• 基本信息
    导师姓名： 左勇 学科代码： 100100
    性别： 男 学科名称： 基础医学
    培养单位： 基础医学院 三级学科
    导师类型： 硕士生导师 专业领域名称：
    联系方式： zuoyong@shsmu.edu.cn 7号楼402室 专业领域代码：
    邮编： 邮箱地址： zuoyong@shsmu.edu.cn
  • 研究方向 (点击浏览详细信息)
  • 社会任职
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    2023310031004671巨噬细胞-成纤维细胞互作在皮肤衰老中的作用和SUMO化调控机制广州蛋壳网络科技有限公司 2023-08~2025-07 50万元  课题负责人
    23ZR1437000激活SENP1-Sirt3轴调控线粒体稳态对保护内皮细胞功能的作 用与机制上海市自然科学基金 2023-04~2026-03 20万元  课题负责人
    81870321SENP1-TFEB轴调控巨噬细胞自噬溶酶体生成的机制及与动脉粥样硬化的关系国家自然基金，面上基金项目 2019-01~2022-12 57万元  课题负责人
    81672880SUMO特异性蛋白酶1对髓系来源抑制性细胞的调控作用及与肿瘤转移的关系国家自然基金，面上基金项目 2017-01~2018-12 25万元  课题负责人
    15140904300利用巨噬细胞特异性SENP1基因敲除小鼠模型研究肥胖导致的胰岛素抵抗上海市市科委 2015-09~2017-08 20万元  课题负责人
    14ZR1423500SUMO特异性蛋白酶1对髓系衍生抑制性细胞的调控与肺癌转移的机制上海市自然科学基金项目 2014-07~2017-06 10万元  课题负责人
    2012CB910100蛋白质小泛素相关修饰（SUMO）对细胞代谢的调控作用科技部973计划“代谢相关蛋白质修饰在肿瘤发生发展过程中的作用及机制”项目 2012-01~2016-08 87.2万元  课题参与人
    30900740SENP1在癌基因诱导的细胞衰老中的作用与机制国家自然基金，青年科学基金项目 2010-01~2012-12 20万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Zhou W, Hu G, He J, Wang T,, Cao Y, Zheng Q, Tu J, Ma J, Cai R, Chen Y, Fan Q, Dong B, Tan H, Wang Q, Xue W, Cheng J  SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization  Cell Rep.  2022  39(2):110660 
    He J, Shangguan X, Zhou W, Cao Y, Zheng Q, Tu J, Hu G, Liang Z, Jiang C, Deng L, Wang S, Yang W,, Ma J, Cai R, Chen Y, Fan Q, Dong B, Xue W, Tan H, Qi Y, Gu J, Su B, Eugene Chin Y, Chen G, Wang Q, Wang T, Cheng J  Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development  Nat Commun.  2021  12(1):4371 
    Kangwei Wang, Zaixue Jiang, Xiaomei Lu, Yaozhong Zhang, Xu Yuan, Dong Luo, Zitian Lin,, QingmingLuo*  Cardiomyocyte-specific deletion of Senp2 contributes to CVB3 viral replication and inflammation.   International Immunopharmacology  2020  Volume 88 
    Wang Y, Tian J, Huang C, Ma J, Hu G, Chen Y, Wang T, Cai R,, Tan H, Fan Q, Dong B, Xue W, Yi J, Chen G, Tu J, Cheng J  P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint  Cell Discov  2020  Apr 21;6:21 
    Jing Xu, Jiahui Wang, Xiaoli Wang, Ruoming Tan, Xiaoling Qi, Zhaojun Liu, Hongping Qu, Tingting Pan, Qingyuan Zhan,, Wen Yang*, Jialin Liu*  Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages  Cell Death Disease  2020  11(10):934 
    梁璆荔,程金科,  ATRA诱导小鼠间充质干细胞棕色成脂分化的分子机制  检验医学  2019  34(5) ：451-456 
    Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R,, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J  SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism  Mol Cell  2019  Epub ahead of print 
    Huang X,, Wang X, Wu X, Tan H, Fan Q, Dong B, Xue W, Chen GQ, Cheng J  SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function  Cancer Res  2019  79(15):3891-3902 
    王秀芝,  PPARγ1的SUMO化修饰对巨噬细胞M2极化的抑制作用  上海交通大学学报（医学版）  2019  39(12)：1402-1408 
    Ma J, Liu B, Yu D,, Cai R, Yang J, Cheng J  SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylation  Br J Haematol  2019  Epub ahead of print 
    Liang Q, Zheng Q,, Chen Y, Ma J, Ni P, Cheng J  SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation  Cell Rep  2019  28(8):2004 -2011 
    缪慧娴,刘子豪,李维娅,黄答,李文博,  SUMO特异性蛋白酶家族与肿瘤生物学行为的关系  上海交通大学学报（医学版）  2018  38(3) : 348-352 
    Yang FM,, Zhou W, Xia C, Hahm B, Sullivan M, Cheng J, Chang HM, Yeh ET  sNASP inhibits TLR signaling to regulate immune response in sepsis  Journal of Clinical Investigation  2018  128(6):2459-2472 
    卢今,严国锋,周晶,肖忠标,朱寅秋,朱莲,汪静,李垚,  传统超声与超声二维斑点追踪技术对小鼠心肌梗死模型评价的比较  实验动物与比较医学  2018  38(5): 356-364 
    Yu T#,, Cai R#, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng J  SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop  Journal of Molecular Cell Biology  2017  9(2):144-153 
    李云逸,陆菁,王秀芝,杨玉颖,费洁,张莉萍,李智,李崇山,  2013-2014年上海市污水中人类肠道病毒的基因型分布  中华预防医学杂志  2017  51（2）:154-159 
    Xia N, Cai J, Wang F, Dong B, Liu S, Chen F, Cheng J,  SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1  Scientific Reports  2016  6:34099 
    Wang YP, Zhou W, Wang J, Huang X,, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK, Lei QY  Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer  Molecular Cell  2016  64(4):673-687 
    李艳,夏南松,  Kif18A的SUMO化修饰及其调控机制  徐州医学院学报  2015  35(8):507-512 
    Mu J,, Yang W, Chen Z, Liu Z, Tu J, Li Y, Yuan Z, Cheng J, He J  Over-expression of small ubiquitin-like modifier proteases 1 predicts chemo-sensitivity and poor survival in non-small cell lung cancer  Chin Med J (Engl)  2014  127(23):4060-5 
    Qi Y#,, Yeh ET, Cheng J  An Essential Role of Small Ubiquitin-like Modifier (SUMO)-specific Protease 2 in Myostatin Expression and Myogenesis  JOURNAL OF BIOLOGICAL CHEMISTRY   2014  289(6):3288-93 
    Liu B, Wang T, Mei W, Li D, Cai R,, Cheng J  Small Ubiquitin-like Modifier (SUMO) Protein-specific Protease 1 De-SUMOylates Sharp-1 Protein and Controls Adipocyte Differentiation  JOURNAL OF BIOLOGICAL CHEMISTRY  2014  289(32):22358-64 
    Sun H #, Lu L #,, Wang Y, Jiao Y, Zeng W, Huang C, Zhu X, Zamponi GW, Zhou T, Xu T, Cheng J, and Li Y  Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation  NATURE COMMUNICATIONS  2014  5:4980 
    Wang Q, Xia N, Li T, Xu Y, Zou Y,, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J  SUMO-specific protease 1 promotes prostate cancer progression and metastasis  Oncogene  2013  32(19):2493-8 
    Wang Y, Sun Y, Li D, Zhang L, Wang K,, Gartner TK, Liu J  Platelet P2Y12 is involved in murine pulmonary metastasis  PLoS One  2013  8(11):e80780 
    Bawa-Khalfe T, Lu LS,, Huang C, Dere R, Lin FM, Yeh ET  Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition  Proc Natl Acad Sci USA  2012  109(43):17466-71 
    Jiang Z, Fan Q, Zhang Z, Zou Y, Cai R, Wang Q,, Cheng J  SENP1 deficiency promotes ER stress-induced apoptosis by increasing XBP1 SUMOylation  Cell Cycle  2012  11(6):1118-22 
    Xu Y, Li J,, Deng J, Wang LS, Chen GQ  SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors  Cancer Letters  2011  309(1):78-84 
    Huang L, Yan Z, Liao X, Li Y, Yang J, Wang ZG,, Kawai H, Shadfan M, Ganapathy S, Yuan ZM  The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo  Proc Natl Acad Sci USA  2011  108(29):12001-6 
    Xu Y,, Zhang H, Kang X, Yue F, Yi Z, Liu M, Yeh ET, Chen G, Cheng J  Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis  JOURNAL OF BIOLOGICAL CHEMISTRY   2010  285(47):36682-8 
    Kang X, Qi Y,, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET  SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development  Molecular Cell  2010  38(2):191-201 
    , Cheng JK   Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer  Asian Journal of Andrology  2009  11(1):36-8 
    , Xiang B, Yang J, Sun X, Wang Y, Cang H, Yi J.   Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1  Cell Research  2009  19(4):449-57