Z, Cai W, Ke F, Zhang L, Zhou H, Wang H, Wang G, Chen X, Zhang H, Wang Z, Florent Ginhoux, Lu C, Su B,
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RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease
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EMBO Molecular Medicine
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2017
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May;9(5):589-604.
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Ke F, Zhang L, Liu Z, Yan S, Xu Z, Bai J, Zhu H, Lou F, Cai W, Sun Y, Gao Y, Wang H,
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sTNFR1 Released by Skin-Derived Mesenchymal Stem Cells is Critical for Inhibiting Th17 Cell Differentiation
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Stem Cells Translational Medicine
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2016
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5(3):301-13
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Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE,
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NF-kB-Induced microRNA-31 Promotes Epidermal Hyperplasia by Repressing Protein Phosphatase 6 in Psoriasis
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Nature Communications
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2015
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6:7652
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Bai J, Liu Z, Xu Z, Ke F, Zhang L, Zhu H, Lou F, Wang H, Fei Y, Shi YL,
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Epigenetic downregulation of SFRP4 contributes to epidermal hyperplasia in psoriasis
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The Journal of Immunology
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2015
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194:4185-4198
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Li H, Li C, Zhang H, Zhang L, Cheng R, Li M, Guo Y, Zhang Z, Lu Z, Zhuang Y, Yan M, Gu Y, Feng X, Liang J, Yu X,, Yao Z*
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Effects of lidocaine on regulatory T cells in atopic dermatitis
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Journal of Allergy and Clinical Immunology
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2015
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S0091-6749(15)
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Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z, Deng J, Li QJ,
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MicroRNA-31 Negatively Regulates Peripherally Derived Regulatory T Cell Generation by Repressing Retinoic Acid-Inducible Protein 3
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Nature Communications
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2015
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6: 7639
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Zhang QQ, Hu XW, Liu YL, Ye ZJ, Gui YH, Zhou DL, Qi CL, He XD,, Wang LJ*
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CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment
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Scientic Reports
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2015
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doi:10.1038/srep15948
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Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, Wang Z, Wang H,
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CCR6 is a Prognostic Marker for Overall Survival in Patients with Colorectal Cancer, and Its Overexpression Enhances Metastasis in vivo
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PLoS ONE
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2014
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Jun 30;9(6):e101137. doi: 10.1371
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Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B,
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Autocrine IL-6 Drives Skin-Derived Mesenchymal Stem Cell Trafficking via Regulating Voltage-Gated Ca2+ Channels
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Stem Cells
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2014
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2014 Jun 6. doi: 10.1002
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Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z,, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B
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The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3
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Immunity
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2013
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39(2):272-85
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Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D,, Liu W, Shi Y, Harley JB, Shen N, Qian Y
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The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α
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Nature Medicine
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2012
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18(7):1077-86.
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Semple K, Nguyen A, Yu Y,, Anasetti C, Yu XZ
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Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling
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Blood
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2011
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117(11):3096-3103
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Liu J, Zhang N, Li Q, Zhang W, Ke F, Leng Q, Wang H, Chen J,
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Tumor-associated Macrophages Recruit CCR6+ Regulatory T cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice
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PLoS ONE
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2011
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8(1):e19495
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Li Q*, Ke F*, Zhang W, Shen X, Xu Q, Wang H, Yu XZ, Leng Q,
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Plasmin Plays an Essential Role in Amplification of Psoriasiform Skin Inflammation in Mice
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PLoS ONE
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2011
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6(2):e16483
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, von Rohrscheidt J, Roehrbein J, Peters T, Sindrilaru A, Kess D, Preissner KT, Scharffetter-Kochanek K
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Extracellular adherence protein of Staphylococcus aureus suppresses disease by inhibiting T cell recruitment in a mouse model of psoriasis
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Journal of Investigative Dermatology
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2010
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130(3):743-754
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, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, Simmet T
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Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis
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The Journal of Immunology
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2009
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183(7):4755-4763
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, Peters T, Sindrilaru A, Scharffetter-Kochanek K
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Key role of macrophages in the pathogenesis of CD18 hypomorphic murine model of psoriasis
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Journal of Investigative Dermatology
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2009
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29 (5):1100-1114
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Sindrilaru A, Peters T, Schymeinsky J, Oreshkova T,, Gompf A, Mannella F, Wlaschek M, Sunderk?tter C, Rudolph KL, Walzog B, Bustelo XR, Fischer KD, Scharffetter-Kochanek K
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Wound healing defect of Vav3-/- mice due to impaired beta2-integrin dependent macrophage phagocytosis of apoptotic neutrophils
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Blood
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2009
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113(21):5266-5276
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Peters T, Weiss JM, Sindrilaru A,, Oreshkova T, Wlaschek M, Maity P, Reimann J, Scharffetter-Kochanek K
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Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity
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Mechanisms of Ageing and Development
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2009
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130(9):564-587
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, Kess D, Lindqvist AK, Peters T, Sindrilaru A, Wlaschek M, Blakytny R, Holmdahl R, Scharffetter-Kochanek K
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A 9-cM region of chromosome 10 controls the T-cell dependent psoriasiform skin disease and arthritis in a murine psoriasis model
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The Journal of Immunology
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2008
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180(8):5520-5529
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, Peters T, Sindrilaru A, Kess D, Oreshkova T, Yu XZ, Seier AM, Schreiber H, Wlaschek M, Blakytny R, R?hrbein J, Schulz G, Weiss JM, Scharffetter-Kochanek K
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TGF-alpha-dependent suppressive function of regulatory T-cells in a psoriasis murine model requires CD18 wild-type levels
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The Journal of Clinical Investigation
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2008
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118(7):2629-2639
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Kess D, Lindqvist AK, Peters T,, Zamek J, Nischt R, Broman KW, Blakytny R, Krieg T, Holmdahl R, Scharffetter-Kochanek K
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Identification of susceptibility loci for skin disease in a murine psoriasis model
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The Journal of Immunology
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2006
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177(7):4612-9
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, Peters T*, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N, Stratis A, Renkl AC, Sunderk?tter C, Wlaschek M, Haase I, Scharffetter-Kochanek K
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Activated Macrophages are Essential in a Murine Model for T Cell-Mediated Chronic Psoriasiform Skin Inflammation
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The Journal of Clinical Investigation
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2006
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116(8):2105-2114
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Peters T, Sindrilaru A,, Oreshkova T, Renkl AC, Kess D, Scharffetter-Kochanek K
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CD18 in Monogenic and Polygenic Inflammatory Processes of the Skin
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J Investig Dermatol Symp Proc
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2006
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126(Supl):7-15
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Peters T, Sindrilaru A, Hinz B, Hinrichs R, Menke A, Al-Azzeh EA, Holzwarth K, Oreshkova T,, Kess D, Walzog B, Sulyok S, Sunderk?tter C, Friedrich W, Wlaschek M, Krieg T, Scharffetter-Kochanek K
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Wound-healing defect of CD18 (-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation
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The EMBO Journal
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2005
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24:3400-3410
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