• 基本信息
    导师姓名: 张先龙 学科代码: 100210
    性别: 学科名称: 外科学
    培养单位: 附属第六人民医院 三级学科 骨外
    导师类型: 博士生导师 专业领域名称: 外科学 专业学位
    联系方式: 秘书:董老师 26858973@qq.com 专业领域代码: 105111
    邮编: 200233 邮箱地址: 2324173807@qq.com
  • 研究方向 (点击浏览详细信息)
  • 社会任职
     
    世界华裔骨科学会理事
    《中华老年骨科与康复电子杂志》特约编委
    《中华骨科杂志》编委
    《中华解剖与临床杂志》副总编辑,JOA中文版副总编辑
    中国医师协会骨科医师分会委员、关节工作委员会副主委、中国人工关节感染专业委员会(PJI)主任委员
    《中国骨与关节杂志》常务编委
    中国医师协会机器人外科医师分会医用机器人分会常委
    SICOT中国部关节外科学会副主任委员
    亚太人工关节学会(ASIA)中国分会理事
    《中华医学杂志》英文版(CMJ)编委
    《中国矫形外科杂志》编委
    世界华裔骨科学会理事
    上海医学会骨科专科分会关节外科学组组长
    中国研究型医院学会关节外科学专业委员会人工关节表界面材料研究学组(CASIS)组长
    《Arthroplasty》副主编
    《中华外科杂志》编委
    ASIA人工关节感染共识编委会主任委员
    中华医学会骨科学分会关节外科学组副组长
    《中华关节外科杂志》(电子版)副总编辑
  • 科研项目
    项目编号项目名称课题来源起止年月批准经费承担职责
    8197090236 免疫调控具有多重生物学效应的聚醚醚酮骨内植物构建及其机制研究国自然面上项目 2020-01~2023-12 56万元  课题负责人
    81772309多级修饰具有表面多孔结构的双活性低模量钛的制备及其生物学研究国自然面上项目 2018-01~2021-12 58万元  课题负责人
    /院级优势特色专业上海市第六人民医院 2016-03~2017-12 14.48万元  课题负责人
    81472109小鼠β-防御素-14调节机体获得性免疫应答抑制生物膜感染的实验研究国家自然基金面上项目 2015-01~2018-12 80万元  课题负责人
    81271962新型医用低模量钛合金及其表面Ag纳米管的制备和生物学基础研究国家自然基金面上项目 2013-01~2016-12 70万元  课题负责人
    81171688以 TAK1 信号传导通路为靶点抑制假体周围骨溶解的实验国家自然基金面上项目 2012-01~2015-12 58万元  课题负责人
  • 学术论文
    作者论文标题期刊名出版年卷期页码
    Jinhua Li#,Wei Liu#,David Kilian,,Michael Gelinsky, Paul K. Chu*  Bioinspired interface design modulates pathogen and immunocyte responses in biomaterialcentered infection combination therapy  Materials Horizons  2019  2019, 6, 1271--1282 
    Wei Liu, Jinhua Li, Mengqi Cheng, Qiaojie Wang, Yebin Qian, Kelvin W.K. Yeung*, Paul K. Chu*,  A surface-engineered polyetheretherketone biomaterial implant with direct and immunoregulatory antibacterial activity against methicillin-resistant Staphylococcus aureus  Biomaterials  2019  208 (2019) 8-20 
    Yuan X, Ouyang L, Luo Y, Sun Z, Yang C, Wang J, Liu X*,  Multifunctional sulfonated polyetheretherketone coating with beta-defensin-14 for yielding durable and broad-spectrum antibacterial activity and osseointegration  Acta Biomater  2019  86:323-337 
    Jinhua Li#, Wei Liu#,, Kelvin W. K*. Yeung, Paul K. Chu*.   Temperature-responsive tungsten doped vanadium dioxide thin film starves bacteria to death  Materials Today  2019  2019; 22, 35-49 
    Wei Liu, Desheng Chen, Qiuyan Li, Dong Wang, Mengqi Cheng*, Guo He*,  A lithium-containing nanoporous coating on entangled titanium scaffold can enhance osseointegration through Wnt/beta-catenin pathway,  Nanomedicine: nanotechnology, biology, and medicine  2018  14(1) (2018) 153-164 
    Wei Liu, Jinhua Li, Kelvin W. K*. Yeung, Paul K. Chu*,  Zinc-modified sulfonated polyetheretherketone surface with immunomodulatory function for guiding cell fate and bone regeneration  Advanced Science   2018  (2018) 1800749 
    Xiangwei Yuan, Huiliang Cao, Jiaxing Wang, Kaiwei Tang, Bin Li, Yaochao Zhao, Mengqi Cheng, Hui Qin, Xuanyong Liu*,  Immunomodulatory Effects of Calcium and Strontium Co-Doped Titanium Oxides on Osteogenesis  Frontiers in Immunology  2017  8: 1196 
    Jiaxing Wang, Huaijuan Zhou, Hao Shen*, Jinhua Li*,  Enhanced Anti-Infective Efficacy of ZnO Nanoreservoirs through a Combination of Intrinsic Anti-Biofilm Activity and Reinforced Innate Defense.  ACS Appl Mater Interfaces  2017  9:33609-33623 
    Bin Li, Yan Hu,  Curcumin attenuates titanium particle-induced inflammation by regulating macrophage polarization in vitro and in vivo  Frontiers in immunology  2017  2017.8 
    Jinhua Li, Jiaxing Wang,, Xuanyong Liu*.   Band Gap Engineering of Titania Film through Cobalt Regulation for Oxidative Damage of Bacterial Respiration and Viability.  ACS Appl Mater Interfaces,  2017  9:27475-27490 
    ,沈灏,王加兴.  1. 人工关节假体感染诊治的研究进展  中华关节外科杂志(电子版)  2017  11(4): 327-330 
    Wei Liu, J. Wang, G. Jiang, J. Guo, Q. Li, B. Li, Q. Wang, M. Cheng*, G. He*,  The improvement of corrosion resistance, biocompatibility and osteogenesis of the novel porous Mg-Nd-Zn alloy   Journal of Materials Chemistry B   2017  5(36) (2017) 7661-7674 
    王俏杰,柴伟,王琦,陈云苏,沈灏,彭晓春,倪明,付君,陈继营,  机器人辅助下膝关节单髁置换术初步临床结果  中华解剖与临床杂志  2016  (22)2:108-115 
    Wang J, Li J, Qian S, Guo G, Wang Q, Tang J, Shen H*, Liu X*,, Chu PK  Antibacterial Surface Design of Titanium-Based Biomaterials for Enhanced Bacteria-Killing and Cell-Assisting Functions Against Periprosthetic Joint Infection.  ACS Appl Mater Interfaces  2016  4;8(17):11162-78 
    Ouyang L, Zhao Y, Jin G, Lu T, Li J, Qiao Y, Ning C,, Chu PK, Liu X*  Influence of sulfur content on bone formation and antibacterial ability of sulfonated PEEK  Biomaterials  2016  83(2016): 15-126 
    Liu W,  Receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin system in bone and other tissues (review)  Mol Med Rep  2015  11(5):3212-8 
    Zhang Yin, He Wenye, Cheng Tao,  Total hip arthroplasty: leg length discrepancy affects functional outcomes and patient’s gait  Cell biochemistry and biophysics  2015  72:1 : 215-219 
    Zhao Y, Cao H, Qin H, Cheng T, Qian S, Cheng M, Peng X, Wang J, Zhang Y, Jin G,, Liu X, Chu PK  Balancing the Osteogenic and Antibacterial Properties of Titanium by Codoping of Mg and Ag: An in Vitro and in Vivo Study  ACS Appl Mater Interfaces  2015  19;7(32):17826-36 
    Zhang Y, Cheng T,  Changes in Intra-pelvic Obliquity Angle 0-2 Years After Total Hip Arthroplasty and Its Effects on Leg Length Discrepancy: A Retrospective Study  Chin Med J (Engl)  2015  20;128(10):1346-50 
    Peng X,, Cheng T, Cheng M, Wang J  Comparison of the quadriceps-sparing and subvastus approaches versus the standard parapatellar approach in total knee arthroplasty: a meta-analysis of randomized controlled trials  BMC Musculoskelet Disord  2015  31;16(1):327 
    Fu H, Wang J, Zhang W, Cheng T,  No clinical benefit of posterior stabilized high-flex total knee arthroplasty. A meta-analysis of randomized controlled trials  J Arthroplasty  2015  30(4):573-9 
    Qin H, Zhao Y, An Z, Cheng M, Wang Q, Cheng T, Wang Q, Wang J, Jiang Y,, Yuan G  Enhanced antibacterial properties, biocompatibility, and corrosion resistance of degradable Mg-Nd-Zn-Zr alloy  Biomaterials  2015  53:211-20 
    Fu H, Wang J, Zhou S, Cheng T, Zhang W, Wang Q,  No difference in mechanical alignment and femoral component placement between patient-specific instrumentation and conventional instrumentation in TKA  Knee Surg Sports Traumatol Arthrosc  2015  23(11):3288-95. 
    Qin H, Zhao Y, Cheng M, Wang Q, Wang Q, Wang J, Jiang Y, An Z,  Anti-biofilm properties of magnesium metal via alkaline pH  Rsc Advances  2015  5 (28),:21434-21444 
    Wang QJ, Shen H,,Jiang Y, Wang Q, Chen YS, Shao JJ  Staged reimplantation for the treatment of fungal peri-prosthetic joint infection following primary total knee arthroplasty  Orthop Traumatol Surg Res  2015  101(2):151-6 
    Zhang Y, Cheng T, Gao H,  Traumatic diaphragmatic hernia associated with pelvic ring fracture  Chin Med J (Engl)  2015  5;128(9):1272-4 
    Jin G, Qin H, Cao H, Qiao Y, Zhao Y, Peng X,, Liu X, Chu PK. Z. Biomaterials  n/Ag micro-galvanic couples formed on titanium and osseointegration effects in the presence of S. aureus  Biomaterials  2015  65:22-31 
    Liu W, Wahafu T, Cheng M, Cheng T, Zhang Y,  The influence of obesity on primary total hip arthroplasty outcomes: A meta-analysis of prospective cohort studies  Orthop Traumatol Surg Res  2015  101(3):289-96 
    Qin H, Cao H, Zhao Y, Jin G, Cheng M, Wang J, Jiang Y, An Z,, Liu X.   Antimicrobial and osteogenic properties of silver-ion-implanted stainless steel  ACS Appl Mater Interfaces  2015  27;7(20):10785-94 
    Shen H, Tang J, Wang Q, Jiang Y,  Sonication of explanted prosthesis combined with incubation in BD bactec bottles for pathogen-based diagnosis of prosthetic joint infection  J Clin Microbiol  2015  53(3):777-81 
    Cheng M, Qiao Y, Wang Q, Jin G, Qin H, Zhao Y, Peng X,, Liu X   Calcium Plasma Implanted Titanium Surface with Hierarchical Microstructure for Improving the Bone Formation  ACS Appl Mater Interfaces  2015  17;7(23):13053-61 
    Liu W, Cheng M, Wahafu T, Zhao Y, Qin H, Wang J,, Wang L  The in vitro and in vivo performance of a strontium-containing coating on the low-modulus Ti35Nb2Ta3Zr alloy formed by micro-arc oxidation  J Mater Sci Mater Med  2015  26(7):203 
    Xiaochun Peng, Tao Cheng, Mengqi Cheng, Jiaxing Wang,  Hierarchically porous CaCO3 monoliths prepared from leaf template  Materials Letters  2014  15; 129(198-201) 
    Zhu C, Wang J, Cheng T, Li Q, Shen H, Qin H, Cheng M,  The potential role of increasing the release of mouse β- defensin-14 in the treatment of osteomyelitis in mice: a primary study  PLoS One  2014  28;9(1):e86874 
    Qin H, Zhu C, An Z, Jiang Y, Zhao Y, Wang J,, Hui B, Zhang X, Wang Y  Silver nanoparticles promote osteogenic differentiation of human urine-derived stem cells at noncytotoxic concentrations  Int J Nanomedicine  2014  20;9:2469-78. 
    Cheng T, Zhu C, Wang J, Cheng M, Peng X, Wang Q,  No clinical benefit of gender-specific total knee arthroplasty  Acta Orthop  2014  85(4):415-21 
    Jin G, Qin H, Cao H, Qian S, Zhao Y, Peng X,, Liu X, Chu PK  Synergistic effects of dual Zn/Ag ion implantation in osteogenic activity and antibacterial ability of titanium  Biomaterials  2014  35(27):7699-713 
    Qin H, Cao H, Zhao Y, Zhu C, Cheng T, Wang Q, Peng X, Cheng M, Wang J, Jin G, Jiang Y,, Liu X, Chu PK  In vitro and in vivo anti-biofilm effects of silver nanoparticles immobilized on titanium  Biomaterials  2014  35(33):9114-25 
    Shen H, Tang J, Mao Y, Wang Q, Wang J, Zhang X,  Pathogenic analysis in different types of orthopedic implant infections  Chin Med J (Engl)  2014  127(15):2748-52 
    Zhu C, Tan H, Cheng T, Shen H, Shao J, Guo Y, Shi S,  Human β-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation  J Surg Res  2013  183(1):204-13 
    Wang J, Zhu C, Cheng T, Peng X, Zhang W, Qin H,  A systematic review and meta-analysis of antibiotic-impregnated bone cement use in primary total hip or knee arthroplasty  PLoS One  2013  12;8(12):e82745 
    Guo Y, Chen D, Cheng M, Lu W, Wang L,  The bone tissue compatibility of a new Ti35Nb2Ta3Zr alloy with a low Young's modulus  Int J Mol Med  2013  31(3):689-97. 
    Guo Y, Chen D, Lu W, Jia Y, Wang L,  Corrosion resistance and in vitro response of a novel Ti35Nb2Ta3Zr alloy with a low Young's modulus  Biomed Mater  2013  8(5):055004 
    Shi S,  Adjunctive use of rifampicin pre-operation can reduce infections in orthopaedic surgery  Scand J Infect Dis  2013  45(4):334-5 
    Cheng M, Chen D, Guo Y, Zhu C,  Comparison of fixed- and mobile-bearing total knee arthroplasty with a mean five-year follow-up: A meta-analysis  Exp Ther Med  2013  6(1):45-51 
    Cheng T, Chen D, Zhu C, Pan X, Mao X, Guo Y,  Fixed- versus mobile-bearing unicondylar knee arthroplasty: are failure modes different  Knee Surg Sports Traumatol Arthrosc  2013  21(11):2433-41 
    Zhu C, Tan H, Cheng T, Shen H, Shao J, Guo Y, Shi S,  Human β-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation  J Surg Res  2013  183(1):204-13. 
    Zhu C, Cheng MQ, Cheng T, Ma RX, Kong R, Guo YY, Qin H, Shi SF,  A novel classification to guide total hip arthroplasty for adult acetabular dysplasia  Exp Ther Med  2013  6(1): 216-222 
    Zhu C, Qin H, Cheng T, Tan HL, Guo YY, Shi SF, Chen DS,  Staphylococcus aureus supernatant induces the release of mouse beta-defensin-14 from osteoblasts via the p38 MAPK and NF-kappaB pathways  Int J Mol Med  2013  31(6): 1484-1494 
    Shao JJ, Parker Vail T, Wang QJ, Shen H, Chen YS, Wang Q, Jiang Y,  Anatomical references for tibial sagittal alignment in total knee arthroplasty: a comparison of three anatomical axes based on 3D reconstructed CT images  Chin Med J (Engl)  2013  126(20): 3840-3844 
    Qin H, Hu C Z,, et al  Surgical treatment of Ideberg type III glenoid fractures with associated superior shoulder suspensory complex injury  Orthopedics  2013  36(10): e1244-e1250 
    Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY, Cheng T,  Biocompatibility of chitosan-coated iron oxide nanoparticles with osteoblast cells.  Int J Nanomedicine  2012  7:5593-602 
    , Zhang W, Shao JJ  Rotational alignment in total knee arthroplasty: nonimage-based navigation system versus conventional technique.   Chin Med J (Engl)  2012  125(2):236-43 
    Mao X, Pan X, Zhao S, Peng X, Cheng T,  Protection against titanium particle-induced inflammatory osteolysis by the proteasome inhibitor bortezomib in vivo.  Inflammation  2012  35(4):1378-91 
    Mao X, Pan X, Peng X, Cheng T,  Inhibition of titanium particle-induced inflammation by the proteasome inhibitor bortezomib in murine macrophage-like RAW 264.7 cells  Inflammation  2012  35(4):1411-8 
    Pan X,, Liu Z, Wen H, Mao X  Treatment for chronic synovitis of knee: arthroscopic or open synovectomy.  Rheumatol Int  2012  32(6):1733-6 
    Pan X, Mao X, Cheng T, Peng X,, Liu Z, Wang Q, Chen Y  Up-regulated expression of MIF by interfacial membrane fibroblasts and macrophages around aseptically loosened implants.  J Surg Res  2012  176(2):484-9 
    Wang Q,, Chen YS, Shen H, Shao JJ  Resurfacing arthroplasty for hip dysplasia: a prospective randomised study.  J Bone Joint Surg Br  2012  94B(6):768-73 
    Mao X, Pan X, Cheng T,  Therapeutic potential of the proteasome inhibitor Bortezomib on titanium particle-induced inflammation in a murine model.  Inflammation  2012  35(3):905-12 
    Zhang W, Zhao H, Peng X, Cheng T,  Low-dose captopril inhibits wear debris-induced inflammatory osteolysis.  J Int Med Res  2011  39(3):798-804 
    Zhang W, Peng X, Cheng T,  Vascular endothelial growth factor gene silencing suppresses wear debris-induced inflammation.  Int Orthop  2011  35(12):1883-8 
    Ning R,, Guo X, Li Q  Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts.  Braz J Infect Dis  2011  15(3):189-94 
    Pan X, Mao X, Cheng T,  Macrophage migration inhibitory factor: a regulator of MMP13 and inflammation in titanium particles-stimulated air pouch in vivo.  Mol Cell Biochem  2011  357(1-2):313-21 
    Liu X,, Chen Y, Wang Q, Jiang Y, Zeng B  Hidden Blood Loss After Total Hip Arthroplasty.  J Arthroplasty  2011  26(7):1100-5 
    Ning R,, Guo X, Li Q  Attachment of Staphylococcus aureus is required for activation of nuclear factor kappa B in human osteoblasts.  Acta Biochim Biophys Sin (Shanghai)  2010  42(12):883-92 
    Hu K, Wang C,  High pressure may inhibit periprosthetic osteogenesis.  J Bone Miner Metab  2010  28(3):289-98