- 基本信息
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导师姓名：
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王刚
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学科代码：
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100204
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性别：
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男
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学科名称：
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神经病学
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培养单位：
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附属瑞金医院
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三级学科
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导师类型：
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博士生导师
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专业领域名称：
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神经病学 专业学位
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联系方式：
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上海市黄浦区瑞金二路197号瑞金医院神经内科
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专业领域代码：
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105104
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邮编：
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200025
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邮箱地址：
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wgneuron@hotmail.com
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- 研究方向 (点击浏览详细信息)
- 社会任职
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中国人脑组织库协作联盟学术委员会委员
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《阿尔茨海默病及相关病杂志》编委
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中国神经科学学会神经退行性疾病分会副主任委员兼秘书长
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Associate Editor of Human Brain Journal
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中国医师协会老年医学分会青年委员
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《诊断学理论与实践杂志》编委
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中国微循环学会神经变性病专委会脑积水学组委员
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中华医学会神经病学分会痴呆及认知障碍学组委员
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中国医师协会神经内科分会第一届青年委员会副主任委员
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《临床内科杂志》编委
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中国医师协会神经内科分会委员
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中国老年保健协会阿尔茨海默病分会（ADC）副主任委员
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上海市衰老与退行性疾病学会老年心理学分会副主委委员
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《内科理论与实践杂志》 特约编委
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上海市衰老与退行性疾病学会衰老与认知障碍分会副主任委员
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中国医师协会神经内科分会脑与脊髓损伤专委会委员
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Associate Editor of Frontier in Aging Neuroscience (ADRD section)
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中国微循环学会神经变性病专委会分子影像学组常委
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Associate Editor of the Journal of Alzheimer's Disease
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中国老年医学学会认知障碍分会常委兼青年委员会副主任委员
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中华医学会老年医学分会青年委员
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《中华老年心脑血管病杂志》编委
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Editoral member of the Journal Gene & Disease
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- 科研项目
| 82271462 | α半胱氨酸串联蛋白介导溶酶体依赖的细胞死亡在帕金森病发病中的机制研究 | 国家自然科学基金委员会 |
2023-01~2026-12
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52万元
| 课题负责人 |
| 2021ZD0201804 | 变性病痴呆影像诊断标准及分子影像技术研究 | 科技部脑科学与类脑研究重大项目课题 |
2022-01~2026-12
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897.6万元
| 课题负责人 |
| ZHYY-ZXYJHZX-202006 | 针药结合治疗轻度阿尔茨海默病的临床疗效及其作用机制研究 | 上海市综合医院中西医结合专项 |
2020-06~2022-06
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10万元
| 课题负责人 |
| 81971068 | microRNA-425调控坏死性凋亡介导多巴胺能神经元变性的机制研究 | 国家自然科学基金委员会 |
2020-01~2023-12
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55万元
| 课题负责人 |
| 19ZR1431500 | ROCK1介导的神经元ELS酸化功能障碍在阿尔茨海默病发病机制中的研究 | 上海市科学技术委员会 |
2019-07~2021-07
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20万元
| 课题负责人 |
| 2018 | 杰出青年医学人才 | 上海市“医苑新星”青年医学人才培养资助计划 |
2019-01~2022-01
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20万元
| 课题负责人 |
| TM201704 | 采用ASR语言评估软件对神经变性疾病进行辅助诊断和预后评估的转化研究 | 上海市转化医学协同创新中心合作研究项目 |
2017-12~2019-11
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19万元
| 课题负责人 |
| 2017 | 外周血sLAG3作为帕金森病潜在生物标志物的临床转化研究 | 上海交通大学医学院高峰高原计划—“研究型医师”
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2017-07~2020-06
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100万元
| 课题负责人 |
| 16SG15 | 重复经颅磁刺激对轻度认知功能障碍及早期AD患者的治疗作用及其机制的临床研究 | 上海市曙光计划 |
2017-01~2019-12
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15万元
| 课题负责人 |
| 2015272 | 采用尿液代谢组学筛选轻度认知功能障碍患者早期生物标志物的转化研究 | 上海交通大学医学院转化医学协同创新中心合作研究项目 |
2015-12~2017-12
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20万元
| 课题负责人 |
| 15PJ1405400 | miR-29调节IGF-1信号通路参与阿尔茨海默病发病及成为潜在治疗靶点和生物学标志物的实验研究 | 上海市科委浦江人才计划(A类) |
2015-07~2017-06
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20万元
| 课题负责人 |
- 学术论文
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Haixia Li, Qiongyao Xiang, Rujing Ren,
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Acupuncture as a Complementary Therapy for Alzheimer’s Disease
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Journal of Alzheimer’s Disease
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2024
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DOI 10.3233/JAD-231250
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Qiu C, Zhou W, Shen H, Wang J, Tang R, Wang T, Xie X, Hong B, Ren R,, Song Z
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Profiles of subgingival microbiomes and gingival crevicular metabolic signatures in patients with amnestic mild cognitive impairment and Alzheimer's disease
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Alzheimers Res Ther
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2024
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16(1):41
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, 李彬寅, 任汝静, 肖金雯, 陈生弟, 陈晓春
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关于抗Aβ单克隆抗体的临床应用建议（2024版）
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中国现代神经疾病杂志
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2024
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24(3): 120-126
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Huang M, Zheng M, Song Q, Ma X, Zhang Q, Chen H, Jiang G, Zhou S, Chen H,, Dai C, Li S, Li P, Wang H, Zhang A, Huang Y, Chen J, Gao X
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Comparative Proteomics Inspired Self-Stimulated Release Hydrogel Reinforces the Therapeutic Effects of MSC-EVs on Alzheimer's Disease
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Adv Mater
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2024
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36(14):e2311420
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Xie XY,Song QX,Dai CX,Cui SS,Tang R,Li SK,Chang J,Li P,Wang JT,Li JP,Gao C,Chen HZ,Chen SD,Ren RJ,Gao XL,
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Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer’s disease: a phase I/II clinical trial
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General Psychiatry
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2023
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36:e101143. doi: 10.1136/gpsych-2023-101143
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Hai-Xia Li, Jin-Tao Wang, Yu Dong, Jian-Ping Li, Jin-Wen Xiao, Ru-Jing Ren, Chun-Bo Li ,
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Blood biomarkers in MCI conversion to Alzheimer’s disease: a systematic review and meta-analysis
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Human Brain
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2023
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2（2）doi:10.37819/hb.2.1758.
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崔诗爽,张冬燕,陈先文,王含,陈伟,承欧梅,窦荣花,黄清,马莎,沈岳飞,商慧芳,王华龙,许顺良,王训,潘小玲,吴琴咪,王玉凯,陈海波,陈生弟,李燕,
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帕金森病血压管理专家共识(第二版)
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中华高血压杂志
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2023
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31（9）：809-820
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Jinwen Xiao, Jianping Li, Jintao Wang, Xingyu Zhang, Cong Wang, Guoping Peng, Hua Hu, Huayan Liu, Jun Liu, Lu Shen, Nan Zhang, Ning Yan, Qinying Ma, Wanzhong Xu, Zhengluan Liao, Rujing Ren, Mingwei Wang, Enyan Yu, Jinzhou Tian, Huali Wang, Yong’an Sun, Hengge Xie ,
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2023 China Alzheimer’s disease: facts and figures
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Human Brain
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2023
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2（3）doi:10.37819/hb.3.1771
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功能性运动障碍的诊断与治疗中国专家共识(第二版)
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中国现代神经疾病杂志
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2023
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23(12): 1061-1071
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Che XQ, Lin GZ, Liu XH,, Zhao QH, Ren RJ.
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Genetic and Neuroimaging Analysis of SIGMAR1 for Frontotemporal Dementia
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J Alzheimers Dis .
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2023
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95(2):469-475. doi: 10.3233/JAD-221195
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Zhang Y, Xie X, Chen B, Pan L, Li J, Wang W, Wang J, Tang R, Huang Q, Chen X, Ren R, Zhang Z, Fu W,
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E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer's disease
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Genes & Diseases
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2023
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Apr 10;11(2):1022-1034. doi: 10.1016/j.gendis.2023.02.051. eCollection 2024 Mar.
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Qiang Huang, Yongfang Zhang, Lin-Jie Li, Eric B. Dammer,Yong-Bo Hu, Xin-Yi Xie, Ran Tang, Jianping Li, Jintao Wang, Xiang-Qian Che,, Ru-Jing Ren
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Adult-onset neuronal ceroid lipofuscinosis with a novel DNAJC5 mutation exhibit aberrant protein palmitoylation
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Frontiers in Aging Neuroscience
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2022
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08 April 2022 | https://doi.org/10.3389/fnagi.2022.829573
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Rujing Ren, Jinlei Qi, Shaohui Lin, Xinya Liu, Peng Yin, Zhihui Wang, Ran Tang, Jintao Wang, Qiang Huang, Jianping Li, Xinyi Xie, Yongbo Hu, Shishuang Cui, Yuan Zhu, Xiaoping Yu, Pengfei Wang, Yikang Zhu, Yiran Wang, Yanyan Huang, Yisong Hu, Ying Wang, Chunbo Li, Maigeng Zhou,
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The China Alzheimer Report 2022
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General Psychiatry
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2022
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35:e100751. doi: 10.1136/gpsych-2022-100751
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Wang HL, Tang R, Ren RJ, Dammer EB, Guo QH, Peng GP, Cui HL, Zhang YM, Wang JT, Xie XY, Huang Q, Li JP, Yan FH, Chen SD, He NY,
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Share Speech silence character as a diagnostic biomarker of early cognitive decline and its functional mechanism: a multicenter cross-sectional cohort study
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BMC Med
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2022
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20(1):380. doi: 10.1186/s12916-022-02584-x.
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Ren RJ, Huang Q, Xu G, Gu K, Dammer EB, Wang CF, Xie XY, Chen W, Shao ZY, Chen SD,
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Association between Alzheimer's disease and risk of cancer: A retrospective cohort study in Shanghai, China
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Alzheimers Dement
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2022
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18(5):924-933. doi: 10.1002/alz.12436. Epub 2021 Sep 5.
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Cao LX,, Guo QH, Zhang W, Bak T, Huang Y
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Utility of Chinese Versions of Addenbrooke's Cognitive Examination: A Narrative Review
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Healthcare (Basel) .
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2022
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10(10):2052
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Hu Y, Peng W, Ren R, Wang Y,
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Sarcopenia and mild cognitive impairment among elderly adults: The first longitudinal evidence from CHARLS.
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J Cachexia Sarcopenia Muscle
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2022
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Sep 4. doi: 10.1002/jcsm.13081. Online ahead of print
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Xie XY, Zhao QH, Huang Q, Dammer E, Chen SD, Ren RJ,
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Genetic profiles of familial late-onset Alzheimer's disease in China: The Shanghai FLOAD study
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Genes & Diseases
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2022
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9(6):1639-1649;doi.org/10.1016/j.gendis.2021.05.001
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Wang JT, Xu G, Ren RJ, Wang Y, Tang R, Huang Q, Li JP, Al-Nusaif M, Le WD,
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The impacts of health insurance and resource on the burden of Alzheimer's disease and related dementias in the world population
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Alzheimers Dement
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2022
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Jul 12. doi: 10.1002/alz.12730. Online ahead of print.
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Hualong Wang, Ying Xu, Rujing Ren, Feng Yao, Mei Chen, Zhihua Sheng, Xin Guo, Yan Li, Shengdi Chen,
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Ambulatory Blood Pressure Characteristics of Patients with Alzheimer's Disease: A Multicenter Study from China
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J Alzheimers Dis
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2021
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83(3):1333-1339
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Hu YB,Zhang YF,Ren RJ,Dammer EB,Xie XY,Chen SW,Huang Q,Huang WY,Zhang R,Chen HZ,Wang H,
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microRNA-425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies
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Aging Cell
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2021
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20(10):e13454
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,陈生弟
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略论运动障碍性疾病的诊断评估思路
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重庆医科大学学报
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2021
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46(7):777-780
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Xie XY, Lin GZ, Huang Q, Li CB, Hallett M, Voon V, Ren RJ, Chen SD,
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Opinions and clinical practice of functional movement disorders: a nationwide survey of clinicians in China
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BMC Neurol
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2021
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21(1):435
|
|
尹豆,王含,张玉虎,倪臻,陈燕,陈先文,窦荣花,洪桢,况伟宏,林国珍,王玉凯,王华龙,薛峥,许顺良,陈伟,陈海波,陈生弟,李春波,
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功能性运动障碍的诊断与治疗中国专家共识
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重庆医科大学学报
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2021
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46(7):732-736
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Chen SW, Wang YK, Dou RH, Xie XY, Hu YB, Ding N, Zhang GH, Jing HF, Zhao WD, Xue Y, Li Y,
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Characteristics of the 24-h ambulatory blood pressure monitoring in patients with Parkinson's disease – the SFC BP multicentre study in China
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Journal of Hypertension
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2020
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38(11):2270-2278
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陈施吾,窦荣花,王玉凯,王含,王晓平,陈先文,陈玲,王训,屈洪党,陈生弟,Susan Fox,李燕,
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帕金森病血压管理专家共识
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内科理论与实践
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2020
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15(03):176-183
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Liu XY, Shi Q,
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Long survival sporadic Creutzfeldt-Jakob disease
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Neurology
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2020
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95(2):87-88
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Qiao Y, Xie XY, Lin GZ, Zou Y, Chen SD, Ren RJ,
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Computer-Assisted Speech Analysis in Mild Cognitive Impairment and Alzheimer's Disease: A Pilot Study from Shanghai, China
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J Alzheimers Dis
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2020
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75(1):211-221. doi: 10.3233/JAD-191056.
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Zhang YQ, Wang CF, Xu G, Zhao QH, Xie XY, Cui HL, Wang Y, Ren RJ, Guo QH,
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Mortality of Alzheimer's Disease Patients: A 10-Year Follow-up Pilot Study in Shanghai.
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Can J Neurol Sci.
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2020
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47(2):226-230. doi: 10.1017/cjn.2019.333
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Cui H, Ren R, Lin G, Zou Y, Jiang L, Wei Z, Li C,
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Repetitive Transcranial Magnetic Stimulation Induced Hypoconnectivity Within the Default Mode Network Yields Cognitive Improvements in Amnestic Mild Cognitive Impairment: A Randomized Controlled Study
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J Alzheimers Dis
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2019
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69(4):1137-1151
|
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Gao Y, Ren RJ, Zhong ZL, Dammer E, Zhao QH, Shan S, Zhou Z, Li X, Zhang YQ, Cui HL, Hu YB, Chen SD, Chen JJ, Guo QH,
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Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease.
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Neurobiol Aging
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2019
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77:154-157
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郭起浩,,武力勇。
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痴呆及相关认知障碍的神经心理诊断流程
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重庆医科大学学报
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2019
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44(4)：393-396
|
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Yue-qi Zhang, Ya-bin Tang, Eric Dammer, Jian-ren Liu, Yu-wu Zhao, Liang Zhu, Ru-jing Ren, Hong-zhuan Chen,, Qi Cheng.
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Dysregulated Urinary Arginine Metabolism in Older Adults With Amnestic Mild Cognitive Impairment
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Front. Aging Neurosci
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2019
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11:90. doi: 10.3389/fnagi.2019.00090. eCollection 2019
|
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Hu YB, Zhang YF, Wang H, Ren RJ, Cui HL, Huang WY, Cheng Q, Chen HZ,
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miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease.
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Cell Death Dis
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2019
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10(8):589.
|
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Cui SS, Du JJ, Liu SH, Meng J, Lin YQ, Li G, He YX, Zhang PC, Chen S,
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Serum soluble lymphocyte activation gene-3 as a diagnostic biomarker in Parkinson's disease: A pilot multicenter study.
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Mov Disord
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2019
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34(1):138-141.
|
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Hu YB, Ren RJ, Zhang YF, Huang Y, Cui HL, Ma C, Qiu WY, Wang H, Cui PJ, Chen HZ,
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Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology.
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Aging Cell
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2019
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Jul 9:e13001.
|
|
Yueqi Zhang,
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Response to: Sudden death in Parkinson's disease: Unjustifiably forgotten
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Parkinsonism Relat Disord
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2018
|
58:87. doi: 10.1016/j.parkreldis.2018.08.013
|
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Ying Gao, Xia Li, Xiao-Hong Liu, Qian-Hua Zhao, Xiang-Qian Che, Qi-Hao Guo, Ru-Jing Ren,
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Determining association of rho kinase 1 gene polymorphisms with risk of Alzheimer’s disease: a multicenter pilot study
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Annals of Translational Medicine
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2018
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6(22):434
|
|
, Hai-lun Cui, Yue Huang
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Reader response: Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium
|
Neurology
|
2018
|
90:300.
|
|
Yueqi Zhang, Chunfang Wang, Ying Wang, Qin Xiao, Jun Liu, Jianfang Ma, Haiyan Zhou, Jing Pan, Yuyan Tan, Shengdi Chen, Gang Xu,
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Mortality from Parkinson's disease in China: Findings from a ten-year follow up study in Shanghai
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Parkinsonism Relat Disord
|
2018
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May 22. pii: S1353-8020(18)30242-6. doi: 10.1016/j.parkreldis.2018.05.012. [Epub ahead of print]
|
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崔海伦,张一帆,管晓军,黄沛钰,刘志蓉,袁园,刘晓云,朱红灿,曹学兵, 陈玲,陈先文,陈燕,商慧芳,杨任民,陈生弟,张敏鸣,
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帕金森病及相关运动障碍的神经影像学诊断专家共识
|
诊断学理论与实践杂志
|
2018
|
17(4):403-408
|
|
, Cui HL.
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Reader response: Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
|
Neurology
|
2018
|
91(8):371-372
|
|
Che XQ, Song N, Gao Y, Ren RJ,
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Precision medicine of frontotemporal dementia: from genotype to phenotype.
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Front Biosci (Landmark Ed).
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2018
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Jan 1;23:1144-1165.
|
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Che XQ, Zhao QH, Huang Y, Li X, Ren RJ, Chen SD, Guo QH,
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Mutation Screening of the CHCHD2 Gene for Alzheimer's Disease and Frontotemporal Dementia in Chinese Mainland Population
|
J Alzheimers Dis
|
2018
|
61(4):1283-1288
|
|
, Hai-Lun Cui, Jun Liu, Qin Xiao, Ying Wang, Jian-Fang Ma, Hai-Yan Zhou, Jing Pan, Yu-Yan Tan, Sheng-Di Chen
|
Current approaches for the management of Parkinson’s disease in Chinese hospitals: a cross-sectional survey
|
BMC Neurology
|
2018
|
18:122
|
|
Qiu W, Zhang H, Bao A, Zhu K, Huang Y, Yan X, Zhang J, Zhong C, Shen Y, Zhou J, Zheng X, Zhang L, Shu Y, Tang B, Zhang Z,, Zhou R, Sun B, Gong C, Duan S, Ma C.
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Standardized Operational Protocol for Human Brain Banking in China.
|
Neurosci Bull
|
2018
|
Nov 8. doi: 10.1007/s12264-018-0306-7
|
|
Zou Y, Song N, Hu YB, Gao Y, Zhang YQ, Zhao QH, Guo QH, Li X, Li GJ, Xiao SF, Chen SD, Ren RJ,
|
Caregivers' attitude toward disclosure of Alzheimer's disease diagnosis in Urban China.
|
Int Psychogeriatr.
|
2017
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29(11):1849-1855
|
|
Che XQ, Zhao QH, Huang Y, Li X, Ren RJ, Chen SD,, Guo QH.
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Genetic Features of MAPT, GRN, C9orf72 and CHCHD10 Gene Mutations in Chinese Patients with Frontotemporal Dementia
|
Curr Alzheimer Res
|
2017
|
14(10):1102-1108
|
|
,吕发金.
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痴呆及相关认知障碍的神经影像学诊断流程建议
|
重庆医科大学学报
|
2017
|
42(6):680-682
|
|
Shi-Shuang Cui, Ru-Jing Ren, Ying Wang,,Sheng-Di Chen
|
Tics as an initial manifestation of juvenile Huntington’s disease: case report and literature review
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BMC Neurology
|
2017
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17(1):152.
|
|
Yang SS, Zhang R,, Zhang YF
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The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease.
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Transl Neurodegener
|
2017
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6:19.
|
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Zhang B, Wang LL, Ren RJ, Dammer EB, Zhang YF, Huang Y, Chen S,
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MicroRNA-146a represses LRP2 translation and leads to cell apoptosis in Alzheimer's disease.
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FEBS Lett
|
2016
|
590(14):2190-200
|
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Clin Chim Acta
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Ren RJ, Wang LL, Fang R, Liu LH, Wang Y, Tang HD, Deng YL, Xu W,, Chen SD
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The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population
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J Neurol Sci
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Visual hallucinations and associated factors in Chinese patients with Parkinson's disease: roles of RBD and visual pathway deficit.
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Parkinsonism Relat Disord
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2010
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