- 基本信息
导师姓名:
|
吕志宝
|
学科代码:
|
100210
|
|
性别:
|
男
|
学科名称:
|
外科学
|
培养单位:
|
附属儿童医院
|
三级学科
|
普外
|
导师类型:
|
博士生导师
|
专业领域名称:
|
外科学 专业学位
|
联系方式:
|
|
专业领域代码:
|
105111
|
邮编:
|
2000062
|
邮箱地址:
|
lvzhibao@sohu.com
|
- 研究方向 (点击浏览详细信息)
- 社会任职
|
《临床儿科杂志》编委
|
中国医师协会小儿外科分会常务委员
|
上海医学会小儿外科分会候任主任委员
|
儿科专业委员会--国际肝胆胰协会中国分会副主任委员
|
中华医学会小儿外科分会委员
|
中国抗癌协会小儿肿瘤专业委员会常务委员
|
世界内镜医师协会中国协会小儿外科内镜与微创专业委员会理事
|
中华医学会小儿外科分会肿瘤学组委员
|
《中华小儿科杂志》编委
|
中华医学会小儿外科分会微创学组委员
|
《临床小儿外科杂志》编委
|
中华医学会小儿外科分会肛肠学组副组长
|
中国医师协会住院医师规范化培训儿外科专业委员会委员
|
- 科研项目
82371711 | 新生儿坏死性小肠结肠炎中去泛素化酶USP15调控ILC3分化损伤肠道粘膜屏障的致病机制研究 | 国家自然科学基金委员会 |
2024-01~2027-12
|
49万元
| 课题负责人 |
82171696 | 新生儿坏死性小肠结肠炎中胆汁酸受体FXR调控肠道上皮细胞屏障通透性和树突状细胞分化的致病机制研究 | 国家自然科学基金委员会 |
2022-01~2025-12
|
54万元
| 课题负责人 |
81871194 | 新生儿坏死性小肠结肠炎中肠道菌群失调介导肠道粘膜屏障损伤的病理机制研究 | 国家自然科学基金委员会
|
2019-01~2022-12
|
57万元
| 课题负责人 |
18ZR1431300 | S1P/S1PR1信号通路对新生儿坏死性小肠结肠炎中Th17/Treg平衡的调控作用及机制研究 | 上海市科学技术委员会
|
2018-06~2021-05
|
20万元
| 课题负责人 |
G2015ZD13 | 构建电化学传感器用于坏死性小肠结肠炎肠道氢气分布监测的研究 | 上海交通大学医工交叉基金项目 |
2016-01~2018-12
|
60万元
| 课题负责人 |
SHDC12013124 | 婴儿胆道闭锁早期筛查诊断及预后评估体系的建立 | 上海申康医院管理中心市级医院新兴前沿技术联合攻关项目 |
2014-01~2016-12
|
50万元
| 主要责任人 |
81370743 | Nrf2-ARE信号通路在氢气干预新生儿坏死性小肠结肠炎中的机制研究 | 国家自然科学基金 |
2014-01~2017-12
|
70万元
| 课题负责人 |
124119a6500 | 氢饱和生理盐水治疗新生儿坏死性小肠结肠炎的研究 | 上海市科委引导类重点课题 |
2012-10~2015-09
|
30万元
| 课题负责人 |
12411952405 | 神经母细胞瘤分子生物学预后评估体系的初步构建 | 上海市科委科技攻关重大项目 |
2012-09~2015-12
|
70万元
| 子课题负责人 |
12DZ2295006 | 儿童肿瘤、遗传代谢性和出生缺陷性疾病的样本库与应用示范 | 上海市科委研发平台专项基金 |
2012-09~2014-09
|
75万元
| 子课题负责人 |
YZ1036 | 缝隙连接蛋白43与先天性巨结肠发生关系的研究 | 上海交通大学医学院科技基金 |
2010-06~2012-06
|
5万元
| 课题负责人 |
- 学术论文
Kezhe Tan; Jialin Mo; Meng Li; Yu Dong; Yujie Han; Xi Sun; Yingxuan Ma; Kai Zhu; Wei Wu;
Li Lu; Jiangbin Liu; Kewen Zhao; Lei Zhang; Yujie Tang; Zhibao Lv
|
SMAD9-MYCN positive feedback loop represents a unique dependency for MYCN-amplified neuroblastoma
|
Journal of Experimental & Clinical Cancer Research
|
2022
|
41(1)
|
Xiuhao Zhao; Wenhua Liang; Yonghui Wang; Ruirong Yi; Lingjie Luo; Weifang Wang; Nannan
Sun; Mingcheng Yu; Weijue Xu; Qingfeng Sheng; Li Lu; Jianfeng Pang; Zhibao Lv; Feng Wang
|
Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis
|
Cell & Bioscience
|
2022
|
12(3)
|
Chen, Jianglong; Chen, Tong; Zhou, Jin; Zhao, Xiuhao; Sheng,, Zhibao
|
MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis
|
Frontiers in Cell and Developmental Biology
|
2021
|
8: 594143
|
Zhao, Xiuhao; Zhou, Jin; Liang, Wenhua; Sheng, Qingfeng; Lu, Li; Chen, Tong; Chen, Jianglong; Tan,, Zhibao
|
Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway
|
CELL AND BIOSCIENCE
|
2021
|
11(1): 20
|
Chen, Tong; Chen, Jianglong; Zhao, Xiuhao; Zhou, Jing; Sheng, Qingfeng; Zhu,, Zhibao,
|
beta Klotho, a direct target of miR-206, contributes to the growth of hepatoblastoma through augmenting PI3K/Akt/mTOR signaling
|
American Journal of Cancer Research
|
2021
|
11(5): 1982
|
Yu S, Lv Z, Gao Z, Shi J, Sheng Q, Zheng L, Zhou J,
|
Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis
|
Front Pediatr
|
2021
|
9:710382
|
Chen, Tong; Tian, Linlin; Chen, Jianglong; Zhao, Xiuhao; Zhou, Jing; Guo, Ting; Sheng, Qingfeng; Zhu, Linlin; Liu,, Zhibao
|
A Comprehensive Genomic Analysis Constructs miRNA-mRNA Interaction Network in Hepatoblastoma
|
Frontiers in Cell and Developmental Biology
|
2021
|
9: 655703
|
Lu, Li; Xu, Weijue; Liu, Jiangbin; Chen, Liping; Hu, Shaohua; Sheng, Qingfeng; Zhang,, Zhibao
|
DRG1 Maintains Intestinal Epithelial Cell Junctions and Barrier Function by Regulating RAC1 Activity in Necrotizing Enterocolitis
|
Digestive Diseases and Sciences
|
2021
|
66(12):4237-4250
|
Chen, Tong; Ge, Guijie; Chen, Jianglong; Zhao, Xiuhao; Sheng, Qingfeng; Zhu, Linlin; Xu, Weijue; Liu,, Zhibao
|
Pyriform Sinus Fistula in Children: Preferred Imaging Modality and Risk Factors for Diagnostic Delay
|
Frontiers in Pediatrics
|
2020
|
8: 575812
|
Chen Tong; Chen Jianglong; Sheng Qingfeng; Zhu Linlin; Bai Xiaoling; Xu Weijue; Liu Jiangbin; Li Xiaoyan; Lv Zhibao
|
Pyriform sinus fistula in children: A comparison of endoscopic-assisted surgery and endoscopic radiofrequency ablation
|
Journal of Pediatric Surgery
|
2020
|
9,(1):18497
|
Chen, Liping; Lv, Zhibao; Gao, Zhimei; Ge, Guijie; Wang, Xueli; Zhou,, Qingfeng
|
Human beta-defensin-3 reduces excessive autophagy in intestinal epithelial cells and in experimental necrotizing enterocolitis
|
Scientific Reports
|
2019
|
9(1): 19890
|
Sheng Qingfeng, Lv Zhibao, Xu Weijue,
|
Differences in the diagnosis and management of pyriform sinus fistula between newborns and children
|
Scientific Reports
|
2019
|
9,(1):18497
|
Wu Wei, Lu Li, Xu Weijue,
|
Whole Exome Sequencing Identifies a Novel Pathogenic RET Variant in Hirschsprung Disease
|
Frontiers in Genetics
|
2019
|
9:752
|
Fu, Dong; Li, Peng; Sheng,, Zhibao
|
beta-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis
|
Aging-US
|
2019
|
11(19): 8294-8312
|
Li, Peng; Fu, Dong; Sheng, Qingfeng; Yu, Shenghua; Bao,, Zhibao
|
TUDCA attenuates intestinal injury and inhibits endoplasmic reticulum stress-mediated intestinal cell apoptosis in necrotizing enterocolitis
|
International Immunopharmacology
|
2019
|
74: 105665
|
WEI WU1, SHAO JINGBO2, WEIJUE XU1, JIANGBIN LIU1,, QINGFENG SHENG1 and ZHIBAO LV1
|
S?trityl?L?cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma
|
ONCOLOGY LETTERS
|
2018
|
16: 1023-1030, 2018
|
Guo-Gang Ye1*, Peng Li2*,, Xu-Fei Duan3, Yi-Fa Chen4, Wei-Jue Xu1, Jiang-Bin Liu1, Sheng-Lin Le2
|
Case Report Solid pseudopapillary tumor of the pancreas: a case series of 11 children
|
Int J Clin Exp Med
|
2018
|
2018;11(6):6283-6292
|
余胜华 史婧奕 高志梅 郑露露 吕志宝
|
含氢培养基调节巨噬细胞RAW264.7 极化的机制研究
|
国际免疫学杂志
|
2018
|
:2018,41(9):486-493
|
陈发玲 吕志宝 刘江斌
|
儿童原发性大网膜扭转坏死的诊断与治疗
|
临床小儿外科杂志
|
2018
|
2018,17(9):699-702
|
余胜华,
|
巨噬细胞极化与新生儿坏死性小肠结肠炎
|
中华小儿外科杂志
|
2017
|
2017,38(2):156-160
|
Zhu LL, Xu WJ, Liu JB, Huang X,
|
Comparison?of?laparoscopic?hernia?repair?and?open?herniotomy?in children: a?retrospectivecohort?study
|
Hernia
|
2017
|
2017,21(3):417-423
|
吴伟,刘江斌,徐伟珏,余胜华,
|
畸胎瘤样肾母细胞瘤治疗体会及文献回顾
|
中华小儿外科杂志
|
2017
|
2017,37(10):749-752
|
Shao JB1,?Gao ZM2,?Huang WY3,?Lu ZB
|
The mechanism of epithelial-mesenchymal transition induced by TGF-β1 in neuroblastoma cells
|
Internation journal of oncology
|
2017
|
2017,50(5):1623-1633
|
吴一波,,徐伟珏,刘江斌,郑露露
|
血清ACE2在评估胆道闭锁肝纤维化及其预后中的应用价值
|
临床与病理杂志
|
2017
|
2017,37(12): 2555-2560
|
Zheng L1,,?Gong Z1,?Sheng Q1,?Gao Z3,?Zhang Y1,?Yu S1,?Zhou J1,?Xi Z4,?Wang X4.
|
Fn14 hepatic progenitor cells are associated with liver fibrosis in biliary atresia.
|
Pediatric Surgery International
|
2017
|
2017,33(5):593-599
|
Wu W1,, Xu W, Liu J, Sheng Q.
|
An analysis of foreign body ingestion treatment below the pylorus in children
|
Medicine (Baltimore).
|
2017
|
2017,96(38):
|
Wu W1,,?Xu W,?Liu J,?Jia W.
|
VACTER syndrome with situs inversus totalis: Case report and a new syndrome
|
Medicine
|
2017
|
2017,96(25)
|
Sheng Q1,,?Xu W1,?Xiao X2,?Liu J1,?Wu Y1.
|
Reoperation After Cyst Excision with Hepaticojejunostomy for Choledochal Cysts: Our Experience in 18 Cases
|
Medical science
|
2017
|
2017;23:1371-1377
|
Sheng Q1,?Xu W1,?Liu J1,?Shen B2,,?Wu Y1,?Wu W1,?Yu S1,?Wang X3,?Lv Z1.
|
Pancreatic solitary fibrous tumor in a toddler managed by pancreaticoduodenectomy: a case report and review of the literature
|
Onco Targets and Therapy
|
2017
|
2017;10:1853-1858
|
余胜华,
|
血小板活化因子在新生儿坏死性小肠结肠炎发病中的作用
|
中华小儿外科杂志
|
2017
|
2017,38(6):475-479
|
陈丽萍 吕志宝
|
新生儿坏死性小肠结肠炎小分子药物作用机制的研究进展
|
中国小儿急救医学
|
2017
|
2017,24(12) : 934-938
|
黄一敏,
|
女童先天性耻骨前窦道的诊断和治疗
|
中华小儿外科杂志
|
2016
|
2016,37(6):464-470
|
吴伟,徐伟珏,
|
儿童幽门下消化道异物治疗分析
|
国际儿科杂志
|
2016
|
2016,43(10)
|
郑露露,
|
生物标记物早期诊断胆道闭锁的研究进展
|
中华小儿外科杂志
|
2016
|
2016,37(5):387-390
|
Sheng Q,, Xu W, Liu J, Wu Y, Shi J, Xi Z
|
Short-term surgical outcomes of preterm infants with necrotizing enterocolitis: A single-center experience
|
Medicine
|
2016
|
2016,95(30)
|
史婧奕,
|
双歧杆菌三联活菌散预防早产儿坏死性小肠结肠炎的初步探讨
|
临床小儿外科杂志
|
2016
|
2016,15(1) :72-76
|
Qingfeng Sheng,
|
Endoscopic-Assisted Surgery for Pyriform Sinus Fistula in Chinese Children: A 73-Consecutive-Case Study
|
J Laparoendosc Adv Surg Tech A
|
2016
|
2016,26(1):70-74
|
叶国刚 段栩飞 吕志宝 刘江斌 乐盛麟 李鹏
|
婴儿期外科相关性胆汁淤积症临床分析
|
中华普通外科杂志
|
2016
|
2016,31(2):137-140
|
邵静波,
|
microRNA在神经母细胞瘤的研究进展
|
国际儿科学杂志
|
2016
|
2016,43(4):271-274
|
吴伟,
|
Eg5蛋白靶向抑制剂S-Trity-L-Cysteine对神经母细胞瘤增殖和分裂的影响
|
中华小儿外科杂志
|
2016
|
2016,37(6):464-470
|
Jiangbin Liu,,Xianmin Xiao
|
Laparoscopic radical nephrectomy of Wilm’s tumor and renal cancer in children: preliminary experience from a two-center study in China
|
J Laparoendosc Adv Surg Tech A
|
2015
|
25:516-521
|
穆怀博,盛庆丰,吴伟,
|
氢气对氧化损伤结肠腺癌细胞的保护作用及机制
|
山东医药
|
2015
|
55(6):4-7
|
Qingfeng Sheng,,Weijue Xu,Jiangbin Liu,Yibo Wu,Zhengjun Xi
|
A Case Report of Adrenocortical Adenoma Mimicking Congenital Adrenal Hyperplasia in a Young Girl
|
Medicine
|
2015
|
94(25)
|
刘江斌,李会,吴一波,徐伟珏,
|
3D高清腹腔镜在小儿外科的临床应用初探
|
中华小儿外科杂志
|
2015
|
37(7):532-535
|
史静奕,
|
肠屏障功能障碍与新生儿坏死性小肠结肠炎
|
国际儿科学杂志
|
2015
|
42(4):427-430
|
吴伟,邵静波,周君梅,李玲玲,
|
三氧化二砷对神经母细胞瘤细胞株诱导作用的初步研究
|
中华实用儿科临床杂志
|
2015
|
30(15):1164-1167
|
Linlin Zhu,,Jiangbin Liu,Weijue Xu
|
Choledochocele: A Case Report and Discussion of Diagnosis Criteria
|
Eur J Pediatr Surg Rep
|
2015
|
3:85-89
|
,刘江斌
|
小儿胃肠道腔镜手术的近况与认识
|
中华小儿外科杂志
|
2015
|
36(11):801-804
|
盛庆丰,,蔡威,宋还雷,钱林溪,穆怀博,王雪莉
|
重组人β-防御素3干预新生大鼠坏死性小肠结肠炎模型的研究
|
中华小儿外科杂志
|
2015
|
26(2):109-112
|
邵静波,吴伟,李玲玲,
|
13-顺式-维甲酸体外诱导三种神经母细胞瘤细胞株分化研究
|
中华实用儿科临床杂志
|
2015
|
30(15):1152-1156
|
吴伟,
|
儿童颈部梨状窝瘘诊治进展
|
国际儿科学杂志
|
2014
|
41(4):418-420
|
刘江斌,肖现民,谢华,陈方,
|
腹腔镜根治性肾切除术治疗小儿肾脏恶性肿瘤的初步经验
|
中华小儿外科杂志
|
2014
|
35(6):448-451
|
|
先天性巨结肠再手术问题
|
中华实用儿科临床杂志
|
2014
|
29(23):1771-1773
|
盛庆丰,
|
人β防御素在机体免疫应答反应中作用的研究进展
|
国际免疫学杂志
|
2014
|
37(1):40-43
|
Qingfeng Sheng,,Wei Cai
|
Human beta-defensin-3 promototes intestinal epithelial cell migration and reduces the development of necrotizing enterocolitis in a neonatal rat model
|
Pediatr Res
|
2014
|
76(3):269-279
|
Sheng Q,, Xiao X, Zheng S, Huang Y, Huang X, Li H, Wu Y, Dong K, Liu J
|
Diagnosis and management of pyriform sinus fistula: experience in 48 cases
|
J Pediatr Surg
|
2014
|
49(3):455-459
|
吴伟,
|
神经母细胞瘤病原基因研究回顾及进展
|
中华小儿外科杂志
|
2014
|
35(1):70-72
|
许灵苍,周君梅,李会,
|
肥大细胞在先天性巨结肠各表型中的分布及其作用
|
中华小儿外科杂志
|
2014
|
35(7):415-419
|
盛庆丰,
|
干细胞移植治疗先天性巨结肠的研究进展
|
中华小儿外科杂志
|
2013
|
34(1): 66-68
|
Qingfeng Sheng,, Wei Cai, Huanlei Song, Linxi Qian, Xueli Wang
|
Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats
|
Journal of Pediatric Surgery
|
2013
|
48(8): 1697-1706
|
Li H, Xu W, Huang Y, Huang X, Xu L,
|
Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo
|
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
|
2012
|
30(5):1081-6
|
许灵苍,
|
慢传输型便秘和肠神经系统关系的研究进展
|
临床小儿外科杂志
|
2012
|
11(6):468-470
|
Qingfeng Sheng,,Xianmin Xiao
|
Re-operation for Hirschsprung’s disease: experience in 24 patients from China
|
Pediatr Surg Int
|
2012
|
28(5):501-506
|
盛庆丰,,周以明,肖现明,郑珊
|
先天性巨结肠根治术后再次手术方法探讨
|
中华小儿外科杂志
|
2012
|
33(4):288-291
|
许灵苍,
|
先天性巨结肠的微环境病因学研究
|
国际儿科学杂志
|
2012
|
39(5):488-490
|
于怡,赵晓鸣,
|
二氧化碳对小鼠神经母细胞瘤细胞跨间皮细胞迁移影响的实验研究
|
中华小儿外科杂志
|
2011
|
32(5):376-379
|
于怡,高萱,
|
氧化亚氮气腹对新生猪循环、呼吸功能影响的实验研究
|
中华小儿外科杂志
|
2011
|
32(2):135-138
|
于怡,华广美,
|
长时间人工气腹对心功能不全新生猪循环功能影响的实验研究
|
中华小儿外科杂志
|
2011
|
32(1):53-56
|
于怡,赵晓鸣,
|
不同气体条件对腹膜形态影响的实验研究
|
中华小儿外科杂志
|
2011
|
32(7):539-542
|
,李会,肖现民,郑珊,陈功,刘江斌
|
小儿先天性胆管扩张症根治术后在再手术原因分析及并发症
|
中华小儿外科杂志
|
2010
|
31(12):817-821
|
, Xiao X, Zheng J, Liu J, Chen G.
|
Modified Soave procedure for the treatment of vascular malformations involving anorectum and sigmoid colon.
|
Journal of Pediatric Surgery
|
2009
|
44(12):2359-2363
|
|